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Free Radical Biology and Medicine, ISSN 0891-5849, 11/2017, Volume 112, pp. 24 - 35
Bile acid transporters and the nuclear factor erythroid 2-related factor (Nrf-2)-mediated adaptive response play important roles in the development of... 
HepG2 cells | Rifampicin | Bile acid transporters | Nrf2 | TUDCA | Adaptive response | DRUG | SALT EXPORT PUMP | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM STRESS | RIFAMYCIN SV | INDUCED LIVER-INJURY | CHOLESTATIC RAT-LIVER | INHIBITION | ENDOCRINOLOGY & METABOLISM | CANALICULAR MEMBRANES | INDUCED HEPATOTOXICITY | Adaptation, Physiological | Aspartate Aminotransferases - genetics | L-Lactate Dehydrogenase - metabolism | RNA, Small Interfering - genetics | ATP Binding Cassette Subfamily B Member 11 - antagonists & inhibitors | Humans | Alkaline Phosphatase - metabolism | Stress, Physiological | Rifampin - antagonists & inhibitors | NF-E2-Related Factor 2 - agonists | Adenosine Triphosphate | Bilirubin | Organic Anion Transporters, Sodium-Dependent - genetics | Taurochenodeoxycholic Acid - pharmacology | Alanine Transaminase - genetics | ATP Binding Cassette Subfamily B Member 11 - metabolism | ATP Binding Cassette Transporter, Sub-Family B - agonists | Membrane Transport Proteins - genetics | ATP Binding Cassette Subfamily B Member 11 - agonists | Membrane Transport Proteins - metabolism | Multidrug Resistance-Associated Proteins - genetics | NF-E2-Related Factor 2 - genetics | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Solute Carrier Organic Anion Transporter Family Member 1b1 - genetics | Alkaline Phosphatase - genetics | Signal Transduction | Gene Expression Regulation | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | gamma-Glutamyltransferase - metabolism | Antibiotics, Antitubercular - pharmacology | Symporters - metabolism | Aspartate Aminotransferases - metabolism | Hep G2 Cells | gamma-Glutamyltransferase - genetics | L-Lactate Dehydrogenase - genetics | NF-E2-Related Factor 2 - metabolism | Solute Carrier Organic Anion Transporter Family Member 1b1 - metabolism | Symporters - genetics | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Multidrug Resistance-Associated Proteins - agonists | Alanine Transaminase - metabolism | Rifampin - pharmacology | ATP Binding Cassette Transporter, Sub-Family B - genetics | Multidrug Resistance-Associated Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | ATP Binding Cassette Subfamily B Member 11 - genetics | RNA, Small Interfering - metabolism | Drug resistance in microorganisms | Phosphatases | Liver | Muscle proteins | Rifampin | Adenosine triphosphate | Deoxycholic acid | Proteins | Liver diseases | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1400 - 1407
The elimination process of the endothelin receptor antagonist bosentan (Tracleer) in humans is entirely dependent on metabolism mediated by two cytochrome P450... 
PHARMACOKINETICS | METABOLISM | HEALTHY MALE-SUBJECTS | PHARMACOLOGY & PHARMACY | ANION TRANSPORTING POLYPEPTIDES | HUMAN LIVER | RIFAMYCIN SV | EXPRESSION | DISPOSITION | ENDOTHELIN RECEPTOR ANTAGONIST | DRUG-DRUG INTERACTION | Cytochrome P-450 CYP2C9 | Organic Anion Transporters, Sodium-Independent - genetics | Estradiol - analogs & derivatives | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Cricetulus | Cytochrome P-450 Enzyme Inhibitors | Cyclosporine - pharmacology | Cytochrome P-450 CYP3A | Humans | Warfarin - metabolism | Cytochrome P-450 Enzyme System - metabolism | Dehydroepiandrosterone Sulfate - metabolism | Sulfones - pharmacology | Organic Anion Transporters - metabolism | Pyrimidines - chemistry | Pyrimidines - metabolism | Sildenafil Citrate | Organic Anion Transporters - genetics | Bosentan | Drug Interactions | Organic Anion Transporters, Sodium-Independent - metabolism | Biological Transport - drug effects | Molecular Structure | Solute Carrier Organic Anion Transporter Family Member 1B3 | CHO Cells | Estradiol - metabolism | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cricetinae | Organic Anion Transporters - antagonists & inhibitors | Sulfonamides - chemistry | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Piperazines - pharmacology | Sulfonamides - pharmacokinetics | Aryl Hydrocarbon Hydroxylases - metabolism | Animals | Estrone - analogs & derivatives | Estrone - metabolism | Sulfonamides - metabolism | Liver-Specific Organic Anion Transporter 1 | Rifampin - pharmacology | Index Medicus
Journal Article
Journal Article
FASEB Journal, ISSN 0892-6638, 07/2013, Volume 27, Issue 7, pp. 2713 - 2722
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 03/2012, Volume 40, Issue 3, pp. 504 - 514
Heme oxygenase (HO-1), the rate-limiting enzyme in the physiological breakdown of heme, is ubiquitous, and its expression can be increased by arsenite [... 
