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Applied Microbiology and Biotechnology, ISSN 0175-7598, 11/2018, Volume 102, Issue 22, pp. 9585 - 9594
The specific targeting of immunotoxins enables their wide application in cancer therapy. The A-chain of the ricin protein (RTA) is an N-glycosidase that... 
Life Sciences | Biotechnology | Ricin A | Localization peptide | Microbiology | Recombinant immunotoxin | Microbial Genetics and Genomics | Cancer cell | HER2 | Specific targeting | ABRIN | ESCHERICHIA-COLI | TOXIC LECTINS | INCREASES | RICIN-A-CHAIN | GLUCOSE-REGULATED PROTEIN | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PHASE-I | EXPRESSION | CYTOTOXICITY | Lung Neoplasms - drug therapy | Receptor, ErbB-2 - genetics | Recombinant Fusion Proteins - pharmacology | Humans | Lung Neoplasms - metabolism | Receptor, ErbB-2 - metabolism | Endoplasmic Reticulum - metabolism | Immunotoxins - pharmacology | Recombinant Fusion Proteins - metabolism | Ovarian Neoplasms - genetics | Single-Chain Antibodies - metabolism | Single-Chain Antibodies - genetics | HEK293 Cells | Immunotoxins - metabolism | Female | Ovarian Neoplasms - metabolism | Receptor, ErbB-2 - antagonists & inhibitors | Ovarian Neoplasms - drug therapy | Lung Neoplasms - genetics | Endoplasmic Reticulum - genetics | Single-Chain Antibodies - pharmacology | Oligopeptides - genetics | Oligopeptides - metabolism | Amino Acid Motifs | Protein Transport | Ricin - pharmacology | Immunotoxins - genetics | Protein Sorting Signals - genetics | Ricin - metabolism | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Ricin - genetics | Single-Chain Antibodies - chemistry | Prevention | Antibody-toxin conjugates | Endoplasmic reticulum | Health aspects | Production processes | Cancer cells | rRNA 28S | Ovarian carcinoma | Toxicity | Ricin | Lung cancer | Adenine | Chains | ErbB-2 protein | Ovarian cancer | Anticancer properties | Proteins | Immunotoxins | Cell death | N-glycosidase | Immunofluorescence | Cytoplasm | Cancer | Recombinant | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 2010, Volume 141, Issue 2, pp. 231 - 242
Journal Article
The FEBS Journal, ISSN 1742-464X, 10/2012, Volume 279, Issue 20, pp. 3925 - 3936
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2004, Volume 383, Issue 2, pp. 285 - 293
Cells expressing ricin B chain within the secretory pathway are significantly more resistant to intoxication by ricin holotoxin but not to other cytotoxins... 
Toxin | Protein disulphide-isomerase | Endoplasmic reticulum-associated protein degradation (ERAD) | Retrograde transport | Oxidoreductase | Ricin | TRANSLOCATION | ricin | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein disulphide-isomerase | retrograde transport | encloplasmic reticulum-associated protein degradation (ERAD) | SECRETORY PATHWAY | toxin | REDUCTION | CYTOSOL | oxidoreductase | CYTOTOXICITY | BINDING | CELL-LINE | CHOLERA-TOXIN | SUBUNIT | Disulfides - metabolism | Oxidation-Reduction | Protein Disulfide-Isomerases - metabolism | Humans | Endoplasmic Reticulum - metabolism | Abrin - pharmacology | Protein Folding | Ricin - pharmacology | Endocytosis | Sulfhydryl Compounds - metabolism | Biological Transport | Ricin - chemistry | Ricin - metabolism | Protein Structure, Quaternary | Ricin - genetics | Sulfhydryl Compounds - chemistry | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | Dimerization | Peptide Hydrolases - metabolism | ATA, abrin isoform F A chain | ATB, abrin B chain | RTB, ricin toxin B chain | endo H, endoglycosidase H | SFM, serum-free medium | endoplasmic reticulum-associated protein degradation (ERAD) | CTA, cholera toxin A | DTT, dithiothreitol | FCS, foetal calf serum | DMEM, Dulbecco's modified Eagle's medium | PE, Pseudomonas exotoxin A | NEM, N-ethylmaleimide | SLT, Shiga-like toxin 1 | DMM, deoxymannojirimycin | CST, castanospermine | Tn, tunicamycin | CNX, calnexin | RTA, ricin toxin A chain | BFA, Brefeldin A | BMH, bis-maleimidohexane | ER, endoplasmic reticulum | PDI, protein disulphide-isomerase
Journal Article
Journal Article
Biochimica et biophysica acta. Molecular cell research, ISSN 0167-4889, 09/2019, p. 118554
The generally accepted model of ricin intoxication assumes that direct inactivation of ribosomes by depurination of a specific adenine residue within the... 
