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1. Full Text Severe persistent allergic rhinitis inflammation but no histologic features of structural upper airway remodeling
by Eifan, Aarif O and Orban, Nara T and Jacobson, Mikila R and Durham, Stephen R
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 12/2015, Volume 192, Issue 12, pp. 1431 - 1439
Rationale: Increases in airway smooth muscle, extracellular matrix, and vascularity are prominent features of airway remodeling in asthma, whereas the extent... 
Angiogenesis | Lymphangiogenesis | Allergic rhinitis | Collagen | Allergen | allergen | NASAL-MUCOSA | MESSENGER-RNA EXPRESSION | angiogenesis | EOSINOPHILS | collagen | HYPERRESPONSIVENESS | MATRIX METALLOPROTEINASES | EPITHELIUM | RESPIRATORY SYSTEM | lymphangiogenesis | GENE-EXPRESSION | ASTHMA | allergic rhinitis | GROWTH-FACTOR | CRITICAL CARE MEDICINE | Humans | Middle Aged | Male | Rhinitis, Allergic - metabolism | Vascular Endothelial Growth Factor A - metabolism | Rhinitis, Allergic - physiopathology | Myofibroblasts - metabolism | Young Adult | Inflammation - complications | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Inflammation - metabolism | Matrix Metalloproteinase 9 - metabolism | Adult | Female | Nasal Mucosa - metabolism | Biomarkers - metabolism | Cytokines - metabolism | Endothelial Cells - metabolism | Airway Remodeling | Collagen - metabolism | Adolescent | HSP47 Heat-Shock Proteins - metabolism | Chronic Disease | Rhinitis, Allergic - complications | Inflammation - physiopathology
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2. Full Text Rapid recruitment of CD14+ monocytes in experimentally induced allergic rhinitis in human subjects
by Eguíluz-Gracia, Ibon, MD and Bosco, Anthony, PhD and Dollner, Ralph, MD, PhD and Melum, Guro Reinholt, MD, PhD and Lexberg, Maria H., PhD and Jones, Anya C., PhD and Dheyauldeen, Sinan Ahmed, MD and Holt, Patrick G., PhD and Bækkevold, Espen S., PhD and Jahnsen, Frode Lars, MD, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 137, Issue 6, pp. 1872 - 1881.e12
Background Activated TH 2 cells and eosinophils are hallmarks of the allergic inflammation seen in patients with allergic rhinitis (AR). However, which cells... 
Allergy and Immunology | CD14+ monocytes | nasal mucosa | dendritic cells | TH2-associated chemokines | resident macrophages | human airway allergy | monocytes | 2-associated chemokines | CD14 | NASAL-MUCOSA | ACTIVATION | LYMPH-NODES | UPPER AIRWAY MUCOSA | T(H)2-associated chemokines | MITE ALLERGEN | IMMUNOLOGY | CD14(+) monocytes | ALLERGY | ASTHMA | ANTIGEN-PRESENTING CELLS | DIFFERENTIATION | T-CELLS | T-Lymphocyte Subsets - immunology | Cytokines - metabolism | Signal Transduction | Rhinitis, Allergic - immunology | Dendritic Cells - immunology | Humans | Monocytes - metabolism | Gene Expression Profiling | Monocytes - immunology | Rhinitis, Allergic - metabolism | Nasal Mucosa - pathology | Rhinitis, Allergic - diagnosis | Lipopolysaccharide Receptors - metabolism | Allergens - immunology | Biopsy | Models, Biological | Nasal Mucosa - immunology | T-Lymphocyte Subsets - metabolism | Inflammation Mediators - metabolism | Adult | Nasal Mucosa - metabolism | Chemotaxis, Leukocyte - immunology | Dendritic Cells - metabolism | Cluster Analysis | Proteins | Antigens | Flow cytometry | Immunoglobulins | Dendritic cells | Lymphocytes | Cloning | Kinases | Gene expression | Allergies | Asthma
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3. Full Text miR-143 inhibits interleukin-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients by targeting IL13Rα1
by Teng, Yaoshu and Zhang, Ruxin and Liu, Chunhui and Zhou, Lingling and Wang, Hong and Zhuang, Wenjie and Huang, Yu and Hong, Zhicong
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2015, Volume 457, Issue 1, pp. 58 - 64
Allergic rhinitis (AR) is a common chronic inflammatory condition of the nasal mucosal tissue. The interleukin-13 (IL-13) signaling pathway is of great... 
