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Nature, ISSN 0028-0836, 05/2016, Volume 534, Issue 7605, pp. 55 - 62
Somatic mutations have been extensively characterized in breast cancer, but the effects of these genetic alterations on the proteomic landscape remain poorly... 
PATHWAYS | HETEROGENEITY | PIK3CA MUTATIONS | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | GENES | BIOLOGY | RECEPTOR | EXPRESSION | SIGNATURE | REVEALS | Protein Kinases - metabolism | Focal Adhesion Kinase 1 - genetics | Receptor, Epidermal Growth Factor - genetics | Protein Kinases - genetics | Cyclin-Dependent Kinases - metabolism | Receptor, ErbB-2 - genetics | Receptors, G-Protein-Coupled - metabolism | Genomics | Humans | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Phosphoproteins - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Tumor Suppressor Protein p53 - genetics | Breast Neoplasms - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Breast Neoplasms - enzymology | Receptor, Epidermal Growth Factor - metabolism | Phosphoproteins - analysis | Mass Spectrometry | src-Family Kinases - metabolism | Female | Cyclin-Dependent Kinases - genetics | Focal Adhesion Kinase 1 - metabolism | Chromosomes, Human, Pair 5 - genetics | Breast Neoplasms - classification | Chromosome Deletion | p21-Activated Kinases - genetics | Signal Transduction | Molecular Sequence Annotation | Calcium-Binding Proteins - deficiency | Phosphoproteins - genetics | Mutation - genetics | S-Phase Kinase-Associated Proteins - metabolism | p21-Activated Kinases - metabolism | Phosphatidylinositol 3-Kinases - genetics | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Proteomics | S-Phase Kinase-Associated Proteins - genetics | Receptors, G-Protein-Coupled - genetics | src-Family Kinases - genetics | Calcium-Binding Proteins - genetics | Breast cancer | Genetic aspects | Research | Oncology, Experimental | Cancer | Physiological aspects | Methods | Mutation (Biology) | Proteins | Gene amplification | Peptides | Protein expression | Genomes | Mutation | Kinases | Deoxyribonucleic acid--DNA | Tumors | Index Medicus
Journal Article
Science Signaling, ISSN 1945-0877, 06/2012, Volume 5, Issue 230, pp. ra46 - ra46
Journal Article
Cancer Letters, ISSN 0304-3835, 10/2017, Volume 406, pp. 36 - 46
Journal Article
Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 374 - 379
Cellular senescence has been recently shown to have an important role in opposing tumour initiation and promotion. Senescence induced by oncogenes or by loss... 
BOX PROTEIN SKP2 | TUMOR SUPPRESSION | PATHWAY | MULTIDISCIPLINARY SCIENCES | IN-VIVO | PTEN | ACCUMULATION | ONCOGENE-INDUCED SENESCENCE | EXPRESSION | CANCER | P53 | Proto-Oncogene Proteins p21(ras) - genetics | Cellular Senescence - drug effects | Male | Prostate - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | S-Phase Kinase-Associated Proteins - antagonists & inhibitors | Adenovirus E1A Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Fibroblasts | Prostatic Neoplasms - prevention & control | Prostatic Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - metabolism | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | PTEN Phosphohydrolase - deficiency | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | PTEN Phosphohydrolase - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | S-Phase Kinase-Associated Proteins - metabolism | Tumor Suppressor Protein p53 - deficiency | Animals | Activating Transcription Factor 4 - metabolism | Adenovirus E1A Proteins - genetics | Prostate - cytology | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | S-Phase Kinase-Associated Proteins - genetics | Mice | Cell Transformation, Neoplastic - drug effects | Prevention | Care and treatment | Physiological aspects | Aging | Tumor suppressor genes | Genetic aspects | Research | Cells | Tumors | Cell cycle | Apoptosis | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 4, pp. 774 - 789
For many years, a connection between circadian clocks and cancer has been postulated. Here we describe an unexpected function for the circadian repressor CRY2... 
MYC | circadian rhythm | CRY2 | cryptochrome | FBXL3 | circadian clock | ubiquitin | CIRCADIAN CLOCK | CRYPTOCHROME | PROTEIN | UBIQUITIN LIGASE | TUMOR SUPPRESSION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | GENE-EXPRESSION | CANCER-RISK | FACTOR PERIOD 2 | CELL BIOLOGY | Humans | Gene Expression Regulation, Neoplastic | Cryptochromes - genetics | Circadian Clocks - genetics | Lymphoma - mortality | Lymphoma - metabolism | S-Phase Kinase-Associated Proteins - chemistry | Cell Transformation, Neoplastic - genetics | Proteolysis | HEK293 Cells | Cullin Proteins - metabolism | Fibroblasts | Carrier Proteins - chemistry | Lymphoma - pathology | Protein Stability | Cryptochromes - metabolism | Protein Structure, Secondary | Signal Transduction | F-Box Proteins - metabolism | F-Box Proteins - chemistry | Circadian Rhythm - genetics | Lymphoma - genetics | Models, Molecular | S-Phase Kinase-Associated Proteins - metabolism | Cell Transformation, Neoplastic - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Mice, Knockout | Cullin Proteins - chemistry | Cullin Proteins - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Survival Analysis | S-Phase Kinase-Associated Proteins - genetics | Cryptochromes - chemistry | Mice | Proto-Oncogene Proteins c-myc - genetics | Cell Transformation, Neoplastic - pathology | Proto-Oncogene Proteins c-myc - chemistry | F-Box Proteins - genetics | Ubiquitin | Physiological aspects | Drug discovery | Research institutes | Ligases | Index Medicus | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell and Molecular Biology | Medicinska och farmaceutiska grundvetenskaper | Cell- och molekylärbiologi
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 3765 - 3773
S-phase kinase-associated protein 2 (SKP2) is a component of the E3 ubiquitin ligase SKP1-Cul1-Fbox complex. Overexpression of SKP2 results in cell cycle... 
