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PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e62082
Some potent chemotherapy drugs including tubulin-binding agents had been developed from nature plants, such as podophyllotoxin and paclitaxel. However, poor... 
MITOSIS | ANTIMITOTIC ACTIVITY | MICROTUBULES | NATURAL-PRODUCTS | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | RESISTANCE | TUBULIN | BINDING AGENTS | EXPRESSION | KINASES | Lung Neoplasms - drug therapy | Podophyllotoxin - pharmacology | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Apoptosis - genetics | Endoplasmic Reticulum Stress - genetics | Microtubules - metabolism | Podophyllotoxin - toxicity | Drug Evaluation, Preclinical | Disease Models, Animal | DNA Damage - drug effects | Lung Neoplasms - genetics | M Phase Cell Cycle Checkpoints - drug effects | Endoplasmic Reticulum Stress - drug effects | Antineoplastic Agents, Phytogenic - toxicity | Xenograft Model Antitumor Assays | Animals | Mitosis - drug effects | Signal Transduction - drug effects | Tumor Burden - drug effects | Cell Cycle Checkpoints - drug effects | Models, Biological | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Protein Multimerization - drug effects | Podophyllotoxin - analogs & derivatives | Chemotherapy | Podophyllotoxin | Analysis | Lung cancer | Polymerization | Stress (Physiology) | Tubulins | Health aspects | Apoptosis | Cancer | Drugs | Flow cytometry | Toxicity | Mitosis | Leukemia | DNA damage | Cytotoxicity | Selectivity | Drug development | Kinases | Cancer therapies | Anticancer properties | Metastases | Proteins | Signal transduction | Tubulin | Paclitaxel | Xenografts | Cell cycle | Inhibition | Stains | Deoxyribonucleic acid--DNA | Stresses | Plants (botany) | Hematology | Injection | Survivin | Tumor cell lines | Gene expression | Stress | Aurora B protein | Signaling | Side effects | Cell lines | Colonization | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e62087
Silica nanoparticles have become promising carriers for drug delivery or gene therapy. Endothelial cells could be directly exposed to silica nanoparticles by... 
PATHWAYS | MAINTENANCE | AIR-POLLUTION | OXIDATIVE STRESS | CHK1 | PARTICLES | MULTIDISCIPLINARY SCIENCES | DISEASE | MITOCHONDRIA | SIZE-DEPENDENT CYTOTOXICITY | CANCER | Protein Kinases - metabolism | Reactive Oxygen Species - metabolism | Nanoparticles - chemistry | Apoptosis - drug effects | Humans | Membrane Potential, Mitochondrial - drug effects | Necrosis | Flow Cytometry | G2 Phase Cell Cycle Checkpoints - drug effects | Human Umbilical Vein Endothelial Cells - drug effects | Intracellular Space - drug effects | Subcellular Fractions - drug effects | Endocytosis - drug effects | Nanoparticles - ultrastructure | Hydrodynamics | Static Electricity | Comet Assay | Nanoparticles - toxicity | Subcellular Fractions - metabolism | Particle Size | Human Umbilical Vein Endothelial Cells - enzymology | Silicon Dioxide - toxicity | Intracellular Space - metabolism | Checkpoint Kinase 1 | Human Umbilical Vein Endothelial Cells - pathology | DNA Damage | Oxidative Stress - drug effects | Drugs | Nanoparticles | Drug delivery systems | DNA | DNA damage | Superoxide | Radiation, Background | DNA repair | Silica | Vehicles | Endothelium | Cdc2 protein | Reactive oxygen species | Intravenous administration | Toxicity | Cytology | Cytotoxicity | Superoxide dismutase | Drug delivery | Kinases | Cyclin B1 | Silicon dioxide | Signal transduction | Mitochondria | Peroxidase | Membrane potential | Damage | Heart diseases | Deoxyribonucleic acid--DNA | Glutathione | Glutathione peroxidase | Outdoor air quality | CHK1 protein | Lactate dehydrogenase | Exposure | Hazards | Malondialdehyde | L-Lactate dehydrogenase | Endothelial cells | Signaling | Lactic acid | Mutation | Gene therapy | Cardiovascular diseases | Viability | Apoptosis | Deoxyribonucleic acid
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e98207
Recent studies have demonstrated that the anti-diabetic drug, metformin, can exhibit direct antitumoral effects, or can indirectly decrease tumor proliferation... 
