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rnf4 (112) 112
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Biochemical Journal, ISSN 0264-6021, 07/2013, Volume 453, Issue 1, pp. 137 - 145
Journal Article
Nature Cell Biology, ISSN 1465-7392, 05/2008, Volume 10, Issue 5, pp. 547 - 555
In acute promyelocytic leukaemia (APL), arsenic trioxide induces degradation of the fusion protein encoded by the PML-RARA oncogene, differentiation of... 
LOCALIZATION | PROTEIN | TRIOXIDE | SNURF RNF4 | DEGRADATION | NUCLEAR-BODY FORMATION | IDENTIFICATION | MASS-SPECTROMETRY | SUMOYLATION | ACUTE PROMYELOCYTIC LEUKEMIA | CELL BIOLOGY
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2014, Volume 457, Issue 1, pp. 207 - 214
RNF4 (RING finger protein 4) is a STUbL [SUMO (small ubiquitin-related modifier)-targeted ubiquitin ligase] controlling PML (promyelocytic leukaemia) nuclear... 
Avidity | Protein degradation | Small ubiquitin-like modifier (SUMO) | RING finger protein 4 (RNF4) | Promyelocytic leukaemia | SUMO-targeted ubiquitin ligase | BINDING MOTIF | UBIQUITIN E3 LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | RAR-ALPHA | IDENTIFICATION | PML | SUMOYLATION | avidity | promyelocytic leukaemia | PROMYELOCYTIC LEUKEMIA | SNURF RNF4 | UBIQUITYLATION | small ubiquitin-like modifier (SUMO) | protein degradation | Amino Acid Sequence | Transcription Factors - chemistry | Protein Interaction Domains and Motifs - physiology | Humans | Molecular Sequence Data | Substrate Specificity | Nuclear Proteins - metabolism | Sumoylation - physiology | Nuclear Proteins - chemistry | Transcription Factors - metabolism | SUMO-1 Protein - metabolism | HeLa Cells | Binding Sites | Saccharomyces cerevisiae | Protein Binding - physiology | SIM, SUMO-interaction motif | STUbL, SUMO-target ubiquitin ligase | ITC, isothermal titration calorimetry | wt, wild-type | NB, nuclear body | Accelerated Publication | HA, haemagglutinin | SEC, size-exclusion chromatography | SUMO, small ubiquitin-related modifier | APL, acute promyelocytic leukaemia | RARα, retinoic acid receptor α | RNF4, RING finger protein 4 | PIAS, protein inhibitor of activated STAT (signal transducer and activator of transcription) | PML, promyelocytic leukaemia
Journal Article
Journal Article
SCIENCE SIGNALING, ISSN 1937-9145, 12/2012, Volume 5, Issue 253
The DNA repair function of the breast cancer susceptibility protein BRCA1 depends in part on its interaction with RAP80, which targets BRCA1 to DNA... 
E3 LIGASE | RING FINGER PROTEIN | REPAIR | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOUBLE-STRAND BREAKS | POLYUBIQUITIN CHAINS | LIGASE RNF4 | IDENTIFICATION | BINDING | SUMOYLATION | CELL BIOLOGY
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 01/2014, Volume 1843, Issue 1, pp. 75 - 85
Covalent posttranslational modification with SUMO (small ubiquitin-related modifier) modulates functions of a wide range of proteins in eukaryotic cells.... 
Slx5 | Arkadia | Rnf4 | Uls1 | SIM | Slx8 | RING FINGER PROTEIN | STRAND BREAK REPAIR | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEAT-SHOCK | REGULATORY PROTEIN ICP0 | SACCHAROMYCES-CEREVISIAE | MASS-SPECTROMETRY | CELL BIOLOGY | E3 LIGASE | IN-VIVO IDENTIFICATION | SlM | NUCLEAR-BODY FORMATION | DNA-REPAIR | Post-translational modification | Ubiquitin | Sumo | Ligases | DNA repair
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 06/2008, Volume 8, Issue 6, pp. 407 - 407
Journal Article
Cell Reports, ISSN 2211-1247, 03/2015, Volume 10, Issue 10, pp. 1778 - 1791
Small ubiquitin-like modifiers play critical roles in the DNA damage response (DDR). To increase our understanding of SUMOylation in the mammalian DDR, we... 
NUCLEAR-BODIES | STRAND BREAK REPAIR | PROTEIN | UBIQUITIN E3 LIGASE | TRANSCRIPTIONAL REPRESSION | HOMOLOGOUS RECOMBINATION | CELL-CYCLE PROGRESSION | RNF4 | SUMOYLATION | SIGNALING NETWORKS | CELL BIOLOGY
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 09/2015, Volume 290, Issue 37, pp. 22678 - 22685
Covalent modification of the proteome by SUMO is critical for genetic stability and cell growth. Equally crucial to these processes is the removal of SUMO from... 
E3 LIGASE | ISOPEPTIDASE | LOCALIZATION | MAINTENANCE | UBIQUITIN-SELECTIVE SEGREGASE | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACCUMULATION | RNF4 | SUMOYLATION | ULP2
Journal Article
Frontiers in Oncology, ISSN 2234-943X, 2013, Volume 3, p. 125
The tumor suppressor promyelocytic leukemia (PML) protein is fused to the retinoic acid receptor alpha in patients suffering from acute promyelocytic leukemia... 
Virus | SUMO | TRIM | SIM | PML isoforms | CK2 | PML nomenclature | RNF4 | virus
Journal Article
PROTEOMICS, ISSN 1615-9853, 11/2019, Volume 19, Issue 21-22, pp. 1900185 - n/a
Covalent modifications by Small Ubiquitin‐like MOdifier (SUMO) and ubiquitin conjugation are now recognized as independent posttranslational modifications... 
SUMOylation | RNF4 | ubiquitination | protein stability | Ubiquitin | Circuits | Maintenance | Complexity | Proteins | Neurological diseases | SUMO protein | Signaling | Ubiquitination | Immunology | Aging | Tumorigenesis | Conjugation | Cardiovascular diseases | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 05/2008, Volume 10, Issue 5, pp. 538 - 546
Journal Article