X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (9479) 9479
Publication (1783) 1783
Book Chapter (82) 82
Book Review (65) 65
Conference Proceeding (24) 24
Dissertation (12) 12
Magazine Article (3) 3
Paper (2) 2
Book / eBook (1) 1
Data Set (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (5511) 5511
humans (4486) 4486
phosphorylation (4323) 4323
index medicus (4074) 4074
biochemistry & molecular biology (2680) 2680
signal transduction (2576) 2576
mice (2573) 2573
cell biology (2150) 2150
ribosomal protein s6 kinases, 70-kda - metabolism (1902) 1902
male (1812) 1812
rats (1630) 1630
p70 s6 kinase (1610) 1610
activation (1566) 1566
s6 kinase (1473) 1473
rapamycin (1464) 1464
ribosomal protein s6 kinases - metabolism (1410) 1410
proteins (1359) 1359
tor serine-threonine kinases - metabolism (1359) 1359
mammalian target (1354) 1354
female (1341) 1341
mtor (1284) 1284
tor serine-threonine kinases (1256) 1256
signal transduction - drug effects (1200) 1200
cell line (1152) 1152
oncology (1118) 1118
cells, cultured (1111) 1111
protein kinases - metabolism (1095) 1095
proto-oncogene proteins c-akt - metabolism (1093) 1093
kinases (1074) 1074
sirolimus - pharmacology (1045) 1045
cell line, tumor (1033) 1033
protein-serine-threonine kinases - metabolism (1015) 1015
ribosomal protein s6 kinases, 90-kda - metabolism (970) 970
phosphatidylinositol 3-kinases - metabolism (959) 959
enzyme activation (956) 956
apoptosis (953) 953
expression (940) 940
cancer (906) 906
insulin (897) 897
phosphorylation - drug effects (854) 854
research (825) 825
signal transduction - physiology (824) 824
growth (817) 817
phosphoproteins - metabolism (812) 812
article (783) 783
physiological aspects (709) 709
enzyme inhibitors - pharmacology (703) 703
protein biosynthesis (688) 688
gene expression (686) 686
physiology (674) 674
pathway (665) 665
research article (638) 638
cells (636) 636
molecular sequence data (631) 631
cell proliferation (621) 621
amino acid sequence (614) 614
inhibition (603) 603
activated protein-kinase (599) 599
phosphatidylinositol 3-kinase (594) 594
ribosomal protein s6 kinases (566) 566
blotting, western (565) 565
in-vivo (560) 560
gene-expression (557) 557
protein kinases (556) 556
protein-kinase (551) 551
akt (550) 550
multidisciplinary sciences (550) 550
analysis (549) 549
map kinase (542) 542
protein binding (540) 540
cell proliferation - drug effects (539) 539
rats, sprague-dawley (527) 527
ribosomal s6 kinase (522) 522
endocrinology & metabolism (521) 521
carrier proteins - metabolism (519) 519
neurosciences (516) 516
time factors (509) 509
ribosomal protein s6 (508) 508
mutation (505) 505
insulin - pharmacology (504) 504
protein synthesis (490) 490
tor protein (489) 489
proto-oncogene proteins c-akt (484) 484
mechanistic target of rapamycin complex 1 (476) 476
mitogen-activated protein kinases - metabolism (474) 474
proto-oncogene proteins - metabolism (472) 472
signaling pathway (471) 471
kinase (464) 464
enzyme activation - drug effects (460) 460
rodents (456) 456
apoptosis - drug effects (447) 447
models, biological (446) 446
dose-response relationship, drug (435) 435
mice, inbred c57bl (434) 434
metabolism (433) 433
autophagy (427) 427
proliferation (426) 426
transfection (425) 425
translation (422) 422
skeletal-muscle (418) 418
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (9443) 9443
Chinese (55) 55
Japanese (19) 19
Russian (7) 7
French (5) 5
German (4) 4
Korean (2) 2
Polish (2) 2
Spanish (2) 2
Ukrainian (2) 2
Czech (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | SUBSTRATE-SPECIFICITY | HYDROPHOBIC MOTIF PHOSPHORYLATION | cancer | serum and glucocorticoid protein kinase (SGK) | COMPLEX 2 | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 01/2009, Volume 104, Issue 1, pp. 15 - 18
Ischemic postconditioning (IPoC) reduces infarct size following ischemia/reperfusion. Whether or not phosphorylation of RISK (reperfusion injury salvage... 
