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International Journal of Cancer, ISSN 0020-7136, 04/2012, Volume 130, Issue 7, pp. 1695 - 1705
Lung cancer is one of the most commonly occurring malignancies. It has been reported that mammalian target of rapamycin (mTOR) is phosphorylated in lung cancer... 
lung cancer | signaling | PI3K | fisetin | mTOR | Akt | flavonoid | dual inhibition | ACTIVATED PROTEIN-KINASE | CYCLE ARREST | KAPPA-B | TUBEROUS-SCLEROSIS | ONCOLOGY | PROSTATE-CANCER | GROWTH | TUMOR-SUPPRESSOR | MTOR INHIBITORS | PI3K/AKT/MTOR PATHWAY | EXPRESSION | Protein Kinases - metabolism | Lung Neoplasms - drug therapy | TOR Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - antagonists & inhibitors | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Lung Neoplasms - metabolism | Eukaryotic Initiation Factor-4E - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Regulatory-Associated Protein of mTOR | Flavonoids - pharmacology | Phosphorylation - drug effects | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Tumor Suppressor Proteins - metabolism | Lung Neoplasms - enzymology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | MTOR Associated Protein, LST8 Homolog | Carcinoma, Non-Small-Cell Lung - metabolism | Carrier Proteins - antagonists & inhibitors | PTEN Phosphohydrolase - metabolism | Eukaryotic Initiation Factor-4E - antagonists & inhibitors | Carrier Proteins - metabolism | Cell Line, Tumor | Stem Cells - drug effects | Cell Proliferation - drug effects | Carcinoma, Non-Small-Cell Lung - drug therapy | Adaptor Proteins, Signal Transducing - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Kinases | Phosphorylation | Lung cancer
Journal Article
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 113, Issue 26, pp. 6669 - 6680
Journal Article
Cancer Research, ISSN 0008-5472, 08/2011, Volume 71, Issue 15, pp. 5204 - 5213
Most cancer cells utilize aerobic glycolysis, and activation of the phosphoinositide 3-kinase/Akt/mTOR pathway can promote this metabolic program to render... 
CANCER-CELLS | APOPTOSIS | ONCOLOGY | PATHWAY | AEROBIC GLYCOLYSIS | GROWTH-FACTORS | KINASE | BH3 MIMETIC ABT-737 | FACTOR-INDEPENDENT SURVIVAL | MTOR | TRANSLATIONAL CONTROL | Proto-Oncogene Proteins c-bcl-2 - physiology | Humans | Multiprotein Complexes | Neoplasm Proteins - physiology | Cell Line, Tumor - drug effects | Glycolysis - drug effects | Mechanistic Target of Rapamycin Complex 1 | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | T-Lymphocytes - drug effects | Adenosine Triphosphate - metabolism | Membrane Proteins - metabolism | Phosphoproteins - physiology | Gene Expression Regulation, Neoplastic - drug effects | Proto-Oncogene Proteins - metabolism | Proteins - physiology | Proto-Oncogene Proteins - antagonists & inhibitors | Lymphoma, Large B-Cell, Diffuse - pathology | Cell Survival | Proto-Oncogene Proteins c-akt - physiology | Sulfonamides - pharmacology | Piperazines - pharmacology | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Apoptosis Regulatory Proteins - metabolism | Adaptor Proteins, Signal Transducing - physiology | Animals | Membrane Proteins - antagonists & inhibitors | Myeloid Cell Leukemia Sequence 1 Protein | Apoptosis Regulatory Proteins - antagonists & inhibitors | Glucose - metabolism | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Mice | Ribosomal Protein S6 Kinases - physiology | TOR Serine-Threonine Kinases | Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Jurkat Cells - drug effects | mTOR | ABT-737 | Mcl-1 | apoptosis | glycolysis
Journal Article
Cancer Cell, ISSN 1535-6108, 04/2016, Volume 29, Issue 4, pp. 548 - 562
Although glycolysis is substantially elevated in many tumors, therapeutic targeting of glycolysis in cancer patients has not yet been successful, potentially... 
NOVO PYRIMIDINE SYNTHESIS | MTORC1 | ONCOLOGY | PATHWAY | GROWTH | 2-DEOXY-D-GLUCOSE | PROLIFERATION | CARBOXYLATION | CONTRIBUTES | DEHYDROGENASE | GLUTAMINE-METABOLISM | CELL BIOLOGY | Neoplasms - metabolism | Metabolomics | Pentose Phosphate Pathway - drug effects | Glutaminase - physiology | Humans | Neoplasm Proteins - physiology | Ovarian Neoplasms - pathology | Glutamine - metabolism | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Ribosomal Protein S6 Kinases, 70-kDa - physiology | Adenosine Triphosphate - biosynthesis | Molecular Targeted Therapy | Glycolysis - drug effects | Glucose-6-Phosphate Isomerase - genetics | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | Deoxyglucose - therapeutic use | TOR Serine-Threonine Kinases - antagonists & inhibitors | RNA Interference | Deoxyglucose - pharmacology | Everolimus - therapeutic use | Female | TOR Serine-Threonine Kinases - physiology | Carcinoma - pathology | Cytokines - genetics | Tumor Stem Cell Assay | Pentose Phosphate Pathway - physiology | Everolimus - pharmacology | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Combined Modality Therapy | Glutaminase - antagonists & inhibitors | Citric Acid Cycle | Hep G2 Cells | Multiprotein Complexes - physiology | Neoplasms - drug therapy | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Mice, Nude | RNA, Small Interfering - therapeutic use | Glucose-6-Phosphate Isomerase - antagonists & inhibitors | Cell Line, Tumor | Mice | Cytokines - antagonists & inhibitors | Energy Metabolism - drug effects | Phosphates | Glucose metabolism | Cancer cells | Glucose | Molecular biology | Dextrose | Cancer
Journal Article
Cell, ISSN 0092-8674, 2004, Volume 119, Issue 7, pp. 969 - 979
The regulation of ribosome biogenesis in response to environmental conditions is a key aspect of cell growth control. Ribosomal protein (RP) genes are... 
