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Biochemical Journal, ISSN 0264-6021, 02/2010, Volume 426, Issue 1, pp. 109 - 118
Activation of AMPK (AMP-activated protein kinase) by phosphorylation at Thr(172) is catalysed by at least two distinct upstream kinases, i.e. the tumour... 
calmodulin-dependent protein kinase (CaMK) | AMP-activated protein kinase-related kinase (ARK) | calmodulin-dependent protein kinase kinase (CaMKK) | AMP-activated protein kinase (AMPK) | TUMOR-SUPPRESSOR LKB1 | RESPIRATORY-CHAIN | CELLS | LOCALIZATION | ENERGY | Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CASCADE | UPSTREAM KINASE | Ca2+/calmodulin-dependent protein kinase (CaMK) | SUBSTRATE-SPECIFICITY | METABOLISM | Amino Acid Sequence | Cell Line | AMP-Activated Protein Kinases - metabolism | Immunoprecipitation | Calcium - metabolism | Humans | Molecular Sequence Data | Calcimycin - pharmacology | Phenformin - pharmacology | Cyclic AMP - pharmacology | Sequence Homology, Amino Acid | Calcium - physiology | Adenosine Triphosphate - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism | Protein Binding | Adenosine Diphosphate - metabolism | HeLa Cells | Phosphorylation - drug effects | Ionophores - pharmacology | Index Medicus | ACC, acetyl-CoA carboxylase | calmodulin-dependent protein kinase kinase | HEK, human embryonic kidney | MARK, microtubule affinity-regulating kinase | AMPK, AMP-activated protein kinase | TBS, Tris-buffered saline | BRSK, brain-specific kinase | UBA, ubiquitin-associated | MO25, mouse protein 25 | CaMK, Ca2 | ARK, AMPK-related kinase | NUAK, SNF1 (sucrose-non-fermenting kinase-1)-like kinase | AMPactivated protein kinase-related kinase (ARK) | GST, glutathione transferase | STRAD, Ste20-related adaptor | GFP, green fluorescent protein | calmodulin-dependent protein kinase | SIK, salt-inducible kinase | calmodulindependent protein kinase (CaMK) | Ca2 | AICAR, 5-amino-4-imidazolecarboxamide riboside | FBS, foetal bovine serum | CaMKK, Ca2
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2004, Volume 23, Issue 4, pp. 833 - 843
We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and... 
cancer | cell polarity | PAR1/MARK kinase | Peutz–Jeghers syndrome | TOF–TOF mass spectrometry | diabetes | TOF-TOF mass spectrometry | Cell polarity | Diabetes | Peutz-Jeghers syndrome | Cancer | SERINE-THREONINE KINASE | PEUTZ-JEGHERS-SYNDROME | CYTOPLASMIC LOCALIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT PROTEIN-KINASE | UPSTREAM KINASES | CELL BIOLOGY | GENE | SALT-INDUCIBLE KINASE | C-ELEGANS EMBRYOS | TUMOR-SUPPRESSOR | YEAST SNF1 | Amino Acid Sequence | Cell Line | Phosphorylation | Humans | Adaptor Proteins, Vesicular Transport - genetics | Protein-Serine-Threonine Kinases - genetics | Molecular Sequence Data | Multienzyme Complexes - metabolism | Substrate Specificity | Multienzyme Complexes - genetics | Adaptor Proteins, Vesicular Transport - metabolism | AMP-Activated Protein Kinases | Protein Subunits - metabolism | Peptides - metabolism | Protein Binding | Enzyme Activation | Mutation | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Protein Subunits - genetics | BRSK1 protein | MARK4 protein | QIK protein | SIK protein | MARK2 protein | MARK3 protein | LKB1 protein | NUAK2 protein | NUAK1 protein | phenformin | MARK1 protein | BRSK2 protein | MELK protein | QSK protein | Index Medicus | PAR1 | MARK kinase | Biological Sciences | Naturvetenskap | Biokemi och molekylärbiologi | Biochemistry and Molecular Biology | Biologi | Natural Sciences
Journal Article
The FEBS Journal, ISSN 1742-464X, 02/2018, Volume 285, Issue 3, pp. 467 - 480
The salt‐inducible kinase ( SIK ) family regulates cellular gene expression via the phosphorylation of cAMP‐regulated transcriptional coactivators ( CRTC s)... 