PERMEABILITY TRANSITION PORE | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTECTION | REPERFUSION | reperfusion injury | NECROSIS-FACTOR-ALPHA | ADENOSINE RECEPTORS | infarct size | INHIBITION | MYOCARDIAL INFARCT SIZE | cardioprotection | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | MOUSE HEARTS | SIGNAL TRANSDUCER | Glycogen Synthase Kinase 3 - physiology | MAP Kinase Kinase 2 - physiology | Nitriles - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Glycogen Synthase Kinase 3 beta | Ribosomal Protein S6 Kinases, 70-kDa - physiology | MAP Kinase Kinase 1 - physiology | Myocardial Reperfusion Injury - enzymology | Ribosomal Protein S6 Kinases, 70-kDa - biosynthesis | Protein Processing, Post-Translational - drug effects | Swine | Mitogen-Activated Protein Kinase 3 - biosynthesis | Myocardial Infarction - pathology | Swine, Miniature | Phosphorylation - drug effects | Myocardial Infarction - enzymology | MAP Kinase Kinase 1 - antagonists & inhibitors | Butadienes - pharmacology | Glycogen Synthase Kinase 3 - biosynthesis | Mitogen-Activated Protein Kinase 1 - physiology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Coronary Occlusion - enzymology | Enzyme Induction | Proto-Oncogene Proteins c-akt - physiology | Enzyme Activation - drug effects | Mitogen-Activated Protein Kinase 3 - physiology | Mitogen-Activated Protein Kinase 1 - biosynthesis | Proto-Oncogene Proteins c-akt - biosynthesis | Animals | Androstadienes - pharmacology | Myocardial Reperfusion | MAP Kinase Kinase 2 - antagonists & inhibitors | Coronary Occlusion - pathology | Phosphatidylinositol 3-Kinases - physiology | Protein Kinase Inhibitors - pharmacology | Myocardial Reperfusion Injury - prevention & control | Proto-Oncogene Proteins c-akt - antagonists & inhibitors
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2010, Volume 427, Issue 1, pp. 69 - 78
More than 200 phosphorylated 14-3-3-binding sites in the literature were analysed to define 14-3-3 specificities, identify relevant protein kinases, and give... 
Evolution | 14-3-3 protein | Disrupted-in-schizophrenia 1 (DISC1) | calmodulin-dependent protein kinase | AGC protein kinase | NEURONAL MIGRATION | SIGNALING PATHWAYS | MEMBRANE H+-ATPASE | REGULATING 14-3-3 BINDING | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | EUKARYOTIC PROTEIN-KINASES | evolution | NUCLEAR-LOCALIZATION | EXOENZYME-S | STRUCTURAL BASIS | Ca2+/calmodulin-dependent protein kinase | disrupted-in-schizophrenia 1 (DISC1) | ENDOPLASMIC-RETICULUM | Protein Kinases - metabolism | Phosphorylation | Immunoprecipitation | Humans | RNA, Messenger - genetics | Cells, Cultured | Computational Biology | Kidney - cytology | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | 14-3-3 Proteins - metabolism | Nerve Tissue Proteins - metabolism | Kidney - metabolism | Carrier Proteins - metabolism | Protein Binding | Binding Sites | Dimerization | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | 14-3-3 Proteins - genetics | Bcl-2-associated death promoter | AANAT, serotonin acetyltransferase | FOXO, Forkhead box O | KLC, kinesin light chain | CDK5, cyclin-dependent kinase 5 | HEK, human embryonic kidney | MARK, microtubule affinity-regulating kinase | AMPK, AMP-activated protein kinase | EST, expressed sequence tag | PKB, protein kinase B | RSK, ribosomal S6 kinase | CaMK, Ca2 | GLUT4, glucose transporter 4 | protein kinase G | GST, glutathione transferase | HDAC, histone deacetylase | HAP1A, Huntingtin-associated protein 1A | DIG, digoxigenin | PKC, protein kinase C | BAD, Bcl-XL | PP2A, protein phosphatase 2A | DSTT, Division of Signal Transduction Therapy | HA, haemagglutinin | AGC, protein kinase A | Ca2 | PI4K, phosphoinositide 4-kinase | DISC1, disrupted-in-schizophrenia 1 | protein kinase C family kinase | YAP1, yes-associated protein 1
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | ACTIVATED PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | MSK1 | INDUCTION | IDENTIFICATION | INACTIVATION | CREB | GROWTH | BI-DI870 | SUPPRESSES | phosphorylation | kinase-specific inhibitor | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | protein kinase C | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2005, Volume 392, Issue 2, pp. 249 - 261
The MAPK (mitogen-activated protein kinase) pathway is one of the most important and intensively studied signalling pathways. It is at the heart of a... 
