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ribosomal protein s6 kinases, 70-kda - metabolism (1970) 1970
animals (1411) 1411
humans (1374) 1374
phosphorylation (1152) 1152
signal transduction (703) 703
tor serine-threonine kinases - metabolism (699) 699
male (697) 697
mice (693) 693
proto-oncogene proteins c-akt - metabolism (622) 622
signal transduction - drug effects (527) 527
rats (506) 506
mtor (501) 501
female (475) 475
activation (467) 467
cell biology (467) 467
tor serine-threonine kinases (466) 466
cell line, tumor (465) 465
biochemistry & molecular biology (444) 444
mammalian target (432) 432
rapamycin (428) 428
ribosomal protein s6 kinases, 70-kda - genetics (395) 395
sirolimus - pharmacology (385) 385
apoptosis (368) 368
phosphatidylinositol 3-kinases - metabolism (367) 367
phosphorylation - drug effects (366) 366
oncology (351) 351
proteins (339) 339
expression (337) 337
phosphoproteins - metabolism (334) 334
cells, cultured (327) 327
protein kinases - metabolism (302) 302
growth (296) 296
cancer (290) 290
cell proliferation - drug effects (281) 281
cell line (267) 267
kinases (266) 266
signal transduction - physiology (260) 260
physiology (258) 258
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protein-serine-threonine kinases - metabolism (232) 232
inhibition (226) 226
apoptosis - drug effects (223) 223
akt (219) 219
cell proliferation (218) 218
blotting, western (211) 211
insulin (208) 208
rats, sprague-dawley (205) 205
ribosomal protein s6 kinases, 70-kda - antagonists & inhibitors (205) 205
carrier proteins - metabolism (201) 201
p70 s6 kinase (189) 189
time factors (187) 187
protein biosynthesis (186) 186
research (186) 186
adult (184) 184
tor serine-threonine kinases - genetics (184) 184
physiological aspects (180) 180
adaptor proteins, signal transducing - metabolism (177) 177
dose-response relationship, drug (177) 177
enzyme activation (177) 177
analysis (173) 173
endocrinology & metabolism (173) 173
autophagy (171) 171
kinase (169) 169
muscle, skeletal - metabolism (169) 169
gene expression (168) 168
enzyme inhibitors - pharmacology (166) 166
tor serine-threonine kinases - antagonists & inhibitors (164) 164
proliferation (163) 163
tor protein (162) 162
mechanistic target of rapamycin complex 1 (161) 161
middle aged (149) 149
s6 kinase (147) 147
skeletal-muscle (144) 144
mice, inbred c57bl (143) 143
proto-oncogene proteins c-akt (143) 143
translation (140) 140
metabolism (137) 137
protein kinase inhibitors - pharmacology (137) 137
rna, messenger - metabolism (137) 137
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aged (134) 134
protein synthesis (133) 133
gene-expression (131) 131
cell survival - drug effects (129) 129
multidisciplinary sciences (129) 129
extracellular signal-regulated map kinases - metabolism (125) 125
hypertrophy (124) 124
protein-synthesis (124) 124
cell cycle (122) 122
proto-oncogene proteins - metabolism (122) 122
neurosciences (120) 120
amp-activated protein kinases - metabolism (119) 119
cells (119) 119
protein kinases (119) 119
rna interference (119) 119
pharmacology & pharmacy (118) 118
protein binding (118) 118
proto-oncogene proteins c-akt - genetics (118) 118
signaling pathway (118) 118
phosphatidylinositol 3-kinase (117) 117
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Progress in neuro-psychopharmacology & biological psychiatry, ISSN 0278-5846, 2011, Volume 35, Issue 7, pp. 1774 - 1779
...) signaling pathway, leading to increased synaptic proteins in the prefrontal cortex (PFC) of rats. Our postmortem studies indicate robust deficits in prominent postsynaptic proteins including N-methyl-d-aspartate... 