Epithelial cell | Inflammation | miR-143 | Allergic rhinitis | Interleukin-13 | Rhinitis, Allergic - genetics | Epithelial Cells - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Epithelial Cells - drug effects | Humans | Middle Aged | Male | MicroRNAs - metabolism | Mucus - drug effects | Rhinitis, Allergic - metabolism | Nasal Mucosa - pathology | RNA, Messenger - metabolism | Lentivirus - metabolism | Young Adult | Inflammation Mediators - metabolism | Mucins - metabolism | Adult | Female | Mucus - metabolism | Chemokine CCL11 - metabolism | RNA, Messenger - genetics | Down-Regulation - drug effects | Interleukin-13 - pharmacology | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Interleukin-13 Receptor alpha1 Subunit - genetics | Up-Regulation - drug effects | MicroRNAs - genetics | Mucins - genetics | Interleukin-13 Receptor alpha1 Subunit - metabolism
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4. Full Text Dendritic cells revisited in human allergic rhinitis and asthma
by Froidure, A and Shen, C and Pilette, C
Allergy, ISSN 0105-4538, 02/2016, Volume 71, Issue 2, pp. 137 - 148
The role of dendritic cells (DCs) in airway allergy has been studied for 15 years; recent data has highlighted the cross talk with airway epithelial cells and... 
allergic inflammation | dendritic cells | bronchial epithelium | Asthma | Asthma - metabolism | Immunoglobulins - immunology | Dendritic Cells - immunology | Humans | Receptors, Fc - metabolism | Gene Expression Regulation | Immunophenotyping | Rhinitis, Allergic - metabolism | Th2 Cells - immunology | Environmental Exposure | Th2 Cells - metabolism | Mucous Membrane - metabolism | Host-Pathogen Interactions | Phenotype | Animals | Allergens - immunology | Mucous Membrane - immunology | Rhinitis, Allergic - etiology | Asthma - therapy | Receptors, Fc - genetics | Asthma - etiology | Toll-Like Receptors - metabolism | Dendritic Cells - metabolism | Rhinitis, Allergic - therapy | Dendritic cells | Allergens | Analysis | Allergies | Cells
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5. Full Text Gender difference, sex hormones, and immediate type hypersensitivity reactions
by Chen, W and Mempel, M and Schober, W and Behrendt, H and Ring, J
Allergy, ISSN 0105-4538, 11/2008, Volume 63, Issue 11, pp. 1418 - 1427
Gender differences in the development and prevalence of human diseases have long been recognized. Immense interest grows in the understanding of the role of... 
immediate hypersensitivity | androgen | estrogen | gender | progesterone | Gender | Progesterone | Androgen | Immediate hypersensitivity | Estrogen | RISK-FACTORS | HISTAMINE-RELEASE | IMMUNOLOGY | ADVERSE-REACTIONS | ATOPIC-DERMATITIS | PRESCHOOL-CHILDREN | ALLERGY | REPLACEMENT THERAPY | CONTRAST-MEDIA | NONALLERGIC RHINITIS | WASP VENOM ALLERGY | ALLERGIC-LIKE REACTIONS | Menopause - immunology | Asthma - metabolism | Humans | Angioedema - metabolism | Hypersensitivity - immunology | Male | Angioedema - immunology | Food Hypersensitivity - immunology | Hypersensitivity - metabolism | Asthma - immunology | Dermatitis, Atopic - immunology | Anaphylaxis - immunology | Conjunctivitis, Allergic - metabolism | Female | Contraceptives, Oral - immunology | Food Hypersensitivity - metabolism | Menstruation - immunology | Gonadal Steroid Hormones - metabolism | Urticaria - metabolism | Sex Characteristics | Urticaria - immunology | Menstruation - metabolism | Animals | Menopause - metabolism | Contraceptives, Oral - metabolism | Anaphylaxis - metabolism | Dermatitis, Atopic - metabolism | Gonadal Steroid Hormones - immunology | Conjunctivitis, Allergic - immunology | Immunoglobulin E | Allergy | Hormones, Sex | Allergic reaction | Gender differences | Hormones | Allergies | Medical immunity
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6. Full Text Intralymphatic treatment of flagellin–ovalbumin mixture reduced allergic inflammation in murine model of allergic rhinitis
by Kim, E. H and Kim, J. H and Samivel, R and Bae, J.‐S and Chung, Y.‐J and Chung, P.‐S and Lee, S. E and Mo, J.‐H
Allergy, ISSN 0105-4538, 05/2016, Volume 71, Issue 5, pp. 629 - 639
Background Bacterial flagellin, a Toll‐like receptor 5 agonist, is used as an adjuvant for immunomodulation. In this study, we aimed to evaluate the effect and... 