Receptor tyrosine kinase | Signalling network | Systems biology | Extracellular-signal-regulated kinase (ERK) | Computational modelling | Mitogen-activated protein kinase (MAPK) | systems biology | EARLY GENE-PRODUCTS | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | BIOCHEMICAL NETWORKS | QUANTITATIVE-ANALYSIS | ERK ACTIVATION | extracellular-signal-regulated kinase (ERK) | GROWTH-FACTOR RECEPTOR | COMPLEX-FORMATION | signalling network | DUAL PHOSPHORYLATION | computational modelling | receptor tyrosine kinase | SIGNAL-REGULATED KINASE | Mitogen-Activated Protein Kinase Kinases - metabolism | Animals | Receptor Protein-Tyrosine Kinases - metabolism | Models, Biological | Computer Simulation | MAP Kinase Signaling System | MEK, MAPK | ODE, ordinary differential equation | MAPKK | MP1, MEK partner 1 | NGF, nerve growth factor | MKP, MAPK phosphatase | Review | MCA, Metabolic Control Analysis | ERK kinase | ERK, extracellular-signal-regulated kinase | PKA, cAMP-activated protein kinase | Shc, Src homology and collagen homology | STAT5, signal transduction and activator of transcription 5 | RSK, ribosomal S6 kinase | FBA, Flux Balance Analysis | SOS, son of sevenless | CD domain, common docking domain | MKKK, MAPKK kinase | PLCγ, phospholipase Cγ | EGF(R), epidermal growth factor (receptor) | FGF, fibroblast growth factor | MKK, MAPK kinase | SBML, Systems Biology Markup Language | JIP, JNK (c-Jun N-terminal kinase)-interacting protein | PDE4, phosphodiesterase 4 | KSR, kinase suppressor of Ras | MAPKKK | Grb2, growth-factor-receptor-bound protein 2 | RTK, receptor tyrosine kinase | GAP, GTPase-activating protein | PDGF, platelet-derived growth factor | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2004, Volume 384, Issue 3, pp. 477 - 488
We detected a protein in rabbit skeletal muscle extracts that was phosphorylated rapidly by SGK1 (serum- and glucocorticoid-induced kinase 1), but not by... 
Phosphorylation | Glycogen synthase kinase 3 (GSK3) | N-myc down-stream-regulated gene (NDRG) | p53 | Serum- and glucocorticoid-induced kinase 1 (SGK1) | glycogen synthase kinase 3 (GSK3) | EPITHELIAL NA+ CHANNEL | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCOGEN-SYNTHASE KINASE-3 | TRANSCRIPTION | SERUM | P70 S6 KINASE | n-myc downstream-regulated gene (NDRG) | IN-VIVO | GENE FAMILY | serum- and glucocorticoid-induced kinase 1 (SGK1) | MAPKAP KINASE-1 | phosphorylation | Antibody Specificity | Multigene Family | Molecular Weight | Humans | Molecular Sequence Data | Substrate Specificity | Cell Cycle Proteins - classification | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Immediate-Early Proteins | Cell Cycle Proteins - immunology | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Antibodies - immunology | Cell Cycle Proteins - genetics | Proteins - classification | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Cell Line | Rabbits | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Intracellular Signaling Peptides and Proteins | Nuclear Proteins - metabolism | Glycogen Synthase Kinase 3 - metabolism | Phosphoserine - metabolism | Proteins - immunology | Proteins - genetics | Proto-Oncogene Proteins c-akt | Animals | Proteins - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Mice | HeLa Cells | Tumor Suppressor Proteins | SGK1, serum- and glucocorticoid-induced kinase 1 | PDK1, 3-phosphoinositide-dependent kinase 1 | LDS, lithium dodecyl sulphate | RSK, p90 ribosomal S6 kinase | ENaC, epithelial sodium channel | FOXO3a, forkhead box O3a | ERK, extracellular-signal-regulated kinase | MALDI-TOF, matrix-assisted laser-desorption ionization–time-of-flight | PKB, protein kinase B | SAPK, stress-activated protein kinase | CDK, cyclin-dependent kinase | IGF-1, insulin-like growth factor-1 | DYRK1A, dual-specificity tyrosine phosphorylated and regulated kinase 1A | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | GSK3, glycogen synthase kinase 3 | siRNA, small interfering RNA | KESTREL, kinase substrate tracking and elucidation | MAPK, mitogen-activated protein kinase | NDRG, n-myc downstream-regulated gene
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, p. e100880
Tumor cells upregulate many cell signaling pathways, with AKT being one of the key kinases to be activated in a variety of malignancies. GSK2110183 and... 