MEDICINE, RESEARCH & EXPERIMENTAL | UBIQUITIN-MEDIATED DEGRADATION | BOX PROTEIN SKP2 | ENTEROPATHY | DISRUPTION | P27 | MOUSE | SCURFY | EXPRESSION | CELL-CYCLE INHIBITION | P27(KIP1) | Oncogene Proteins - genetics | RNA, Small Interfering - genetics | Receptor, ErbB-2 - genetics | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Receptor, ErbB-2 - metabolism | Repressor Proteins - antagonists & inhibitors | Breast Neoplasms - metabolism | Genes, X-Linked | S-Phase Kinase-Associated Proteins - antagonists & inhibitors | Cell Transformation, Neoplastic - genetics | Forkhead Transcription Factors - metabolism | Mice, Mutant Strains | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Cullin Proteins - metabolism | Female | Forkhead Transcription Factors - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - genetics | Repressor Proteins - metabolism | Tumor Suppressor Proteins - metabolism | RNA, Small Interfering - pharmacology | Cell Cycle Proteins - metabolism | Gene Silencing | Oncogene Proteins - metabolism | Repressor Proteins - genetics | Forkhead Transcription Factors - genetics | S-Phase Kinase-Associated Proteins - metabolism | Cell Transformation, Neoplastic - metabolism | Oncogene Proteins - antagonists & inhibitors | Cullin Proteins - genetics | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Ploidies | Cell Line, Tumor | Heterozygote | S-Phase Kinase-Associated Proteins - genetics | Mice | Mice, Inbred BALB C | Cell Transformation, Neoplastic - pathology | Tumor suppressor genes | Breast cancer | Genetic aspects | Research | DNA binding proteins | Identification and classification | Health aspects | Risk factors | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Cell Stem Cell, ISSN 1934-5909, 2011, Volume 9, Issue 3, pp. 272 - 281
Journal Article
Cancer Cell, ISSN 1535-6108, 05/2017, Volume 31, Issue 5, pp. 669 - 684.e7
Polyploidy can lead to aneuploidy and tumorigenesis. Here, we report that the Hippo pathway effector Yap promotes the diploid-polyploid conversion and... 
p27 | polyploidy | Hippo | Yap | tumorigenesis | genomic instability | Skp2 | UBIQUITIN-MEDIATED DEGRADATION | ORGAN SIZE | ACTIVATION | DEPENDENT REGULATION | ONCOLOGY | PATHWAY | SIZE-CONTROL | TUMOR SUPPRESSORS | MAMMALIAN-CELLS | CANCER | GENOMIC INTEGRITY | CELL BIOLOGY | Cell Proliferation | Humans | Gene Expression Regulation, Neoplastic | Phosphoproteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Cytosol - enzymology | Transfection | RNA Interference | Time Factors | Cell Transformation, Neoplastic - genetics | Forkhead Transcription Factors - metabolism | Proteolysis | Carcinoma, Hepatocellular - genetics | Female | Liver Neoplasms - pathology | Acetylation | Protein Stability | Liver Neoplasms - enzymology | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Genetic Predisposition to Disease | Liver Neoplasms - genetics | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Carcinoma, Hepatocellular - enzymology | Phosphoproteins - genetics | Forkhead Transcription Factors - genetics | S-Phase Kinase-Associated Proteins - metabolism | Cell Transformation, Neoplastic - metabolism | Hep G2 Cells | Pregnancy | p300-CBP Transcription Factors - metabolism | Phenotype | Animals | Epistasis, Genetic | Ploidies | Adaptor Proteins, Signal Transducing - genetics | Carcinoma, Hepatocellular - pathology | S-Phase Kinase-Associated Proteins - genetics | Mice | Adaptor Proteins, Signal Transducing - metabolism | Cell Transformation, Neoplastic - pathology | Cyclin-Dependent Kinase Inhibitor p27 - genetics | Medical colleges | Molecular biology | Ligases | Liver | Cells | Tumors | Index Medicus
Journal Article