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Arthritis & Rheumatology, ISSN 2326-5191, 12/2015, Volume 67, Issue 12, pp. 3234 - 3244
Objective To determine the relationships between systemic sclerosis (SSc)–related autoantibodies, as well as their clinical associations, in a... 
ANTIBODIES | ANTRAL VASCULAR ECTASIA | SUBSETS | CLASSIFICATION | PREVALENCE | RHEUMATOLOGY | JAPANESE PATIENTS | FRENCH | RNA-POLYMERASE-III | CLINICAL-SIGNIFICANCE | FEATURES | Receptors, Platelet-Derived Growth Factor - immunology | Gastric Antral Vascular Ectasia - immunology | Humans | Middle Aged | Centromere Protein B - immunology | Immunoblotting | Male | Raynaud Disease - etiology | DNA Topoisomerases, Type I - immunology | Esophageal Motility Disorders - etiology | Centromere Protein A | Scleroderma, Systemic - complications | Ribonucleoproteins - immunology | Female | Contracture - immunology | Gastric Antral Vascular Ectasia - etiology | Telangiectasis - immunology | Principal Component Analysis | DNA-Binding Proteins - immunology | Exoribonucleases - immunology | RNA-Binding Proteins - immunology | Scleroderma, Systemic - immunology | RNA Polymerase III - immunology | Scleroderma, Systemic - epidemiology | Chromosomal Proteins, Non-Histone - immunology | Autoantibodies - immunology | Ku Autoantigen | Telangiectasis - etiology | Smoking - epidemiology | Autoantigens - immunology | Sex Factors | Aged | Exosome Multienzyme Ribonuclease Complex - immunology | Pol1 Transcription Initiation Complex Proteins - immunology | Raynaud Disease - immunology | Australia | Esophageal Motility Disorders - immunology | Antigens, Nuclear - immunology | Neoplasms - epidemiology | Cohort Studies | Contracture - etiology | Principal components analysis | RNA polymerase | Autoimmune diseases | Patients
Journal Article
Immunity, ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 475 - 487
Interleukin-17 (IL-17) induces pathology in autoimmunity and infections; therefore, constraint of this pathway is an essential component of its regulation. We... 
negative regulation | Regnase-1 | fungal immunity | autoimmunity | signal transduction | IL-17 | Autoimmunity | Signal transduction | Fungal immunity | Negative regulation | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | IL-17 RECEPTOR | TARGET GENES | CANDIDA-ALBICANS | C/EBP-BETA | GENE-EXPRESSION | HOST-DEFENSE | NECROSIS-FACTOR-ALPHA | MESSENGER-RNA STABILITY | T-CELL | IMMUNOLOGY | Candidiasis - genetics | Oncogene Proteins - genetics | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Immunoblotting | Male | Receptors, Interleukin-17 - genetics | Ribonucleases - metabolism | Host-Pathogen Interactions - immunology | Inflammation - metabolism | Lipocalins - genetics | Adaptor Proteins, Signal Transducing - immunology | Pneumonia - immunology | Candida albicans - physiology | Encephalomyelitis, Autoimmune, Experimental - genetics | Receptors, Interleukin-17 - metabolism | Interleukin-6 - metabolism | Pneumonia - genetics | Interleukin-6 - genetics | Oncogene Proteins - metabolism | Signal Transduction - genetics | Candida albicans - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Interleukin-17 - metabolism | Lipocalin-2 | Lipocalins - immunology | Interleukin-6 - immunology | Pneumonia - metabolism | Ribonucleases - genetics | Encephalomyelitis, Autoimmune, Experimental - metabolism | Receptors, Interleukin-17 - immunology | Interleukin-17 - immunology | Acute-Phase Proteins - genetics | Candidiasis - microbiology | Signal Transduction - immunology | HEK293 Cells | Female | Candidiasis - immunology | Nuclear Proteins - genetics | Oncogene Proteins - immunology | Lipocalins - metabolism | Cell Line | Acute-Phase Proteins - metabolism | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Inflammation - immunology | Nuclear Proteins - immunology | Animals | Ribonucleases - immunology | Adaptor Proteins, Signal Transducing - genetics | Inflammation - genetics | Adaptor Proteins, Signal Transducing - metabolism | Acute-Phase Proteins - immunology | Medical colleges | Nucleases | Interleukins | RNA | Cellular signal transduction | Inflammation | Proteins | Cytokines | Rodents | Fibroblasts | Infections | Kinases | Laboratory animals | Gene expression | Experiments
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2013, Volume 190, Issue 2, pp. 650 - 658
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2011, Volume 286, Issue 30, pp. 26487 - 26495
Dendritic cells (DCs) and macrophages (MFs) are important multifunctional immune cells. Like other cell types, they express hundreds of different microRNAs... 
