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Cellular Signalling, ISSN 0898-6568, 08/2018, Volume 48, pp. 13 - 24
Mitochondrial morphology, which is associated with changes in metabolism, cell cycle, cell development and cell death, is tightly regulated by the balance... 
Metabolic shift | OxPhos | Mitophagy | Fission | S6K1 | Drp1 | SHAPE CHANGES | PROTEIN | FUSION | PHOSPHORYLATION | DEATH | AUTOPHAGY | MAMMALIAN-CELLS | CELL BIOLOGY | DYNAMICS | DEGRADATION | Glucose metabolism | Medical colleges | Cell death
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 07/2019, Volume 855, pp. 202 - 207
It is not clear whether inhibition of p70 ribosomal S6 kinase 1 (S6K1) is neuroprotective in cerebral ischemia-reperfusion. Decreasing blood-brain barrier... 
S6K1 inhibitor | Blood-brain barrier | 14C-α-aminoisobutyric acid | Brain protection | PF-4708671 | Cerebral ischemia-reperfusion | RAPAMYCIN | TARGET | C-14-alpha-aminoisobutyric acid | ISOFLURANE | INJURY | AKT | MODEL | PATHWAY | BRAIN-BARRIER DISRUPTION | PHARMACOLOGY & PHARMACY | RICTOR | HIF-1-ALPHA | Dextran | Anesthesia | Neurosciences | Cerebral ischemia | Permeability | Neurons
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 10/2015, Volume 466, Issue 3, pp. 499 - 504
p70 ribosomal S6 kinase 1 (S6K1) is an important serine/threonine kinase and downstream target of the mechanistic target of rapamycin complex 1 (mTORC1)... 
Kelch-like ECH-associated protein 1 (Keap1) | Nuclear factor erythroid 2-related factor 2 (Nrf2) | PF-4708671 | p62 | Autophagy | p70 ribosomal S6 kinase 1 (S6K1) | INDUCED CELL-DEATH | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | MECHANISMS | SELECTIVE AUTOPHAGY | CANCER | INACTIVATION | TRANSCRIPTION FACTOR NRF2 | BIOPHYSICS | PATHWAY | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Cytoskeletal Proteins - genetics | Sequestosome-1 Protein | Humans | Autophagy - physiology | RNA, Messenger - metabolism | Autophagy - drug effects | Heat-Shock Proteins - deficiency | Heat-Shock Proteins - genetics | Proteolysis - drug effects | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Cytoskeletal Proteins - metabolism | Kelch-Like ECH-Associated Protein 1 | Heat-Shock Proteins - metabolism | RNA, Messenger - genetics | Cells, Cultured | Imidazoles - pharmacology | Piperazines - pharmacology | Animals | Signal Transduction - drug effects | Adaptor Proteins, Signal Transducing - deficiency | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Apoptosis - physiology | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus | OXIDATION | APOPTOSIS | PHOSPHORYLATION | TRANSFERASES | BENZOQUINONES | 60 APPLIED LIFE SCIENCES | FIBROBLASTS | NAD | HEME | SERINE | GLUTATHIONE | MICE | THREONINE | OXIDOREDUCTASES
Journal Article
Journal Article
Journal of Ginseng Research, ISSN 1226-8453, 2018
Background: The biological and pharmacological effects of BST204, a fermented ginseng extract, have been reported in various disease conditions. However, its... 
Wnt genes | H2BS36 phosphorylation | BST204 | Adipogenesis | S6K1
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biopolymers and Cell, ISSN 0233-7657, 2015, Volume 31, Issue 4, pp. 294 - 300
Aim. Generation of polyclonal antibodies specific to the ribosomal protein S6 kinase isoform – p85S6K1 and directed to the N-terminal (1–23 aa) extension of... 
Ribosomal protein S6 kinase 1 (S6K1) | P85 S6K1 | S6K1 isoforms | P70 S6K1 | Polyclonal antibodies | p70 S6K1 | p85 S6K1 | polyclonal antibodies
Journal Article
Chinese Journal of Cancer Biotherapy, ISSN 1007-385X, 2014, Volume 21, Issue 4, pp. 459 - 463
Objective: To optimize the construction of eukaryotic expression vectors encoding p70/p85 ribosomal protein S6 kinase 1 (S6K1) and to evaluate the function of... 
