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Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2011, Volume 54, Issue 6, pp. 1812 - 1824
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2011, Volume 54, Issue 13, pp. 4462 - 4473
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2013, Volume 56, Issue 21, pp. 8588 - 8598
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 2011, Volume 44, Issue 6, pp. 978 - 988
Genome instability, a hallmark of cancer progression, is thought to arise through DNA double strand breaks (DSBs). Studies in yeast and mammalian cells have... 
GROSS CHROMOSOMAL REARRANGEMENTS | II TRANSCRIPTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | TRANSCRIPTION ELONGATION | TOPOISOMERASE-I | POLYMERASE-II | SACCHAROMYCES-CEREVISIAE | S-PHASE CHECKPOINT | MITOTIC RECOMBINATION | DNA-REPLICATION | CELL BIOLOGY | Nucleic Acid Hybridization | Ribonucleases - genetics | Histone Deacetylases - genetics | Saccharomyces cerevisiae - genetics | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Saccharomyces cerevisiae Proteins - genetics | Ribonucleases - metabolism | Chromosomes, Artificial, Yeast - genetics | RNA - genetics | DNA - genetics | RNA - biosynthesis | Cell Cycle | Rad52 DNA Repair and Recombination Protein - metabolism | Chromosomes, Artificial, Yeast - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae - enzymology | Transcription, Genetic | Mutation | Genomic Instability - genetics | Repressor Proteins - metabolism | Ribonuclease H - genetics | Ribonuclease H - metabolism | RNA | Oncology, Experimental | Genomics | DNA | Genetic research | Genomes | Biosynthesis | Research | Ribonuclease | Cells | Cancer | Enzymes | Hybrids | Splicing | Transcription | DNA damage | Ribonuclease H | Mammalian cells | Gene silencing | RNA transport | Evolution | Elongation | Rad52 protein | RNA-DNA hybrids | RNase H | transcription | genome instability
Journal Article
Journal Article
Journal Article
DNA Repair, ISSN 1568-7864, 12/2019, Volume 84, p. 102672
RNases H are a family of endonucleases that hydrolyze RNA residues in various nucleic acids. These enzymes are present in all branches of life, and their... 
Ribonuclease H | RNase H3 | RNase H2 | RNase H1 | Two-Metal-Ion catalysis | COLI RIBONUCLEASE HI | DOUBLE-STRANDED-RNA | CRYSTAL-STRUCTURE | REVERSE-TRANSCRIPTASE | MURINE LEUKEMIA-VIRUS | SACCHAROMYCES-CEREVISIAE | RNA/DNA HYBRID | SUBSTRATE-SPECIFICITY | GENETICS & HEREDITY | TOXICOLOGY | CATALYTIC MECHANISM | ANTISENSE OLIGONUCLEOTIDES
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2018, Volume 155, pp. 714 - 724
We reported herein the design, synthesis and biological evaluation of a series of 5-hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as HIV-1 reverse... 
HIV-1 IN | HIV-1 dual inhibitors | RNase H | 5-hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives | Privileged structure | HAART | RNASE-H | DESIGN | CHEMISTRY, MEDICINAL | RALTEGRAVIR | COLORIMETRIC ASSAY | POTENT | REPLICATION | DIKETO ACID-DERIVATIVES | ANTIVIRALS | DNA polymerases | Antiviral agents | Ribonuclease | HIV (Viruses) | Analysis
Journal Article
Journal Article