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1. Full Text Sorption of emerging trace organic compounds onto wastewater sludge solids
by Stevens-Garmon, John and Drewes, Jörg E and Khan, Stuart J and McDonald, James A and Dickenson, Eric R.V
Water Research, ISSN 0043-1354, 2011, Volume 45, Issue 11, pp. 3417 - 3426
This work examined the sorption potential to wastewater primary- and activated-sludge solids for 34 emerging trace organic chemicals at environmentally... 
Sorption | Personal care products | Pharmaceutically-active compounds | Household chemicals | Steroidal hormones | Inactivation | Wastewater treatment | Primary and activated sludge | SEWAGE-SLUDGE | CHROMATOGRAPHY/TANDEM MASS-SPECTROMETRY | COEFFICIENT K-D | ACTIVATED-SLUDGE | MUSK FRAGRANCES | WATER RESOURCES | ENVIRONMENTAL SCIENCES | ENDOCRINE DISRUPTORS | ENGINEERING, ENVIRONMENTAL | TREATMENT PLANTS | FLUOROQUINOLONE ANTIBACTERIAL AGENTS | BETA-BLOCKERS | Amitriptyline - chemistry | Household Products - analysis | Sewage - chemistry | Hydroxyzine - analysis | Cosmetics - chemistry | Organic Chemicals - chemistry | Water Pollutants, Chemical - chemistry | Hydroxyzine - chemistry | Risperidone - chemistry | Waste Disposal, Fluid | Water Pollutants, Chemical - analysis | Organic Chemicals - analysis | Verapamil - chemistry | Amitriptyline - analysis | Risperidone - analysis | Adsorption | Clozapine - chemistry | Verapamil - analysis | Cosmetics - analysis | Pharmaceutical Preparations - chemistry | Pharmaceutical Preparations - analysis | Clozapine - analysis | Mathematical models | Hydrophobicity | Hormones | Sludge | Organic compounds | Waste water
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2. Full Text The interaction of antipsychotic drugs with lipids and subsequent lipid reorganization investigated using biophysical methods
by Alves, Isabel and Staneva, Galya and Tessier, Cedric and Salgado, Gilmar F and Nuss, Philippe
BBA - Biomembranes, ISSN 0005-2736, 2011, Volume 1808, Issue 8, pp. 2009 - 2018
The interaction of antipsychotic drugs (AP) with lipids and the subsequent lipid reorganization on model membranes was assessed using a combination of several... 
Differential scanning calorimetry | Docking calculations | Antipsychotic drugs | Membrane domains | Fluorescence microscopy | Plasmon waveguide resonance | BILAYER-MEMBRANES | BIOCHEMISTRY & MOLECULAR BIOLOGY | X-RAY-DIFFRACTION | ANTIMICROBIAL PEPTIDES | THERMOTROPIC PHASE-BEHAVIOR | CHLORPROMAZINE | BIOPHYSICS | CHOLESTEROL HOMEOSTASIS | BINDING-PROPERTIES | PHOSPHATIDYLCHOLINE | Surface Plasmon Resonance | Molecular Conformation | Structure-Activity Relationship | Membrane Lipids - chemistry | Pyrimidines - chemistry | Cell Membrane - chemistry | Cholesterol - chemistry | X-Ray Diffraction | Receptors, Dopamine D2 - chemistry | 1,2-Dipalmitoylphosphatidylcholine - chemistry | Molecular Structure | Dopamine Antagonists - chemistry | Haloperidol - pharmacology | Cell Membrane - drug effects | Paliperidone Palmitate | Risperidone - pharmacology | Membranes, Artificial | Models, Molecular | Risperidone - chemistry | Isoxazoles - chemistry | Phosphatidylcholines - chemistry | Pyrimidines - pharmacology | Haloperidol - chemistry | Isoxazoles - pharmacology | Antipsychotic Agents - chemistry | Dopamine Antagonists - pharmacology | Calorimetry, Differential Scanning | Sphingomyelins - chemistry | Antipsychotic Agents - pharmacology | Dopamine D2 Receptor Antagonists | Microscopy, Fluorescence
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3. Full Text Biosynthesis of fluorinated analogs of drugs using human cytochrome P450 enzymes followed by deoxyfluorination and quantitative nuclear magnetic resonance spectroscopy to improve metabolic stability
by Obach, R. Scott and Walker, Gregory S and Brodney, Michael A
Drug Metabolism and Disposition, ISSN 0090-9556, 05/2016, Volume 44, Issue 5, pp. 634 - 646
Replacement of hydrogen with fluorine is a useful drug design strategy when decreases in cytochrome P450 (P450) metabolic lability are needed. In this paper, a... 