CYTOCHROME-P450 | METABOLISM | MECHANISM | DOWN-REGULATION | GENE-EXPRESSION | AH RECEPTOR | PHARMACOLOGY & PHARMACY | HUMAN LIVER | INDUCTION | PRIMARY CULTURES | PREGNANE-X-RECEPTOR | Arsenites - pharmacology | Cytochrome P-450 CYP1A1 - genetics | Heme - metabolism | Receptors, Steroid - metabolism | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Male | Hepatocytes - metabolism | Cytochromes - genetics | Metalloporphyrins - pharmacology | Cell Nucleus - metabolism | Cytochrome P-450 CYP3A - genetics | Protein Processing, Post-Translational - drug effects | Polychlorinated Dibenzodioxins - pharmacology | Cytochromes - metabolism | Receptors, Aryl Hydrocarbon - metabolism | Cytochrome P-450 CYP1A2 | Membrane Proteins - metabolism | Heme Oxygenase (Decyclizing) - antagonists & inhibitors | Heme Oxygenase (Decyclizing) - metabolism | Hepatocytes - drug effects | Cell Survival - drug effects | Membrane Proteins - genetics | Heat-Shock Proteins - metabolism | RNA, Messenger - genetics | Cells, Cultured | Rats | Cytochrome P-450 CYP1A1 - metabolism | Rats, Sprague-Dawley | Aryl Hydrocarbon Hydroxylases - metabolism | Polychlorinated Dibenzodioxins - analogs & derivatives | Animals | Cytochrome P-450 CYP3A - metabolism | Cytochrome P-450 Enzyme System - genetics | Cytosol - metabolism | Trans-Activators - metabolism | Rifampin - pharmacology | Index Medicus
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 2011, Volume 43, Issue 4, pp. 297 - 307
While the utility of cryopreserved human hepatocyte suspensions (CHHS) for drug metabolism assays has been established, less is known about the effects of... 
Drug transport | Cryopreserved human hepatocytes | Drug interaction | OATP | Hepatic drug uptake | NTCP | COLLAGEN-SANDWICH CONFIGURATION | CHOLYL-GLYCYLAMIDO-FLUORESCEIN | METABOLIC-CLEARANCE | HEPATIC-UPTAKE | HEPATOBILIARY DISPOSITION | PROTEASE INHIBITORS | ORGANIC CATION TRANSPORTERS | CULTURED RAT HEPATOCYTES | PHARMACOLOGY & PHARMACY | HUMAN LIVER | ANION TRANSPORTER | Organic Anion Transporters, Sodium-Independent - genetics | Estradiol - analogs & derivatives | Corticosterone - pharmacology | Digoxin - metabolism | Taurocholic Acid - metabolism | Humans | Middle Aged | Male | Organic Cation Transporter 1 - metabolism | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Organic Cation Transport Proteins - antagonists & inhibitors | Biological Transport | Cryopreservation | Organic Anion Transporters, Sodium-Independent - metabolism | Prazosin - pharmacology | Adult | Membrane Transport Proteins - metabolism | 1-Methyl-4-phenylpyridinium - metabolism | Solute Carrier Organic Anion Transporter Family Member 1B3 | Estradiol - metabolism | Organic Cation Transport Proteins - metabolism | RNA, Messenger - genetics | Symporters - metabolism | Estrone - analogs & derivatives | Estrone - metabolism | Adolescent | Organic Cation Transporter 1 - antagonists & inhibitors | Rifampin - pharmacology | Organic Anion Transporters, Sodium-Dependent - metabolism | Messenger RNA | Gastrointestinal agents | Peptides | Digoxin | Corticosterone | Analysis | Drug interactions | Sulfates | Rifampin | Estradiol | Index Medicus
Journal Article
Brain, ISSN 0006-8950, 05/2016, Volume 139, Issue 5, pp. 1568 - 1586
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 03/2010, Volume 38, Issue 3, pp. 516 - 525
HepaRG cells possess the unique property to differentiate in vitro and to express various functions of mature hepatocytes, including the major cytochromes P450... 
COCKTAIL | TRANSPORTER | IN-VITRO MODEL | LIVER | LINE | CULTURED HUMAN HEPATOCYTES | PHARMACOLOGY & PHARMACY | INDUCTION | MICROSOMAL-ENZYME INDUCERS | TANDEM MASS-SPECTROMETRY | DRUG-METABOLISM | Phenobarbital - pharmacology | Humans | Cytochrome P-450 Enzyme System - metabolism | Hepatocytes - metabolism | Receptors, Cytoplasmic and Nuclear - biosynthesis | RNA, Messenger - metabolism | Glucuronosyltransferase - genetics | Hepatocytes - cytology | Glutathione Transferase - genetics | Time Factors | Isoenzymes - metabolism | Membrane Transport Proteins - genetics | Enzyme Induction - drug effects | Membrane Transport Proteins - metabolism | Omeprazole - pharmacology | Cell Differentiation | Xenobiotics - metabolism | Cell Culture Techniques | Hepatocytes - drug effects | Drug Evaluation, Preclinical - methods | Reproducibility of Results | Isoenzymes - genetics | Cells, Cultured | Glutathione Transferase - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Gene Expression Regulation - drug effects | Glutathione Transferase - biosynthesis | Membrane Transport Proteins - biosynthesis | Glucuronosyltransferase - metabolism | Cytochrome P-450 Enzyme System - biosynthesis | Cytochrome P-450 Enzyme System - genetics | Rifampin - pharmacology | Isoenzymes - biosynthesis | Glucuronosyltransferase - biosynthesis | Cell Line, Transformed | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | Receptors, Cytoplasmic and Nuclear | Life Sciences | Glutathione Transferase | Xenobiotics | Drug Evaluation, Preclinical | Glucuronosyltransferase | Hépatology and Gastroenterology | Isoenzymes | Gene Expression Regulation | Enzyme Induction | Cytochrome P-450 Enzyme System | Omeprazole | Human health and pathology | Phenobarbital | Hepatocytes | Membrane Transport Proteins | RNA, Messenger | Rifampin
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 07/2018, Volume 46, Issue 7, pp. 953 - 963
Journal Article
Journal Article