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JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 09/2013, Volume 202, Issue 6, pp. 901 - 916
Reorganization of the actin cytoskeleton is responsible for dynamic regulation of endothelial cell (EC) barrier function. Circumferential actin bundles (CAB)... 
P21-ACTIVATED KINASE | EXCHANGE FACTOR | SMOOTH-MUSCLE | REGULATORY LIGHT-CHAIN | RHO-KINASE | BARRIER FUNCTION | VE-CADHERIN | ADHERENS JUNCTIONS | CDC42-BINDING KINASE | GROWTH-FACTOR | CELL BIOLOGY | RNA, Small Interfering - genetics | Phosphorylation | Cell Proliferation | rho GTP-Binding Proteins - antagonists & inhibitors | Human Umbilical Vein Endothelial Cells - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Actins - metabolism | cdc42 GTP-Binding Protein - metabolism | Immunoenzyme Techniques | rho-Associated Kinases - antagonists & inhibitors | Telomere-Binding Proteins - genetics | Protein-Tyrosine Kinases - genetics | Myosin Type II - metabolism | rho-Associated Kinases - metabolism | Human Umbilical Vein Endothelial Cells - cytology | cdc42 GTP-Binding Protein - antagonists & inhibitors | Cell Membrane - metabolism | Myosin Type II - genetics | Telomere-Binding Proteins - metabolism | Myotonin-Protein Kinase | rho GTP-Binding Proteins - genetics | Cells, Cultured | Intercellular Junctions - metabolism | rho-Associated Kinases - genetics | Cell Adhesion | Telomere-Binding Proteins - antagonists & inhibitors | Blotting, Western | cdc42 GTP-Binding Protein - genetics | rho GTP-Binding Proteins - metabolism | Cell Movement | Protein-Tyrosine Kinases - antagonists & inhibitors | Junctional complexes (Epithelium) | Cell junctions | Physiological aspects | Actin | Myosin | Endothelium
Journal Article
Biological Chemistry, ISSN 1431-6730, 11/2013, Volume 394, Issue 11, pp. 1399 - 1410
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2007, Volume 405, Issue 2, pp. 307 - 317
Mutations in the LRRK2 (leucine-rich repeat kinase-2) gene cause late-onset PD (Parkinson's disease). LRRK2 contains leucine-rich repeats, a GTPase domain, a... 
Kinase substrate tracking and elucidation screening (KESTREL screening) | Ezrin/radixin/moesin family of proteins (ERM proteins) | Protein kinase | Leucine-rich repeat kinase 2 (LRRK2) | Mass spectrometry (MS) | Parkinson's disease (PD) | SITE | GENE LRRK2 | DOMAIN | ERM PROTEINS | ezrin/radixin/moesin family of proteins (ERM proteins) | F-ACTIN BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | leucine-rich repeat kinase 2 (LRRK2) | protein kinase | kinase substrate tracking and elucidation screening (KESTREL screening) | IN-VITRO | EZRIN | MUTATIONS | ASSOCIATION | mass spectrometry (MS) | Amino Acid Sequence | Humans | Protein-Serine-Threonine Kinases - genetics | Rats | Parkinson Disease - genetics | Threonine - metabolism | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Animals | Cytoskeletal Proteins - metabolism | Membrane Proteins - metabolism | Microfilament Proteins - metabolism | Parkinson Disease - metabolism | Protein-Serine-Threonine Kinases - metabolism | LRRKtide, RLGRDKYKTLRQIRQ | BUBR1, Bub (budding uninhibited by benomyl)-related 1 | ezrin | GbpC, cGMP-binding protein C | moesin family of proteins (ERM proteins) | CRMP2, collapsin response mediator protein 2 | WD40, Trp-Asp 40 | MALDI-TOF, matrix-assisted laser-desorption ionization–time-of-flight | NCBI, National Center for Biotechnology Information | radixin | TSSK1, testis-specific serine kinase 1 | LRRK2, leucine-rich repeat kinase 2 | RIPK, Rho-interacting protein kinase | GST, glutathione S-transferase | LDS, lithium dodecyl sulfate | ROCK-II, Rho-associated kinase-2 | ERM, ezrin | PD, Parkinson's disease | MBP, myelin basic protein | moesin | COR, C-terminal of Roc (Ras of complex) | FERM, four-point-one | KESTREL, kinase substrate tracking and elucidation
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 05/2011, Volume 300, Issue 5, pp. 1181 - 1192
Enhanced vascular arginase activity impairs endothelium-dependent vasorelaxation by decreasing l-arginine availability to endothelial nitric oxide (NO)... 
