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Progress in Neuropsychopharmacology & Biological Psychiatry, ISSN 0278-5846, 08/2011, Volume 35, Issue 7, pp. 1774 - 1779
Recent studies demonstrate that rapid antidepressant response to ketamine is mediated by activation of the mammalian target of rapamycin (mTOR) signaling... 
Prefrontal cortex | Translation initiation pathway | Major depressive disorder | Postmortem | PHOSPHORYLATION | INITIATION | PSYCHIATRY | RECEPTOR | SYNAPTIC PLASTICITY | PROTEIN-SYNTHESIS | NEUROSCIENCES | CLINICAL NEUROLOGY | KETAMINE | PHARMACOLOGY & PHARMACY | EUKARYOTIC TRANSLATION | Ribosomal Protein S6 Kinases, 70-kDa - analysis | TOR Serine-Threonine Kinases - metabolism | Depressive Disorder, Major - metabolism | Humans | Middle Aged | Prefrontal Cortex - physiopathology | Male | Depressive Disorder, Major - immunology | Prefrontal Cortex - pathology | Ribosomal Protein S6 Kinases - immunology | Ribosomal Protein S6 Kinases, 70-kDa - biosynthesis | Signal Transduction - immunology | TOR Serine-Threonine Kinases - genetics | Autopsy | Eukaryotic Initiation Factors - immunology | Aged, 80 and over | Ribosomal Protein S6 Kinases - analysis | Adult | Female | Eukaryotic Initiation Factors - genetics | Prefrontal Cortex - immunology | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Signal Transduction - genetics | Eukaryotic Initiation Factors - biosynthesis | Ribosomal Protein S6 Kinases, 70-kDa - immunology | TOR Serine-Threonine Kinases - immunology | TOR Serine-Threonine Kinases - analysis | Depressive Disorder, Major - genetics | Family | Aged | Eukaryotic Initiation Factors - analysis | Ribosomal Protein S6 Kinases - biosynthesis | Ribosomal Protein S6 Kinases - genetics | Proteins | Methyl aspartate | Glutamate | Antidepressants | Index Medicus | major depressive disorder | prefrontal cortex; translation initiation pathway | postmortem
Journal Article
Neuron, ISSN 0896-6273, 10/2012, Volume 76, Issue 2, pp. 325 - 337
Fragile X syndrome (FXS) is the leading inherited cause of autism and intellectual disability. Aberrant synaptic translation has been implicated in the... 
MAMMALIAN TARGET | RAPAMYCIN SIGNALING PATHWAY | FMR1 KNOCKOUT MOUSE | MESSENGER-RNA | MEMORY | LONG-TERM DEPRESSION | PHOSPHOINOSITIDE 3-KINASE-AKT-MAMMALIAN TARGET | TRANSLATION | MENTAL-RETARDATION PROTEIN | NEUROSCIENCES | MTOR | Electric Stimulation | Fragile X Syndrome - pathology | Male | Fragile X Mental Retardation Protein - metabolism | Synapses - genetics | Recognition (Psychology) - physiology | Phosphorylation - genetics | TOR Serine-Threonine Kinases - genetics | Ribosomal Protein S6 Kinases, 70-kDa - deficiency | Excitatory Postsynaptic Potentials - genetics | Disease Models, Animal | Membrane Potentials - drug effects | Synapses - drug effects | Maze Learning - physiology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Dendritic Spines - physiology | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Behavior, Animal - physiology | Mice, Transgenic | Hippocampus - pathology | Mutation - genetics | Patch-Clamp Techniques | Phenotype | Analysis of Variance | Mice | Long-Term Synaptic Depression - genetics | Neurons - pathology | Membrane Potentials - genetics | Fragile X Syndrome - physiopathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Long-Term Synaptic Depression - drug effects | Excitatory Postsynaptic Potentials - drug effects | Extracellular Signal-Regulated MAP Kinases - genetics | Exploratory Behavior - physiology | Neurons - classification | Female | Interpersonal Relations | Fragile X Syndrome - genetics | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Biophysics | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Motor Activity - genetics | Rotarod Performance Test | Animals | Fragile X Syndrome - prevention & control | Dendritic Spines - classification | Fragile X Mental Retardation Protein - genetics | In Vitro Techniques | Depression, Mental | Analysis | Genetic research | Protein biosynthesis | Genetic aspects | Fragile X syndrome | Genetic translation | Proteins | Phosphorylation | Brain research | Kinases | Protein synthesis | Rodents | Index Medicus | Animal models | Translation | Translation initiation | Pattern recognition | Mental retardation | Ribosomal protein S6 kinase | Autism | Dendritic spines | Molecular modelling | Social interactions | Etiology | p70 S6 kinase | Long-term depression | Elongation
Journal Article
Cancer Cell, ISSN 1535-6108, 03/2012, Volume 21, Issue 3, pp. 374 - 387
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 02/2010, Volume 30, Issue 4, pp. 908 - 921
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2016, Volume 126, Issue 5, pp. 1704 - 1716
A classic metabolic concept posits that insulin promotes energy storage and adipose expansion, while catecholamines stimulate release of adipose energy stores... 
