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s6k1 (224) 224
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Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical and biophysical research communications, ISSN 0006-291X, 10/2015, Volume 466, Issue 3, pp. 499 - 504
p70 ribosomal S6 kinase 1 (S6K1) is an important serine/threonine kinase and downstream target of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway... 
Kelch-like ECH-associated protein 1 (Keap1) | Nuclear factor erythroid 2-related factor 2 (Nrf2) | PF-4708671 | p62 | Autophagy | p70 ribosomal S6 kinase 1 (S6K1) | INDUCED CELL-DEATH | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | MECHANISMS | SELECTIVE AUTOPHAGY | CANCER | INACTIVATION | TRANSCRIPTION FACTOR NRF2 | BIOPHYSICS | PATHWAY | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Cytoskeletal Proteins - genetics | Sequestosome-1 Protein | Humans | Autophagy - physiology | RNA, Messenger - metabolism | Autophagy - drug effects | Heat-Shock Proteins - deficiency | Heat-Shock Proteins - genetics | Proteolysis - drug effects | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Cytoskeletal Proteins - metabolism | Kelch-Like ECH-Associated Protein 1 | Heat-Shock Proteins - metabolism | RNA, Messenger - genetics | Cells, Cultured | Imidazoles - pharmacology | Piperazines - pharmacology | Animals | Signal Transduction - drug effects | Adaptor Proteins, Signal Transducing - deficiency | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Apoptosis - physiology | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | OXIDATION | APOPTOSIS | PHOSPHORYLATION | TRANSFERASES | BENZOQUINONES | 60 APPLIED LIFE SCIENCES | FIBROBLASTS | NAD | HEME | SERINE | GLUTATHIONE | MICE | THREONINE | OXIDOREDUCTASES
Journal Article
Biochemical journal, ISSN 0264-6021, 04/2014, Volume 459, Issue 2, pp. 275 - 287
The insulin/IGF-1 (insulin-like growth factor 1)-activated protein kinase Akt (also known as protein kinase B... 
Tumour suppressor | Akt | AMP-activated protein kinase (AMPK) | Cross-talk | Cancer | Protein Structure, Tertiary | Amino Acid Sequence | PTEN Phosphohydrolase - genetics | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Humans | Models, Molecular | PTEN Phosphohydrolase - metabolism | Proto-Oncogene Proteins c-akt - genetics | Down-Regulation - physiology | Animals | HEK293 Cells | Protein Binding | Protein Conformation | Proto-Oncogene Proteins c-akt - metabolism | Gene Expression Regulation, Neoplastic - physiology | AMP-Activated Protein Kinases - genetics | mTORC1, mammalian (or mechanistic) target of rapamycin complex 1 | ACC, acetyl-CoA carboxylase | WT, wild-type | PI3K, phosphoinositide 3-kinase | cross-talk | HEK, human embryonic kidney | AMPK, AMP-activated protein kinase | STRADα, Ste20-related adapter protein-α | BRSK, brain-specific kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | MO25α, mouse protein-25α | S6K1, S6 kinase 1 | ST loop, serine | LKB1, liver kinase B1 | tumour suppressor | PKA, protein kinase A (cAMP-dependent protein kinase) | GSK3, glycogen synthase kinase 3 | IGF-1, insulin-like growth factor 1 | threonine-rich loop | DMEM, Dulbecco’s modified Eagle’s medium | MEF, mouse embryonic fibroblast | AICAR, 5-amino-4-imidazolecarboxamide riboside | cancer | CaMKK, calmodulin-dependent kinase kinase β | NEAA, non-essential amino acid
Journal Article
Journal of applied physiology (1985), ISSN 1522-1601, 2010, Volume 108, Issue 5, pp. 1199 - 1209
Journal Article
Cellular signalling, ISSN 0898-6568, 2016, Volume 28, Issue 5, pp. 412 - 424
.... These processes are critically dependent upon signalling via the mammalian or mechanistic target of rapamycin complex 1 (mTORC1... 
