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Nature (London), ISSN 1476-4687, 03/2010, Volume 464, Issue 7287, pp. 374 - 379
Cellular senescence has been recently shown to have an important role in opposing tumour initiation and promotion. Senescence induced by oncogenes or by loss... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Proto-Oncogene Proteins p21(ras) - genetics | Cellular Senescence - drug effects | Male | Prostate - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | S-Phase Kinase-Associated Proteins - antagonists & inhibitors | Adenovirus E1A Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Fibroblasts | Prostatic Neoplasms - prevention & control | Prostatic Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - metabolism | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | PTEN Phosphohydrolase - deficiency | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | PTEN Phosphohydrolase - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | S-Phase Kinase-Associated Proteins - metabolism | Tumor Suppressor Protein p53 - deficiency | Animals | Activating Transcription Factor 4 - metabolism | Adenovirus E1A Proteins - genetics | Prostate - cytology | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | S-Phase Kinase-Associated Proteins - genetics | Mice | Cell Transformation, Neoplastic - drug effects | Prevention | Care and treatment | Physiological aspects | Aging | Tumor suppressor genes | Genetic aspects | Research | Cells | Tumors | Cell cycle | Apoptosis | Index Medicus
Journal Article
Molecular cell, ISSN 1097-2765, 04/2007, Volume 26, Issue 1, pp. 131 - 143
The ubiquitin-mediated proteolysis of cyclin E plays a central role in cell-cycle progression, and cyclin E accumulation is a common event in cancer. Cyclin E... 
CELLCYCLE | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Phosphorylation | S-Phase Kinase-Associated Proteins - isolation & purification | Humans | Ubiquitin - metabolism | Molecular Sequence Data | Substrate Specificity | Structure-Activity Relationship | Threonine - metabolism | Cell Cycle Proteins - chemistry | S-Phase Kinase-Associated Proteins - chemistry | Saccharomyces cerevisiae - metabolism | Transfection | Cyclin-Dependent Kinase Inhibitor Proteins | Binding Sites | Dimerization | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Phosphopeptides - chemistry | F-Box Proteins - metabolism | F-Box Proteins - chemistry | Cell Cycle Proteins - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | Saccharomyces cerevisiae Proteins - genetics | S-Phase Kinase-Associated Proteins - metabolism | Ubiquitin-Protein Ligases - chemistry | Cyclin E - chemistry | Serine - metabolism | Saccharomyces cerevisiae - chemistry | Sequence Homology, Amino Acid | Models, Biological | Saccharomyces cerevisiae Proteins - metabolism | Phosphopeptides - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | F-Box Proteins - isolation & purification | Saccharomyces cerevisiae Proteins - chemistry | Index Medicus | NEOPLASMS | BASIC BIOLOGICAL SCIENCES | PHOSPHORYLATION | SUBSTRATES | DIMERIZATION | national synchrotron light source | IN VIVO | PROTEOLYSIS | PEPTIDES | IN VITRO | YEASTS | LIGASES | PHOSPHATES | CELL CYCLE
Journal Article
The EMBO journal, ISSN 1460-2075, 02/2006, Volume 25, Issue 5, pp. 1126 - 1136
Replication licensing is carefully regulated to restrict replication to once in a cell cycle. In higher eukaryotes, regulation of the licensing factor Cdt1 by... 
replication | Cdt1 | Geminin | cell cycle | proteolysis | Replication | Proteolysis | Cell cycle | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Cycle Proteins - pharmacology | Phosphorylation | Kidney - embryology | SKP Cullin F-Box Protein Ligases - genetics | Humans | Ubiquitin - metabolism | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Kidney - metabolism | S-Phase Kinase-Associated Proteins - antagonists & inhibitors | Ultraviolet Rays | DNA Replication - radiation effects | Cell Cycle Proteins - genetics | Cullin Proteins - metabolism | Fibroblasts - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Cullin Proteins - antagonists & inhibitors | Cyclin A - metabolism | RNA, Small Interfering - pharmacology | Cell Cycle Proteins - metabolism | Cells, Cultured | Gene Silencing | SKP Cullin F-Box Protein Ligases - metabolism | DNA-Binding Proteins - genetics | S-Phase Kinase-Associated Proteins - metabolism | SKP Cullin F-Box Protein Ligases - antagonists & inhibitors | Peptide Hydrolases - chemistry | Cullin Proteins - genetics | Animals | S-Phase Kinase-Associated Proteins - genetics | Mice | Cyclin E - metabolism | DNA Damage | HeLa Cells | Proliferating Cell Nuclear Antigen - metabolism | Amino acids | Eukaryotes | Index Medicus
Journal Article
Journal Article