Prefrontal cortex | Translation initiation pathway | Major depressive disorder | Postmortem | PHOSPHORYLATION | INITIATION | PSYCHIATRY | RECEPTOR | SYNAPTIC PLASTICITY | PROTEIN-SYNTHESIS | NEUROSCIENCES | CLINICAL NEUROLOGY | KETAMINE | PHARMACOLOGY & PHARMACY | EUKARYOTIC TRANSLATION | Ribosomal Protein S6 Kinases, 70-kDa - analysis | TOR Serine-Threonine Kinases - metabolism | Depressive Disorder, Major - metabolism | Humans | Middle Aged | Prefrontal Cortex - physiopathology | Male | Depressive Disorder, Major - immunology | Prefrontal Cortex - pathology | Ribosomal Protein S6 Kinases - immunology | Ribosomal Protein S6 Kinases, 70-kDa - biosynthesis | Signal Transduction - immunology | TOR Serine-Threonine Kinases - genetics | Autopsy | Eukaryotic Initiation Factors - immunology | Aged, 80 and over | Ribosomal Protein S6 Kinases - analysis | Adult | Female | Eukaryotic Initiation Factors - genetics | Prefrontal Cortex - immunology | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Signal Transduction - genetics | Eukaryotic Initiation Factors - biosynthesis | Ribosomal Protein S6 Kinases, 70-kDa - immunology | TOR Serine-Threonine Kinases - immunology | TOR Serine-Threonine Kinases - analysis | Depressive Disorder, Major - genetics | Family | Aged | Eukaryotic Initiation Factors - analysis | Ribosomal Protein S6 Kinases - biosynthesis | Ribosomal Protein S6 Kinases - genetics | Proteins | Methyl aspartate | Glutamate | Antidepressants | major depressive disorder | prefrontal cortex; translation initiation pathway | postmortem
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2012, Volume 76, Issue 2, pp. 325 - 337
.... We sought to perturb p70 ribosomal S6 kinase 1 (S6K1), a key translation initiation and elongation regulator, in FXS model mice... 
MAMMALIAN TARGET | RAPAMYCIN SIGNALING PATHWAY | FMR1 KNOCKOUT MOUSE | MESSENGER-RNA | MEMORY | LONG-TERM DEPRESSION | PHOSPHOINOSITIDE 3-KINASE-AKT-MAMMALIAN TARGET | TRANSLATION | MENTAL-RETARDATION PROTEIN | NEUROSCIENCES | MTOR | Electric Stimulation | Fragile X Syndrome - pathology | Male | Fragile X Mental Retardation Protein - metabolism | Synapses - genetics | Recognition (Psychology) - physiology | Phosphorylation - genetics | TOR Serine-Threonine Kinases - genetics | Ribosomal Protein S6 Kinases, 70-kDa - deficiency | Excitatory Postsynaptic Potentials - genetics | Disease Models, Animal | Membrane Potentials - drug effects | Synapses - drug effects | Maze Learning - physiology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Dendritic Spines - physiology | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Behavior, Animal - physiology | Mice, Transgenic | Hippocampus - pathology | Mutation - genetics | Patch-Clamp Techniques | Phenotype | Analysis of Variance | Mice | Long-Term Synaptic Depression - genetics | Neurons - pathology | Membrane Potentials - genetics | Fragile X Syndrome - physiopathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Long-Term Synaptic Depression - drug effects | Excitatory Postsynaptic Potentials - drug effects | Extracellular Signal-Regulated MAP Kinases - genetics | Exploratory Behavior - physiology | Neurons - classification | Female | Interpersonal Relations | Fragile X Syndrome - genetics | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Biophysics | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Motor Activity - genetics | Rotarod Performance Test | Animals | Fragile X Syndrome - prevention & control | Dendritic Spines - classification | Fragile X Mental Retardation Protein - genetics | In Vitro Techniques | Depression, Mental | Analysis | Genetic research | Protein biosynthesis | Genetic aspects | Fragile X syndrome | Genetic translation | Proteins | Phosphorylation | Brain research | Kinases | Protein synthesis | Rodents | Animal models | Translation | Translation initiation | Pattern recognition | Mental retardation | Ribosomal protein S6 kinase | Autism | Dendritic spines | Molecular modelling | Social interactions | Etiology | p70 S6 kinase | Long-term depression | Elongation
Journal Article
Cancer cell, ISSN 1535-6108, 2012, Volume 21, Issue 3, pp. 374 - 387
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2012, Volume 142, Issue 7, pp. 1504 - 1515.e3
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 02/2010, Volume 30, Issue 4, pp. 908 - 921
Journal Article
The Journal of clinical investigation, ISSN 1558-8238, 2016, Volume 126, Issue 5, pp. 1704 - 1716
... through beta-adrenergic receptor (beta ARs) and protein kinase A (PKA) signaling. Here, we have shown that a key hub in the insulin signaling pathway, activation of p70 ribosomal S6 kinase (S6K1... 
MEDICINE, RESEARCH & EXPERIMENTAL | UNCOUPLING PROTEIN-1 GENE | WHITE FAT | GLUCOSE-HOMEOSTASIS | CYCLIC-AMP | ADIPOCYTE PROLIFERATION | INITIATION-FACTOR 4E | SMOOTH-MUSCLE-CELLS | ADULT HUMANS | DIET-INDUCED OBESITY | INSULIN SENSITIVITY | TOR Serine-Threonine Kinases - metabolism | Humans | Adipose Tissue, White - metabolism | Multiprotein Complexes - genetics | Uncoupling Protein 1 - biosynthesis | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Adipose Tissue, White - cytology | Cyclic AMP-Dependent Protein Kinases - genetics | TOR Serine-Threonine Kinases - genetics | HEK293 Cells | Regulatory-Associated Protein of mTOR | Insulin - genetics | Cyclic AMP-Dependent Protein Kinases - metabolism | Uncoupling Protein 1 - genetics | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - genetics | 3T3-L1 Cells | Mice, Knockout | Adipose Tissue, Brown - cytology | Insulin - metabolism | Animals | Receptors, Adrenergic, beta - genetics | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Adipose Tissue, Brown - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 2, p. e57289
...), and thus it is a potential target for therapy. However, the mTORC1/S6K axis also mediates negative feedback loops that attenuate signaling via insulin/IGF receptor and other tyrosine kinase receptors... 