Gene recombination | Cell death | Eukaryotic expression | Breast cancer | Vector construction | MCF-7 cell | Ribosomal protein S6 kinase 1(S6K1)
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2003, Volume 373, Issue 2, pp. 583 - 591
Journal Article
Journal of Applied Physiology, ISSN 8750-7587, 05/2010, Volume 108, Issue 5, pp. 1199 - 1209
The loss of skeletal muscle mass during aging, sarcopenia, increases the risk for falls and dependence. Resistance exercise (RE) is an effective rehabilitation... 
Occlusion | Aging | Sarcopenia | S6 kinase 1 | Skeletal muscle | Resistance exercise | MAMMALIAN TARGET | SPORT SCIENCES | MESSENGER-RNA TRANSLATION | PHYSIOLOGY | INTENSITY RESISTANCE EXERCISE | MODERATE VASCULAR OCCLUSION | S6K1 PHOSPHORYLATION | HUMAN SKELETAL-MUSCLE | MYOFIBER HYPERTROPHY | occlusion | ECCENTRIC EXERCISE | GENE-EXPRESSION | resistance exercise | aging | ESSENTIAL AMINO-ACIDS | skeletal muscle | sarcopenia | Phosphorylation | Age Factors | Fibrin Fibrinogen Degradation Products - metabolism | Humans | Multiprotein Complexes | Male | Quadriceps Muscle - blood supply | Recovery of Function | Mechanistic Target of Rapamycin Complex 1 | Muscle Proteins - biosynthesis | Proteins | Resistance Training | Time Factors | Thrombosis - blood | Hormones - blood | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Organ Size | Biomarkers - blood | Regional Blood Flow | Blotting, Western | Oxygen - blood | Muscle Proteins - genetics | Transcription Factors - metabolism | Insulin - metabolism | Muscle Contraction | Quadriceps Muscle - anatomy & histology | Biopsy | Ribosomal Protein S6 - metabolism | Sex Factors | Aged | TOR Serine-Threonine Kinases | Quadriceps Muscle - metabolism | Mitogen-Activated Protein Kinases - metabolism | Blood pressure | Exercise | Protein synthesis | Older people | Men | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2014, Volume 459, Issue 2, pp. 275 - 287
The insulin/IGF-1 (insulin-like growth factor 1)-activated protein kinase Akt (also known as protein kinase B) phosphorylates Ser487 in the 'ST loop'... 
Tumour suppressor | Akt | AMP-activated protein kinase (AMPK) | Cross-talk | Cancer | Protein Structure, Tertiary | Amino Acid Sequence | PTEN Phosphohydrolase - genetics | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Humans | Models, Molecular | PTEN Phosphohydrolase - metabolism | Proto-Oncogene Proteins c-akt - genetics | Down-Regulation - physiology | Animals | HEK293 Cells | Protein Binding | Protein Conformation | Proto-Oncogene Proteins c-akt - metabolism | Gene Expression Regulation, Neoplastic - physiology | AMP-Activated Protein Kinases - genetics | Index Medicus | mTORC1, mammalian (or mechanistic) target of rapamycin complex 1 | ACC, acetyl-CoA carboxylase | WT, wild-type | PI3K, phosphoinositide 3-kinase | cross-talk | HEK, human embryonic kidney | AMPK, AMP-activated protein kinase | STRADα, Ste20-related adapter protein-α | BRSK, brain-specific kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | MO25α, mouse protein-25α | S6K1, S6 kinase 1 | ST loop, serine | LKB1, liver kinase B1 | tumour suppressor | PKA, protein kinase A (cAMP-dependent protein kinase) | GSK3, glycogen synthase kinase 3 | IGF-1, insulin-like growth factor 1 | threonine-rich loop | DMEM, Dulbecco’s modified Eagle’s medium | MEF, mouse embryonic fibroblast | AICAR, 5-amino-4-imidazolecarboxamide riboside | cancer | CaMKK, calmodulin-dependent kinase kinase β | NEAA, non-essential amino acid
Journal Article