14‐3‐3 protein | protein phosphorylation | catalytic activity | transcriptional regulation | 14-3-3 protein | LOCALIZATION | CREB | STRUCTURAL BASIS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | LKB1 | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Transcription Factors - chemistry | Humans | Protein Kinases - chemistry | Substrate Specificity | Recombinant Fusion Proteins - metabolism | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Conserved Sequence | Protein Interaction Domains and Motifs | Active Transport, Cell Nucleus | Binding Sites | Cyclic AMP - metabolism | Peptide Fragments - genetics | Protein-Serine-Threonine Kinases - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Peptide Fragments - metabolism | Protein-Serine-Threonine Kinases - genetics | Recombinant Fusion Proteins - chemistry | Transcription Factors - genetics | 14-3-3 Proteins - metabolism | Transcription Factors - metabolism | Peptide Fragments - chemistry | Animals | Peptide Fragments - antagonists & inhibitors | Mice | Protein Processing, Post-Translational | Protein-Serine-Threonine Kinases - chemistry | Mutation | Transcription Factors - agonists | Amino Acid Substitution | Proteins | Cyclic adenylic acid | Protein binding | Protein kinase A | Repressing | Salts | Transcription | Cyclic AMP | Substrate inhibition | Catalytic activity | Kinases | Gene expression | Substrates | Signaling | Evolutionary conservation | Salt-inducible kinase | Catalysis | Binding sites | Cytoplasm | Index Medicus
Journal Article
The Biochemical journal, ISSN 0264-6021, 02/2014, Volume 458, Issue 1, pp. 41 - 56
The LKB1 tumour suppressor protein kinase functions to activate two isoforms of AMPK (AMP-activated protein kinase) and 12 members of the AMPK-related family... 
Amino Acid Sequence | Phosphorylation | Humans | Protein-Serine-Threonine Kinases - genetics | Molecular Sequence Data | Protein Prenylation | Serine - metabolism | Animals | Adenylate Kinase - metabolism | HEK293 Cells | Cysteine - metabolism | Mice | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | STRAD, STE20-related kinase adaptor | ACC, acetyl-CoA carboxylase | PI3K, phosphoinositide 3-kinase | SIK3, salt-inducible kinase 3 | HEK, human embryonic kidney | AMPK, AMP-activated protein kinase | ARK5, AMPK-related protein kinase 5 | EDL, extensor digitorum longus | ERK, extracellular-signal-regulated kinase | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | RSK, ribosomal S6 kinase | DMEM, Dulbecco's modified Eagle's medium | NUAK1, NUAK family, SNF1-like kinase | phenformin | BRSK, BR serine | SAD-A | threonine kinase | mTOR, mammalian target of rapamycin | Bub2 | HSP90, heat-shock protein 90 | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | SAD-B kinase | MARK4, MAP | signal transduction | 5-amino-4-imidazolecarboxamide riboside (AICAR) | PKA, cAMP-dependent protein kinase | HA, haemagglutinin | BiP, immunoglobulin heavy-chain-binding protein | PH, pleckstrin homology | raptor, regulatory associated protein of mTOR | Cdc16) domain family, member 1 | TBC1D1, TBC (Tre-2 | BDNF, brain-derived neurotrophic factor | ACTH, adrenocorticotropic hormone | MAPKAPK, MAPKAP (MAPK-activated protein) kinase | MEF, mouse embryonic fibroblast | AICAR, 5-amino-4-imidazolecarboxamide riboside | AMP-activated protein kinase-related kinase (AMPK-related kinase) | monoclonal antibody | microtubule affinity-regulating kinase 4 | ER, endoplasmic reticulum | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2015, Volume 465, Issue 2, pp. 271 - 279
Macrophages switch to an anti-inflammatory, 'regulatory'-like phenotype characterized by the production of high levels of interleukin (IL)-10 and low levels of... 
Chemical biology | Dasatinib | Inflammation | Interleukin-10 | Salt-inducible kinase | Bosutinib | REGULATORY MACROPHAGES | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IL-10 PRODUCTION | interleukin-10 | MYELOID-LEUKEMIA PATIENT | SIGNAL-TRANSDUCTION | BRUTONS TYROSINE KINASE | dasatinib | chemical biology | inflammation | salt-inducible kinase | ENDOTOXIN TOLERANCE | IN-VIVO | SELECTIVITY | bosutinib | Aniline Compounds - pharmacology | Tumor Necrosis Factor Ligand Superfamily Member 14 - immunology | Immunity, Innate - drug effects | Nitriles - pharmacology | Phosphotransferases (Alcohol Group Acceptor) - immunology | Cells, Cultured | Macrophages - cytology | Pyrimidines - pharmacology | Quinolines - pharmacology | Arginase - immunology | Animals | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cyclic AMP Response Element-Binding Protein - immunology | Protein-Serine-Threonine Kinases - immunology | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Transcription Factors - immunology | Macrophages - immunology | Cytokines - immunology | Index Medicus | IRF, interferon regulatory factor | TLR, Toll-like receptor | IKK, IκB kinase | PGE2, prostaglandin E2 | Btk, Bruton’s tyrosine kinase | JNK, c-Jun N-terminal kinase | SIK, salt-inducible kinases | CREB, cAMP-response-element-binding protein | qPCR, quantitative real-time PCR | MSK, mitogen- and stress-activated protein kinases | HDAC, histone deacetylase | IκB, inhibitor of NF-κB | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | CRTC, CREB-regulated transcription co-activator | NF-κB, nuclear factor κB | Pam3CSK4, tripalmitoylcysteinylseryl-(lysyl)4 | M-CSF, macrophage colony-stimulating factor | HA, haemagglutinin | 2, extracellular-signal-regulated kinase 1 | DMEM, Dulbecco’s modified Eagle’s medium | IL, interleukin | LPS, lipopolysaccharide | ERK 1 | TBK1, TANK-binding kinase 1 | MAPK, mitogen-activated protein kinase
Journal Article
Science, ISSN 0036-8075, 12/2017, Volume 358, Issue 6367, p. eaan4368
Kinase inhibitors are important cancer therapeutics. Polypharmacology is commonly observed, requiring thorough target deconvolution to understand drug... 