MEDICINAL CHEMISTRY | PHENOLS | RAMELTEON | PHARMACOLOGY & PHARMACY | RISPERIDONE | EXCRETION | MIDAZOLAM | Magnetic Resonance Spectroscopy - methods | Hydroxylation | Diethylamines - chemistry | Humans | Microsomes, Liver - metabolism | Cytochrome P-450 Enzyme System - metabolism | Risperidone - chemistry | Indenes - chemistry | Celecoxib - chemistry | Midazolam - chemistry | Halogenation | Pharmaceutical Preparations - chemistry | Fluorine - chemistry | Aldehydes - chemistry
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4. Full Text Microparticles produced by the hydrogel template method for sustained drug delivery
by Lu, Ying and Sturek, Michael and Park, Kinam
International Journal of Pharmaceutics, ISSN 0378-5173, 01/2014, Volume 461, Issue 1-2, pp. 258 - 269
Polymeric microparticles have been used widely for sustained drug delivery. Current methods of microparticle production can be improved by making homogeneous... 
Methylprednisolone acetate | PVA template method | PLGA microparticle | Risperidone | Controlled release | Paclitaxel | IN-VITRO RELEASE | Met hylprednisolone acetate | STABILITY | SOLVENT SELECTION | SIZE | ENCAPSULATION | FORMULATION | VANCOMYCIN | PLGA MICROSPHERES | DEGRADATION | PHARMACOLOGY & PHARMACY | FABRICATION | microparticle | Viscosity | Polyvinyl Alcohol - chemistry | Lactic Acid - chemistry | Molecular Weight | Hydrogels | Drug Compounding - methods | Solvents - chemistry | Risperidone - administration & dosage | Risperidone - chemistry | Methylprednisolone - analogs & derivatives | Drug Carriers - chemistry | Drug Delivery Systems | Particle Size | Paclitaxel - chemistry | Polyglycolic Acid - chemistry | Polymers - chemistry | Paclitaxel - administration & dosage | Delayed-Action Preparations | Methylprednisolone - chemistry | Methylprednisolone - administration & dosage | Drugs | Drug delivery systems | Methods | Vehicles | methylprednisolone acetate | paclitaxel | controlled release | PLGA Microparticle | risperidone
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5. Full Text Alginate gel-coated oil-entrapped alginate–tamarind gum–magnesium stearate buoyant beads of risperidone
by Bera, Hriday and Boddupalli, Shashank and Nandikonda, Sridhar and Kumar, Sanoj and Nayak, Amit Kumar
International Journal of Biological Macromolecules, ISSN 0141-8130, 07/2015, Volume 78, pp. 102 - 111
A novel alginate gel-coated oil-entrapped calcium-alginate–tamarind gum (TG)–magnesium stearate (MS) composite floating beads was developed for intragastric... 
