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Science, ISSN 0036-8075, 11/2010, Volume 330, Issue 6008, pp. 1203 - 1209
Crystal structures of prokaryotic ribosomes have described in detail the universally conserved core of the translation mechanism. However, many facets of the... 
Proteins | Yeasts | RESEARCH ARTICLE | Messenger RNA | RNA | Prokaryotes | Ribosomes | Crystals | Eukaryotic cells | Transfer RNA | Crystal structure | E-SITE | ANGSTROM RESOLUTION | TRANSLOCATION | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | MOVEMENT | TRANSLATION INITIATION | TRANSFER-RNA | 70S RIBOSOME | 80S RIBOSOME | SUBUNIT | Ribosomal Proteins - analysis | Ribosomal Proteins - chemistry | RNA, Fungal - analysis | Ribosome Subunits, Large, Eukaryotic - ultrastructure | Protein Biosynthesis | Ribosome Subunits, Small, Eukaryotic - chemistry | Saccharomyces cerevisiae - genetics | RNA, Messenger - analysis | Ribosomes - metabolism | Crystallography, X-Ray | Peptide Chain Initiation, Translational | Saccharomyces cerevisiae - ultrastructure | RNA, Messenger - metabolism | Ribosomal Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Ribosome Subunits, Large, Eukaryotic - metabolism | Nucleic Acid Conformation | RNA, Transfer - chemistry | RNA, Transfer - metabolism | Ribosome Subunits, Large, Eukaryotic - chemistry | RNA, Fungal - chemistry | RNA, Ribosomal - chemistry | Crystallization | Ribosomes - chemistry | Models, Molecular | RNA, Ribosomal - metabolism | Ribosome Subunits, Small, Eukaryotic - ultrastructure | Saccharomyces cerevisiae - chemistry | RNA, Fungal - metabolism | Ribosomes - ultrastructure | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Protein Conformation | RNA, Messenger - chemistry | RNA, Ribosomal - analysis | Ribosome Subunits, Small, Eukaryotic - metabolism | Saccharomyces cerevisiae Proteins - analysis | Saccharomyces cerevisiae Proteins - chemistry | Composition | Eukaryotes | Physiological aspects | Protein biosynthesis | Research | Structure | Conformation | Networks | Protein synthesis | Bacteria | Mathematical models | Ratcheting | Translations | Index Medicus
Journal Article
Science, ISSN 0036-8075, 11/2011, Volume 334, Issue 6058, pp. 941 - 948
Protein synthesis in all organisms is catalyzed by ribosomes. In comparison to their prokaryotic counterparts, eukaryotic ribosomes are considerably larger and... 
Proteins | Yeasts | RESEARCH ARTICLE | RNA | Ribosomal proteins | Antibiotics | Protein synthesis | Ribosomes | Tunnels | Transfer RNA | Crystal structure | CYCLOHEXIMIDE RESISTANCE | EXIT TUNNEL | YEAST | BLACKFAN ANEMIA | PROTEIN | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | SHWACHMAN-DIAMOND SYNDROME | TRANSLATION ELONGATION | TRANSFER-RNA | 80S RIBOSOME | Ribosomal Proteins - chemistry | Ribosome Subunits, Large, Eukaryotic - ultrastructure | RNA, Ribosomal, 5.8S - chemistry | Tetrahymena thermophila - chemistry | Molecular Sequence Data | Crystallography, X-Ray | RNA, Ribosomal, 5.8S - metabolism | Peptide Chain Initiation, Translational | Ribosomal Proteins - metabolism | Protozoan Proteins - metabolism | Ribosome Subunits, Large, Eukaryotic - metabolism | Base Sequence | Protozoan Proteins - chemistry | Nucleic Acid Conformation | Binding Sites | Eukaryotic Initiation Factors - chemistry | Eukaryotic Initiation Factors - metabolism | Protein Structure, Secondary | Ribosome Subunits, Large, Eukaryotic - chemistry | Tetrahymena thermophila - metabolism | RNA, Ribosomal - chemistry | Crystallization | Models, Molecular | RNA, Ribosomal - metabolism | Anti-Bacterial Agents - metabolism | Cycloheximide - metabolism | RNA, Protozoan - chemistry | RNA, Protozoan - metabolism | Protein Conformation | Physiological aspects | Protein biosynthesis | Research | Structure | Ribonucleic acid--RNA | Eukaryotes | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7519, pp. 517 - 522
The ribosome is a molecular machine responsible for protein synthesis and a major target for small-molecule inhibitors. Compared to the wealth of structural... 
