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Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2000, Volume 346, Issue 1, pp. 1 - 8
Journal Article
Oncogene, ISSN 0950-9232, 03/2019, Volume 38, Issue 13, pp. 2364 - 2379
Journal Article
Journal Article
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 06/2019, Volume 10, Issue 1, pp. 2653 - 13
Ribonucleotide reductases (RNRs) use a conserved radical-based mechanism to catalyze the conversion of ribonucleotides to deoxyribonucleotides. Within the RNR... 
SYSTEM | SITE | ENZYME | SMALL-ANGLE SCATTERING | SPECTROSCOPY | MULTIDISCIPLINARY SCIENCES | SALMONELLA-TYPHIMURIUM | X-RAY-SCATTERING | PROTEINS | RADICAL TRANSFER | SUBUNIT | Reductases | Electron microscopy | Small angle X ray scattering | Crystallography | Convergence | Ribonucleotides | X-ray scattering | Deoxyribonucleotides | Ribonucleotide reductase | Filaments | X ray scattering | Gymnastics | Reductase
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 04/2013, Volume 21, Issue 7, pp. 1992 - 2000
Journal Article
Leukemia Research, ISSN 0145-2126, 2007, Volume 32, Issue 1, pp. 71 - 77
Abstract Triapine® is a potent ribonucleotide reductase (RR) inhibitor that depletes intracellular deoxyribonculeotide pools, especially dATP. We designed a... 
Hematology, Oncology and Palliative Medicine | Rbonucleotide reductase | Fludarabine | Myeloproliferative disorders | Triapine | Refractory acute leukemia | CHRONIC MYELOGENOUS LEUKEMIA | CELLS | RESPONSE CRITERIA | NERVOUS-SYSTEM TOXICITY | HYDROXYUREA | myeloproliferative disorders | rbonucleotide reductase | INTERNATIONAL WORKING GROUP | INDUCTION THERAPY | METABOLISM | ONCOLOGY | refractory acute leukemia | fludarabine | ARA-C | HEMATOLOGY | MYELODYSPLASTIC SYNDROMES | Recurrence | Pyridines - administration & dosage | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Treatment Outcome | Myeloproliferative Disorders - drug therapy | Vidarabine - analogs & derivatives | Thiosemicarbazones - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Precursor Cell Lymphoblastic Leukemia-Lymphoma - diet therapy | Leukemia, Myeloid, Acute - drug therapy | Adult | Female | Aged | Vidarabine - administration & dosage | Myelodysplastic Syndromes - drug therapy | Antimitotic agents | Care and treatment | Oncology, Experimental | Bone marrow | Nucleosides | Clinical trials | Transplantation | Research | Antineoplastic agents | Cancer | Adenosine | nucleoside analogs | Ribonucleoside-triphosphate reductase | Toxicity | Leukemia | Malignancy | Fever | Metabolic acidosis | Myeloproliferative diseases | triapine | ribonucleotide reductase
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2007, Volume 50, Issue 6, pp. 1254 - 1265
Journal Article