MESSENGER-RNA DEGRADATION | TARGET | ACTIVATION | IMMUNE-SYSTEM | IMMUNOTHERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | DIFFERENTIATION | TRANSLATION | PROTEIN-SYNTHESIS | CANCER | Cell Adhesion Molecules - genetics | B7-1 Antigen - genetics | Toll-Like Receptor 4 - biosynthesis | Monocytes - cytology | Dendritic Cells - immunology | Humans | Lectins, C-Type - immunology | MicroRNAs - metabolism | Monocytes - metabolism | Gene Expression Profiling | Monocytes - immunology | Cell Adhesion Molecules - immunology | Lectins, C-Type - genetics | Gene Knockdown Techniques | Lipopolysaccharide Receptors - metabolism | Lectins, C-Type - metabolism | Ribonuclease III - immunology | HEK293 Cells | DEAD-box RNA Helicases - metabolism | Cell Differentiation - physiology | Dendritic Cells - metabolism | Macrophages - immunology | Ribonuclease III - genetics | Ribonuclease III - metabolism | B7-1 Antigen - immunology | Gene Expression Regulation - physiology | Receptors, Cell Surface - metabolism | Toll-Like Receptor 4 - genetics | Lipopolysaccharide Receptors - immunology | MicroRNAs - biosynthesis | B7-1 Antigen - metabolism | Toll-Like Receptor 4 - immunology | Macrophages - cytology | MicroRNAs - immunology | Cell Adhesion Molecules - metabolism | Receptors, Cell Surface - immunology | DEAD-box RNA Helicases - genetics | Macrophages - metabolism | DEAD-box RNA Helicases - immunology | Lipopolysaccharide Receptors - genetics | Dendritic Cells - cytology | MicroRNAs - genetics | Receptors, Cell Surface - genetics | Toll-like Receptors (TLR) | Gene Expression | Immunology | Dendritic Cells | MicroRNA | CD80 | Microarray | Mannose Receptor
Journal Article
Journal of immunology (Baltimore, Md, ISSN 0022-1767, 2015, Volume 194, Issue 8, pp. 3623 - 3633
Aicardi-Goutières syndrome (AGS) is a monogenic inflammatory encephalopathy caused by mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, or MDA5.... 
INTERFERON-ALPHA | ACTIVATION | TREX1 | DNA | MUTATIONS | IMMUNOLOGY | SAMHD1 | RIBONUCLEOTIDES | ASTROCYTES | EXPRESSION | CEREBRAL VASCULOPATHY | Phosphoproteins - immunology | RNA-Binding Proteins - genetics | Exodeoxyribonucleases - immunology | Nervous System Malformations - immunology | Humans | Astrocytes - pathology | SAM Domain and HD Domain-Containing Protein 1 | Monomeric GTP-Binding Proteins - immunology | Autoimmune Diseases of the Nervous System - pathology | Autoimmune Diseases of the Nervous System - mortality | Ribonuclease H - immunology | Neural Stem Cells - immunology | Astrocytes - immunology | Interferon-alpha - genetics | Autoimmune Diseases of the Nervous System - genetics | HEK293 Cells | Exodeoxyribonucleases - genetics | Nervous System Malformations - genetics | Cytokines - genetics | Cytokines - immunology | Ribonuclease H - genetics | Adenosine Deaminase - genetics | Nervous System Malformations - pathology | RNA-Binding Proteins - immunology | Gene Silencing | Monomeric GTP-Binding Proteins - genetics | Phosphoproteins - genetics | Neural Stem Cells - pathology | Interferon-alpha - immunology | Endothelial Cells - immunology | Autoimmune Diseases of the Nervous System - immunology | Nervous System Malformations - mortality | Mutation | Endothelial Cells - pathology | Adenosine Deaminase - immunology
Journal Article
Trends in Immunology, ISSN 1471-4906, 2015, Volume 36, Issue 3, pp. 179 - 188
Highlights • The nonsense-mediated decay (NMD) pathway defends cells against RNA virus invasion. • NMD targets viral RNAs for degradation, including by the RNA... 
