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PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, p. e0148089
Cellular energy regulation relies on complex signaling pathways that respond to fuel availability and metabolic demands. Dysregulation of these networks is... 
LIFE-SPAN | PPAR-ALPHA | ENERGY | FATTY-ACID-COMPOSITION | GLUCOSE | MULTIDISCIPLINARY SCIENCES | RECEPTOR NHR-49 | GENE-EXPRESSION | C-ELEGANS | LACTIC-ACIDOSIS | DIETARY RESTRICTION | Humans | Caenorhabditis elegans Proteins - metabolism | Oxygen - metabolism | Protein Subunits - metabolism | Aminoimidazole Carboxamide - pharmacology | Ribonucleotides - pharmacology | Cell Respiration - drug effects | Transcription, Genetic | Energy Metabolism - genetics | Fatty Acids - metabolism | Protein-Serine-Threonine Kinases - metabolism | Protein Subunits - genetics | Caenorhabditis elegans - metabolism | Signal Transduction | Caenorhabditis elegans - genetics | Lactic Acid - metabolism | Metformin - pharmacology | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Mitochondria - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Longevity - genetics | Mitochondria - drug effects | Transcription Factors - genetics | Transcription Factors - metabolism | Animals | Caenorhabditis elegans - drug effects | Aminoimidazole Carboxamide - analogs & derivatives | Oxygen Consumption - drug effects | Glucose - metabolism | Caenorhabditis elegans Proteins - genetics | Energy Metabolism - drug effects | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Cell metabolism | Caenorhabditis elegans | Genetic aspects | Research | Protein kinases | Oxidative stress | Energy metabolism | Regulators | Transcription factors | Phosphorylation | Transcription | Oxidative metabolism | Homeostasis | Lipids | Kinases | AMP-activated protein kinase | Protein turnover | Proteins | Mitochondria | Energy | Evolutionary conservation | Physiology | Catalysis | Worms | Enzymes | AMP | Oxygen consumption | Fluxes | Metabolism | Mammals | Gene expression | Fatty acids | Strain | Signaling | Nematodes | Glycolysis | Diabetes | Lactic acid | Metformin | Metabolic disorders
Journal Article
Acta Physiologica, ISSN 1748-1708, 05/2009, Volume 196, Issue 1, pp. 81 - 98
As the liver is central in the maintenance of glucose homeostasis and energy storage, knowledge of the physiology as well as physiopathology of hepatic energy... 
hepatic glucose production | fatty liver | type 2 diabetes | AMP-activated protein kinase | liver | energy metabolism | AMP‐activated protein kinase | Type 2 diabetes | Energy metabolism | Fatty liver | Hepatic glucose production | Liver | PHYSIOLOGY | LIPID-METABOLISM | CREB COACTIVATOR TORC2 | ACETYL-COA CARBOXYLASE | MICE LACKING ADIPONECTIN | LIVER-DISEASE | ISOLATED RAT HEPATOCYTES | SKELETAL-MUSCLE | FATTY-ACID OXIDATION | INSULIN-RESISTANCE | ADIPOSE-TISSUE | AMP-Activated Protein Kinases - metabolism | Liver - enzymology | Hypoglycemic Agents - metabolism | Humans | Homeostasis | Protein Subunits - metabolism | Liver Cirrhosis - metabolism | Aminoimidazole Carboxamide - metabolism | Energy Metabolism - physiology | Protein Subunits - genetics | Liver Cirrhosis - drug therapy | Dyslipidemias - drug therapy | Ribonucleotides - metabolism | Fatty Liver - metabolism | Fatty Liver - physiopathology | Lipid Metabolism | Mitochondria - metabolism | AMP-Activated Protein Kinases - chemistry | Fatty Liver - drug therapy | Gluconeogenesis - physiology | Animals | Aminoimidazole Carboxamide - analogs & derivatives | Dyslipidemias - metabolism | Glucose - metabolism | Protein Conformation | Liver - cytology | Protein Subunits - chemistry | Liver Cirrhosis - physiopathology | AMP-Activated Protein Kinases - genetics | Dyslipidemias - physiopathology | Glucose metabolism | Enzymes | Liver diseases | Physiological aspects | Protein biosynthesis | Insulin resistance | Glucose | Protein kinases | Health aspects | Fatty acids | Dextrose | cytology | Protein Subunits | Dyslipidemias | AMP-Activated Protein Kinases | therapeutic | Hypoglycemic Agents | Aminoimidazole Carboxamide | Mitochondria | genetics | Gluconeogenesis | chemistry | drug therapy | physiology | Liver Cirrhosis | enzymology | Fatty Liver | physiopathology | Ribonucleotides | Energy Metabolism | analogs & derivatives | MP-activated protein kinase | metabolism
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2009, Volume 284, Issue 41, pp. 27780 - 27789
Depletion of mtDNA in myocytes causes insulin resistance and alters nuclear gene expression that may be involved in rescuing processes against cellular stress.... 