Tamarind gum | Emulsion gel beads | Alginate | SYSTEM | MUCOADHESIVE BEADS | HYDROGELS | METFORMIN HCL | DRUG-DELIVERY | BIOCHEMISTRY & MOLECULAR BIOLOGY | STERCULIA GUM | RELEASE | FORMULATION | IN-VITRO EVALUATION | OPTIMIZATION | Risperidone - administration & dosage | Hexuronic Acids - chemistry | Plant Gums - chemistry | Spectroscopy, Fourier Transform Infrared | Stearic Acids - chemistry | Chemistry, Pharmaceutical | Particle Size | Microspheres | Magnesium - chemistry | X-Ray Diffraction | Alginates - chemistry | Drug Liberation | Gels - chemistry | Tamarindus - chemistry | Glucuronic Acid - chemistry | Drugstores | Antipsychotic drugs | Magnesium compounds | Pharmacy
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6. Full Text Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone
by Wang, Sheng and Che, Tao and Levit, Anat and Shoichet, Brian K and Wacker, Daniel and Roth, Bryan L and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Nature, ISSN 0028-0836, 03/2018, Volume 555, Issue 7695, pp. 269 - 273
Dopamine is a neurotransmitter that has been implicated in processes as diverse as reward, addiction, control of coordinated movement, metabolism and hormonal... 
LIGANDS | CLONING | CRYSTAL-STRUCTURE | PHARMACOLOGY | MULTIDISCIPLINARY SCIENCES | CHARGES | RHODOPSIN | MODEL | BETA-ADRENERGIC RECEPTOR | DISCOVERY | AGONIST | Receptors, Dopamine D4 - chemistry | Humans | Receptors, Dopamine D3 - chemistry | Receptors, Dopamine D3 - metabolism | Mutant Proteins - genetics | Models, Molecular | Crystallography, X-Ray | Mutant Proteins - metabolism | Risperidone - chemistry | Receptors, Dopamine D2 - metabolism | Receptors, Dopamine D2 - genetics | Antipsychotic Agents - chemistry | Mutant Proteins - chemistry | Drug Design | Hydrophobic and Hydrophilic Interactions | Receptors, Dopamine D2 - chemistry | Antipsychotic Agents - metabolism | Ligands | Receptors, Dopamine D4 - metabolism | Risperidone - metabolism | Kinetics | Mutation | Binding Sites | Pharmacology, Experimental | Drug interactions | Physiological aspects | Research | Risperidone | Structure | Dopamine receptors | Drugs | Attention deficit disorder | Neuroleptics | Parkinson's disease | Molecular structure | Mental disorders | Parkinsons disease | Schizophrenia | Mental depression | Proteins | Psychotropic drugs | Receptors | Vomiting | Reinforcement | Dopamine D2 receptors | Movement disorders | Crystal structure | Dopamine | Neurodegenerative diseases | Secretion | Attention deficit hyperactivity disorder | Nausea | Metabolism | Side effects | Addiction | Structure-function relationships
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7. Full Text Polyester-based microparticles of different hydrophobicity: the patterns of lipophilic drug entrapment and release
by Korzhikov, Viktor and Averianov, Ilia and Litvinchuk, Evgeniia and Tennikova, Tatiana B
Journal of Microencapsulation, ISSN 0265-2048, 04/2016, Volume 33, Issue 3, pp. 199 - 208
The paper is devoted to the investigation of the effect of polyester hydrophobicity and ability for crystallisation on lipophilic drug loading and release from... 
Biodegradable particles | drug release | drug encapsulation | risperidone | POLY(L-LACTIDE) | CRYSTALLINITY | MICROSPHERES | POLYMERIZATION | DELIVERY | ENGINEERING, CHEMICAL | NANOPARTICLES | IN-VITRO | PHARMACOLOGY & PHARMACY | CHEMISTRY, APPLIED | Lactic Acid - chemistry | Humans | Risperidone - administration & dosage | Crystallization | Delayed-Action Preparations - chemistry | Risperidone - chemistry | Dopamine Antagonists - administration & dosage | Antipsychotic Agents - administration & dosage | Polyesters - chemistry | Antipsychotic Agents - chemistry | Macrolides - chemistry | U937 Cells | Polyglycolic Acid - chemistry | Drug Liberation | Hydrophobic and Hydrophilic Interactions | Dopamine Antagonists - chemistry
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8. Full Text Alginate–sterculia gum gel-coated oil-entrapped alginate beads for gastroretentive risperidone delivery
by Bera, Hriday and Kandukuri, Saisharan Goud and Nayak, Amit Kumar and Boddupalli, Shashank
Carbohydrate Polymers, ISSN 0144-8617, 04/2015, Volume 120, pp. 74 - 84
Novel floating-mucoadhesive oil-entrapped alginate beads coated with crossslinked alginate–sterculia gum gel membrane was developed for gastroretentive... 