Allergy and Immunology | type I interferon | RNA exosome | nonsense-mediated decay | pattern-recognition receptor | Aicardi-Goutières syndrome | MDA5 | Nonsense-mediated decay | Type I interferon | Pattern-recognition receptor | RIG-I | IMMUNOLOGY | EXONUCLEASE TREX1 | MAMMALS NO NEWS | AICARDI-GOUTIERES-SYNDROME | UNFOLDED PROTEIN RESPONSE | EDITING ENZYME ADAR1 | MESSENGER-RNA | RIBONUCLEASE H2 | Aicardi-Goutieres syndrome | ROUS-SARCOMA-VIRUS | Autoimmunity | Nervous System Malformations - immunology | Endoribonucleases - metabolism | Signal Transduction | Nervous System Malformations - pathology | Humans | Viruses - immunology | Immunity, Innate | Interferon Type I - immunology | Autoimmune Diseases of the Nervous System - pathology | Host-Pathogen Interactions | Autoimmune Diseases of the Nervous System - immunology | Nonsense Mediated mRNA Decay - immunology | Lupus Erythematosus, Systemic - genetics | Autoimmune Diseases of the Nervous System - genetics | Lupus Erythematosus, Systemic - immunology | Interferon Type I - genetics | RNA, Viral - immunology | Exosome Multienzyme Ribonuclease Complex - immunology | RNA, Viral - metabolism | Nervous System Malformations - genetics | Lupus Erythematosus, Systemic - pathology | Endoribonucleases - immunology | RNA | Proteins | Reading | Surveillance | Genes | Viruses | Infections | Cytoplasm | Deoxyribonucleic acid--DNA | Immune system | Review
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, p. e0131139
Background Several soluble factors have been reported to have the capacity of inhibiting HIV replication at different steps of the virus life cycle, without... 
TRACT | CELLS | PLASMA | MESSENGER-RNA | SERONEGATIVE INDIVIDUALS | MULTIDISCIPLINARY SCIENCES | SERPIN A1 | ALPHA-1-ANTITRYPSIN | RESTRICTION | HIV-1 INFECTION | SAMHD1 | HIV Infections - prevention & control | Ribonucleases - genetics | Antiviral Agents - immunology | Humans | Middle Aged | SAM Domain and HD Domain-Containing Protein 1 | Male | Monomeric GTP-Binding Proteins - immunology | Elafin - immunology | HIV Long-Term Survivors | Aminohydrolases - genetics | RNA, Messenger - metabolism | Case-Control Studies | Host-Pathogen Interactions - immunology | Lymphoid Tissue - immunology | Young Adult | HIV Infections - immunology | Aminohydrolases - immunology | Adult | Female | alpha 1-Antitrypsin - immunology | Carrier Proteins - immunology | Elafin - genetics | alpha 1-Antitrypsin - genetics | Cross-Sectional Studies | Genitalia, Female - immunology | HIV Infections - virology | RNA, Messenger - genetics | Mouth Mucosa - immunology | Virus Replication - immunology | Monomeric GTP-Binding Proteins - genetics | Disease Progression | HIV Seronegativity - immunology | Carrier Proteins - genetics | Host-Pathogen Interactions - genetics | Ribonucleases - immunology | Cohort Studies | Infection | Antiviral agents | Somatotropin | RNA | Analysis | Exhibitions | Ribonuclease | Health aspects | HIV infection | Controllers | Antiretroviral drugs | Enzymes | Polypeptides | Mucosa | Viruses | Leukocytes (mononuclear) | Infections | Lymphoid tissue | Apolipoproteins | Gene expression | Blood | Virology | Proteins | Disease resistance | Acquired immune deficiency syndrome--AIDS | Gut-associated lymphoid tissues | Human immunodeficiency virus--HIV | Life cycle engineering | Peripheral blood mononuclear cells | Replication | Ribonuclease 7 | Life cycles | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
Journal Article
Immunological Reviews, ISSN 0105-2896, 01/2009, Volume 227, Issue 1, pp. 176 - 188
Journal Article