SKELETAL-MUSCLE | CELLS | CONTRACTION | GENE | FATTY-ACID OXIDATION | GLUT4 TRANSLOCATION | INSULIN-RESISTANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLUCOSE-TRANSPORT | ACETYL-COA CARBOXYLASE | ACRP30/ADIPONECTIN | RNA, Small Interfering - genetics | AMP-Activated Protein Kinases - metabolism | Glucose Transporter Type 4 - metabolism | Humans | Receptors, Adiponectin - metabolism | DNA, Mitochondrial | Male | Intracellular Signaling Peptides and Proteins - metabolism | Diabetes Mellitus, Type 2 - metabolism | Insulin Receptor Substrate Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Acetyl-CoA Carboxylase - genetics | Proto-Oncogene Proteins c-akt - genetics | Ribonucleotides - genetics | Mitochondria - genetics | Collagen - genetics | Membrane Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Aminoimidazole Carboxamide - metabolism | Insulin Receptor Substrate Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Fatty Acids - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Disease Models, Animal | Cell Line | Ribonucleotides - metabolism | Glucose Transporter Type 4 - genetics | Membrane Proteins - genetics | Mice, Inbred C57BL | Muscle Cells - metabolism | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Mitochondria - metabolism | Muscle Cells - cytology | Collagen - metabolism | Rats, Inbred OLETF | Animals | Aminoimidazole Carboxamide - analogs & derivatives | Glucose - metabolism | Recombinant Fusion Proteins - genetics | Mice, Obese | Mice | Enzyme Activation | AMP-Activated Protein Kinases - genetics | Acetyl-CoA Carboxylase - metabolism | Receptors, Adiponectin - genetics | RNA, Small Interfering - metabolism | Metabolism and Bioenergetics
Journal Article
Diabetes, ISSN 0012-1797, 01/2006, Volume 55, Issue 1, pp. 120 - 127
Activation of AMP-Activated Protein Kinase Reduces Hyperglycemia-Induced Mitochondrial Reactive Oxygen Species Production and Promotes Mitochondrial Biogenesis... 
DEPENDENT DIABETES-MELLITUS | OXIDATIVE STRESS | TRANSCRIPTION | ENDOCRINOLOGY & METABOLISM | MUSCLE | RAT-HEART | COMPLICATIONS | AICAR | BLOOD-GLUCOSE CONTROL | INTENSIVE INSULIN THERAPY | NEPHROPATHY | Reactive Oxygen Species - metabolism | Humans | Multienzyme Complexes - metabolism | RNA, Messenger - metabolism | AMP-Activated Protein Kinases | DNA-Binding Proteins - metabolism | Heat-Shock Proteins - genetics | Mitochondrial Proteins - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Hyperglycemia - pathology | Aminoimidazole Carboxamide - metabolism | Protein-Serine-Threonine Kinases - metabolism | Superoxide Dismutase - metabolism | Ribonucleotides - metabolism | DNA, Mitochondrial - metabolism | Heat-Shock Proteins - metabolism | Metformin - pharmacology | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Mitochondria - metabolism | Multienzyme Complexes - genetics | Transcription Factors - genetics | Enzyme Activation - drug effects | NF-E2-Related Factor 1 - metabolism | Hypoglycemic Agents - pharmacology | Hyperglycemia - metabolism | Transcription Factors - metabolism | Aminoimidazole Carboxamide - analogs & derivatives | Endothelial Cells - cytology | Endothelial Cells - enzymology | Research | Diabetes | Endothelial growth factors | Health aspects | Protein kinases
Journal Article
Circulation Research, ISSN 0009-7330, 02/2007, Volume 100, Issue 3, pp. 328 - 341
The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status that is conserved in all eukaryotic cells. It is activated by... 