Alginate | Olive oil | Floatation | Mucoadhesion | Risperidone | Sterculia gum | SYSTEM | MUCOADHESIVE | POLYMER SCIENCE | MICROSPHERES | DRUG-DELIVERY | CALCIUM SILICATE | CHEMISTRY, ORGANIC | RELEASE | FORMULATION | IN-VITRO EVALUATION | CHEMISTRY, APPLIED | Microspheres | Serotonin Antagonists - administration & dosage | Alginates - chemistry | Risperidone - administration & dosage | Sterculia - chemistry | Hexuronic Acids - chemistry | Oils - chemistry | Glucuronic Acid - chemistry | Drugstores | Pharmacy | Antipsychotic drugs
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9. Full Text Discriminative stimulus properties of the atypical antipsychotic amisulpride: comparison to its isomers and to other benzamide derivatives, antipsychotic, antidepressant, and antianxiety drugs in C57BL/6 mice
by Donahue, Timothy J and Hillhouse, Todd M and Webster, Kevin A and Young, Richard and De Oliveira, Eliseu O and Porter, Joseph H
Psychopharmacology, ISSN 0033-3158, 12/2017, Volume 234, Issue 23, pp. 3507 - 3520
Racemic (RS)-amisulpride (Solian®) is an atypical antipsychotic drug used to treat schizophrenia and dysthymia. Blockade of dopamine D2/D3 and/or serotonin... 
Drug discrimination | Neurosciences | Amisulpride | Schizophrenia | Isomers | Anxiolytics | Discriminative stimulus | Antipsychotics | Biomedicine | Antidepressants | C57BL/6 mice | Benzamides | Pharmacology/Toxicology | Psychiatry | CORTICAL MEMBRANES | PSYCHIATRY | HIGH-AFFINITY | MAJOR DEPRESSION | D-2 RECEPTORS | NEUROSCIENCES | RECEPTOR ANTAGONIST | LIMBIC SELECTIVITY | 5-HT7 RECEPTOR | PHARMACOLOGY & PHARMACY | MOLECULAR-CLONING | RAT-BRAIN | DOPAMINE-RECEPTORS | Sulpiride - pharmacology | Conditioning, Operant - physiology | Male | Sulpiride - analogs & derivatives | Clozapine - pharmacology | Discrimination Learning - drug effects | Clozapine - chemistry | Conditioning, Operant - drug effects | Antidepressive Agents - chemistry | Anti-Anxiety Agents - chemistry | Antidepressive Agents - pharmacology | Benzamides - pharmacology | Quetiapine Fumarate - pharmacology | Benzamides - chemistry | Quetiapine Fumarate - chemistry | Mice, Inbred C57BL | Chlorpromazine - chemistry | Risperidone - pharmacology | Anti-Anxiety Agents - pharmacology | Chlorpromazine - pharmacology | Risperidone - chemistry | Discrimination Learning - physiology | Animals | Antipsychotic Agents - chemistry | Mice | Antipsychotic Agents - pharmacology | Sulpiride - chemistry | Dosage and administration | Antipsychotic drugs | Comparative analysis | Drug interactions | Antianxiety agents | Stereoisomers | Drugs | Neuroleptics | Olanzapine | Operant conditioning | Mental disorders | Aripiprazole | Benzamide | Metoclopramide | Chlorpromazine | Sulpiride | Serotonin S7 receptors | Psychotropic drugs | Imipramine | Receptors | Bupropion | Mianserin | Risperidone | Dopamine D2 receptors | Drug dosages | Quetiapine | Raclopride | Dopamine | Serotonin | Dopamine D3 receptors | Chlordiazepoxide | Pharmacology | Clozapine | Derivatives | Properties (attributes) | Serotonin receptors
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10. Full Text Parenteral nanoemulsions as promising carriers for brain delivery of risperidone: Design, characterization and in vivo pharmacokinetic evaluation
by Đorđević, Sanela M and Cekić, Nebojša D and Savić, Miroslav M and Savić, Snežana D and Savić, Saša R and Isailović, Tanja M and Ranđelović, Danijela V and Marković, Bojan D and Stamenić, Tamara Timić and Daniels, Rolf
International Journal of Pharmaceutics, ISSN 0378-5173, 09/2015, Volume 493, Issue 1-2, pp. 40 - 54
This paper describes design and evaluation of parenteral lecithin-based nanoemulsions intended for brain delivery of risperidone, a poorly water-soluble... 
