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Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 11/2015, Volume 28, Issue 5, pp. 557 - 568
Histone H3K36 trimethylation (H3K36me3) is frequently lost in multiple cancer types, identifying it as an important therapeutic target. Here we identify a... 
WEE1 inhibitor | KDM4A | SETD2 | DNA replication | RRM2 | histone modification | synthetic lethality | CDK | ChIP | H3.3K36M | H3K36me3 | AZD1775 | epigenetic target | iPOND | ATR inhibitor | CHK1 inhibitor | cancer | Synthetic lethality | IPOND | Histone modification | Epigenetic target | Cancer | EPIGENETIC REGULATORS | METHYLTRANSFERASE SETD2 | REPAIR | THERAPEUTIC STRATEGY | ONCOLOGY | GENOME INTEGRITY | S-PHASE | STRAND DNA BREAKS | HOMOLOGOUS RECOMBINATION | REPLICATION INITIATION | RENAL-CELL CARCINOMA | CELL BIOLOGY | Neoplasms - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Cell Survival - genetics | Molecular Sequence Data | Nucleotides - genetics | Neoplasms - prevention & control | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - genetics | Neoplasms - genetics | RNA Interference | Base Sequence | Cell Cycle Proteins - genetics | Lysine - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Ribonucleoside Diphosphate Reductase - metabolism | Nuclear Proteins - genetics | Pyrazoles - pharmacology | Amino Acid Sequence | Cell Survival - drug effects | Histone-Lysine N-Methyltransferase - genetics | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Ribonucleoside Diphosphate Reductase - genetics | Pyrimidines - pharmacology | Nucleotides - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Sequence Homology, Nucleic Acid | Blotting, Western | Sequence Homology, Amino Acid | Xenograft Model Antitumor Assays | Lysine - genetics | Animals | Histones - genetics | Histone-Lysine N-Methyltransferase - metabolism | Methylation - drug effects | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice, Inbred BALB C | Histones - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Medical colleges | Starvation | Hospitals | Epigenetic inheritance | Index Medicus
Journal Article
Protein Engineering, Design & Selection, ISSN 1741-0126, 8/2010, Volume 23, Issue 8, pp. 633 - 641
Ribonucleotide reductase (RNR) synthesizes deoxyribonucleotides for DNA replication and repair and is controlled by sophisticated allosteric regulation... 
Bacillus anthracis | inhibitors | interaction constants | biotin-streptavidin immobilization | nucleotides | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | DIPHOSPHATE REDUCTASE | EFFECTORS | PROTEIN R1 | INHIBITION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BINDING | Surface Plasmon Resonance | Enzymes, Immobilized - metabolism | Ribonucleotide Reductases - chemistry | Allosteric Regulation | Bacterial Proteins - chemistry | Substrate Specificity | Guanosine Triphosphate - metabolism | Bacillus anthracis - enzymology | Biotin - chemistry | Adenosine Triphosphate - metabolism | Escherichia coli - metabolism | Biotin - metabolism | Guanosine Diphosphate - metabolism | Ribonucleoside Diphosphate Reductase - metabolism | Bacillus anthracis - genetics | Bacillus anthracis - metabolism | Binding Sites | Streptavidin - chemistry | Enzymes, Immobilized - chemistry | Escherichia coli - enzymology | Bacterial Proteins - genetics | Escherichia coli Proteins - metabolism | Ribonucleoside Diphosphate Reductase - genetics | Enzymes, Immobilized - genetics | Streptavidin - metabolism | Escherichia coli - genetics | Biosensing Techniques | Ribonucleotide Reductases - metabolism | Escherichia coli Proteins - genetics | Protein Binding | Bacterial Proteins - metabolism | Ribonucleotide Reductases - genetics | Escherichia coli Proteins - chemistry | Ribonucleoside Diphosphate Reductase - chemistry | Original | Biological Sciences | Biology | Molekylärbiologi | Naturvetenskap | Biokemi och molekylärbiologi | Biologiska vetenskaper | Cell and molecular biology | Biochemistry and Molecular Biology | Biologi | Natural Sciences | Molecular biology | Cell- och molekylärbiologi
Journal Article
Cancer Research, ISSN 0008-5472, 04/2006, Volume 66, Issue 7, pp. 3928 - 3935
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 11/2015, Volume 14, Issue 11, pp. 2411 - 2421
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2009, Volume 284, Issue 27, pp. 18085 - 18095
Journal Article
Journal Article
by Wang, N and Zhan, T and Ke, T and Huang, X and Ke, D and Wang, Q and Li, H
British Journal of Cancer, ISSN 0007-0920, 02/2014, Volume 110, Issue 4, pp. 1034 - 1044
Journal Article