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Journal Article
Journal Article
Journal Article
Journal Article
Leukemia Research, ISSN 0145-2126, 2007, Volume 32, Issue 1, pp. 71 - 77
Abstract Triapine® is a potent ribonucleotide reductase (RR) inhibitor that depletes intracellular deoxyribonculeotide pools, especially dATP. We designed a... 
Hematology, Oncology and Palliative Medicine | Rbonucleotide reductase | Fludarabine | Myeloproliferative disorders | Triapine | Refractory acute leukemia | RESPONSE CRITERIA | ACUTE MYELOGENOUS LEUKEMIA | HYDROXYUREA | 1-BETA-D-ARABINOFURANOSYLCYTOSINE | CYTARABINE | myeloproliferative disorders | rbonucleotide reductase | GEMCITABINE | INTERNATIONAL WORKING GROUP | INDUCTION THERAPY | METABOLISM | ONCOLOGY | refractory acute leukemia | fludarabine | ARA-C | HEMATOLOGY | Recurrence | Pyridines - administration & dosage | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Treatment Outcome | Myeloproliferative Disorders - drug therapy | Vidarabine - analogs & derivatives | Thiosemicarbazones - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Precursor Cell Lymphoblastic Leukemia-Lymphoma - diet therapy | Leukemia, Myeloid, Acute - drug therapy | Adult | Female | Aged | Vidarabine - administration & dosage | Myelodysplastic Syndromes - drug therapy | Antimitotic agents | Care and treatment | Oncology, Experimental | Bone marrow | Nucleosides | Clinical trials | Transplantation | Research | Antineoplastic agents | Cancer | Adenosine | nucleoside analogs | Ribonucleoside-triphosphate reductase | Toxicity | Leukemia | Malignancy | Fever | Metabolic acidosis | Myeloproliferative diseases | triapine | ribonucleotide reductase
Journal Article
Journal Article
Cancer, ISSN 0008-543X, 01/2013, Volume 119, Issue 2, pp. 454 - 462
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 02/2012, Volume 52, Issue 4, pp. 803 - 810
Ribonucleotide reductase (RNR) activity requires an electron donor, which in bacteria, yeast, and plants is usually either reduced thioredoxin (Trx) or reduced... 
DNA replication | Hepatocyte | Mouse | Thioredoxin reductase | Glutathione | EARLY EMBRYONIC LETHALITY | THIOREDOXIN REDUCTASE 1 | MAMMALIAN THIOREDOXIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE | RESPONSE ELEMENT | REDOX SYSTEMS | GENE | ENDOCRINOLOGY & METABOLISM | S-PHASE | HYDROGEN DONOR SYSTEM | Cell Proliferation | Liver - enzymology | Exons | Glutathione - metabolism | Molecular Sequence Data | Thioredoxin Reductase 1 - deficiency | Glutathione Disulfide - metabolism | Hepatocytes - metabolism | Liver - growth & development | Isoenzymes - metabolism | Base Sequence | Thioredoxins - metabolism | Transcription, Genetic | Hepatocytes - physiology | Isoenzymes - genetics | Liver - metabolism | Mice, Inbred C57BL | DNA Replication | Thioredoxin Reductase 2 - genetics | Glutathione - physiology | Thioredoxin Reductase 2 - metabolism | Animals | Heterozygote | Liver - cytology | Mice | Thioredoxin Reductase 1 - genetics | Histones - metabolism | Proliferating Cell Nuclear Antigen - metabolism | Hepatocytes - enzymology | Thioredoxin Reductase 1 - metabolism | Antigen-antibody reactions | Messenger RNA | Growth | Liver | DNA | Genes | Albumin | Genetic research | Thioredoxin | Cells | RNA | DNA polymerases | DNA biosynthesis | Enzymes | Thioredoxin-disulfide reductase | Buthionine sulfoximine | Hepatocytes | Ribonucleoside-triphosphate reductase | Glutaredoxin | Replication | mRNA | glutathione reductase | mouse | hepatocyte | glutathione | thioredoxin reductase
Journal Article