MEDICINE, RESEARCH & EXPERIMENTAL | UNCOUPLING PROTEIN-1 GENE | WHITE FAT | GLUCOSE-HOMEOSTASIS | CYCLIC-AMP | ADIPOCYTE PROLIFERATION | INITIATION-FACTOR 4E | SMOOTH-MUSCLE-CELLS | ADULT HUMANS | DIET-INDUCED OBESITY | INSULIN SENSITIVITY | TOR Serine-Threonine Kinases - metabolism | Humans | Adipose Tissue, White - metabolism | Multiprotein Complexes - genetics | Uncoupling Protein 1 - biosynthesis | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Adipose Tissue, White - cytology | Cyclic AMP-Dependent Protein Kinases - genetics | TOR Serine-Threonine Kinases - genetics | HEK293 Cells | Regulatory-Associated Protein of mTOR | Insulin - genetics | Cyclic AMP-Dependent Protein Kinases - metabolism | Uncoupling Protein 1 - genetics | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - genetics | 3T3-L1 Cells | Mice, Knockout | Adipose Tissue, Brown - cytology | Insulin - metabolism | Animals | Receptors, Adrenergic, beta - genetics | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Adipose Tissue, Brown - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 09/2004, Volume 431, Issue 7005, pp. 200 - 205
Journal Article
Cell, ISSN 0092-8674, 2003, Volume 115, Issue 5, pp. 577 - 590
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 11/2015, Volume 21, Issue 21, pp. 4922 - 4934
Purpose: To investigate the involvement of hsa-miRNA-195-5p (miR-195) in progression andprognosis ofhuman prostate cancer. Experimental Design: qRT-PCR was... 
BREAST-CANCER | TRANSITION | HEPATOCELLULAR-CARCINOMA | BIOGENESIS | ONCOLOGY | PATHWAY | GENE-EXPRESSION | RESISTANCE | CELL-CYCLE | MICRORNAS | P70 S6 KINASE | Prostatic Neoplasms - metabolism | Prognosis | Cadherins - metabolism | Humans | Gene Expression Regulation, Neoplastic | Apoptosis - genetics | Male | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Cell Movement - genetics | Matrix Metalloproteinase 9 - metabolism | Prostatic Neoplasms - genetics | RNA Interference | Matrix Metalloproteinase 9 - genetics | Base Sequence | bcl-Associated Death Protein - metabolism | Tumor Burden - genetics | Proteomics - methods | 3' Untranslated Regions | Cadherins - genetics | Binding Sites | Disease Models, Animal | bcl-Associated Death Protein - genetics | Prostatic Neoplasms - pathology | RNA, Messenger - genetics | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Disease Progression | Prostatic Neoplasms - mortality | Ribosomal Protein S6 Kinases, 70-kDa - chemistry | Xenograft Model Antitumor Assays | Animals | Cell Line, Tumor | Neovascularization, Pathologic - genetics | RNA, Messenger - chemistry | Mice | MicroRNAs - genetics | MicroRNAs - chemistry | Index Medicus | 70kDa | prostate cancer | polypeptide 1 | microRNA-195 | ribosomal protein S6 kinase | tumor suppressor | prognosis
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e57289 - e57289
The mTOR pathway is aberrantly stimulated in many cancer cells, including pancreatic ductal adenocarcinoma (PDAC), and thus it is a potential target for... 
PATHWAY ACTIVATION | DIABETIC-PATIENTS | INSULIN-RECEPTOR | PROTEIN-COUPLED RECEPTOR | COMPETITIVE MAMMALIAN TARGET | MULTIDISCIPLINARY SCIENCES | KINASE | TUMOR-SUPPRESSOR | RISK | GROWTH-FACTOR | SIGNALING SYSTEMS | Pancreatic Neoplasms - metabolism | Antibiotics, Antineoplastic - pharmacology | TOR Serine-Threonine Kinases - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Carcinoma, Pancreatic Ductal - genetics | Pancreatic Neoplasms - drug therapy | TOR Serine-Threonine Kinases - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Neurotensin - pharmacology | Indoles - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Insulin - pharmacology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Purines - pharmacology | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Metformin - pharmacology | Pancreatic Neoplasms - pathology | Morpholines - pharmacology | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Pancreatic Neoplasms - genetics | Pyrimidines - pharmacology | Carcinoma, Pancreatic Ductal - pathology | Sirolimus - pharmacology | Hypoglycemic Agents - pharmacology | Carcinoma, Pancreatic Ductal - drug therapy | Signal Transduction - drug effects | Cell Line, Tumor | Feedback, Physiological - drug effects | Cell Proliferation - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Type 2 diabetes | Tyrosine | Pancreatic cancer | Cancer cells | Neuropeptides | Rapamycin | Metformin | Neurotensin | Drug therapy | TOR protein | Adenocarcinoma | Cell proliferation | Therapy | Phosphorylation | Thoracic surgery | G protein-coupled receptors | AKT protein | Insulin-like growth factors | Activation | Feedback loops | Kinases | Proteins | Receptors | Negative feedback | Cell growth | Allosteric properties | Pathways | Feedback | Inhibition | Protein-tyrosine kinase | Extracellular signal-regulated kinase | Insulin | Medicine | Signaling | Inhibitors | Protein synthesis | Diabetes | Aberration | Molecular biology | Cancer | Index Medicus
Journal Article