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International Journal of Chronic Obstructive Pulmonary Disease, ISSN 1178-2005, 01/2018, Volume 13, p. 3399
Journal Article
International Journal of Chronic Obstructive Pulmonary Disease, ISSN 1178-2005, 01/2018, Volume 13, p. 2337
Journal Article
Drug Design, Development and Therapy, ISSN 1177-8881, 01/2018, Volume 10, p. 4047
Journal Article
Behavioural Brain Research, ISSN 0166-4328, 04/2016, Volume 303, pp. 26 - 33
Enhancement of central availability of the second messenger cAMP is a promising approach to improve cognitive function. Pharmacological inhibition of... 
PDE4 inhibition | Rolipram | PDE4 | Memory | Cognition | Roflumilast | cAMP | Emesis | CAMP | TARGET | LONG-TERM-MEMORY | DEPENDENT MEMORY | NEUROSCIENCES | PHOSPHODIESTERASE INHIBITORS | IN-VITRO | ENHANCE | OBJECT RECOGNITION | BEHAVIORAL SCIENCES | SPATIAL MEMORY | Gastrointestinal agents | Rodents | Neurosciences | Lung diseases, Obstructive | Analysis | Cyclic adenylic acid | Drug approval
Journal Article
Oncotarget, 2017, Volume 8, Issue 68, pp. 112341 - 112353
Journal Article
Chest, ISSN 0012-3692, 2013, Volume 143, Issue 5, pp. 1302 - 1311
Journal Article
Monaldi Archives for Chest Disease - Cardiac Series, ISSN 1122-0643, 2013, Volume 79, Issue 3-4, pp. 29 - 34
The case of a 72-year-old man with a long history of chronic obstructive pulmonary disease (COPD, patient D according to Guidelines GOLD 2013) in a subject... 
Case report | Roflumilast | COPD
Journal Article
Annals of Pharmacotherapy, ISSN 1060-0280, 04/2012, Volume 46, Issue 4, pp. 521 - 529
Journal Article
American Journal of Pathology, ISSN 0002-9440, 10/2018, Volume 188, Issue 10, pp. 2195 - 2206
The most important risk factor for chronic obstructive pulmonary disease (COPD) is cigarette smoking. Until now, smoking cessation (SC) is the only treatment... 
OBSTRUCTIVE PULMONARY-DISEASE | PROTECTION | MOUSE | ENDOTOXIN | CIGARETTE-SMOKE | INDUCED EMPHYSEMA | PATHOLOGY | INHIBITOR | ROFLUMILAST | COPD | OXIDANTS
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2017, Volume 60, Issue 24, pp. 10026 - 10046
Phosphodiesterase 4 (PDE4) is a key cAMP-metabolizing enzyme involved in the pathogenesis of inflammatory disease, and its pharmacological inhibition has been... 
OBSTRUCTIVE PULMONARY-DISEASE | CHEMISTRY, MEDICINAL | PRECLINICAL PHARMACOLOGY | CILOMILAST | PHOSPHODIESTERASE-4 INHIBITOR | ROFLUMILAST | SOFTWARE | PROGRAM | COPD | Index Medicus
Journal Article
DMW - Deutsche Medizinische Wochenschrift, ISSN 0012-0472, 05/2015, Volume 140, Issue 11, pp. 782 - 782
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 10/2015, Volume 192, Issue 8, pp. 934 - 942
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2009, Volume 52, Issue 6, pp. 1522 - 1524
In this communication, we report the discovery of 1S (apremilast), a novel potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-α... 
OBSTRUCTIVE PULMONARY-DISEASE | CHEMISTRY, MEDICINAL | ANALOGS | PDE4 INHIBITION | ASTHMA | ROFLUMILAST | PSORIASIS
Journal Article
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