REFINEMENT | PROTEIN | CHEMICAL PROTEOMICS | INHIBITOR SELECTIVITY | DATA QUALITY | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | INTEGRATIVE GENOMICS VIEWER | SALT-INDUCIBLE KINASES | CANCER | COMPREHENSIVE ANALYSIS | fms-Like Tyrosine Kinase 3 - antagonists & inhibitors | Lung Neoplasms - drug therapy | Lung Neoplasms - enzymology | Cytokines - metabolism | Humans | Drug Discovery - methods | Antineoplastic Agents - chemistry | Molecular Targeted Therapy | Xenograft Model Antitumor Assays | Leukemia, Myeloid, Acute - enzymology | Protein Kinase Inhibitors - chemistry | Animals | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Line, Tumor | Leukemia, Myeloid, Acute - drug therapy | Antineoplastic Agents - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Proteomics - methods | Salts | Target recognition | Lung cancer | Selectivity | Drug development | Cancer therapies | Signal transduction | Biomolecules | Protein-tyrosine kinase | Tyrosine | Medical research | Imatinib | Decision making | Medical treatment | Mass spectroscopy | Tumor necrosis factor-α | Embryos | Bruton's tyrosine kinase | Mode of action | Side effects | Inhibitors | Interleukin 10 | Affinity | Drug discovery | Mass spectrometry | Acute myeloid leukemia | Drugs | Deregulation | Leukemia | Interleukin | Medical services | Clinical trials | Leucine | Kinases | Biological effects | Epidermal growth factor | Salt-inducible kinase | Xenografts | Cell survival | Epidermal growth factor receptors | Research & development--R&D | Therapeutic applications | Myeloid leukemia | Markers | Data processing | Lead compounds | Leucine zipper proteins | Signaling | Proteomics | Cancer | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2013, Volume 450, Issue 2, pp. 351 - 363
ERK1/2 (extracellular-signal-regulated kinase 1/2) and their substrates RSKs (p90 ribosomal S6 kinases) phosphorylate different transcription factors,... 
Endothelin | α1-adrenergic receptor | P90 ribosomal S6 kinase (p90 RSK) | Transcriptomics | Cardiomyocyte | Mitogen-activated protein kinase (MAPK) | SNK, Student–Newman–Keuls | Lif, leukaemia inhibitory factor | Olr1, oxidized low-density lipoprotein (lectin-like) receptor 1 | Dusp, dual-specificity phosphatase | MNK, MAPK-interacting protein kinase | CREB, cAMP-response-element-binding protein | PKB, protein kinase B | ERK1 | RSK, ribosomal S6 kinase | transcriptomics | PE, phenylephrine | p90 ribosomal S6 kinase (p90 RSK) | AR, adrenergic receptor | Egr, early growth response | BH-MTC, Benjamini and Hochberg multiple testing correction | mitogen-activated protein kinase (MAPK) | ET-1, endothelin-1 | β, glycogen synthase kinase 3α | AMPKα, AMP-activated protein kinase α | Areg, amphiregulin | MKK, MAPK kinase | Rgs2, regulator of G-protein signalling 2, 24 kDa | 2, extracellular-signal-regulated kinase 1 | Atf3, activating transcription factor 3 | Klf, Krüppel-like factor | endothelin | GSK3α | Gapdh, glyceraldehyde 3-phosphate dehydrogenase | Plk2, polo-like kinase 2 | Nr4a, nuclear receptor subfamily 4, group A | Sik1, salt-inducible kinase 1 | cardiomyocyte | FDR, false discovery rate | Fosb, FBJ murine osteosarcoma viral oncogene homologue B | MSK, mitogen- and stress-activated protein kinase | IL11, interleukin 11 | NPE, nuclear protein-enriched | MAPK, mitogen-activated protein kinase | Ptgs2, prostaglandin-endoperoxide synthase 2, qPCR, quantitative PCR | Has, hyaluronan synthase
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2017, Volume 127, Issue 10, pp. 3810 - 3826
The kidney glomerular capillaries are frequent sites of immune complex deposition and subsequent neutrophil accumulation in post-infectious and rapidly... 