BREAST-CANCER | APOPTOSIS | ACTIVATING MUTATION | PHOSPHORYLATION | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | PLECKSTRIN HOMOLOGY DOMAIN | RICTOR | INDUCTION | EGFR | Ribosomal Protein S6 Kinases - metabolism | Pyrazoles - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Gene Expression Regulation, Neoplastic | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | Pancreatic Neoplasms - drug therapy | PTEN Phosphohydrolase - antagonists & inhibitors | Female | Antineoplastic Agents - pharmacology | Drug Evaluation, Preclinical | MAP Kinase Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - metabolism | Pyrazoles - pharmacology | PTEN Phosphohydrolase - genetics | Protein Kinase Inhibitors - chemical synthesis | Signal Transduction | Administration, Oral | MAP Kinase Kinase Kinases - genetics | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - enzymology | PTEN Phosphohydrolase - metabolism | Pancreatic Neoplasms - genetics | MAP Kinase Kinase Kinases - metabolism | Mice, SCID | Drug Synergism | Phosphatidylinositol 3-Kinases - genetics | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Cell Line, Tumor | Diamines - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Blood Glucose - metabolism | Diamines - chemical synthesis | Ribosomal Protein S6 Kinases - antagonists & inhibitors | Ribosomal Protein S6 Kinases - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Cellular signal transduction | Glucose | Phosphotransferases | Dextrose | Tumors | Biotechnology | Phosphorylation | Animal models | Leukemia | Homeostasis | Oncology | AKT protein | Kinases | K-Ras protein | Anticancer properties | Feedback | Polyethylene glycol | Inhibition | Enzymes | Tumor cells | MAP kinase | Breast cancer | Bioavailability | Substrates | 1-Phosphatidylinositol 3-kinase | Studies | Signaling | Inhibitors | Pancreatic cancer | Cell lines | Mutation | Laboratory animals | ATP | PTEN protein | Cancer | Apoptosis
Journal Article
Cellular Signalling, ISSN 0898-6568, 2006, Volume 18, Issue 9, pp. 1351 - 1359
Follicle-stimulating hormone (FSH) is necessary and sufficient to induce maturation of ovarian follicles to a mature, preovulatory phenotype in the intact... 
Protein kinase A | Mitogen-activated protein kinase | Follicle-stimulating hormone | Female reproduction | Hypoxia-induced factor 1 | Histone H3 | histone H3 | SIDE-CHAIN CLEAVAGE | follicle-stimulating hormone | OVARIAN-FOLLICLE | ELEMENT-BINDING PROTEIN | HISTONE H3 PHOSPHORYLATION | hypoxia-induced factor 1 | STEROIDOGENIC FACTOR-I | TRANSCRIPTION FACTOR FKHR | female reproduction | P38 MAP KINASE | LUTEINIZING-HORMONE | CELL BIOLOGY | mitogen-activated protein kinase | FOLLICLE-STIMULATING-HORMONE | protein kinase A | GROWTH-FACTOR-I | Cyclic AMP-Dependent Protein Kinases - metabolism | Follicle Stimulating Hormone - metabolism | Tumor Suppressor Proteins - metabolism | Granulosa Cells - physiology | Gene Expression Regulation | Protein Tyrosine Phosphatases - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Animals | Forkhead Transcription Factors - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Female | Signal Transduction - physiology | p38 Mitogen-Activated Protein Kinases - metabolism | Enzyme Activation | Histones - metabolism | Tyrosine | Chromatin | Phosphatases | Corticosteroids | Peptides | Tuberous sclerosis | Glycoproteins | DNA binding proteins | Hormones | Gene expression | Phosphatidylinositol | Luteinizing hormone | Mitogens | Vascular endothelial growth factor | Protein kinases | Growth factors | Protein binding | GIOT-1, gonadotropin-inducible ovarian transcription factor-1 | p70S6K, p70 ribosomal S6 kinase | TGFβ, transforming growth factor β | EGF, epidermal growth factor | CREB, cAMP response element binding protein | PDE, phosphodiesterase | R, PKA regulatory subunits | GPCR, G-protein-coupled receptor | MAP2D, microtubule-associated protein 2D | Sp1 | Epac, exchange proteins activated by cAMP | PI3K, phosphatidylinositol 3-kinase | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | AKAP, A kinase anchoring protein | Sp3, specific protein 1 | PKI, PKA inhibitor peptide | PKC, protein kinase C | SCC, P450 cholesterol side chain cleavage | VEGF, vascular endothelial growth factor | CBP, CREB binding protein | ERK, extracellular regulated kinase | MNK, MAPK-interacting kinase | Aromatase, P450 aromatase | ChIP, chromatin immunoprecipitation assay | HIF-1, hypoxia-induced factor-1 | Egr-1, early growth response protein-1 | LH, luteinizing hormone | MEK, mitogen- and extracellular-regulated kinase kinase | TSC, tuberous sclerosis complex tumor suppressor gene | SF-1, steroidogenic factor-1 | SGK, serum glucocorticoid kinase | RSK, p90 ribosomal S6 protein kinase | LRH-1, liver receptor homolog-1 | MAPK, mitogen-activated protein kinase | PKA, protein kinase A | PTP, protein tyrosine phosphatase | FSH, follicle-stimulating hormone | MK, MAPK-activated protein kinases
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2007, Volume 407, Issue 2, pp. 231 - 241
AS 160 (Akt substrate of 160 kDa) mediates insulin-stimulated GLUT4 (glucose transporter 4) translocation, but is widely expressed in insulin-insensitive... 
