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ribosomal protein s6 kinases, 90-kda - metabolism (712) 712
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ribosomal protein s6 kinases, 90-kda - genetics (435) 435
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ribosomal protein s6 kinases, 90-kda - antagonists & inhibitors (136) 136
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ribosomal s6 kinase (106) 106
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extracellular signal-regulated map kinases - metabolism (93) 93
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tor serine-threonine kinases - metabolism (71) 71
analysis (70) 70
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protein-serine-threonine kinases - metabolism (68) 68
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cyclic amp response element-binding protein - metabolism (66) 66
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phosphatidylinositol 3-kinases - metabolism (58) 58
msk1 (57) 57
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Molecular and Cellular Biology, ISSN 0270-7306, 02/2010, Volume 30, Issue 4, pp. 908 - 921
Journal Article
Biochemical journal, ISSN 1470-8728, 2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B (also known as Akt), PKC, S6K p70 (ribosomal S6 kinase), RSK... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | ACTIVATED PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | MSK1 | INDUCTION | IDENTIFICATION | INACTIVATION | CREB | GROWTH | BI-DI870 | SUPPRESSES | phosphorylation | kinase-specific inhibitor | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | protein kinase C | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
Oncogene, ISSN 0950-9232, 06/2013, Volume 32, Issue 24, pp. 2917 - 2926
The Ras/mitogen-activated protein kinase (MAPK) signalling cascade regulates various biological functions, including cell growth, proliferation and survival... 
mTOR | BRAF | RSK | MAPK | Melanoma | PROTEIN-KINASE PATHWAY | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT TRANSLATION | INITIATION-FACTOR 4E | TRANSLATION INITIATION | CELL-PROLIFERATION | CELL BIOLOGY | ONCOLOGY | GENETICS & HEREDITY | TUBEROUS SCLEROSIS | B-RAF | S6 KINASE | MOLECULAR-MECHANISMS | TOR Serine-Threonine Kinases - metabolism | Humans | Melanoma - enzymology | Ribosomal Protein S6 Kinases, 90-kDa - deficiency | ras Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | RNA, Messenger - metabolism | raf Kinases - metabolism | Eukaryotic Initiation Factor-4F - metabolism | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | RNA Interference | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Female | Gene Expression Regulation, Neoplastic - drug effects | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | RNA, Messenger - genetics | Melanoma - pathology | Enzyme Activation - drug effects | Animals | MAP Kinase Signaling System - drug effects | Cell Transformation, Neoplastic | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Growth | Physiological aspects | Rapamycin | Genetic aspects | Research | Gene expression | Health aspects | Mitogen-activated protein kinases | Signaling | Cells | Tumors
Journal Article
Nature immunology, ISSN 1529-2916, 2016, Volume 17, Issue 5, pp. 514 - 522
.... Here we found that infection with DNA viruses induced interaction of the metabolic checkpoint kinase mTOR downstream effector and kinase S6K1 and the signaling adaptor STING in a manner dependent on the DNA sensor cGAS... 
Ovalbumin - immunology | Cytosol - immunology | Dendritic Cells - immunology | Humans | Immunoblotting | Interferon Regulatory Factor-3 - genetics | Herpesvirus 1, Human - physiology | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Bone Marrow Cells - immunology | HEK293 Cells | Adenoviridae - genetics | Herpesvirus 1, Human - immunology | Membrane Proteins - metabolism | Nucleotidyltransferases - metabolism | Adenoviridae - immunology | Dendritic Cells - metabolism | Protein-Serine-Threonine Kinases - metabolism | Interferon Regulatory Factor-3 - immunology | Ovalbumin - genetics | DNA - immunology | Immunization - methods | Membrane Proteins - genetics | Mice, Inbred C57BL | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Membrane Proteins - immunology | DNA - metabolism | Cytosol - virology | Ribosomal Protein S6 Kinases, 90-kDa - immunology | Herpes Simplex - immunology | Mice, Knockout | DNA - genetics | Herpes Simplex - virology | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Interferon Regulatory Factor-3 - metabolism | Nucleotidyltransferases - genetics | Protein Binding | Cytosol - metabolism | Protein-Serine-Threonine Kinases - immunology | Nucleotidyltransferases - immunology | Bone Marrow Cells - metabolism | Transcription factors | Genetic aspects | Regulation | Immune response | Properties | Cellular control mechanisms | Factors de transcripció | Gene expression | Expressió gènica
Journal Article
Molecular cell, ISSN 1097-2765, 09/2010, Volume 39, Issue 6, pp. 886 - 900
.... Here, we show that the mitogen- and stress-activated kinases (MSK), through a mechanism that involves promoter recruitment, histone H3K27me3S28 phosphorylation, and displacement of PcG proteins, lead to gene activation... 