IMMUNE-COMPLEXES | MEDICINE, RESEARCH & EXPERIMENTAL | SYSTEMIC-LUPUS-ERYTHEMATOSUS | RESPIRATORY BURST | ABL FAMILY KINASES | IN-VIVO | ANTIENDOTHELIAL CELL ANTIBODIES | LEUKOCYTE ADHESION | SALT-INDUCIBLE KINASES | APPROVED DRUGS | IMAGING REVEALS | Capillaries - pathology | Nitriles - pharmacology | Proto-Oncogene Proteins c-abl - antagonists & inhibitors | Humans | Quinolines - pharmacology | Receptors, IgG - genetics | Immunoglobulin G - immunology | Proto-Oncogene Proteins c-abl - immunology | Neutrophils - pathology | Proto-Oncogene Proteins c-abl - genetics | Aniline Compounds - pharmacology | src-Family Kinases - antagonists & inhibitors | Glomerulonephritis - genetics | Neutrophils - immunology | Glomerulonephritis - immunology | Kidney Glomerulus - pathology | Receptors, IgG - immunology | src-Family Kinases - immunology | Mice, Knockout | Animals | Glomerulonephritis - pathology | HL-60 Cells | Capillaries - immunology | Mice | Kidney Glomerulus - immunology | Tyrosine | Lupus | Glomerulonephritis | Nephritis | Immunoglobulins | Kidneys | Syngeneic grafts | Leukemia | Immunoglobulin G | Neutrophils | Polymerization | Arthritis | Leukocytes (neutrophilic) | Inflammation | Fc receptors | Microscopy | Actin | Rodents | Ligands | Physiology | Capillaries | Protein-tyrosine kinase | Kidney transplantation | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 01/2012, Volume 120, Issue 1, pp. 165 - 176
Microtubule‐associated protein tau is abnormally hyperphosphorylated in the filamentous inclusions of human tauopathies. Phosphorylation of S262/S356 is known... 
tau | Phosphorylation | tauopathy | Alzheimer’s disease | AMPK‐related kinases | AMPK-related kinases | Alzheimer's disease | NEUROFIBRILLARY TANGLES | ALZHEIMERS-DISEASE BRAIN | DROSOPHILA MODEL | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMYOTROPHIC-LATERAL-SCLEROSIS | ALPHA-SYNUCLEIN | FRONTOTEMPORAL LOBAR DEGENERATION | NEUROSCIENCES | MASS-SPECTROMETRY | TANDEM REPEATS | PAIRED HELICAL FILAMENTS | GLYCOGEN-SYNTHASE KINASE | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Line | Microtubule-Associated Proteins - metabolism | Humans | Rats | Recombinant Proteins - chemistry | tau Proteins - metabolism | Down-Regulation - drug effects | Epitopes - genetics | Rats, Sprague-Dawley | Blotting, Western | Animals | Microtubules - drug effects | Plasmids - genetics | Polymerase Chain Reaction | Protein Kinase Inhibitors - pharmacology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Neurons - drug effects | Antibodies, Monoclonal - chemistry | Phosphotransferases | Nervous system diseases | Proteins | Neurochemistry | Kinases | Neurological disorders | Index Medicus | Calcium | Neurodegenerative diseases | Cortex | Antibodies | Embryos | Ca super(2+)/calmodulin-dependent protein kinase | Tau protein | Microtubule-associated proteins | salt-inducible kinase | Dementia disorders | Immunoreactivity
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2018, Volume 69, Issue 6, pp. 1017 - 1027.e6
The lineage-specific transcription factor (TF) MEF2C is often deregulated in leukemia. However, strategies to target this TF have yet to be identified. Here,... 
HDAC4 | MEF2C | kinase | acute myeloid leukemia | transcription | salt-inducible kinase | SIK3 | SIK2 | MLL | LKB1 | CELLS | ACTIVATION | HUMAN GENOME | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TARGETS | TRANSCRIPTION FACTOR MEF2C | MODEL | DIFFERENTIATION | CLASS IIHDAC | EXPRESSION | CELL BIOLOGY | Epigenetic inheritance | Index Medicus
Journal Article