PROSTATE | OBESITY | ACTIVATED PROTEIN-KINASE | INHIBITION | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GROWTH | AKT | AUTOPHAGY | TUMOR SUPPRESSORS | AMP-Activated Protein Kinases - metabolism | Oxidants - pharmacology | Hydrogen - pharmacology | Apoptosis - drug effects | Humans | Metformin - pharmacology | Enzyme Activation - drug effects | Neoplasm Proteins - metabolism | Breast Neoplasms - metabolism | Hypoglycemic Agents - pharmacology | Breast Neoplasms - pathology | Forkhead Transcription Factors - metabolism | Cell Line, Tumor | Female | Resting Phase, Cell Cycle - drug effects | Oxidative Stress - drug effects | Forkhead Box Protein O3 | G1 Phase Cell Cycle Checkpoints - drug effects | AMP-Activated Protein Kinases - genetics | Oxidative stress | Cancer cells | Cell cycle | Breast cancer | Metformin | Diabetes therapy | Apoptosis | Flow cytometry | Cell culture | Phosphorylation | Hydrogen peroxide | Bax protein | Bcl-2 protein | AKT protein | Superoxide dismutase | Biology | Activation | Kinases | Caspase-3 | Cancer therapies | Western blotting | Necrosis | Proteins | Signal transduction | Cell growth | Catalase | Penicillin | FOXO3 protein | G1 phase | Diabetes mellitus | Extracellular signal-regulated kinase | Caspase | MAP kinase | Pharmacology | Gene expression | Insulin | Zinc | Polymerase chain reaction | Cytometry | Molecular modelling | Cell number | Diabetes | Viability | Prostate | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e94298
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 42, pp. 30320 - 30329
Journal Article
International Journal of Cancer, ISSN 0020-7136, 04/2014, Volume 134, Issue 8, pp. 1991 - 2002
Journal Article
Investigational New Drugs, ISSN 0167-6997, 10/2014, Volume 32, Issue 5, pp. 825 - 837
The G1 restriction point is critical for regulating the cell cycle and is controlled by the Rb pathway (CDK4/6-cyclin D1-Rb-p16/ink4a). This pathway is... 
Medicine & Public Health | Cell cycle | Oncology | In vivo antitumor activity | Pharmacology/Toxicology | Combination therapy | LY2835219 | Kinase inhibitor | CDK4/6 inhibitor | Cdk4/6 inhibitor | LUNG | HUMAN BREAST | PHOSPHORYLATION | CANCER | DEPENDENT KINASE 4/6 | CONSTITUTIVELY ACTIVATED FLT3 | ONCOLOGY | BRAIN METASTASES | RESTRICTION POINT | TUMOR-SUPPRESSOR | PHARMACOLOGY & PHARMACY | EXPRESSION | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Neoplasms - metabolism | Humans | Deoxycytidine - pharmacology | Antineoplastic Agents - therapeutic use | Deoxycytidine - therapeutic use | Aminopyridines - therapeutic use | Female | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Drug Therapy, Combination | Benzimidazoles - therapeutic use | Retinoblastoma Protein - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Protein Kinase Inhibitors - therapeutic use | Aminopyridines - pharmacology | Retinoblastoma Protein - antagonists & inhibitors | Cell Line, Tumor | Benzimidazoles - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | G1 Phase Cell Cycle Checkpoints - drug effects | Neoplasms - pathology | Deoxycytidine - analogs & derivatives | Dosage and administration | Research | Gemcitabine | Studies | Protein expression | Inhibitor drugs | Kinases | Cancer therapies | Analysis | CDK4 | Preclinical Studies | 6 inhibitor
Journal Article