Calcium signaling | Signaling pathways | Diabetes | Metabolism | Insulin | RAT-LIVER | CARDIAC & CARDIOVASCULAR SYSTEMS | insulin | 5-AMINOIMIDAZOLE-4-CARBOXAMIDE RIBONUCLEOSIDE | STIMULATED GLUCOSE-TRANSPORT | calcium signaling | N-TERMINAL KINASE | ACETYL-COA CARBOXYLASE | VEIN ENDOTHELIAL-CELLS | COENZYME-A CARBOXYLASE | HUMAN SKELETAL-MUSCLE | signaling pathways | FATTY-ACID OXIDATION | PANCREATIC BETA-CELLS | PERIPHERAL VASCULAR DISEASE | metabolism | HEMATOLOGY | diabetes | Consensus Sequence | Protein Subunits | Protein-Serine-Threonine Kinases - deficiency | Insulin - physiology | Obesity - drug therapy | Humans | Muscle Cells - drug effects | Adipocytes - drug effects | AMP-Activated Protein Kinases | Aminoimidazole Carboxamide - pharmacology | Multienzyme Complexes - deficiency | Calcium - physiology | Adenosine Triphosphate - metabolism | Energy Metabolism - physiology | Binding Sites | Peptide Hormones - physiology | Hypoglycemic Agents - therapeutic use | Amino Acid Sequence | Diabetes Mellitus - drug therapy | Models, Molecular | Rats | Hypoglycemic Agents - pharmacology | Mice, Knockout | Calcium-Calmodulin-Dependent Protein Kinase Kinase | Carbohydrate Metabolism - physiology | Aminoimidazole Carboxamide - analogs & derivatives | Diabetes Mellitus - therapy | Protein-Serine-Threonine Kinases - drug effects | Mice | Protein-Serine-Threonine Kinases - chemistry | Cell Cycle - drug effects | Energy Metabolism - drug effects | Lipid Metabolism - physiology | Multienzyme Complexes - drug effects | Carbohydrate Metabolism - drug effects | Phosphorylation | Metformin - therapeutic use | Molecular Sequence Data | Hepatocytes - metabolism | Ribonucleotides - pharmacology | Hepatocytes - drug effects | Adenosine Monophosphate - metabolism | Protein-Serine-Threonine Kinases - physiology | Metformin - pharmacology | Muscle Cells - metabolism | Protein-Serine-Threonine Kinases - genetics | Diabetes Mellitus - metabolism | Neoplasms - enzymology | Multienzyme Complexes - genetics | Enzyme Activation - drug effects | Protein Processing, Post-Translational - physiology | Multienzyme Complexes - chemistry | Obesity - metabolism | Sequence Homology, Amino Acid | Sequence Alignment | Animals | Oxygen Consumption - drug effects | Adipocytes - metabolism | Multienzyme Complexes - physiology | Lipid Metabolism - drug effects | Cell Cycle - physiology | Neoplasms - pathology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2014, Volume 111, Issue 29, pp. 10574 - 10579
Metformin, a first-line diabetes drug linked to cancer prevention in retrospective clinical analyses, inhibits cellular transformation and selectively kills... 