General factorial design | Brain targeting | Poorly water-soluble drugs | Parenteral nanoemulsions | Pharmacokinetics | Physical stability | LONG-TERM STABILITY | BLOCK-COPOLYMERS | DRUG-DELIVERY | RATS | FORMULATION | INTRAVENOUS LIPID EMULSION | NANOPARTICLES | PHYSICOCHEMICAL CHARACTERIZATION | PHARMACOLOGY & PHARMACY | OPTIMIZATION | ORAL DELIVERY | Poloxamer - chemistry | Nanoparticles - chemistry | Polysorbates - chemistry | Rats, Wistar | Emulsions - chemistry | Drug Stability | Risperidone - administration & dosage | Risperidone - pharmacokinetics | Solubility | Rats | Male | Polyethylene Glycols - chemistry | Stearic Acids - chemistry | Chemistry, Pharmaceutical | Drug Delivery Systems | Brain - metabolism | Particle Size | Technology, Pharmaceutical | Animals | Lecithins - chemistry | Emulsifying Agents | Drugstores | Pharmacy | Antipsychotic drugs
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11. Full Text Disturbances of glucose metabolism associated with the use of psychotropic drugs: A post-mortem evaluation
by Palmiere, Cristian and Augsburger, Marc and Varlet, Vincent
Forensic Science International, ISSN 0379-0738, 2016, Volume 274, pp. 33 - 37
Highlights • Antipsychotic and antidepressant treatment may be associated impaired glycemic control. • Reported complications included diabetic ketoacidosis... 
Pathology | Antipsychotics | Glucose metabolism | Postmortem biochemistry | Antidepressants | Autopsy | INDUCED HYPERGLYCEMIC KETOACIDOSIS | MEDICINE, LEGAL | ONSET DIABETIC-KETOACIDOSIS | SCHIZOPHRENIA | RISPERIDONE | MELLITUS | HYPERTRIGLYCERIDEMIA | ATYPICAL ANTIPSYCHOTICS | OLANZAPINE TREATMENT | MIRTAZAPINE THERAPY | ACUTE-PANCREATITIS | Antipsychotic Agents - adverse effects | Bile - chemistry | Humans | Middle Aged | Pericardial Fluid - chemistry | Hair - chemistry | Male | Diabetes Mellitus | Liver - chemistry | Vitreous Body - chemistry | Diabetic Ketoacidosis | Young Adult | Antipsychotic Agents - analysis | Gastrointestinal Contents - chemistry | Muscle, Skeletal - chemistry | Glucose - metabolism | Adult | Female | Aged | Brain Chemistry | Retrospective Studies | Psychotropic drugs | Physiological aspects | Biochemistry | Research | Postmortem changes | Drugs | Neuroleptics | Olanzapine | Forensic engineering | Pathogenesis | Glucose | Drug development | Toxicology | Metabolites | Drug metabolism | Risperidone | Quetiapine | Autopsies | Forensic science | Complications | Diabetes mellitus | Mortality | Clozapine | Metabolism | Ketoacidosis | Fatalities | Death | Index Medicus
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12. Full Text Risperidone oral disintegrating mini-tablets: A robust-product for pediatrics
by El-Say, Khalid M and Ahmed, Tarek A and Abdelbary, Maged F and Ali, Bahaa E and Aljaeid, Bader M and Zidan, Ahmed S
Acta Pharmaceutica, ISSN 1330-0075, 12/2015, Volume 65, Issue 4, pp. 365 - 382
This study was aimed at developing risperidone oral disintegrating mini-tablets (OD-mini-tablets) as age-appropriate formulations and to assess their... 
