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index medicus (6) 6
s1ra (6) 6
male (5) 5
animals (4) 4
e 52862 (4) 4
mice (4) 4
neuropathic pain (4) 4
receptors, sigma - antagonists & inhibitors (4) 4
analysis (3) 3
neurosciences (3) 3
pain (3) 3
pain measurement (3) 3
pharmacology & pharmacy (3) 3
sigma-1 receptor (3) 3
analgesics - pharmacology (2) 2
care and treatment (2) 2
carrageenan (2) 2
electric stimulation (2) 2
female (2) 2
morpholines - pharmacology (2) 2
neurons (2) 2
opioid analgesia (2) 2
peripheral-nerve injury (2) 2
pharmacokinetics, pharmacology (2) 2
phosphorylation (2) 2
pyrazoles - pharmacology (2) 2
rat (2) 2
sigma‐1 receptor (2) 2
spinal cord - drug effects (2) 2
4 [2 [ 1h pyrazol 3 yl (1) 1
4 [2 [[5 methyl 1 1h pyrazol 3 yl]oxy]ethyl]morpholine (1) 1
activation (1) 1
adenosine a2 receptors (1) 1
adult (1) 1
adverse drug reaction, clinical trial, drug dose, drug therapy (1) 1
allodynia (1) 1
alpha 1a adrenergic receptor (1) 1
analgesics, opioid - therapeutic use (1) 1
anatomy & morphology (1) 1
anesthesiology (1) 1
animal-models (1) 1
animals, newborn (1) 1
antagonists (1) 1
anti-inflammatory agents, non-steroidal - therapeutic use (1) 1
antinociception (1) 1
antinociceptive agent (1) 1
behavior, animal (1) 1
behavior, animal - drug effects (1) 1
behavioral sciences (1) 1
biochemistry & molecular biology (1) 1
calcitonin gene-related peptide (1) 1
capsaicin - toxicity (1) 1
carrageenan - toxicity (1) 1
carrageenin (1) 1
cc chemokine receptors (1) 1
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central sensitization (1) 1
chemokine receptors (1) 1
cholecystokinin receptors (1) 1
clinical neurology (1) 1
clinical trials (1) 1
clonidine (1) 1
complete freund's adjuvant (1) 1
concentric microdialysis (1) 1
cord (1) 1
cortical-neurons (1) 1
disease models, animal (1) 1
dopamine receptors (1) 1
dorsal root ganglia (1) 1
dorsal root ganglion (1) 1
dorsal roots (1) 1
dorsal-horn (1) 1
dose-response relationship, drug (1) 1
double-blind method (1) 1
drug comparison, drug concentration, drug dose, drug therapy (1) 1
e-52862 (1) 1
edema - drug therapy (1) 1
edema - etiology (1) 1
electrocardiogram (1) 1
electrocardiography (1) 1
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evoked release (1) 1
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formalin-induced pain (1) 1
formyl peptide receptors (1) 1
freund's adjuvant - toxicity (1) 1
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galanin receptors (1) 1
gene expression regulation - drug effects (1) 1
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1. Full Text Pharmacological properties of S1RA, a new sigma‐1 receptor antagonist that inhibits neuropathic pain and activity‐induced spinal sensitization
by Romero, L and Zamanillo, D and Nadal, X and Sánchez‐Arroyos, R and Rivera‐Arconada, I and Dordal, A and Montero, A and Muro, A and Bura, A and Segalés, C and Laloya, M and Hernández, E and Portillo‐Salido, E and Escriche, M and Codony, X and Encina, G and Burgueño, J and Merlos, M and Baeyens, JM and Giraldo, J and López‐García, JA and Maldonado, R and Plata‐Salamán, CR and Vela, JM
British Journal of Pharmacology, ISSN 0007-1188, 08/2012, Volume 166, Issue 8, pp. 2289 - 2306
BACKGROUND AND PURPOSE The sigma‐1 (σ1) receptor is a ligand‐regulated molecular chaperone that has been involved in pain, but there is limited understanding... 