intralymphatic injection | flagellin | innate cytokine | allergic rhinitis | mouse model | Immunohistochemistry | Eosinophils - metabolism | Spleen - immunology | Ovalbumin - immunology | Rhinitis, Allergic - immunology | Rhinitis, Allergic - metabolism | Nasal Mucosa - pathology | Eosinophils - immunology | Rhinitis, Allergic - diagnosis | Allergens - administration & dosage | Immunoglobulin E - immunology | Allergens - immunology | Antibody Specificity - immunology | Flagellin - administration & dosage | Female | Eosinophils - pathology | Nasal Mucosa - metabolism | Cytokines - genetics | Disease Models, Animal | Neutrophil Infiltration - immunology | Severity of Illness Index | Flagellin - immunology | Cytokines - metabolism | Immunization - methods | Spleen - cytology | Animals | Ovalbumin - administration & dosage | Spleen - metabolism | Nasal Mucosa - immunology | Mice | Rhinitis, Allergic - therapy | Immunoglobulin E | Albumin | Inflammation | Rhinitis | Analysis | Cytokines | Nose | Allergies | Chemokines
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7. Full Text Protease‐activated receptor‐2 suppresses interleukin (IL)‐10 expression in B cells via upregulating Bcl2L12 in patients with allergic rhinitis
by Xue, J.‐M and Yang, L.‐T and Yang, G and Geng, X.‐R and Liu, Z.‐Q and Wang, S and Zhao, H.‐L and Liu, Z.‐G and Zhao, C.‐Q and Yang, P.‐C
Allergy, ISSN 0105-4538, 11/2017, Volume 72, Issue 11, pp. 1704 - 1712
Background and aims The function of interleukin (IL)‐10‐producing B cells (B10 cell) is compromised in patients with allergic diseases. Protease‐activated... 
Bcl2L12 | B cells | mouse model | Allergic rhinitis | Protease‐activated receptor 2 | Protease-activated receptor 2 | TOLERANCE | MECHANISMS | INDUCTION | IMMUNOLOGY | GLIOBLASTOMA | ALLERGY | IMMUNE-RESPONSES | DISEASE | Up-Regulation | B-Lymphocytes - enzymology | Rhinitis, Allergic - genetics | Humans | RNA, Small Interfering - pharmacology | Rhinitis, Allergic - metabolism | Muscle Proteins - genetics | Animals | Interleukin-10 - metabolism | Receptor, PAR-2 - physiology | Mice | RNA, Small Interfering - administration & dosage | Proto-Oncogene Proteins c-bcl-2 - genetics | B-Lymphocytes - metabolism | Interleukins | Rhinitis | Proteases | Analysis | Lymphocyte receptors | Cytokines | Immunoregulation | Interleukin | Hypersensitivity | Activation | Allergic diseases | Gene expression | Patients | BCL2L12 gene | Lipopolysaccharides | Respiratory tract | Immunosuppression | Cell activation | Par-2 protein | Lymphocytes B | Protease | Peripheral blood | Interleukin 10 | Liposomes
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8. Full Text "Allergic mood" - Depressive and anxiety symptoms in patients with seasonal allergic rhinitis (SAR) and their association to inflammatory, endocrine, and allergic markers
by Trikojat, K and Luksch, H and Rosen-Wolff, A and Plessow, F and Schmitt, J and Buske-Kirschbaum, A
BRAIN BEHAVIOR AND IMMUNITY, ISSN 0889-1591, 10/2017, Volume 65, pp. 202 - 209
A growing number of studies show an association between seasonal allergic rhinitis (SAR) with depression and anxiety. The underlying mechanisms of a link... 