mini-tablets | optimization design | disintegration | risperidone | pediatrics | PHARMACOLOGY & PHARMACY | SALIVA | Pediatrics | Age Factors | Tablets | Humans | Child, Preschool | Infant | Saliva - chemistry | Spectroscopy, Fourier Transform Infrared | Cellulose - chemistry | Excipients - chemistry | Surface Properties | Child | Administration, Oral | Risperidone - administration & dosage | Silicon Dioxide - chemistry | Solubility | Risperidone - chemistry | Chemistry, Pharmaceutical | Antipsychotic Agents - administration & dosage | Povidone - chemistry | Starch - analogs & derivatives | Starch - chemistry | Antipsychotic Agents - chemistry | Mannitol - chemistry | Kinetics
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13. Full Text Validation of USP apparatus 4 method for microsphere in vitro release testing using Risperdal ® Consta
by Rawat, Archana and Stippler, Erika and Shah, Vinod P and Burgess, Diane J
International Journal of Pharmaceutics, ISSN 0378-5173, 2011, Volume 420, Issue 2, pp. 198 - 205
The current manuscript addresses the need for a validated release testing method for controlled release parenteral microspheres. A USP apparatus 4 method was... 
Validation | In vitro release | USP apparatus 4 | PLGA microspheres | DEGRADATION | PHARMACOLOGY & PHARMACY | MICROCAPSULES | Reproducibility of Results | Temperature | Chemistry, Pharmaceutical - methods | Lactic Acid - chemistry | Molecular Weight | Delayed-Action Preparations - chemistry | Risperidone - chemistry | Drug Carriers - chemistry | Chemistry, Pharmaceutical - instrumentation | Microspheres | Antipsychotic Agents - chemistry | Polyglycolic Acid - chemistry | Hydrogen-Ion Concentration
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14. Full Text Formation Mechanism and In Vitro Evaluation of Risperidone-Containing PLGA Microspheres Fabricated by Ultrafine Particle Processing System
by Huang, Zhengwei and Huang, Ying and Chen, Xiaona and Fu, Han and Wen, Xinguo and Ma, Cheng and Zhang, Jiwen and Wu, Chuanbin and Wu, Chuanyu and Pan, Xin
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 11/2017, Volume 106, Issue 11, pp. 3363 - 3371
Ultrafine particle processing system (UPPS) was developed previously by our group to provide a new solution to microsphere fabrication. The UPPS was supposed... 
drug delivery systems | controlled release | microspheres | dissolution | material science | CHEMISTRY, MEDICINAL | VIVO | NANOFIBERS | SIZE | RELEASE | FORMULATION | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | NANOPARTICLES | REACTOR | SOLVENTS | PHARMACOLOGY & PHARMACY | MICROENCAPSULATION | Viscosity | Lactic Acid - chemistry | Drug Compounding - methods | Risperidone - administration & dosage | Delayed-Action Preparations - chemistry | Risperidone - chemistry | Antipsychotic Agents - administration & dosage | Particle Size | Microspheres | Antipsychotic Agents - chemistry | Polyglycolic Acid - chemistry | Surface Properties | Drug Liberation | Diffusion
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