central sensitization | neuropathic pain | S1RA (E‐52862) | sigma‐1 receptor | S1RA (E-52862)σ-1 receptor | NMDA RECEPTOR | ACTIVATION | RAT | PHOSPHORYLATION | S1RA (E-52862) | sigma-1 receptor | GUINEA-PIG BRAIN | PERIPHERAL-NERVE INJURY | CORTICAL-NEURONS | OPIOID ANALGESIA | PHARMACOLOGY & PHARMACY | FORMALIN TEST | METHYL-D-ASPARTATE | Analgesics - pharmacology | Electric Stimulation | Capsaicin - toxicity | Gene Expression Regulation - physiology | Morpholines - pharmacology | Male | Receptors, sigma - antagonists & inhibitors | Neuralgia - drug therapy | Behavior, Animal | Gene Expression Regulation - drug effects | Animals | Mice | Formaldehyde - toxicity | Pain Measurement | Pyrazoles - pharmacology | Physiological aspects | Care and treatment | Pain | Analysis | Medical research | Research Papers
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2. Full Text Effects of the selective sigma‐1 receptor antagonist S1RA on formalin‐induced pain behavior and neurotransmitter release in the spinal cord in rats
by Vidal‐Torres, Alba and Fernández‐Pastor, Begoña and Carceller, Alicia and Vela, José Miguel and Merlos, Manuel and Zamanillo, Daniel
Journal of Neurochemistry, ISSN 0022-3042, 05/2014, Volume 129, Issue 3, pp. 484 - 494
We have previously shown that the selective sigma‐1 receptor (σ1R) antagonist S1RA (E‐52862) inhibits neuropathic pain and activity‐induced spinal... 
concentric microdialysis | noradrenaline | S1RA | spinal cord | glutamate | sigma‐1 receptor | sigma-1 receptor | SPONTANEOUS GLUTAMATE RELEASE | SUBARACHNOID SPACE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACILITATES INHIBITORY TRANSMISSION | NEUROSCIENCES | DORSAL-HORN | NEUROPATHIC PAIN | SUBSTANTIA-GELATINOSA | ENDOPLASMIC-RETICULUM | EVOKED RELEASE | LUMBAR CATHETERIZATION | PROSTAGLANDIN E | Spinal Cord - drug effects | Spinal Cord - metabolism | Rats, Wistar | Neuralgia - metabolism | Morpholines - pharmacology | Rats | Male | Receptors, sigma - antagonists & inhibitors | Animals | Microdialysis | Neuralgia - chemically induced | Behavior, Animal - drug effects | Pain Measurement | Neurotransmitter Agents - secretion | Pyrazoles - pharmacology | GABA | Glutamate | Noradrenaline | Formaldehyde | Neurochemistry | Neurotransmitters | Spinal cord | Pain | Rodents
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3. Full Text Safety, tolerability and pharmacokinetics of single and multiple doses of a novel sigma‐1 receptor antagonist in three randomized phase I studies
by Abadias, Montserrat and Escriche, Marisol and Vaqué, Anna and Sust, Mariano and Encina, Gregorio
British Journal of Clinical Pharmacology, ISSN 0306-5251, 01/2013, Volume 75, Issue 1, pp. 103 - 117
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • A novel and highly selective sigma‐1 receptor antagonist (S1RA) provides a new approach for pain management. S1RA... 
pharmacokinetics | pain | pharmacodynamics | safety | tolerability | S1RA (E‐52862) | Pharmacodynamics | Tolerability | Pain | Safety | Pharmacokinetics | S1RA (E-52862) | OPIOID ANALGESIA | PHARMACOLOGY | PHARMACOLOGY & PHARMACY | Pyrazoles - administration & dosage | Double-Blind Method | Humans | Morpholines - administration & dosage | Adult | Female | Male | Receptors, sigma - antagonists & inhibitors | Morpholines - pharmacokinetics | Pyrazoles - pharmacokinetics | Morpholines - adverse effects | Pyrazoles - adverse effects | Care and treatment | Safety and security measures | Analysis | Electrocardiogram | Clinical trials | Electrocardiography | Clinical Trials
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4. Full Text S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice
by Gris, Georgia and Merlos, Manuel and Vela, José M and Zamanillo, Daniel and Portillo-Salido, Enrique
Behavioural Pharmacology, ISSN 0955-8810, 2014, Volume 25, Issue 3, pp. 226 - 235
The therapeutic potential of S1RA (E-52862), a selective sigma-1 receptor (sigma R-1) antagonist, has been explored in experimental neuropathic pain, but not... 