PATHWAY ACTIVATION | DIABETIC-PATIENTS | INSULIN-RECEPTOR | PROTEIN-COUPLED RECEPTOR | COMPETITIVE MAMMALIAN TARGET | MULTIDISCIPLINARY SCIENCES | KINASE | TUMOR-SUPPRESSOR | RISK | GROWTH-FACTOR | SIGNALING SYSTEMS | Pancreatic Neoplasms - metabolism | Antibiotics, Antineoplastic - pharmacology | TOR Serine-Threonine Kinases - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Carcinoma, Pancreatic Ductal - genetics | Pancreatic Neoplasms - drug therapy | TOR Serine-Threonine Kinases - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Neurotensin - pharmacology | Indoles - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Insulin - pharmacology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Purines - pharmacology | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Metformin - pharmacology | Pancreatic Neoplasms - pathology | Morpholines - pharmacology | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Pancreatic Neoplasms - genetics | Pyrimidines - pharmacology | Carcinoma, Pancreatic Ductal - pathology | Sirolimus - pharmacology | Hypoglycemic Agents - pharmacology | Carcinoma, Pancreatic Ductal - drug therapy | Signal Transduction - drug effects | Cell Line, Tumor | Feedback, Physiological - drug effects | Cell Proliferation - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Type 2 diabetes | Tyrosine | Pancreatic cancer | Cancer cells | Neuropeptides | Rapamycin | Metformin | Neurotensin | Drug therapy | TOR protein | Adenocarcinoma | Cell proliferation | Therapy | Phosphorylation | Thoracic surgery | G protein-coupled receptors | AKT protein | Insulin-like growth factors | Activation | Feedback loops | Kinases | Proteins | Receptors | Negative feedback | Cell growth | Allosteric properties | Pathways | Feedback | Inhibition | Protein-tyrosine kinase | Extracellular signal-regulated kinase | Insulin | Medicine | Signaling | Inhibitors | Protein synthesis | Diabetes | Aberration | Molecular biology | Cancer
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 7, p. e0131464
.... One possible mechanism for resistance is upregulation of autophagy, a pathway that helps recycle intracellular proteins and promotes cell survival... 
CANCER-CELLS | IN-VITRO | ACTIVATION | INHIBITION | THERAPY | INDUCED APOPTOSIS | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | RIBOSOMAL-PROTEIN | AUTOPHAGY | MTOR | Epithelial Cells - metabolism | Kidney - pathology | Ribosomal Protein S6 Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Epithelial Cells - drug effects | Humans | Gene Expression Regulation, Neoplastic | Bortezomib - pharmacology | Glycolysis - drug effects | Autophagy - drug effects | Glycolysis - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Kidney - metabolism | Proteasome Endopeptidase Complex - drug effects | TOR Serine-Threonine Kinases - genetics | Antineoplastic Agents - pharmacology | Kidney - drug effects | Everolimus - pharmacology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Epithelial Cells - pathology | Mitochondria - metabolism | Mitochondria - drug effects | Oxygen Consumption - drug effects | Cell Line, Tumor | Hydroxychloroquine - pharmacology | Cell Proliferation - drug effects | Proteasome Endopeptidase Complex - metabolism | Ribosomal Protein S6 Kinases - antagonists & inhibitors | Ribosomal Protein S6 Kinases - genetics | Proteins | Glucose metabolism | Carcinoma | Apoptosis | Cancer | TOR protein | Biotechnology | Phosphorylation | Laboratories | Downstream effects | Biology | Kinases | Autophagy | Cancer therapies | Metastases | Mitochondria | Cell cycle | Inhibition | Downstream | Vector-borne diseases | Immunoglobulins | Oxygen | Bortezomib | Cell survival | Malaria | Oxygen consumption | Tumor cell lines | Hydroxychloroquine | Inhibitors | Protein synthesis | Kidney cancer | Glycolysis | Autoimmune diseases | Clear cell-type renal cell carcinoma | Phagocytosis | Kidney transplantation
Journal Article
Nature (London), ISSN 1476-4687, 2004, Volume 431, Issue 7005, pp. 200 - 205
Journal Article