Lactates | Energy metabolism | Cellular metabolism | Epithelial cells | Cell lines | Stem cells | Glycolysis | Transformed cell line | Breast cancer | Cancer | Metabolic profiling | Cancer metabolism | Metabolism | COMPLEX I | RESPIRATORY-CHAIN | MULTIDISCIPLINARY SCIENCES | glycolysis | metabolic profiling | DECREASES | CHEMOTHERAPY | cancer metabolism | BREAST-CANCER | DIABETIC-PATIENTS | GROWTH | MITOCHONDRIAL DYSFUNCTION | metabolism | INFLAMMATORY RESPONSE | Biguanides - pharmacology | Ribonucleotides - metabolism | Neoplastic Stem Cells - drug effects | Humans | Metformin - pharmacology | Citric Acid Cycle - drug effects | Glycerophosphates - metabolism | Endoplasmic Reticulum - metabolism | Nucleotides - metabolism | Glycolysis - drug effects | Phenformin - pharmacology | Lactates - metabolism | Aminoimidazole Carboxamide - analogs & derivatives | Metabolome - drug effects | Neoplastic Stem Cells - metabolism | Endoplasmic Reticulum - drug effects | Tamoxifen - pharmacology | src-Family Kinases - metabolism | Cell Line, Tumor | Folic Acid - metabolism | Neoplastic Stem Cells - pathology | Aminoimidazole Carboxamide - metabolism | Cell Line, Transformed | Pharmaceutical research | Stem cell research | Analysis | Drug interactions | Cancer cells | Dosage and administration | Metformin | Research | Health aspects | Biological Sciences
Journal Article
Cell Metabolism, ISSN 1550-4131, 06/2016, Volume 23, Issue 6, pp. 1140 - 1153
Journal Article
Molecular Cell, ISSN 1097-2765, 09/2012, Volume 47, Issue 6, pp. 980 - 986
Journal Article
Lymphatic Research and Biology, ISSN 1539-6851, 02/2018, Volume 16, Issue 1, pp. 43 - 55
Background: Lymphatic endothelial cells (LECs) derived from lymphatic malformations (LMs) bear activated PIK3CA alleles yet display an inflammatory gene... 
PIK3CA | endothelial cells | lymphatic malformations | MEDICINE, RESEARCH & EXPERIMENTAL | PHYSIOLOGY | PERCUTANEOUS SCLEROTHERAPY | PHOSPHORYLATION | PROTEIN-KINASE | CANCER | FAT STORAGE | PI3K | INSULIN-RESISTANCE | AMPK | MUTATIONS | LIPID DROPLETS | Interleukin-8 - genetics | Heme Oxygenase-1 - metabolism | Class I Phosphatidylinositol 3-Kinases - genetics | Vesicular Transport Proteins - metabolism | Humans | Aminoimidazole Carboxamide - pharmacology | Cyclooxygenase 2 - genetics | E-Selectin - genetics | Lipid Metabolism - genetics | Interleukin-8 - metabolism | Interleukin-6 - metabolism | Repressor Proteins - metabolism | Histone Deacetylases - genetics | Interleukin-6 - genetics | Signal Transduction | Endothelial Cells - metabolism | Membrane Proteins - genetics | Lymphoid Tissue - metabolism | Repressor Proteins - genetics | Lymphatic Abnormalities - pathology | Lymphoid Tissue - pathology | Aminoimidazole Carboxamide - analogs & derivatives | Vascular Endothelial Growth Factor C - metabolism | Angiopoietin-like 4 Protein - metabolism | Mutation | Endothelial Cells - pathology | Autophagy-Related Proteins - metabolism | AMP-Activated Protein Kinases - genetics | Angiopoietin-like 4 Protein - genetics | Lymphatic Abnormalities - genetics | AMP-Activated Protein Kinases - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Ribonucleotides - pharmacology | Heme Oxygenase-1 - genetics | Membrane Proteins - metabolism | Autophagy-Related Proteins - genetics | Cell Line | Vesicular Transport Proteins - genetics | Gene Expression Regulation | Lymphatic Abnormalities - metabolism | E-Selectin - metabolism | Histone Deacetylases - metabolism | Transcription Factors - genetics | Vascular Endothelial Growth Factor C - genetics | Transcription Factors - metabolism | Ankyrins - genetics | Alleles | Ankyrins - metabolism | Cyclooxygenase 2 - metabolism | Primary Cell Culture | Endothelial Cells - drug effects
Journal Article