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06/2010
Biological outputs of insulin/IGF signaling are regulated through essential mediators, such as IRSs, PI3-kinase, and PKB/Akt. These mediators serve critical... 
0369 | 0379 | Drosophila | Mice | PDZ-RhoGEF | DRhoGEF2
Dissertation
Genomics, ISSN 0888-7543, 10/2019
Journal Article
Journal of Structural Biology, ISSN 1047-8477, 04/2018, Volume 202, Issue 1, pp. 13 - 24
Rho family GTPases regulate a wide range of cellular processes. This includes cellular dynamics where three subfamilies, Rho, Rac, and Cdc42, are known to... 
Membrane localization | RhoGEF | GTPase | Crosstalk | PH domain | Crystal structure | LOCALIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | LARG | GEFS | BINDING PROTEIN | IDENTIFICATION | CELL BIOLOGY | ELEMENTS | BIOPHYSICS | NUCLEOTIDE EXCHANGE FACTOR | PLECKSTRIN HOMOLOGY DOMAIN | PDZ-RHOGEF | FOCAL ADHESION KINASE
Journal Article
SCIENCE, ISSN 0036-8075, 01/2010, Volume 327, Issue 5963, pp. 340 - 343
Integrins mediate cell adhesion to the extracellular matrix and transmit signals within the cell that stimulate cell spreading, retraction, migration, and... 
ACTIVATION | P115 RHOGEF | SRC | ROLES | PLATELETS | MULTIDISCIPLINARY SCIENCES | SHAPE CHANGE | SWITCH | MODEL | KINASES
Journal Article
Journal Article
The Journal of Biochemistry, ISSN 0021-924X, 10/2011, Volume 150, Issue 4, pp. 357 - 369
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 07/2012, Volume 287, Issue 30, pp. 25490 - 25500
RGS-containing RhoGEFs (RGS-RhoGEFs) represent a direct link between the G(12) class of heterotrimeric G proteins and the monomeric GTPases. In addition to the... 
COMPLEX | PROTEIN | P115 RHOGEF | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEOTIDE EXCHANGE FACTOR | PDZ-RHOGEF | RHO-GTPASES | BINDING | RGRGS DOMAIN | STRUCTURAL DETERMINANTS
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 03/2019, Volume 129, Issue 3, pp. 965 - 968
Primary antibody deficiencies are the most common immunodeficiencies in humans; however, identification of the underlying genetic and biochemical basis for... 
MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | ADHESION | MEMORY B-CELLS | PROTEIN | P115 RHOGEF | LSC
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 08/2003, Volume 278, Issue 31, pp. 28743 - 28749
The small GTPase RhoA is involved in the regulation of various cellular functions like the remodeling of the actin cytoskeleton and the induction of... 
NEURITE RETRACTION | SIGNALING PATHWAYS | SMOOTH-MUSCLE | HETEROTRIMERIC G-PROTEINS | P115 RHOGEF | G-ALPHA | LEUKEMIA-ASSOCIATED RHO | BIOCHEMISTRY & MOLECULAR BIOLOGY | PDZ-RHOGEF | G FAMILY | EXCHANGE FACTORS
Journal Article
CIRCULATION RESEARCH, ISSN 0009-7330, 10/2011, Volume 109, Issue 9, pp. 993 - U42
Rationale: In normal and diseased vascular smooth muscle (SM), the RhoA pathway, which is activated by multiple agonists through G protein-coupled receptors... 
CARDIAC & CARDIOVASCULAR SYSTEMS | vascular smooth muscle | HOMOLOGY DOMAIN | signal transduction | CRYSTAL-STRUCTURE | KINASE | CELL-PROLIFERATION | RhoA | Ca2+ sensitization | RhoGEF | GTPASE-ACTIVATING PROTEINS | CONTAINING RHOGEFS | PERIPHERAL VASCULAR DISEASE | NUCLEOTIDE-EXCHANGE FACTORS | RHO-GTPASES | HEMATOLOGY | HYPERTENSIVE-RATS | MYOSIN PHOSPHATASE
Journal Article
Journal Article
Neurosignals, ISSN 1424-862X, 02/2009, Volume 17, Issue 1, pp. 55 - 70
Journal Article
Genes and Cancer, ISSN 1947-6019, 11/2013, Volume 4, Issue 11-12, pp. 460 - 475
Ect2, a Rho guanine nucleotide exchange factor (RhoGEF), is atypical among RhoGEFs in its predominantly nuclear localization in interphase cells. One current... 
Ect2 | ovarian cancer | Rac | RhoGEF | Original
Journal Article
Small GTPases, ISSN 2154-1248, 05/2019, Volume 10, Issue 3, pp. 169 - 177
Small GTPases play crucial roles in the maintenance of a homeostatic environment and appropriate movements of the cell. In these processes, the direct or... 
ARHGEF10 | RhoGEF | membrane trafficking | RabGTPase
Journal Article
Cell Reports, ISSN 2211-1247, 11/2018, Volume 25, Issue 9, pp. 2417 - 2430.e5
The epithelial-specific splicing regulators Esrp1 and Esrp2 are required for mammalian development, including establishment of epidermal barrier functions.... 
epidermis | REGULATOR | DEFECTS | NETWORK | PROTEIN | ESRP1 | KERATINOCYTES | EPIDERMAL BARRIER | PDZ-RHOGEF | MECHANISMS | RECEPTORS | CELL BIOLOGY
Journal Article
NATURE STRUCTURAL & MOLECULAR BIOLOGY, ISSN 1545-9985, 02/2005, Volume 12, Issue 2, pp. 191 - 197
p115RhoGEF, a guanine nucleotide exchange factor (GEF) for Rho GTPase, is also a GTPase-activating protein (GAP) for G12 and G13 heterotrimeric Galpha... 
EXCHANGE FACTOR | DOMAIN | HETEROTRIMERIC G-PROTEINS | P115 RHOGEF | DBL FAMILY | G-ALPHA | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | BIOPHYSICS | PDZ-RHOGEF | G-ALPHA SUBUNITS | BINDING
Journal Article
Developmental Cell, ISSN 1534-5807, 04/2018, Volume 45, Issue 1, pp. 132 - 145.e3
Animal cells undergo a dramatic series of shape changes as they divide, which depend on re-modeling of cell-substrate adhesions. Here, we show that while focal... 
division | mitotic-rounding | cytokinesis | integrin-based adhesion | EXCHANGE FACTOR | RHOGEF ECT2 | FURROW FORMATION | SPINDLE | DICTYOSTELIUM-DISCOIDEUM | DEVELOPMENTAL BIOLOGY | CHROMOSOME SEGREGATION | RING-INDEPENDENT CYTOKINESIS | CLEAVAGE FURROW | RHOA | PTK2 CELLS | CELL BIOLOGY | Models | Biological products | Molecular biology | Analysis | Integrins
Journal Article