Journal Article
Toxicology Letters, ISSN 0378-4274, 09/2016, Volume 258, pp. 11 - 19
The plant-derived toxins ricin and abrin, operate by site-specific depurination of ribosomes, which in turn leads to protein synthesis arrest. The clinical... 
Abrin | Ricin | Depurination | 28SrRNA | Lung | ACTIVATED PROTEIN-KINASE | RNA | MACROPHAGES | SHIGA TOXIN | DEOXYNIVALENOL | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | CHAIN | TOXICOLOGY | RIBOSOME-INACTIVATING PROTEINS | RIBOTOXIC STRESS-RESPONSE | Poisoning - metabolism | Protein Synthesis Inhibitors - chemistry | Respiratory Mucosa - drug effects | Poisoning - physiopathology | Pneumonia - prevention & control | RNA, Ribosomal, 28S - metabolism | Respiratory Insufficiency - etiology | Ribosomes - metabolism | Cytotoxins - administration & dosage | Ricinus - enzymology | Abrin - administration & dosage | Cytotoxins - toxicity | Abrin - isolation & purification | Protein Synthesis Inhibitors - administration & dosage | Respiratory Mucosa - pathology | Ribosomes - enzymology | Abrus - enzymology | Antitoxins - therapeutic use | Flow Cytometry | Respiratory Insufficiency - prevention & control | Abrin - toxicity | Cytotoxins - metabolism | Female | Lung - metabolism | Ricin - antagonists & inhibitors | Cytotoxins - antagonists & inhibitors | Lung - pathology | Pneumonia - etiology | Protein Synthesis Inhibitors - toxicity | Purines - metabolism | Poisoning - drug therapy | Lethal Dose 50 | Poisoning - pathology | Protein Synthesis Inhibitors - metabolism | Ricin - administration & dosage | Administration, Intranasal | Ricin - toxicity | Abrin - metabolism | Animals | Ricin - metabolism | Lung - drug effects | Ribosomes - drug effects | Mice | Respiratory Mucosa - metabolism | DNA, Complementary - metabolism | Lectins | Enzymes | Protein biosynthesis | Analysis | Index Medicus | Lungs | Catalysts | Catalytic activity | Exposure | Toxins | Intoxication | Damage
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2012, Volume 287, Issue 13, pp. 10602 - 10612
Journal Article
Protein Science, ISSN 0961-8368, 10/2017, Volume 26, Issue 10, pp. 2059 - 2072
Polyvalent antigen display is an effective strategy to enhance the immunogenicity of subunit vaccines by clustering them in an array‐like manner on a scaffold... 
polyvalent antigen display | lumazine synthase | vaccine | ricin | immunogenicity | stability | DESIGN | DRUG-DELIVERY | BIOCHEMISTRY & MOLECULAR BIOLOGY | NANOPARTICLE | RESPONSES | ASSEMBLIES | CRYSTALLOGRAPHIC REFINEMENT | IMMUNODEFICIENCY-VIRUS TYPE-1 | VACCINES | Anthrax Vaccines - chemistry | Immunoglobulin G - blood | Anthrax Vaccines - metabolism | Vaccines, Subunit - genetics | Epitopes, B-Lymphocyte - chemistry | Antigens, Bacterial - immunology | Multienzyme Complexes - immunology | Multienzyme Complexes - metabolism | Epitopes, B-Lymphocyte - immunology | Antigens, Bacterial - genetics | Bacillus anthracis - enzymology | Anthrax Vaccines - immunology | Epitopes, B-Lymphocyte - genetics | Ricin - chemistry | Immunoglobulin G - immunology | Female | Protein Stability | Antibodies, Bacterial - blood | Anthrax Vaccines - genetics | Antigens, Bacterial - chemistry | Vaccines, Subunit - chemistry | Models, Molecular | Multienzyme Complexes - genetics | Vaccines, Subunit - immunology | Multienzyme Complexes - chemistry | Ricin - immunology | Animals | Ricin - metabolism | Vaccines, Subunit - metabolism | Epitopes, B-Lymphocyte - metabolism | Bacillus anthracis - immunology | Antibodies, Bacterial - immunology | Ricin - genetics | Mice | Antigens, Bacterial - metabolism | Medical research | Crosslinked polymers | Immunoglobulin G | Medicine, Experimental | B cells | Immunity | Formaldehyde | Antigenic determinants | Antigen presentation | Antigens | Ricin | Feasibility studies | Crosslinking | Vaccines | Rigidity | Clustering | Thermal stability | Icosahedral phase | Lethal dose | Proteins | Immunogenicity | Lymphocytes B | Antigen-presenting cells | Avidity | Lumazine synthase | Protein structure | Assembly
Journal Article