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Journal of Controlled Release, ISSN 0168-3659, 08/2012, Volume 161, Issue 3, pp. 910 - 917
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 8/2013, Volume 208, Issue 3, pp. 512 - 519
Journal Article
Psychopharmacology, ISSN 0033-3158, 11/2011, Volume 218, Issue 2, pp. 331 - 339
Cyclic AMP (cAMP)–protein kinase A signaling has been implicated in the regulation of ethanol consumption. Phosphodiesterase-4 (PDE4) specifically hydrolyzes... 
Neurosciences | Ethanol intake | Sucrose | Two-bottle choice | Cyclic AMP | Phosphodiesterase-4 (PDE4) | Quinine | Biomedicine | Rolipram | Mice | Pharmacology/Toxicology | Psychiatry | Locomotor activity | MOUSE-BRAIN | PSYCHIATRY | ALCOHOL PREFERENCE | ELEMENT-BINDING PROTEIN | KNOCK-OUT | CAMP RESPONSE | NEUROSCIENCES | INDUCED SEDATION | SPECIES-DIFFERENCES | PHARMACOLOGY & PHARMACY | RECEPTOR BINDING | REDUCED SENSITIVITY | PDE4B ENZYME | Ethanol - administration & dosage | Motor Activity - drug effects | Male | Rolipram - administration & dosage | Brain - metabolism | Central Nervous System Depressants - pharmacology | Dose-Response Relationship, Drug | Ethanol - blood | Phosphodiesterase 4 Inhibitors - administration & dosage | Cyclic Nucleotide Phosphodiesterases, Type 4 - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Rolipram - pharmacology | Alcohol Drinking - prevention & control | Sucrose - administration & dosage | Mice, Inbred C57BL | 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone - administration & dosage | 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Phosphodiesterase 4 Inhibitors - pharmacology | Brain - drug effects | Phosphodiesterase Inhibitors - administration & dosage | Ethanol - pharmacology | Animals | Central Nervous System Depressants - administration & dosage | Quinine - administration & dosage | Central Nervous System Depressants - blood | Proteins | Signal transduction | Ethanol | Rodents | Brain | Drug abuse | Drinking behavior | rolipram | Blood | Drug dependence | phosphodiesterase | Fluid intake | quinine | cyclic AMP | locomotor activity | sucrose | two-bottle choice | mice | phosphodiesterase-4 (PDE4)
Journal Article
American Journal of Obstetrics and Gynecology, ISSN 0002-9378, 2016, Volume 216, Issue 3, pp. 283.e1 - 283.e14
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 03/2018, Volume 99, pp. 947 - 955
Phosphodiesterase-4 (PDE4) plays a fundamental role in a range of central nervous system (CNS) insults, however, the role of PDE4 in early brain injury (EBI)... 
Early brain injury | Phosphodiesterase-4 | Akt | Subarachnoid hemorrhage | Sirtuin1 | Apoptosis | MEDICINE, RESEARCH & EXPERIMENTAL | RESVERATROL | ACTIVATION | ALZHEIMERS-DISEASE | MECHANISMS | MODEL | ROLIPRAM | PROTECTS | INFLAMMATION | PHARMACOLOGY & PHARMACY | SENESCENCE | Sirtuin 1 - metabolism | Apoptosis - drug effects | Heterocyclic Compounds, 3-Ring - pharmacology | Male | Rolipram - administration & dosage | Brain Edema - prevention & control | Benzamides - administration & dosage | Neuroprotective Agents - pharmacology | Phosphodiesterase 4 Inhibitors - administration & dosage | Naphthols - administration & dosage | Cyclic Nucleotide Phosphodiesterases, Type 4 - drug effects | Benzamides - pharmacology | Phosphorylation - drug effects | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Neuroprotective Agents - administration & dosage | Proto-Oncogene Proteins c-akt - metabolism | Rolipram - pharmacology | Subarachnoid Hemorrhage - drug therapy | Naphthols - pharmacology | Rats | Phosphodiesterase 4 Inhibitors - pharmacology | Subarachnoid Hemorrhage - pathology | Rats, Sprague-Dawley | Brain Injuries - prevention & control | Animals | Heterocyclic Compounds, 3-Ring - administration & dosage | Stroke (Disease) | Brain | Medical colleges | Neurons | Surgery | Mortality | Fluorescence | Nervous system | Injuries
Journal Article
Neuropharmacology, ISSN 0028-3908, 01/2013, Volume 64, pp. 205 - 214
Cognitive deficit is a core of schizophrenia and it is not effectively treated by the available antipsychotic drugs, hence new and more effective therapy is... 
