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blotting, western (74) 74
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genetics & heredity (72) 72
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neurosciences (70) 70
tor serine-threonine kinases - metabolism (70) 70
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protein-serine-threonine kinases - metabolism (66) 66
ribosomal protein s6 kinases, 90-kda - physiology (66) 66
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cyclic amp response element-binding protein - metabolism (65) 65
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proto-oncogene proteins c-akt - metabolism (59) 59
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Science, ISSN 0036-8075, 10/2009, Volume 326, Issue 5949, pp. 140 - 144
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 02/2010, Volume 30, Issue 4, pp. 908 - 921
Journal Article
Journal Article
Nature chemical biology, ISSN 1552-4450, 12/2014, Volume 10, Issue 12, pp. 1066 - 1072
Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency and utility for biological studies. Despite these... 
RHEUMATOID-ARTHRITIS | DESIGN | LIGANDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | REACTIVITY | KINASE INHIBITORS | GENERATION | OPTIMIZATION | ELECTROPHILES | PREDICTION | TOOL | Small Molecule Libraries - pharmacology | Humans | Bacterial Proteins - chemistry | Molecular Probes - pharmacology | Janus Kinase 3 - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | beta-Lactamases - genetics | Janus Kinase 3 - chemistry | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Cysteine - metabolism | Bacterial Proteins - antagonists & inhibitors | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cysteine - chemistry | beta-Lactamase Inhibitors - pharmacology | Ribosomal Protein S6 Kinases, 90-kDa - chemistry | Serine - chemistry | Drug Discovery | Serine - metabolism | Gram-Negative Bacteria - enzymology | Gram-Negative Bacteria - drug effects | Small Molecule Libraries - chemistry | beta-Lactamases - chemistry | Molecular Probes - chemistry | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Gram-Negative Bacteria - growth & development | Janus Kinase 3 - genetics | Hydrophobic and Hydrophilic Interactions | Protein Binding | Ligands | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | COS Cells | beta-Lactamase Inhibitors - chemistry | Proteins | Chemical bonds | Biochemistry | Crystal structure | Index Medicus | boronic acid | covalent virtual screening | JAK3 kinase | covalent fragments | covalent inhibition | beta-lactamase | RSK2 kinase | cyanoacrylamide | reversible covalent | covalent electrophile | MSK1 kinase
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2010, Volume 39, Issue 2, pp. 171 - 183
Aberrant activation of the mammalian target of rapamycin complex 1 (mTORC1) is a common molecular event in a variety of pathological settings, including... 
CELLBIO | SIGNALING | Signaling | Cellbio | MAMMALIAN TARGET | RAPAMYCIN | TSC1-TSC2 COMPLEX | KINASE-ACTIVITY | AMINO-ACID | TUBEROUS SCLEROSIS COMPLEX | FATTY-ACID BIOSYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-MYC | CELL-GROWTH | TRANSLATIONAL CONTROL | CELL BIOLOGY | Neoplasms - metabolism | Lipids - genetics | Cell Proliferation | Humans | Multiprotein Complexes | Protein Biosynthesis - physiology | Lipids - biosynthesis | Obesity - genetics | Mechanistic Target of Rapamycin Complex 1 | Proteins | Glycolysis - physiology | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Neoplasms - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Genomics - methods | Sterol Regulatory Element Binding Protein 1 - metabolism | Pentose Phosphate Pathway - physiology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Gene Expression Regulation - physiology | Transcription Factors - genetics | Metabolomics - methods | Obesity - metabolism | Transcription Factors - metabolism | Transcription, Genetic - physiology | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Mice | TOR Serine-Threonine Kinases | Cell Line, Transformed | Phosphates | Metabolites | Oncology, Experimental | Protein biosynthesis | Research | DNA binding proteins | Sugars | Public health | Cancer | Monosaccharides | Index Medicus | Bioenergetics
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2016, Volume 126, Issue 5, pp. 1704 - 1716
A classic metabolic concept posits that insulin promotes energy storage and adipose expansion, while catecholamines stimulate release of adipose energy stores... 
MEDICINE, RESEARCH & EXPERIMENTAL | UNCOUPLING PROTEIN-1 GENE | WHITE FAT | GLUCOSE-HOMEOSTASIS | CYCLIC-AMP | ADIPOCYTE PROLIFERATION | INITIATION-FACTOR 4E | SMOOTH-MUSCLE-CELLS | ADULT HUMANS | DIET-INDUCED OBESITY | INSULIN SENSITIVITY | TOR Serine-Threonine Kinases - metabolism | Humans | Adipose Tissue, White - metabolism | Multiprotein Complexes - genetics | Uncoupling Protein 1 - biosynthesis | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Adipose Tissue, White - cytology | Cyclic AMP-Dependent Protein Kinases - genetics | TOR Serine-Threonine Kinases - genetics | HEK293 Cells | Regulatory-Associated Protein of mTOR | Insulin - genetics | Cyclic AMP-Dependent Protein Kinases - metabolism | Uncoupling Protein 1 - genetics | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - genetics | 3T3-L1 Cells | Mice, Knockout | Adipose Tissue, Brown - cytology | Insulin - metabolism | Animals | Receptors, Adrenergic, beta - genetics | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Adipose Tissue, Brown - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 498, Issue 7454, pp. 325 - 331
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | ACTIVATED PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | MSK1 | INDUCTION | IDENTIFICATION | INACTIVATION | CREB | GROWTH | BI-DI870 | SUPPRESSES | phosphorylation | kinase-specific inhibitor | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | Index Medicus | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | protein kinase C | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
Cell, ISSN 0092-8674, 2005, Volume 123, Issue 4, pp. 569 - 580
Journal Article
Molecular Cell, ISSN 1097-2765, 09/2010, Volume 39, Issue 6, pp. 886 - 900
Epigenetic regulation of chromatin structure is essential for the expression of genes determining cellular specification and function. The Polycomb repressive... 
HISTONE METHYLTRANSFERASE ACTIVITY | MOUSE DEVELOPMENT | TRANSCRIPTIONAL ACTIVATION | EPIGENETIC MARK | STEM-CELLS | METHYLATION | CHROMATIN | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHROMOSOME CONDENSATION | H3 VARIANTS | CELL BIOLOGY | Phosphorylation - physiology | Chromatin - metabolism | Embryonic Stem Cells - metabolism | Gene Expression - drug effects | Gene Expression - genetics | Humans | Neurons - cytology | Protein Transport - physiology | Promoter Regions, Genetic - genetics | Cell Differentiation - genetics | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Peptides - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Antibodies - immunology | DNA Damage - genetics | Lysine - metabolism | Neurons - metabolism | Repressor Proteins - metabolism | Activating Transcription Factor 3 - genetics | Fibroblasts - metabolism | DNA Damage - drug effects | Histones - immunology | Gene Expression Regulation - physiology | Polycomb-Group Proteins | Serine - metabolism | Mitosis - physiology | Cell Differentiation - drug effects | Fibroblasts - drug effects | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Cell Line, Tumor | Anisomycin - pharmacology | HeLa Cells | Histones - metabolism | Methylation | Chromatin - genetics | Protein Binding - physiology | Cell research | Chromatin | Lysine | Gene expression | Embryonic stem cells | Phosphotransferases | Tretinoin | Index Medicus
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 10/2015, Volume 35, Issue 41, pp. 14042 - 14056
Journal Article