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Progress in Neuropsychopharmacology & Biological Psychiatry, ISSN 0278-5846, 08/2011, Volume 35, Issue 7, pp. 1774 - 1779
Recent studies demonstrate that rapid antidepressant response to ketamine is mediated by activation of the mammalian target of rapamycin (mTOR) signaling... 
Prefrontal cortex | Translation initiation pathway | Major depressive disorder | Postmortem | PHOSPHORYLATION | INITIATION | PSYCHIATRY | RECEPTOR | SYNAPTIC PLASTICITY | PROTEIN-SYNTHESIS | NEUROSCIENCES | CLINICAL NEUROLOGY | KETAMINE | PHARMACOLOGY & PHARMACY | EUKARYOTIC TRANSLATION | Ribosomal Protein S6 Kinases, 70-kDa - analysis | TOR Serine-Threonine Kinases - metabolism | Depressive Disorder, Major - metabolism | Humans | Middle Aged | Prefrontal Cortex - physiopathology | Male | Depressive Disorder, Major - immunology | Prefrontal Cortex - pathology | Ribosomal Protein S6 Kinases - immunology | Ribosomal Protein S6 Kinases, 70-kDa - biosynthesis | Signal Transduction - immunology | TOR Serine-Threonine Kinases - genetics | Autopsy | Eukaryotic Initiation Factors - immunology | Aged, 80 and over | Ribosomal Protein S6 Kinases - analysis | Adult | Female | Eukaryotic Initiation Factors - genetics | Prefrontal Cortex - immunology | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Signal Transduction - genetics | Eukaryotic Initiation Factors - biosynthesis | Ribosomal Protein S6 Kinases, 70-kDa - immunology | TOR Serine-Threonine Kinases - immunology | TOR Serine-Threonine Kinases - analysis | Depressive Disorder, Major - genetics | Family | Aged | Eukaryotic Initiation Factors - analysis | Ribosomal Protein S6 Kinases - biosynthesis | Ribosomal Protein S6 Kinases - genetics | Proteins | Methyl aspartate | Glutamate | Antidepressants | Index Medicus | major depressive disorder | prefrontal cortex; translation initiation pathway | postmortem
Journal Article
Journal Article
Neuron, ISSN 0896-6273, 10/2012, Volume 76, Issue 2, pp. 325 - 337
Fragile X syndrome (FXS) is the leading inherited cause of autism and intellectual disability. Aberrant synaptic translation has been implicated in the... 
MAMMALIAN TARGET | RAPAMYCIN SIGNALING PATHWAY | FMR1 KNOCKOUT MOUSE | MESSENGER-RNA | MEMORY | LONG-TERM DEPRESSION | PHOSPHOINOSITIDE 3-KINASE-AKT-MAMMALIAN TARGET | TRANSLATION | MENTAL-RETARDATION PROTEIN | NEUROSCIENCES | MTOR | Electric Stimulation | Fragile X Syndrome - pathology | Male | Fragile X Mental Retardation Protein - metabolism | Synapses - genetics | Recognition (Psychology) - physiology | Phosphorylation - genetics | TOR Serine-Threonine Kinases - genetics | Ribosomal Protein S6 Kinases, 70-kDa - deficiency | Excitatory Postsynaptic Potentials - genetics | Disease Models, Animal | Membrane Potentials - drug effects | Synapses - drug effects | Maze Learning - physiology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Dendritic Spines - physiology | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Behavior, Animal - physiology | Mice, Transgenic | Hippocampus - pathology | Mutation - genetics | Patch-Clamp Techniques | Phenotype | Analysis of Variance | Mice | Long-Term Synaptic Depression - genetics | Neurons - pathology | Membrane Potentials - genetics | Fragile X Syndrome - physiopathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Long-Term Synaptic Depression - drug effects | Excitatory Postsynaptic Potentials - drug effects | Extracellular Signal-Regulated MAP Kinases - genetics | Exploratory Behavior - physiology | Neurons - classification | Female | Interpersonal Relations | Fragile X Syndrome - genetics | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Biophysics | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Motor Activity - genetics | Rotarod Performance Test | Animals | Fragile X Syndrome - prevention & control | Dendritic Spines - classification | Fragile X Mental Retardation Protein - genetics | In Vitro Techniques | Depression, Mental | Analysis | Genetic research | Protein biosynthesis | Genetic aspects | Fragile X syndrome | Genetic translation | Proteins | Phosphorylation | Brain research | Kinases | Protein synthesis | Rodents | Index Medicus | Animal models | Translation | Translation initiation | Pattern recognition | Mental retardation | Ribosomal protein S6 kinase | Autism | Dendritic spines | Molecular modelling | Social interactions | Etiology | p70 S6 kinase | Long-term depression | Elongation
Journal Article
Science, ISSN 0036-8075, 10/2009, Volume 326, Issue 5949, pp. 140 - 144
Journal Article
Journal Article
Journal Article
PLoS Genetics, ISSN 1553-7390, 03/2015, Volume 11, Issue 3, pp. e1004984 - e1004984
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PLoS genetics, ISSN 1553-7390, 2014, Volume 10, Issue 5, pp. e1004371 - e1004371
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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2007, Volume 282, Issue 42, pp. 31019 - 31027
Journal Article
Journal Article