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Journal Article
Drug Design, Development and Therapy, ISSN 1177-8881, 04/2018, Volume 12, pp. 1019 - 1031
Background: Adamantane-based compounds have been identified to interfere with the ionchannel activity of viroporins and thereby inhibit viral infection. To... 
Dimers | HCV | Adamantane | Viroporins | dimers | WILD-TYPE | CHEMISTRY, MEDICINAL | PROTEIN | ION-CHANNEL ACTIVITY | PROTON CHANNEL | DISCOVERY | GENETIC ALGORITHM | SECRETORY PATHWAY | A VIRUS | adamantane | PHARMACOLOGY & PHARMACY | AMANTADINE | INHIBITORS | viroporins | Adamantane - pharmacology | Antiviral Agents - pharmacology | Amantadine - chemical synthesis | Humans | Cells, Cultured | Models, Molecular | Viral Proteins - antagonists & inhibitors | Rimantadine - chemical synthesis | Viral Proteins - metabolism | Rimantadine - chemistry | Adamantane - chemical synthesis | Amantadine - chemistry | Antiviral Agents - chemistry | Viral Matrix Proteins - antagonists & inhibitors | Drug Design | HEK293 Cells | Antiviral Agents - chemical synthesis | Viral Matrix Proteins - metabolism | Molecular Structure | Adamantane - chemistry | Amantadine - pharmacology | Rimantadine - pharmacology | Influenza viruses | Hepatitis C virus | Health aspects | Influenza | Binding | p7 Protein | Amantadine | Channel gating | Viruses | Pharmacology | Kinases | Molecular chains | Oocytes | Blockage | Analogs | Proteins | Hepatitis | Protein folding | Spacer | Inhibition | Hepatitis C | Chemical synthesis | Genotypes | Nuclear magnetic resonance--NMR | Biochemistry | Drug resistance | Genetic algorithms | Chromatography | Chemistry | Recording | Binding sites
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Journal Article
PLoS ONE, ISSN 1932-6203, 02/2010, Volume 5, Issue 2, p. e9388
Background: M2 proton channel of H1N1 influenza A virus is the target protein of anti-flu drugs amantadine and rimantadine. However, the two once powerful... 
A VIRUS | UNITED-STATES | PK(A) VALUES | PROTEIN | MECHANISM | BIOLOGY | ION-CHANNEL | RESISTANCE | SURVEILLANCE | COMBINATION | PREDICTION | Viral Matrix Proteins - genetics | Swine Diseases - virology | Ion Channels - genetics | Molecular Sequence Data | Antiviral Agents - chemistry | Swine | Drug Design | Molecular Structure | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H1N1 Subtype - metabolism | Ion Channels - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Adamantane - pharmacology | Antiviral Agents - pharmacology | Magnetic Resonance Spectroscopy | Orthomyxoviridae Infections - veterinary | Models, Molecular | Binding Sites - genetics | Influenza A Virus, H1N1 Subtype - drug effects | Ion Channels - antagonists & inhibitors | Sequence Homology, Amino Acid | Drug Resistance, Viral - genetics | Rimantadine - chemistry | Animals | Viral Matrix Proteins - chemistry | Viral Matrix Proteins - antagonists & inhibitors | Protein Binding | Protein Conformation | Adamantane - chemistry | Mutation | Orthomyxoviridae Infections - virology | Rimantadine - pharmacology | Influenza viruses | Protons | Nuclear magnetic resonance | Drug resistance | Analysis | Swine influenza | Drugs | Pandemics | Nuclear magnetic resonance--NMR | Viruses | Helices | Drug development | Design | Disease resistance | Docking | Binding | Amantadine | Channel gating | Pharmacology | Biological activity | Inhibitors | Swine flu | Computer aided design--CAD | Influenza | Computer applications | Livestock | Pharmaceuticals | Computer aided design | CAD | NMR
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