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ribosomal protein s6 kinases, 90-kda - metabolism (996) 996
animals (869) 869
humans (718) 718
phosphorylation (703) 703
mice (537) 537
biochemistry & molecular biology (394) 394
ribosomal protein s6 kinases, 90-kda - genetics (385) 385
signal transduction (340) 340
cell biology (336) 336
male (251) 251
activation (241) 241
cell line (228) 228
female (211) 211
cells, cultured (183) 183
cell line, tumor (180) 180
rats (180) 180
ribosomal protein s6 kinases, 90-kda - antagonists & inhibitors (178) 178
phosphorylation - drug effects (174) 174
expression (163) 163
proteins (161) 161
kinases (159) 159
map kinase (154) 154
enzyme activation (147) 147
extracellular signal-regulated map kinases - metabolism (140) 140
apoptosis (139) 139
mitogen-activated protein kinases - metabolism (139) 139
ribosomal s6 kinase (138) 138
oncology (130) 130
signal transduction - drug effects (130) 130
protein binding (128) 128
protein-serine-threonine kinases - metabolism (125) 125
mitogen-activated protein kinase 1 - metabolism (123) 123
gene expression (122) 122
mice, knockout (119) 119
mice, inbred c57bl (111) 111
pathway (106) 106
molecular sequence data (105) 105
protein kinases (104) 104
research (103) 103
amino acid sequence (102) 102
activated protein-kinase (101) 101
cancer (100) 100
blotting, western (99) 99
neurosciences (99) 99
research article (99) 99
enzyme inhibitors - pharmacology (96) 96
rsk (95) 95
tor serine-threonine kinases - metabolism (93) 93
mutation (92) 92
physiological aspects (92) 92
protein-kinase (90) 90
gene-expression (89) 89
proto-oncogene proteins c-akt - metabolism (88) 88
map kinase signaling system (87) 87
cell proliferation (86) 86
cells (86) 86
histones - metabolism (86) 86
kinase (85) 85
signal transduction - physiology (85) 85
growth (84) 84
protein kinase inhibitors - pharmacology (84) 84
ribosomal protein s6 kinases, 90-kda (84) 84
analysis (83) 83
cyclic amp response element-binding protein - metabolism (83) 83
mitogen-activated protein kinase 3 - metabolism (83) 83
identification (82) 82
multidisciplinary sciences (81) 81
serine - metabolism (81) 81
mammalian target (80) 80
enzyme activation - drug effects (78) 78
ribosomal protein s6 kinases, 90-kda - physiology (78) 78
transfection (78) 78
models, biological (77) 77
phosphatidylinositol 3-kinases - metabolism (77) 77
protein kinases - metabolism (75) 75
gene expression regulation (74) 74
map kinase signaling system - drug effects (74) 74
protein (74) 74
transcription (74) 74
p38 mitogen-activated protein kinases - metabolism (73) 73
msk1 (71) 71
time factors (71) 71
erk (70) 70
insulin (70) 70
map kinase signaling system - physiology (69) 69
rapamycin (69) 69
cell proliferation - drug effects (68) 68
rna interference (68) 68
in-vivo (67) 67
mtor (67) 67
rats, sprague-dawley (67) 67
tor serine-threonine kinases (67) 67
hela cells (66) 66
physiology (66) 66
genetic aspects (64) 64
binding sites (63) 63
creb (63) 63
phosphoproteins - metabolism (63) 63
inhibition (62) 62
signal-transduction (61) 61
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Molecular and Cellular Biology, ISSN 0270-7306, 02/2010, Volume 30, Issue 4, pp. 908 - 921
Journal Article
FEBS letters, ISSN 0014-5793, 06/2013, Volume 587, Issue 11, pp. 1681 - 1686
Journal Article
Cell death and differentiation, ISSN 1476-5403, 2018, Volume 25, Issue 10, pp. 1766 - 1780
.... Here we show that the mTOR effector kinases S6 kinase 1 (S6K1) and S6 kinase 2 (S6K2) localise to stress granules in human cells and are required for their assembly and maintenance after mild oxidative stress... 
MESSENGER-RNAS | APOPTOSIS | MTORC1 | INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIQUID DROPLETS | MUTATIONS | TRANSLATION | PROTEINS | EXPRESSION | DOMAINS | CELL BIOLOGY | RNA Helicases - metabolism | Caenorhabditis elegans - metabolism | Poly-ADP-Ribose Binding Proteins - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Regulatory-Associated Protein of mTOR - antagonists & inhibitors | DNA Helicases - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | RNA Interference | Signal Transduction - drug effects | Arsenites - toxicity | Cytoplasmic Granules - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Eukaryotic Initiation Factor-2 - metabolism | HeLa Cells | Oxidative Stress - drug effects | Phosphorylation - drug effects | RNA Recognition Motif Proteins - metabolism | Regulatory-Associated Protein of mTOR - genetics | Regulatory-Associated Protein of mTOR - metabolism | RNA, Small Interfering - metabolism | TOR protein | Oxidative stress | Signal transduction | Translation | Phosphorylation | Cell survival | Neurodegeneration | Granule cells | Translation initiation | Aging | mRNA | Cancer | Life Sciences | Cellular Biology | Cell biology | Genetics
Journal Article
Biochemical journal, ISSN 1470-8728, 2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B (also known as Akt), PKC, S6K p70 (ribosomal S6 kinase), RSK... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | ACTIVATED PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | MSK1 | INDUCTION | IDENTIFICATION | INACTIVATION | CREB | GROWTH | BI-DI870 | SUPPRESSES | phosphorylation | kinase-specific inhibitor | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | protein kinase C | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/1999, Volume 274, Issue 38, pp. 27168 - 27176
Journal Article
Nature chemical biology, ISSN 1552-4469, 2014, Volume 10, Issue 12, pp. 1066 - 1072
Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency and utility for biological studies... 