Endothelial nitric oxide synthase dysfunction | PHYSIOLOGY | BLOOD-PRESSURE | P38 MAP KINASE | CELL BIOLOGY | INCREASED ARGINASE ACTIVITY | NITRIC-OXIDE PRODUCTION | INHIBITION | MOUSE MODEL | endothelial nitric oxide synthase dysfunction | CARDIOVASCULAR-DISEASE | SMOOTH-MUSCLE-CELLS | HYPERTENSIVE-RATS | CONTRIBUTES | Phosphorylation | Endothelial Cells | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Endothelium, Vascular - drug effects | Endothelium, Vascular - enzymology | GTP-Binding Protein alpha Subunits, G12-G13 - antagonists & inhibitors | Simvastatin - pharmacology | Angiotensin II Type 1 Receptor Blockers - pharmacology | rho-Associated Kinases - antagonists & inhibitors | Cattle | Arginase - antagonists & inhibitors | Amides - pharmacology | Cell Line | rho-Associated Kinases - physiology | Angiotensin II - pharmacology | p38 Mitogen-Activated Protein Kinases - physiology | RNA, Small Interfering - pharmacology | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | GTP-Binding Protein alpha Subunits, Gq-G11 - antagonists & inhibitors | Imidazoles - pharmacology | Animals | Signal Transduction - drug effects | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Signal Transduction - physiology | Mice | Pyridines - pharmacology | Arginase - physiology | Angiotensin II - physiology | Boronic Acids - pharmacology | Abnormalities | Angiotensin | Physiological aspects | Vascular endothelium | Genetic aspects | Research | Mitogen-activated protein kinases | Index Medicus | Vascular Biology
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 10/2003, Volume 93, Issue 8, pp. 767 - 775
ABSTRACT—Intracellular signaling pathway mediated by small GTPase Rho and its effector Rho-kinase plays an important role in regulation of vascular smooth... 
Rho-kinase | Superoxide anion | Angiotensin II | Cardiovascular hypertrophy | Arteriosclerosis | NADPH OXIDASE | CARDIAC & CARDIOVASCULAR SYSTEMS | MESSENGER-RNA EXPRESSION | TYROSINE KINASES | arteriosclerosis | CHEMOATTRACTANT PROTEIN-1 EXPRESSION | angiotensin II | cardiovascular hypertrophy | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | superoxide anion | CORONARY-ARTERY SPASM | HYPERTENSIVE-RATS | MYOSIN PHOSPHATASE | NEOINTIMAL FORMATION | NADPH Oxidases - metabolism | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Rats, Inbred WKY | Cardiomegaly - pathology | Endothelium, Vascular - drug effects | Male | Vasoconstrictor Agents - toxicity | Endothelium, Vascular - enzymology | Hypertension - chemically induced | rho-Associated Kinases | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Superoxides - metabolism | Angiotensin II - toxicity | Organ Culture Techniques | Macrophages - physiology | Coronary Vessels - pathology | Protein-Serine-Threonine Kinases - physiology | Endothelium, Vascular - physiopathology | Enzyme Inhibitors - pharmacology | Intracellular Signaling Peptides and Proteins | Rats | Cardiomegaly - enzymology | Aorta, Thoracic - cytology | Cell Movement - drug effects | Animals | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Cardiomegaly - chemically induced | Macrophages - drug effects | Vasodilation - drug effects
Journal Article
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 08/2011, Volume 31, Issue 8, pp. 1898 - 1907
OBJECTIVE—Circulating microparticles are increased in cardiovascular disease and may themselves promote oxidative stress and inflammation. Molecular mechanisms... 
