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Cell Reports, ISSN 2211-1247, 07/2016, Volume 16, Issue 2, pp. 498 - 507
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2016, Volume 11, Issue 10, pp. e0164370 - e0164370
To explore novel genetic abnormalities occurring in myelodysplastic syndromes (MDS) through an integrative study combining array-based comparative genomic... 
PROGNOSTIC SCORING SYSTEM | NORMAL KARYOTYPE | COPY NUMBER ALTERATIONS | SNP-ARRAY | MULTIDISCIPLINARY SCIENCES | CRYPTIC CHROMOSOMAL LESIONS | CHRONIC LYMPHOCYTIC-LEUKEMIA | ACUTE MYELOID-LEUKEMIA | MUTATIONS | CANCER GENOMES | CHRONIC MYELOMONOCYTIC LEUKEMIA | Recurrence | Humans | Middle Aged | Male | Risk | Tumor Suppressor Protein p53 - genetics | DNA Copy Number Variations | Young Adult | DNA Mutational Analysis | Aged, 80 and over | Adult | Female | Child | Proto-Oncogene Proteins - genetics | DNA - metabolism | DNA-Binding Proteins - genetics | DNA - isolation & purification | DNA (Cytosine-5-)-Methyltransferases - genetics | DNA - chemistry | Myelodysplastic Syndromes - diagnosis | Comparative Genomic Hybridization | Adolescent | Chromosome Aberrations | Chromosomes, Human, Pair 13 | Aged | High-Throughput Nucleotide Sequencing | Myelodysplastic Syndromes - genetics | Myelodysplastic Syndromes - pathology | Core Binding Factor Alpha 2 Subunit - genetics | Karyotype | Medical research | Methyltransferases | Genes | Genomics | Medicine, Experimental | Cytogenetics | Genomes | Comparative analysis | Tumor proteins | Health aspects | Myelodysplastic syndromes | Copy number | p53 Protein | Leukemia | Disorders | Hybridization | Gene deletion | DNA repair | Neoplasms | Myelodysplastic syndrome | Genetic abnormalities | Clonal deletion | Deletion | Chromosome 13 | Chromosomes | Deoxyribonucleic acid--DNA | BRCA2 protein | Sequences | Risk groups | Abnormalities | Runx1 protein | Breast cancer | Patients | Studies | Genetic engineering | Mutation | Cancer | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Chemistry & Biodiversity, ISSN 1612-1872, 11/2018, Volume 15, Issue 11, pp. e1800314 - n/a
Polyphyllin I (PPI), a bioactive constituent extracted from traditional medicinal herbs, is cytotoxic to several cancer types. However, whether PPI can be used... 
AML | AML1-ETO | apoptosis | C-KIT | polyphyllin I | cytotoxicity | PATHWAYS | TARGET | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKT | CHEMISTRY, MULTIDISCIPLINARY | FUSION PROTEIN | CANCER STATISTICS | EXPRESSION | Chromosomes, Human, Pair 8 - genetics | Apoptosis - drug effects | Humans | Leukemia, Myeloid, Acute - metabolism | Molecular Conformation | Structure-Activity Relationship | Proto-Oncogene Proteins c-kit - metabolism | Proto-Oncogene Proteins c-kit - antagonists & inhibitors | Dose-Response Relationship, Drug | Leukemia, Myeloid, Acute - drug therapy | RUNX1 Translocation Partner 1 Protein - metabolism | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - drug effects | Diosgenin - analogs & derivatives | Diosgenin - pharmacology | Core Binding Factor Alpha 2 Subunit - metabolism | Medicine, Chinese Traditional | Core Binding Factor Alpha 2 Subunit - antagonists & inhibitors | Leukemia, Myeloid, Acute - pathology | Antineoplastic Agents, Phytogenic - chemistry | RUNX1 Translocation Partner 1 Protein - antagonists & inhibitors | Diosgenin - chemistry | Chromosomes, Human, Pair 21 - genetics | Down-Regulation - drug effects | Signal Transduction - drug effects | Cell Proliferation - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Screening Assays, Antitumor | Medicine, Botanic | Medicine, Herbal | Apoptosis | Medicinal plants | Myeloid leukemia | Therapeutic applications | Leukemia | Medicinal herbs | Staining | Cytotoxicity | AKT protein | Survivin | Dosage | Proteins | Herbal medicine | Time dependence | Signaling | AML1 protein | Cholecystokinin | Acute myeloid leukemia | Cancer | Index Medicus
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 2005, Volume 30, Issue 2, pp. 66 - 69
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 11/2009, Volume 69, Issue 21, pp. 8249 - 8255
Disruption of Runx1/AML1 subnuclear localization, either by a single amino acid substitution or by a chromosomal translocation [e.g., t(8;21)], is linked to... 
AML1-ETO | NORMAL HEMATOPOIESIS | ONCOLOGY | MAP KINASE | PHOSPHATASE | ACUTE MYELOGENOUS LEUKEMIA | FUSION PROTEIN | TUMOR-SUPPRESSOR | MICRORNAS | TRANSCRIPTION FACTOR | CO-REPRESSORS | Chromosomes, Human, Pair 8 - genetics | Translocation, Genetic | Oncogene Proteins, Fusion - metabolism | Cell Proliferation | Humans | Leukemia, Myeloid, Acute - metabolism | MicroRNAs - metabolism | RNA, Messenger - metabolism | Immunoenzyme Techniques | Cell Nucleus - metabolism | Chromatin Immunoprecipitation | Dual-Specificity Phosphatases - genetics | Cell Differentiation | Granulocytes - metabolism | Interleukin-3 - metabolism | Core Binding Factor Alpha 2 Subunit - metabolism | Dual-Specificity Phosphatases - metabolism | Leukemia, Myeloid, Acute - pathology | RNA, Messenger - genetics | Chromosomes, Human, Pair 21 - genetics | Reverse Transcriptase Polymerase Chain Reaction | Mitogen-Activated Protein Kinase Phosphatases - genetics | Blotting, Western | RUNX1 Translocation Partner 1 Protein | Myeloid Progenitor Cells - physiology | Oncogene Proteins, Fusion - genetics | Mitogen-Activated Protein Kinases - genetics | MicroRNAs - genetics | Core Binding Factor Alpha 2 Subunit - genetics | Leukemia, Myeloid, Acute - genetics | Mitogen-Activated Protein Kinase Phosphatases - metabolism | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
Journal Article
Journal Article
Blood, ISSN 0006-4971, 12/2011, Volume 118, Issue 25, pp. 6638 - 6648
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 02/2008, Volume 28, Issue 3, pp. 977 - 987
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2016, Volume 113, Issue 32, pp. 9075 - 9080
Journal Article
Journal Article