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Pflügers Archiv - European Journal of Physiology, ISSN 0031-6768, 8/2007, Volume 454, Issue 5, pp. 821 - 847
Drosophila visual transduction is the fastest known G-protein-coupled signaling cascade and has therefore served as a genetically tractable animal model for... 
Retinal degeneration | Phototransduction | Biomedicine | Human Physiology | Drosophila | retinal degeneration | PROTEIN-KINASE-C | PHYSIOLOGY | PHOSPHATIDYLINOSITOL TRANSFER PROTEIN | CYCLOPHILIN HOMOLOG NINAA | phototransduction | DOMINANT RETINITIS-PIGMENTOSA | PHOTORECEPTOR CELL-SURVIVAL | N-LINKED GLYCOSYLATION | PDZ-DOMAIN PROTEIN | A-BINDING-PROTEIN | RHODOPSIN-ARRESTIN COMPLEXES | LIGHT-SENSITIVE CHANNELS | Photoreceptor Cells, Invertebrate - physiology | Photoreceptor Cells, Invertebrate - anatomy & histology | Rhodopsin - metabolism | Rhodopsin - radiation effects | Vision, Ocular - radiation effects | Drosophila - physiology | Drosophila Proteins - radiation effects | Phosphatidylinositol 4,5-Diphosphate - metabolism | Vision, Ocular - physiology | Calcium Channels - physiology | Drosophila Proteins - physiology | Retinal Degeneration | Light | Transient Receptor Potential Channels - physiology | Eye Proteins - genetics | Genes, Insect - physiology | GTP-Binding Proteins - physiology | Drosophila - anatomy & histology | Multiprotein Complexes - physiology | Adaptation, Ocular - radiation effects | Animals | Rhodopsin - genetics | Eye Proteins - metabolism | Photoreceptor Cells, Invertebrate - pathology | Adaptation, Ocular - physiology | Vitamin A - biosynthesis | Physiological aspects | Insects | Retina | Apoptosis | Adaptations
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 04/2014, Volume 23, Issue 8, pp. 2164 - 2175
The molecular chaperone Hsp90 is important for the functional maturation of many client proteins, and inhibitors are in clinical trials for multiple... 
LEBER CONGENITAL AMAUROSIS | GENE | MUTANT RHODOPSIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEAT-SHOCK RESPONSE | MOUSE MODEL | KINASE | GENETICS & HEREDITY | RHODOPSIN-ARRESTIN COMPLEXES | CGMP PHOSPHODIESTERASE | QUALITY-CONTROL | DOMINANT RETINITIS-PIGMENTOSA | Retina - drug effects | Retina - metabolism | Vision, Ocular - drug effects | Rhodopsin - metabolism | Immunoenzyme Techniques | Vision, Ocular - physiology | Genes, Dominant | G-Protein-Coupled Receptor Kinase 1 - metabolism | Female | HSP90 Heat-Shock Proteins - genetics | Real-Time Polymerase Chain Reaction | Electroretinography | Genetic Predisposition to Disease | Rats, Transgenic | Tomography, Optical Coherence | Mice, Inbred C57BL | RNA, Messenger - genetics | Cells, Cultured | Rats | Retinitis Pigmentosa - genetics | Pyrimidines - pharmacology | Mutation - genetics | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Blotting, Western | Retinitis Pigmentosa - prevention & control | Animals | Rhodopsin - genetics | HSP90 Heat-Shock Proteins - antagonists & inhibitors | G-Protein-Coupled Receptor Kinase 1 - genetics | HSP90 Heat-Shock Proteins - metabolism | Mice | Retina - pathology | Retinitis Pigmentosa - pathology | Pyridones - pharmacology | Rhodopsin-arrestin complexes | Molecular genetics | Oftalmologia | Ciències de la salut | Dominant retinitis-pigmentosa | Mutant rhodopsin CGMP Phosphediesterase | Heat-shock response | Gene | Genètica molecular | Quality-control | Kinase | Leber congenital amaurosis | Mouse model | Ophthalmology | Medicina | Àrees temàtiques de la UPC
Journal Article
Journal Article
Neuron, ISSN 0896-6273, 01/2008, Volume 57, Issue 1, pp. 69 - 79
Neutral ceramidase, a key enzyme of sphingolipid metabolism, hydrolyzes ceramide to sphingosine. These sphingolipids are critical structural components of cell... 
PROTEINS | MOLNEURO | SIGNALING | NEUTRAL CERAMIDASE | RETINAL DEGENERATION | VISUAL TRANSDUCTION | APOPTOSIS | DROSOPHILA-MELANOGASTER | MEMBRANE | RHODOPSIN-ARRESTIN COMPLEXES | SPHINGOLIPIDS | ENDOCYTOSIS | NEUROSCIENCES | SPHINGOSINE 1-PHOSPHATE | Electroretinography - methods | Membrane Potentials - genetics | Protein Binding - genetics | Fat Body - ultrastructure | Apoptosis - radiation effects | Photoreceptor Cells, Invertebrate - physiology | Apoptosis - genetics | Retinal Degeneration - etiology | Membrane Potentials - radiation effects | Drosophila Proteins - metabolism | Rhodopsin - metabolism | Retinal Degeneration - metabolism | Mutation - physiology | Ceramidases | Sphingosine - metabolism | Fat Body - metabolism | Arrestin - metabolism | Gene Expression Regulation, Developmental - physiology | Eye - metabolism | Eye - ultrastructure | Animals, Genetically Modified | Retinal Degeneration - genetics | Drosophila | Animals | Photic Stimulation - methods | Amidohydrolases - physiology | Homeostasis - physiology | Embryo, Nonmammalian | Drosophila Proteins - genetics | Homeostasis | Physiological aspects | Sphingolipids | Sphingosine | Medical research | Enzymes | Cell culture | Membranes | Cloning | Experiments | Proteins | Insects | Mutagenesis | Light | Photoreceptors | Mutation | Labeling | Evacuations & rescues | Apoptosis
Journal Article
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