HEAD PROTEIN | YEAST | RAPAMYCIN | RECRUITMENT | RNA-POLYMERASE-I | SIGNALING PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-GROWTH | FHA DOMAIN | SACCHAROMYCES-CEREVISIAE | MASS-SPECTROMETRY | CELL BIOLOGY | Consensus Sequence | Transcription Factors - chemistry | Saccharomyces cerevisiae - genetics | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Repressor Proteins - antagonists & inhibitors | Ribosomal Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Cell Nucleus - metabolism | Protein Binding - drug effects | Trans-Activators - genetics | Active Transport, Cell Nucleus | Phosphorylation - drug effects | Genes, Fungal - genetics | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Gene Expression Regulation, Fungal | Promoter Regions, Genetic | Ribosomal Proteins - genetics | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins | Repressor Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | Sirolimus - pharmacology | Amino Acid Motifs | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Transcription Factors - metabolism | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Two-Hybrid System Techniques | Saccharomyces cerevisiae Proteins - metabolism | Trans-Activators - metabolism | Trans-Activators - antagonists & inhibitors | Forkhead Transcription Factors | Saccharomyces cerevisiae Proteins - chemistry | Rapamycin | Chemical properties | Research | Ribosomal proteins | Genetic regulation | Protein kinases | Life Sciences
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Cancer Cell, ISSN 1535-6108, 02/2014, Volume 25, Issue 2, pp. 243 - 256
Mutations in are prevalent in human cancers and universally predictive of resistance to anticancer therapeutics. Although it is widely accepted that... 
ACTIVATION | INHIBITION | ONCOGENIC RAS | TUMOR PROGRESSION | CHK1 | ONCOLOGY | INITIATION | COMBINATION | SUPPRESSION | ATR | KINASES | CELL BIOLOGY | Neoplasms - metabolism | Protein Kinases - metabolism | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Humans | ras Proteins - metabolism | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | GTP Phosphohydrolases - antagonists & inhibitors | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Flow Cytometry | Neoplasms - genetics | DNA Damage - genetics | Female | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | DNA Damage - drug effects | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Membrane Proteins - genetics | Proto-Oncogene Proteins - genetics | Mutation - genetics | Animals | GTP Phosphohydrolases - metabolism | Membrane Proteins - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - metabolism | GTP Phosphohydrolases - genetics | Mice, Nude | Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors | Checkpoint Kinase 1 | Mice | Cell Transformation, Neoplastic - pathology | Neoplasms - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Chemotherapy | DNA damage | DNA | Genetic research | DNA repair | Cancer | Tumors
Journal Article
Nature chemical biology, ISSN 1552-4450, 12/2014, Volume 10, Issue 12, pp. 1066 - 1072
Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency and utility for biological studies. Despite these... 
DESIGN | PLACEBO | LIGANDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | REACTIVITY | OPTIMIZATION | GENERATION | INHIBITORS | COORDINATE | CYSTEINES | PREDICTION | Small Molecule Libraries - pharmacology | Humans | Bacterial Proteins - chemistry | Molecular Probes - pharmacology | Janus Kinase 3 - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | beta-Lactamases - genetics | Janus Kinase 3 - chemistry | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Cysteine - metabolism | Bacterial Proteins - antagonists & inhibitors | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cysteine - chemistry | beta-Lactamase Inhibitors - pharmacology | Ribosomal Protein S6 Kinases, 90-kDa - chemistry | Serine - chemistry | Drug Discovery | Serine - metabolism | Gram-Negative Bacteria - enzymology | Gram-Negative Bacteria - drug effects | Small Molecule Libraries - chemistry | beta-Lactamases - chemistry | Molecular Probes - chemistry | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Gram-Negative Bacteria - growth & development | Janus Kinase 3 - genetics | Hydrophobic and Hydrophilic Interactions | Protein Binding | Ligands | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | COS Cells | beta-Lactamase Inhibitors - chemistry | Proteins | Chemical bonds | Biochemistry | Crystal structure | boronic acid | covalent virtual screening | JAK3 kinase | covalent fragments | covalent inhibition | beta-lactamase | RSK2 kinase | cyanoacrylamide | reversible covalent | covalent electrophile | MSK1 kinase
Journal Article
Journal Article
Journal Article