Rheb | TSC2 | 4E-BP1 | PP2A | Akt | S6K1 | Deferoxamine | ACTIVATION | ACID | HYPOXIA | PROTEIN-SYNTHESIS | DEFICIENCY | CELL BIOLOGY | MTORC1 | DEPENDENT REGULATION | MESSENGER-RNA | GROWTH | EXPRESSION | Caco-2 Cells | Deferoxamine - pharmacology | Intestinal Mucosa - metabolism | Protein Biosynthesis | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | TOR Serine-Threonine Kinases - metabolism | Down-Regulation | Humans | Transcription Factors - biosynthesis | Mechanistic Target of Rapamycin Complex 1 | Transcription Factors - metabolism | Amino Acids - metabolism | Multiprotein Complexes - metabolism | Iron Chelating Agents - pharmacology | Signal Transduction - drug effects | Intestinal Mucosa - enzymology | Iron - deficiency | Protein Phosphatase 2 - metabolism | Cell Proliferation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Proteins | Protein biosynthesis | Phosphatases | Protein binding | Reduction | Phosphorylation | Depletion | Protein synthesis | Mathematical models | Iron | Signalling | S6K1, ribosomal protein S6 kinase 1 | PP2A, protein phosphatase 2A | 4E-BP1, eIF4E-binding protein 1 | DMT-1, divalent metal transporter-1 | TfR, transferrin receptor | HIF, hypoxia-inducible factor | S6, ribosomal protein S6 | DFO, deferoxamine | PI3K, phosphatidylinositol 3-kinase | mTOR, mammalian target of rapamycin | REDD1, regulated in DNA damage and development 1 | IRS, insulin receptor substrate
Journal Article
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2012, Volume 130, Issue 5, pp. 1159 - 1166.e6
Background The IL-1 family cytokine IL-33 is involved in the induction of airway inflammation in allergic patients and after viral infection. Several cell... 
Allergy and Immunology | mammalian target of rapamycin | asthma | innate lymphoid cells | IL-33 | TH2 | rapamycin | HYPERREACTIVITY | PHOSPHATIDYLINOSITOL 3-KINASE | CYTOKINE | IMMUNOLOGY | MTOR | T(H)2 | ST2 | EFFECTOR | ALLERGY | DIFFERENTIATION | INHIBITORS | SELECTIVITY | EXPRESSION | Interleukin-1 Receptor-Like 1 Protein | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Ribosomal Protein S6 Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Immunity, Innate - genetics | Th2 Cells - immunology | Th2 Cells - drug effects | Immunity, Cellular - drug effects | Pneumonia - chemically induced | Pneumonia - immunology | Immunity, Cellular - genetics | Immunity, Innate - drug effects | Interleukin-33 | Interleukin-5 - metabolism | Cells, Cultured | Interleukin-13 - metabolism | Receptors, Interleukin - genetics | Mice, Knockout | Animals | Pneumonia - drug therapy | Interleukins - administration & dosage | Signal Transduction - drug effects | Mice | Mice, Inbred BALB C | Th2 Cells - transplantation | Virus diseases | T cells | Inflammation | Flow cytometry | Cell growth | Phosphorylation | Lungs | Rodents | Kinases | Viral infections | Methods | rpS6, Ribosomal protein S6 | S6K1, Ribosomal protein S6 kinase 1 | TCR, T-cell receptor | 2), Mammalian target of rapamycin (complex 1 | Lin, Lineage-specific marker | ICOS, Inducible costimulator | BAL, Bronchoalveolar lavage | WT, Wild-type | APC, Allophycocyanin | TSLP, Thymic stromal lymphopoietin | mTOR(C1 | PE, Phycoerythrin | PI3K, Phosphoinositide 3-kinase | ILC, Innate lymphoid cell | AHR, Airway hyperresponsiveness | Mechanisms of Allergy and Clinical Immunology
Journal Article