FUTURE-DIRECTIONS | CYTOKINES | Seasonal allergic rhinitis | Depression | Psychoneuroimmunology | NECROSIS-FACTOR-ALPHA | MAJOR DEPRESSION | IMMUNOLOGY | HAY-FEVER | INTERLEUKIN-6 | NEUROSCIENCES | IL-6 | Sleep | IMMUNE-SYSTEM | ASTHMA | Anxiety | STRESS | Tumor Necrosis Factor-alpha - metabolism | Rhinitis, Allergic, Seasonal - metabolism | Humans | Male | Interferon-gamma - metabolism | Affect | Rhinitis, Allergic, Seasonal - immunology | Depression - etiology | Inflammation - metabolism | Immunoglobulin E - immunology | Tumor Necrosis Factor-alpha - immunology | Interleukin-10 - metabolism | Adult | Female | Pollen | Interleukin-6 - metabolism | Hypersensitivity | Immunoglobulin E - metabolism | Inflammation - immunology | Biomarkers - blood | Allergens - metabolism | Anxiety - immunology | Rhinitis, Allergic, Seasonal - psychology | Anxiety - etiology | Depression - immunology | Care and treatment | Corticosteroids | Rhinitis | Interleukins | Depression, Mental | Immunoglobulin E
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9. Full Text Effect of the potent and selective DP1 receptor antagonist, asapiprant (S-555739), in animal models of allergic rhinitis and allergic asthma
by Takahashi, Go and Asanuma, Fujio and Suzuki, Noriko and Hattori, Maki and Sakamoto, Shingo and Kugimiya, Akira and Tomita, Yasuhiko and Kuwajima, Goro and Abraham, William M and Deguchi, Masashi and Arimura, Akinori and Shichijo, Michitaka
European Journal of Pharmacology, ISSN 0014-2999, 10/2015, Volume 765, pp. 15 - 23
Prostaglandin (PG) D elicits responses through either the DP and/or DP receptor. Experimental evidence suggests that stimulation of the DP receptor contributes... 
Synthetic DP1 receptor antagonist | Nasal congestion | Prostaglandin D2 | Allergic rhinitis | Asapiprant | Synthetic DP 1 receptorantagonist | Prostaglandin D 2 | CELLS | CHEMOTAXIS | EOSINOPHILS | SHEEP | Prostaglandin D-2 | NASAL ALLERGY | CRTH2 | PHARMACOLOGY & PHARMACY | DERIVATIVES | EXPRESSION | ANTIGEN | Thiophenes - therapeutic use | Asthma - metabolism | Prostaglandins - pharmacology | Rhinitis, Allergic - immunology | Humans | Receptors, Prostaglandin - physiology | Male | Rhinitis, Allergic - metabolism | Prostaglandins - chemistry | Rats, Inbred BN | Respiratory Hypersensitivity - drug therapy | Asthma - immunology | Female | Receptors, Prostaglandin - antagonists & inhibitors | Disease Models, Animal | Prostaglandins - therapeutic use | Guinea Pigs | Respiratory Hypersensitivity - metabolism | Rats | Thiophenes - pharmacology | Treatment Outcome | Respiratory Hypersensitivity - immunology | Asthma - drug therapy | Animals | Dogs | Sheep | Thiophenes - chemistry | Rhinitis, Allergic - drug therapy | Rhinitis | Analysis | Models | Medicine, Experimental | Antigens | Medical research
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10. Full Text A rapid differential display analysis of nasal swab fingerprints to distinguish allergic from non‐allergic rhinitis subjects by mesoporous silica particles and MALDI‐TOF mass spectrometry
by Lombardo, Nicola and Preianò, Mariaimmacolata and Maggisano, Giuseppina and Murfuni, Maria Stella and Messina, Luigi and Pelaia, Girolamo and Savino, Rocco and Terracciano, Rosa
PROTEOMICS, ISSN 1615-9853, 03/2017, Volume 17, Issue 6, pp. 1600215 - n/a
Discriminating different rhinitis cases can sometimes be difficult as the diagnostic criteria used to identify the various subgroups are not always... 
Biomarkers | MALDI‐TOF‐MS | Peptidomics | Rhinitis | Respiratory system | MALDI-TOF-MS | BRONCHOALVEOLAR LAVAGE FLUIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | LYSOZYME | 2-DIMENSIONAL GEL-ELECTROPHORESIS | CHRONIC SINUSITIS | CHRONIC RHINOSINUSITIS | SECRETIONS | ANTIBACTERIAL ACTIVITY | BIOMARKER DISCOVERY | ASTHMA | PROTEOMICS | Reproducibility of Results | Humans | Middle Aged | Nose - chemistry | Silicon Dioxide - chemistry | Male | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods | Peptide Mapping - methods | Rhinitis, Allergic - metabolism | Rhinitis, Allergic - diagnosis | Case-Control Studies | Young Adult | Peptides - metabolism | Proteomics | Adult | Female | Porosity | Proteome - metabolism | Peptides | Mass spectrometry | Silica | Analysis | Invasiveness | Mass spectroscopy | Patients | Subgroups | Silicon dioxide | Inflammatory diseases | Histamine | Allergic rhinitis | Nose | Collection | Diagnostic systems | Differential display
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