MK-801 | PDE7 | Amphetamine | Cognitive enhancer | VP1.15 | Memory | Schizophrenia | Antipsychotic | Mice | GSK-3 | PREPULSE INHIBITION | GLYCOGEN-SYNTHASE KINASE-3 | BINDING-PROTEIN | NEUROSCIENCES | ROLIPRAM | PHOSPHODIESTERASE INHIBITORS | CYCLIC-AMP | MOUSE MODEL | PHARMACOLOGY & PHARMACY | LONG-TERM POTENTIATION | MOOD STABILIZERS | Memory - drug effects | Phosphodiesterase Inhibitors - therapeutic use | Triazoles - administration & dosage | Drugs, Investigational - therapeutic use | Male | Molecular Targeted Therapy | Dose-Response Relationship, Drug | Enzyme Inhibitors - administration & dosage | Cognition Disorders - prevention & control | Antipsychotic Agents - therapeutic use | Schizophrenia - physiopathology | Cognition Disorders - etiology | Behavior, Animal - drug effects | Quinazolines - administration & dosage | Spatial Behavior - drug effects | Triazoles - therapeutic use | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Mice, Inbred C57BL | Nootropic Agents - therapeutic use | Enzyme Inhibitors - therapeutic use | Antipsychotic Agents - administration & dosage | Phosphodiesterase Inhibitors - administration & dosage | Animals | Nootropic Agents - administration & dosage | Quinazolines - therapeutic use | Drugs, Investigational - administration & dosage | Cyclic Nucleotide Phosphodiesterases, Type 7 - antagonists & inhibitors | Schizophrenia - drug therapy | Neural Inhibition - drug effects | Proteins | Synthesis | Antipsychotic drugs | Glycogen | Smart drugs and nutrients | Pharmaceutical industry
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2015, Volume 59, Issue 12, pp. 7581 - 7592
Journal Article
Pulmonary Pharmacology & Therapeutics, ISSN 1094-5539, 2006, Volume 19, Issue 5, pp. 343 - 352
Roflumilast is an oral, once-daily phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity. We compared the anti-inflammatory effects of... 
Tumor necrosis factor-alpha | PDE4 inhibitor | AHR | Neutrophil | Airway hyperresponsiveness | Asthma | airway hyperresponsiveness | NEUTROPHILIA | ADENOSINE | asthma | neutrophil | ROLIPRAM | tumor necrosis factor-alpha | PHOSPHODIESTERASE INHIBITORS | RESPIRATORY SYSTEM | PHARMACOLOGY & PHARMACY | MICE | BROWN-NORWAY RATS | Phosphodiesterase Inhibitors - therapeutic use | Serotonin - administration & dosage | Cyclic Nucleotide Phosphodiesterases, Type 4 | Pneumonia - prevention & control | Male | Rolipram - administration & dosage | Rolipram - therapeutic use | Cyclopropanes - therapeutic use | Nitriles - administration & dosage | Benzamides - administration & dosage | Respiratory Hypersensitivity - drug therapy | Benzamides - therapeutic use | Aminopyridines - therapeutic use | Cyclopropanes - administration & dosage | Pneumonia - chemically induced | Respiratory Hypersensitivity - prevention & control | Carboxylic Acids - therapeutic use | Bronchoalveolar Lavage Fluid - cytology | Carboxylic Acids - administration & dosage | Disease Models, Animal | Neutrophils - pathology | Pyridines - therapeutic use | Aminopyridines - administration & dosage | Pyridines - administration & dosage | Administration, Oral | Immunization - methods | Neutrophils - drug effects | Tumor Necrosis Factor-alpha - secretion | Neutrophils - immunology | Respiratory Hypersensitivity - metabolism | Rats | Treatment Outcome | Phosphodiesterase Inhibitors - administration & dosage | Animals | Ovalbumin - administration & dosage | Pneumonia - drug therapy | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors | Bronchial Spasm - prevention & control | Cyclohexanecarboxylic Acids | Bronchial Spasm - chemically induced | Nitriles - therapeutic use
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 05/2016, Volume 298, pp. 9 - 18
Chlorine is a commonly used, reactive compound to which humans can be exposed accidental or intentional release resulting in acute lung injury. Formulations of... 
Acute lung injury | Airway hyperreactivity | Microencapsulation | Pulmonary edema | BUDESONIDE | CONTROLLED DRUG-DELIVERY | TOXICITY | INHIBITION | INFLAMMATION | ACUTE EXPOSURE | GAS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | CORTICOSTEROIDS | PULMONARY-FIBROSIS | TRIPTOLIDE | Drug Discovery - methods | Male | Rolipram - administration & dosage | Rolipram - therapeutic use | Drug Carriers - chemistry | Phenanthrenes - blood | Diterpenes - administration & dosage | Epoxy Compounds - blood | Acute Lung Injury - prevention & control | Epoxy Compounds - administration & dosage | Surface Properties | Inhalation Exposure - adverse effects | Diterpenes - blood | Epoxy Compounds - therapeutic use | Diterpenes - therapeutic use | Microscopy, Electron, Scanning | Phenanthrenes - therapeutic use | Phenanthrenes - administration & dosage | Injections, Intramuscular | Mice, Inbred Strains | Budesonide - blood | Chlorine - toxicity | Rolipram - blood | Chemistry, Pharmaceutical | Animals | Acute Lung Injury - chemically induced | Budesonide - therapeutic use | Drug Liberation | Budesonide - administration & dosage | Acute respiratory distress syndrome | Respiratory agents | Analysis | Index Medicus | INJURIES | INHALATION | LUNGS | CHLORINE | 60 APPLIED LIFE SCIENCES | GLYCOLIC ACID | EDEMA | IN VITRO | INTRAMUSCULAR INJECTION | SPRAY DRYING | MICE | PHOSPHODIESTERASES | pulmonary edema | airway hyperreactivity | acute lung injury | microencapsulation
Journal Article