complete Freund's adjuvant | allodynia | hypersensitivity | carrageenan | E-52862 | inflammatory pain | sigma-1 receptor | hyperalgesia | S1RA | r1R knockout mouse | RHEUMATOID-ARTHRITIS | THERMAL HYPERALGESIA | RAT | sigma 1R knockout mouse | KNOCKOUT MICE | ANTINOCICEPTION | NEUROSCIENCES | INDUCED SPINAL SENSITIZATION | PERIPHERAL-NERVE INJURY | NEUROPATHIC PAIN | ANIMAL-MODELS | BEHAVIORAL SCIENCES | PHARMACOLOGY & PHARMACY | RODENT MODEL | Inflammation - chemically induced | Ibuprofen - therapeutic use | Pyrazoles - therapeutic use | Freund's Adjuvant - toxicity | Male | Receptors, sigma - antagonists & inhibitors | Inflammation - complications | Time Factors | Pain - drug therapy | Pain - etiology | Carrageenan - toxicity | Morpholines - therapeutic use | Disease Models, Animal | Receptors, sigma - deficiency | Analgesics, Opioid - therapeutic use | Edema - drug therapy | Receptors, sigma - genetics | Mice, Knockout | Edema - etiology | Animals | Hyperalgesia - drug therapy | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Mice | Pain Measurement | Morphine - therapeutic use
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5. Full Text Effects of centrally acting analgesics on spinal segmental reflexes and wind‐up
by Mazo, I and Roza, C and Zamanillo, D and Merlos, M and Vela, J.M and Lopez‐Garcia, J.A
European Journal of Pain, ISSN 1090-3801, 08/2015, Volume 19, Issue 7, pp. 1012 - 1020
Background The spinal cord is a prime site of action for analgesia. Here we characterize the effects of established analgesics on segmental spinal reflexes.... 
CORD | NEONATAL-RAT | PREGABALIN | PAINFUL DIABETIC-NEUROPATHY | S1RA | SIGMA-1 RECEPTOR ANTAGONIST | NEUROSCIENCES | CLINICAL NEUROLOGY | CLONIDINE | IN-VITRO | FORMALIN-INDUCED PAIN | NEURONS | ANESTHESIOLOGY | Animals, Newborn | Analgesics - pharmacology | Receptors, sigma - drug effects | Electric Stimulation | Spinal Cord - drug effects | Mice, Inbred C57BL | Nerve Fibers, Myelinated - drug effects | Male | Dose-Response Relationship, Drug | Animals | Reflex, Monosynaptic - drug effects | Nociception - drug effects | Nerve Fibers, Unmyelinated - drug effects | Female | Mice | Motor Neurons - drug effects | Spinal Nerve Roots - drug effects
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6. Full Text Sigma‐1 Receptor Expression in DRG Neurons During a Carrageenan‐Provoked Inflammation
by Jerčić, Leo and Kostić, Sandra and Vitlov Uljević, Marija and Vukušić Pušić, Tanja and Vukojević, Katarina and Filipović, Natalija
The Anatomical Record, ISSN 1932-8486, 09/2019, Volume 302, Issue 9, pp. 1620 - 1627
ABSTRACT Sigma 1 receptor (σ1R) is a non‐opioid receptor that modulates pain perception and is strongly expressed in dorsal root ganglion (DRG) neurons. We... 
sigma 1 receptor | inflammation | carrageenan | dorsal root ganglion | NEUROPATHIC PAIN | PHOSPHORYLATION | ANATOMY & MORPHOLOGY | SUPERIOR CERVICAL-GANGLIA | MICE | S1RA | Immunohistochemistry | Carrageenin | Neurons | Analysis | Fluorescence | Inflammation | Health aspects | Calcitonin gene-related peptide | Pain perception | Dorsal root ganglia | Opioid receptors | Antagonists | Injection | Neuropathy | Dorsal roots
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