CRYPTOPLEURINE RESISTANCE | AMARYLLIDACEAE ALKALOIDS | SACCHAROMYCES-CEREVISIAE MUTANTS | NUCLEOTIDE RESOLUTION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | PEPTIDE-BOND FORMATION | TRANSLATION INITIATION | TRANSFER-RNA | PROTEIN-SYNTHESIS | AMINOGLYCOSIDE ANTIBIOTICS | Eukaryotic Cells - chemistry | Protein Synthesis Inhibitors - chemistry | Molecular Weight | Species Specificity | Ribosomes - metabolism | Substrate Specificity | Crystallography, X-Ray | Molecular Targeted Therapy | RNA, Messenger - metabolism | Ribosome Subunits, Large, Eukaryotic - metabolism | Base Sequence | Macrolides - pharmacology | RNA, Transfer - genetics | Protein Synthesis Inhibitors - pharmacology | Binding Sites - drug effects | Eukaryotic Cells - enzymology | Peptidyl Transferases - metabolism | RNA, Transfer - metabolism | Ribosome Subunits, Large, Eukaryotic - chemistry | Peptidyl Transferases - chemistry | RNA, Messenger - genetics | Ribosomes - chemistry | Models, Molecular | Drug Resistance - drug effects | Peptide Chain Elongation, Translational - drug effects | Piperidones - pharmacology | Cycloheximide - pharmacology | Saccharomyces cerevisiae - chemistry | Eukaryotic Cells - drug effects | Ribosomes - drug effects | Ribosome Subunits, Large, Eukaryotic - drug effects | Kinetics | Eukaryotes | Analysis | Ribosomes | Ribonucleoproteins | Research | Health aspects | Transfer RNA | Proteins | Yeast | Peptides | Antibiotics | Protein synthesis | Bacteria | Drug resistance | Binding sites | Index Medicus
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 08/2012, Volume 19, Issue 8, pp. 744 - 753
In the final steps of yeast ribosome synthesis, immature translation-incompetent pre-40S particles that contain 20S pre-rRNA are converted to the mature... 
PROTEIN | RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | FACTOR EIF5B | SACCHAROMYCES-CEREVISIAE | INTERNAL TRANSCRIBED SPACER-1 | PIN DOMAIN | CELL BIOLOGY | YEAST | BIOPHYSICS | BIOGENESIS | CYTOPLASMIC MATURATION | RNA Precursors - chemistry | Ribosome Subunits, Small, Eukaryotic - chemistry | Eukaryotic Initiation Factor-2 - chemistry | Saccharomyces cerevisiae - genetics | Molecular Sequence Data | Guanosine Triphosphate - metabolism | RNA, Ribosomal - genetics | Saccharomyces cerevisiae - metabolism | Ribosome Subunits, Large, Eukaryotic - metabolism | Adenosine Triphosphate - metabolism | Base Sequence | Eukaryotic Initiation Factor-2 - metabolism | RNA Precursors - metabolism | RNA, Fungal - genetics | Nucleic Acid Conformation | Binding Sites | RNA Processing, Post-Transcriptional | Ribosome Subunits, Large, Eukaryotic - chemistry | RNA, Fungal - chemistry | RNA, Ribosomal - chemistry | Models, Molecular | RNA, Ribosomal - metabolism | Nuclear Proteins - metabolism | RNA Precursors - genetics | RNA, Fungal - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Conformation | Ribosome Subunits, Small, Eukaryotic - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Physiological aspects | Biosynthesis | Research | Molecular genetics | Genetic translation | Ribosomes | Atoms & subatomic particles | Ribonucleic acid--RNA | Yeast | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 534, Issue 7605, pp. 133 - 137
Ribosome biogenesis is a highly complex process in eukaryotes, involving temporally and spatially regulated ribosomal protein (r-protein) binding and ribosomal... 
60S MATURATION | RNA | BIOGENESIS | PARTICLE | NASCENT RIBOSOMES | MULTIDISCIPLINARY SCIENCES | CRYO-EM | ELECTRON-MICROSCOPY | SACCHAROMYCES-CEREVISIAE | ASSOCIATION | SUBUNIT | RNA, Fungal - ultrastructure | GTP Phosphohydrolases - ultrastructure | Saccharomyces cerevisiae - ultrastructure | DNA, Ribosomal Spacer - metabolism | RNA, Ribosomal - genetics | GTP Phosphohydrolases - chemistry | Saccharomyces cerevisiae - metabolism | Cell Nucleus - metabolism | Ribosome Subunits, Large, Eukaryotic - metabolism | DNA, Ribosomal Spacer - genetics | Base Sequence | DNA, Ribosomal Spacer - ultrastructure | Ribosome Subunits, Large, Eukaryotic - chemistry | Models, Molecular | Ribonucleoproteins - metabolism | Nuclear Proteins - chemistry | Saccharomyces cerevisiae - chemistry | RNA, Ribosomal - ultrastructure | Saccharomyces cerevisiae - cytology | Ribosomal Proteins - isolation & purification | GTP Phosphohydrolases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | GTP-Binding Proteins - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Ribosomal Proteins - chemistry | Ribosome Subunits, Large, Eukaryotic - ultrastructure | Nuclear Proteins - ultrastructure | Molecular Sequence Data | Cytoplasm - metabolism | Ribosomal Proteins - metabolism | Ribosomal Proteins - ultrastructure | Saccharomyces cerevisiae Proteins - isolation & purification | RNA, Fungal - genetics | Active Transport, Cell Nucleus | Ribonucleoproteins - chemistry | Saccharomyces cerevisiae Proteins - ultrastructure | Catalytic Domain | GTP-Binding Proteins - chemistry | RNA, Ribosomal - metabolism | Nuclear Proteins - metabolism | GTP-Binding Proteins - ultrastructure | DNA, Ribosomal Spacer - chemistry | Cell Nucleus - ultrastructure | Rotation | RNA, Fungal - metabolism | Cryoelectron Microscopy | Protein Binding | Cell Nucleus - chemistry | Ribonucleoproteins - ultrastructure | Nucleolus organizer region | Protein research | Research | Ribosomes | Protein binding | Genetic research | Proteins | Polypeptides | Molecular structure | Ribonucleic acid--RNA | Index Medicus
Journal Article