endothelium | microparticles | signal transduction | angiotensin II | reactive oxygen species | NADPH OXIDASE | OXIDATIVE STRESS | SUPEROXIDE-PRODUCTION | HYPERTENSIVE PATIENTS | IN-VITRO | NAD(P)H OXIDASE | PLATELET-DERIVED MICROPARTICLES | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | CIRCULATING MICROPARTICLES | HEMATOLOGY | E-DEFICIENT MICE | Reactive Oxygen Species - metabolism | Tetrazoles - pharmacology | Apolipoproteins E - deficiency | Membrane Microdomains - metabolism | NADPH Oxidases - metabolism | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Male | Angiotensin II Type 1 Receptor Blockers - pharmacology | Endothelial Cells - ultrastructure | Biphenyl Compounds - pharmacology | Cell-Derived Microparticles - drug effects | rho-Associated Kinases - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Acetophenones - pharmacology | Blood Pressure - drug effects | Blood Pressure - physiology | Cell-Derived Microparticles - metabolism | Cell-Derived Microparticles - ultrastructure | Microscopy, Electron, Transmission | Angiotensin II - pharmacology | Angiotensin II - metabolism | Signal Transduction | Endothelial Cells - metabolism | Hypertrophy, Left Ventricular - etiology | Mice, Inbred C57BL | Cells, Cultured | Mice, Knockout | Animals | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Apolipoproteins E - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Vascular Cell Adhesion Molecule-1 - metabolism | Endothelial Cells - drug effects
Journal Article
Development, ISSN 0950-1991, 09/2009, Volume 136, Issue 18, pp. 3109 - 3119
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2005, Volume 392, Issue 3, pp. 641 - 648
Smooth muscle contraction is activated by phosphorylation at Set-19 of LC20 (the 20 kDa light chains of myosin 11) by Ca2+/calmodulin-dependent MLCK (myosin... 
Myosin phosphorylation | Zipper-interacting protein kinase | Microcystin | Integrin-linked kinase | Vascular smooth muscle | Myosin light-chain phosphatase | SWINE MODEL | CA2+ SENSITIZATION | ACTIVATION | vascular smooth muscle | REGULATORY LIGHT-CHAIN | PHOSPHORYLATION | PROTEIN-KINASE | PHOSPHATASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RHO-KINASE | zipper-interacting protein kinase | SIGNAL-TRANSDUCTION | myosin light-chain phosphatase | myosin phosphorylation | integrin-linked kinase | CORONARY-ARTERY SPASM | microcystin | MAP Kinase Kinase Kinases | Calcium - pharmacology | Muscle, Smooth, Vascular - metabolism | Calcium - metabolism | Rats | Peptides, Cyclic - pharmacology | Animals | Muscle Contraction - drug effects | Muscle Contraction - physiology | Myosins - metabolism | Phosphorylation - drug effects | Muscle, Smooth, Vascular - enzymology | Muscle, Smooth, Vascular - physiology | Protein-Serine-Threonine Kinases - metabolism | Microcystins | Muscle, Smooth, Vascular - drug effects | MLCK, myosin light-chain kinase | GST, glutathione S-transferase | MYPT1, myosin-targeting subunit of MLCP | ZIPK, zipper-interacting protein kinase | LC20, 20 kDa light chains of myosin II | PKC, protein kinase C | calmodulin-dependent protein kinases I and II respectively | ILK, integrin-linked kinase | [Ca2+]i, cytosolic free Ca2+ concentration | DTT, dithiothreitol | CaMKI | CPI-17, PKC-potentiated inhibitory protein for PP1 (protein phosphatase type 1) of 17 kDa | II, Ca2 | MAPKAPK2, mitogen-activated-protein-kinase-activated protein kinase-2 | AV25, 25-amino-acid peptide derived from the autoinhibitory domain of MLCK | PGF2α, prostaglandin F2α | ROK, Rho-associated kinase | MLCP, myosin light-chain phosphatase
Journal Article