14-3-3 | Akt/protein kinase B (PKB) | GTPase-activating protein (GAP) | p90 ribosomal S6 kinase (RSK) | Akt substrate of 160 kDa (AS160) | Serum- and glucocorticoid-induced protein kinase (SGK) | MOUSE SKELETAL-MUSCLE | MAMMALIAN TARGET | BIOCHEMISTRY & MOLECULAR BIOLOGY | Akt substrate of 160kDa (AS160) | AKT SUBSTRATE | CELL-GROWTH | GTPASE-ACTIVATING PROTEIN | INSULIN-STIMULATED PHOSPHORYLATION | GLUT4 TRANSLOCATION | S6 KINASE | PROTEOMIC ANALYSIS | RAB-GAP | serum- and glucocorticoid-induced protein kinase (SGK) | Cell Line | Insulin-Like Growth Factor I - pharmacology | Phosphorylation | Humans | GTPase-Activating Proteins - metabolism | Insulin | Amino Acids | Aminoimidazole Carboxamide - pharmacology | Hypoglycemic Agents - pharmacology | 14-3-3 Proteins - metabolism | Ribonucleotides - pharmacology | Aminoimidazole Carboxamide - analogs & derivatives | Protein Binding | Epidermal Growth Factor - pharmacology | Binding Sites | ACC, acetyl-CoA carboxylase | AGC kinase, protein kinase A | AICAR, 5-amino-4-imidazolecarboxamide1-β-D-ribofuranoside | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | TOS motif, mTOR signalling motif | PAS, phospho-Akt substrate | pSer, phosphorylated serine | TSC, tuberous sclerosis complex | AS160, Akt substrate of 160 kDa | PKB, protein kinase B (also known as Akt) | AMPK, AMP-activated protein kinase | RSK, p90 ribosomal S6 kinase | DSP, dithiobis(succinimidyl propionate) | protein kinase C-family | ERK, extracellular-signal-regulated kinase | PDK1, phosphoinositide-dependent kinase 1 | protein kinase B (PKB) | IGF-1, insulin-like growth factor-1 | Akt substrate of 160 kDa (AS160) | GLUT4, glucose transporter 4 | protein kinase G | mTOR, mammalian target of rapamycin | TORC1, mTOR–raptor (regulatory associated protien of mTOR) complex | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | GST, glutathione S-transferase | PKC, protein kinase C | PP2A, protein phosphatase 2A | Akt | SGK, serum- and glucocorticoid-induced protein kinase | HA, haemagglutinin | GSV, GLUT4 storage vesicle | p70S6K, p70 S6 kinase | PTB, phosphotyrosine binding domain | pThr, phosphorylated threonine | GAP, GTPase-activating protein | HEK-293, human embryonic kidney-293 | IRAP, insulin-responsive aminopeptidase | Rheb, Ras enriched in brain | MAPK, mitogen-activated protein kinase
Journal Article
FEBS Letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
The specificity of 4,5,6,7‐tetrabromo‐2‐azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase‐2 (CK2), has been examined... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | DRB, 1-(β | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | ribofuranosyl)-5,6-dichlorobenzimidazole | PKA, cAMP-dependent protein kinase | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | CATALYTIC SUBUNIT | ZEA-MAYS | TYROSINE KINASE | CRYSTAL-STRUCTURE | COMPETITIVE INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein phosphorylation | IMMUNOPHILIN FPR3 | SACCHAROMYCES-CEREVISIAE | protein kinase | CELL BIOLOGY | casein kinase | BIOPHYSICS | inhibitor | CELL-CYCLE | BETA-SUBUNIT | casein kinase-2 | MAMMARY-GLAND | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects
Journal Article