DESIGN | PLACEBO | LIGANDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | REACTIVITY | OPTIMIZATION | GENERATION | INHIBITORS | COORDINATE | CYSTEINES | PREDICTION | Small Molecule Libraries - pharmacology | Humans | Bacterial Proteins - chemistry | Molecular Probes - pharmacology | Janus Kinase 3 - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | beta-Lactamases - genetics | Janus Kinase 3 - chemistry | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Cysteine - metabolism | Bacterial Proteins - antagonists & inhibitors | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cysteine - chemistry | beta-Lactamase Inhibitors - pharmacology | Ribosomal Protein S6 Kinases, 90-kDa - chemistry | Serine - chemistry | Drug Discovery | Serine - metabolism | Gram-Negative Bacteria - enzymology | Gram-Negative Bacteria - drug effects | Small Molecule Libraries - chemistry | beta-Lactamases - chemistry | Molecular Probes - chemistry | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Gram-Negative Bacteria - growth & development | Janus Kinase 3 - genetics | Hydrophobic and Hydrophilic Interactions | Protein Binding | Ligands | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | COS Cells | beta-Lactamase Inhibitors - chemistry | Proteins | Chemical bonds | Biochemistry | Crystal structure | Life Sciences | boronic acid | covalent virtual screening | JAK3 kinase | covalent fragments | covalent inhibition | beta-lactamase | RSK2 kinase | cyanoacrylamide | reversible covalent | covalent electrophile | MSK1 kinase
Journal Article
The Journal of clinical investigation, ISSN 1558-8238, 2016, Volume 126, Issue 5, pp. 1704 - 1716
... through beta-adrenergic receptor (beta ARs) and protein kinase A (PKA) signaling. Here, we have shown that a key hub in the insulin signaling pathway, activation of p70 ribosomal S6 kinase (S6K1... 
MEDICINE, RESEARCH & EXPERIMENTAL | UNCOUPLING PROTEIN-1 GENE | WHITE FAT | GLUCOSE-HOMEOSTASIS | CYCLIC-AMP | ADIPOCYTE PROLIFERATION | INITIATION-FACTOR 4E | SMOOTH-MUSCLE-CELLS | ADULT HUMANS | DIET-INDUCED OBESITY | INSULIN SENSITIVITY | TOR Serine-Threonine Kinases - metabolism | Humans | Adipose Tissue, White - metabolism | Multiprotein Complexes - genetics | Uncoupling Protein 1 - biosynthesis | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Adipose Tissue, White - cytology | Cyclic AMP-Dependent Protein Kinases - genetics | TOR Serine-Threonine Kinases - genetics | HEK293 Cells | Regulatory-Associated Protein of mTOR | Insulin - genetics | Cyclic AMP-Dependent Protein Kinases - metabolism | Uncoupling Protein 1 - genetics | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - genetics | 3T3-L1 Cells | Mice, Knockout | Adipose Tissue, Brown - cytology | Insulin - metabolism | Animals | Receptors, Adrenergic, beta - genetics | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Adipose Tissue, Brown - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism
Journal Article
EMBO reports, ISSN 1469-221X, 08/2018, Volume 19, Issue 8, p. n/a
Mitogen‐activated protein kinase (MAPK)/extracellular signal‐regulated kinase (ERK) signalling is implicated in initiation of embryonic stem... 
pluripotency | RSK | signalling feedback | mitogen‐activated protein kinase | embryonic stem cells | mitogen-activated protein kinase | SIGNALING PATHWAYS | GROUND-STATE | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SELF-RENEWAL | PRIMITIVE ENDODERM | FATE DECISIONS | CELL BIOLOGY | TRANSITION | IN-VITRO | INHIBITION | EMBRYONIC STEM-CELLS | Embryonic Stem Cells - metabolism | Small Molecule Libraries - pharmacology | Embryonic Stem Cells - cytology | Pluripotent Stem Cells - cytology | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Mutation - genetics | Phosphoproteins - metabolism | Cell Lineage - drug effects | Pluripotent Stem Cells - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Pluripotent Stem Cells - drug effects | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Feedback, Physiological - drug effects | Phosphorylation - drug effects | Proteome - metabolism | CRISPR | Phosphorylation | Differentiation (biology) | Extracellular signal-regulated kinase | MAP kinase | Activation | Kinases | Cell differentiation | Proteins | Ribosomal protein S6 kinase | Organic chemistry | Signal transduction | Signaling | Negative feedback | Protein kinase | Feedback | Homogeneity | Mutation | Kinetics | Inhibition | Pluripotency | Combinatorial analysis | Genotypes | Stem Cells | Signal Transduction | Post-translational Modifications, Proteolysis & Proteomics
Journal Article
Journal Article