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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2010, Volume 107, Issue 19, pp. 8599 - 8604
Structural features of neurons create challenges for effective production and distribution of essential metabolic energy. We investigated how metabolic energy... 
Mitochondria | Energy metabolism | Neurons | Synaptic transmission | Antibodies | Retina | Photoreceptors | Creatine | Pipettes | Synapses | Phototransduction | ROD CELLS | MITOCHONDRIAL | PHOTORECEPTOR | MULTIDISCIPLINARY SCIENCES | phototransduction | DEFICIENCY | CREATINE-KINASE-B | METABOLISM | ADAPTATION | MAGNETIC-RESONANCE | energy metabolism | SALAMANDER RETINA | BRAIN | Retina - drug effects | Darkness | Mitochondria - enzymology | Retinal Photoreceptor Cell Outer Segment - metabolism | Glutamates - metabolism | Retinal Photoreceptor Cell Outer Segment - radiation effects | Presynaptic Terminals - radiation effects | Urodela - physiology | Retinal Vessels - enzymology | Presynaptic Terminals - enzymology | Retinal Photoreceptor Cell Outer Segment - drug effects | Retinal Cone Photoreceptor Cells - enzymology | Retina - enzymology | Energy Metabolism - radiation effects | Mitochondria - radiation effects | Synaptic Transmission - drug effects | Energy Metabolism - physiology | Creatine Kinase - antagonists & inhibitors | Electroretinography | Retina - radiation effects | Retinal Cone Photoreceptor Cells - radiation effects | Presynaptic Terminals - drug effects | Retinal Vessels - drug effects | Mitochondria - drug effects | Retina - physiology | Animals | Dinitrofluorobenzene - pharmacology | Synaptic Transmission - radiation effects | Models, Biological | Retinal Cone Photoreceptor Cells - cytology | Creatine Kinase - metabolism | Retinal Cone Photoreceptor Cells - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Retinal Vessels - radiation effects | Energy Metabolism - drug effects | Bioenergetics | Physiological aspects | Neural transmission | Research | Proteins | Metabolism | Kinases | Cells | Index Medicus | Biological Sciences | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Oftalmologi | Ophthalmology | Klinisk medicin
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 9, pp. e71570 - e71570
The retina is prone to oxidative stress from many factors which are also involved in the pathogenesis of degenerative diseases. In this study, we used the... 
MITOCHONDRIAL-DNA DAMAGE | OXYGEN | APOPTOSIS | OXIDATIVE STRESS | PIGMENT EPITHELIAL-CELLS | RETINAL EXPLANT SYSTEM | ROD | MULTIDISCIPLINARY SCIENCES | MACULAR DEGENERATION | DEATH | RETINITIS-PIGMENTOSA | Malondialdehyde - metabolism | Retina - radiation effects | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | Oxidative Stress | Membrane Potential, Mitochondrial - radiation effects | Tissue Culture Techniques | Mice, Inbred C57BL | NADPH Oxidases - metabolism | Male | Retinal Photoreceptor Cell Outer Segment - radiation effects | NADPH Oxidase 4 | Gene Expression - radiation effects | NADPH Oxidase 2 | Membrane Glycoproteins - genetics | Retinal Photoreceptor Cell Outer Segment - physiology | Animals | Retina - cytology | Light | NADPH Oxidases - genetics | Female | Mice | Lipid Peroxidation | Oxidases | Antioxidants | Phosphates | Physiological aspects | Niacinamide | Chromophores | Stress (physiology) | Cell culture | Oxidative stress | Biotechnology | Physiological effects | Membranes | Dyes | Toxicity | Pathogenesis | Radiation | Irradiated | Lipid peroxidation | Cytotoxicity | Retina | Segments | NAD(P)H oxidase | Macular degeneration | Proteins | Mitochondria | Oxidation | Membrane potential | Localization | Explants | Enzymes | Photoreception | Light irradiation | NADPH-diaphorase | Cultures | Endothelium | Impingement | Nicotinamide adenine dinucleotide | Irradiation | Hypoxia | Photoreceptors | Nicotinamide | Electron transport | Apoptosis | Index Medicus | Stress
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 37, pp. 15321 - 15328
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2017, Volume 292, Issue 34, pp. 14280 - 14289
The visual photo-transduction cascade is a prototypical G protein-coupled receptor (GPCR) signaling system, in which light-activated rhodopsin (Rho*) is the... 
SMALL-ANGLE SCATTERING | ALPHA-SUBUNIT | signal transduction | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COUPLED RECEPTOR | 7-helix receptor | ADRENERGIC-RECEPTOR | SAXS | rhodopsin | MONOMERIC RHODOPSIN | photo-transduction | HIGH-RESOLUTION | G protein-coupled receptor (GPCR) | G-protein | structural biology | transducin | MEMBRANE-PROTEINS | ARRESTIN-1 BINDING | Rhodopsin - isolation & purification | Recombinant Fusion Proteins - isolation & purification | Retina - metabolism | Rod Cell Outer Segment - metabolism | Detergents - chemistry | Eye Proteins - chemistry | Eye Proteins - isolation & purification | Crystallography, X-Ray | Rhodopsin - metabolism | Recombinant Fusion Proteins - metabolism | Cattle | Retina - enzymology | X-Ray Diffraction | Light | GTP-Binding Protein beta Subunits - isolation & purification | Transducin - metabolism | Eye Proteins - genetics | GTP-Binding Protein beta Subunits - metabolism | Protein Stability - radiation effects | Peptide Fragments - genetics | Rod Cell Outer Segment - radiation effects | Protein Multimerization - radiation effects | Rhodopsin - chemistry | Retina - radiation effects | Transducin - isolation & purification | Transducin - genetics | GTP-Binding Protein gamma Subunits - metabolism | Peptide Fragments - metabolism | GTP-Binding Protein gamma Subunits - chemistry | Peptide Fragments - isolation & purification | Solubility | Models, Molecular | Scattering, Small Angle | Recombinant Fusion Proteins - chemistry | Microscopy, Electron | Transducin - chemistry | GTP-Binding Protein beta Subunits - chemistry | Peptide Fragments - chemistry | Animals | Protein Conformation - radiation effects | Eye Proteins - metabolism | GTP-Binding Protein gamma Subunits - isolation & purification | Rod Cell Outer Segment - enzymology | Index Medicus | Editors' Picks
Journal Article
Journal Article
Journal Article
International Journal of Radiation Biology, ISSN 0955-3002, 10/2013, Volume 89, Issue 10, pp. 765 - 769
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/1999, Volume 96, Issue 7, pp. 3718 - 3722
Journal Article