HISTONE METHYLTRANSFERASE ACTIVITY | RECRUITMENT | METHYLATION | CHROMATIN | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | COMPLEXES | CHROMOSOME CONDENSATION | EZH2 | CELL BIOLOGY | Phosphorylation - physiology | Chromatin - metabolism | Embryonic Stem Cells - metabolism | Gene Expression - drug effects | Gene Expression - genetics | Humans | Neurons - cytology | Protein Transport - physiology | Promoter Regions, Genetic - genetics | Cell Differentiation - genetics | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Peptides - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Antibodies - immunology | DNA Damage - genetics | Lysine - metabolism | Neurons - metabolism | Repressor Proteins - metabolism | Activating Transcription Factor 3 - genetics | Fibroblasts - metabolism | DNA Damage - drug effects | Histones - immunology | Gene Expression Regulation - physiology | Polycomb-Group Proteins | Serine - metabolism | Mitosis - physiology | Cell Differentiation - drug effects | Fibroblasts - drug effects | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Cell Line, Tumor | Anisomycin - pharmacology | HeLa Cells | Histones - metabolism | Methylation | Chromatin - genetics | Protein Binding - physiology | Cell research | Chromatin | Lysine | Gene expression | Embryonic stem cells | Phosphotransferases | Tretinoin
Journal Article
PloS one, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e31378
...). We have previously reported that IKK alpha (I kappaB kinase alpha) plays a key role in CS-induced pro-inflammatory gene transcription by chromatin modifications... 
OXIDATIVE STRESS | TRANSCRIPTIONAL ACTIVATION | RAT LUNGS | INDUCED PHOSPHORYLATION | EPITHELIAL-CELLS | INDUCED LUNG INFLAMMATION | PROTEIN-KINASE | BIOLOGY | PROINFLAMMATORY CYTOKINE RELEASE | IKK-ALPHA | H3 PHOSPHORYLATION | Cell Line | Smoke - adverse effects | Humans | Ribosomal Protein S6 Kinases, 90-kDa - deficiency | Smoking - genetics | Enzyme Activation - drug effects | Promoter Regions, Genetic - genetics | Gene Knockdown Techniques | Smoking - metabolism | p300-CBP Transcription Factors - metabolism | Acetylation - drug effects | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Transcription Factor RelA - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Mice | Histones - metabolism | Phosphorylation - drug effects | Oxidative stress | eIF-2 kinase | Chromatin | Phosphorylation | Transcription factors | Immunoprecipitation | Arsenic | Pathogenesis | Epithelial cells | Genes | Event-related potentials | Biology | Activation | Smoke | Kinases | Recruitment | Proteins | Respiratory tract | Transcription activation | Penicillin | Histones | Fibroblasts | Chronic obstructive pulmonary disease | Acetylation | NF-κB protein | Immunoglobulins | Lung diseases | Environmental health | siRNA | Inflammation | Embryo fibroblasts | Embryos | Substrates | Environmental effects | Promoters | Mutants | Medicine | Histone H4 | Obstructive lung disease | Cell lines | RelA protein | Histone H3 | Cigarette smoke
Journal Article
Scientific reports, ISSN 2045-2322, 2015, Volume 5, Issue 1, p. 14778
The brain-derived neurotrophic factor BDNF plays a critical role in neuronal development and the induction of L-LTP at glutamatergic synapses in several brain... 
DENDRITIC GROWTH | PHOSPHOLIPASE-D | NEURITE OUTGROWTH | COFFIN-LOWRY-SYNDROME | NEUROTROPHIC FACTOR | MULTIDISCIPLINARY SCIENCES | PHOSPHATIDIC-ACID | LONG-TERM POTENTIATION | ERK MAP KINASE | PROTEIN RSK2 | BRAIN | Brain-Derived Neurotrophic Factor - genetics | RNA, Small Interfering - genetics | TOR Serine-Threonine Kinases - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - deficiency | Neurons - cytology | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | Cerebral Cortex - cytology | Cerebral Cortex - metabolism | Endosomes - metabolism | Brain-Derived Neurotrophic Factor - pharmacology | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | TOR Serine-Threonine Kinases - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Brain-Derived Neurotrophic Factor - metabolism | Neurons - metabolism | Phospholipase D - genetics | Cerebral Cortex - drug effects | Neurons - drug effects | Mitogen-Activated Protein Kinase 3 - genetics | Phospholipase D - deficiency | Signal Transduction | Gene Expression Regulation | Phosphoproteins - genetics | Mice, Knockout | Cyclic AMP Response Element-Binding Protein - genetics | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Cyclic AMP Response Element-Binding Protein - metabolism | Protein Binding | Mice | Primary Cell Culture | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | TOR protein | Ribosomal protein S6 kinase | Signal transduction | Brain-derived neurotrophic factor | Molecular modelling | Rodents | Long-term potentiation | Extracellular signal-regulated kinase | Glutamatergic transmission | Retrograde transport | Cyclic AMP response element-binding protein
Journal Article