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Drug and Alcohol Dependence, ISSN 0376-8716, 2014, Volume 146, pp. e48 - e49
Journal Article
The American Journal on Addictions, ISSN 1055-0496, 04/2018, Volume 27, Issue 3, pp. 163 - 165
Background and ObjectiveRecreational use of salvia divinorum (salvia), a potent, naturally occurring hallucinogen, is on the rise internationally. Despite the... 
COCAINE | SUBSTANCE ABUSE | INTERNET | SALVINORIN | AGONIST
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 01/2015, Volume 172, Issue 2, pp. 515 - 531
Background and PurposeAcute activation of opioid (KOP) receptors results in anticocaine-like effects, but adverse effects, such as dysphoria, aversion,... 
dopamine transporter | alvia divinorum | addiction | drug seeking | nociception | cocaine self‐administration | salvinorin | κ opioid receptor | cocaine self-administration | salvinorin A | Salvia divinorum | DOPAMINE TRANSPORTER FUNCTION | NONHUMAN-PRIMATES | ACTIVATED PROTEIN-KINASE | NEOCLERODANE DITERPENES | COCAINE-SEEKING | SURFACE EXPRESSION | P38-ALPHA MAPK | NUCLEUS-ACCUMBENS | opioid receptor | HALLUCINOGEN SALVINORIN | PHARMACOLOGY & PHARMACY | SIGNAL-REGULATED KINASE | Dopamine Plasma Membrane Transport Proteins - metabolism | Humans | Cercopithecus aethiops | Motor Activity - drug effects | Male | Pain - metabolism | Brain - metabolism | Self Administration | Cocaine-Related Disorders - metabolism | Pain - drug therapy | HEK293 Cells | Behavior, Animal - drug effects | Diterpenes - pharmacology | Diterpenes - therapeutic use | Receptors, Opioid, kappa - agonists | Mesylates - therapeutic use | Receptors, Opioid, kappa - metabolism | Rats, Sprague-Dawley | Drug-Seeking Behavior - drug effects | Brain - drug effects | Cocaine - administration & dosage | Animals | MAP Kinase Signaling System - drug effects | Mesylates - pharmacology | Cell Line, Tumor | Cocaine-Related Disorders - drug therapy | Mice | COS Cells | Index Medicus | Opioids | S alvia divinorum | Themed Section | New Pathways to Functional Selectivity
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2018, Volume 28, Issue 16, pp. 2770 - 2772
Salvinorin A (SalA) is a potent and selective agonist of the -opioid receptor (KOR), but its instability has frustrated medicinal chemistry efforts. Treatment... 
Heck reaction | Salvinorin | Total synthesis | Kappa opioid receptor | Conformational analysis | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | SALVINORIN-A | Substitution reactions | Synthesis | Organic compounds | Index Medicus | Total Synthesis
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2016, Volume 113, Issue 21, pp. 6041 - 6046
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 12/2016, Volume 59, Issue 24, pp. 11027 - 11038
Opioids are widely used to treat millions suffering from pain, but their analgesic utility is limited due to associated side effects. Herein we report the... 
CHEMISTRY, MEDICINAL | PAIN | ANALOGS | PHARMACOLOGY | RATS | RECEPTOR AGONIST | SALVINORIN-A | HERKINORIN | SCAFFOLD
Journal Article
Anesthesia & Analgesia, ISSN 0003-2999, 06/2019, Volume 128, Issue 6, pp. 1328 - 1335
BACKGROUND:Opioid dependence is a major public health issue without optimal therapeutics. This study investigates the potential therapeutic effect of dezocine,... 
SYSTEM | ACTIVATION | STRESS-INDUCED REINSTATEMENT | BUPRENORPHINE | PLACE PREFERENCE | ANESTHESIOLOGY | RECEPTOR GENE | MICE | SALVINORIN-A | EXTINCTION | WITHDRAWAL SYNDROME
Journal Article
Journal Article
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 12/2017, Volume 139, Issue 51, pp. 18428 - 18431
The clerodane diterpene family possesses an impressive range of bioactivities and high synthetic challenge due to their unique amalgamation of rings,... 
OXIDATION | CONCISE | CYCLOADDITION | ACTIVATION | DIELS-ALDER REACTIONS | PROTECTION | CLERODANE DITERPENES | SALVINORIN-A | BOND | CHEMISTRY, MULTIDISCIPLINARY | CONIA-ENE
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 5/2013, Volume 56, Issue 9, pp. 3435 - 3443
The neoclerodane diterpene salvinorin A is the major active component of the hallucinogenic mint plant Salvia divinorum Epling & Játiva (Lamiaceae). Since the... 
salvinorin A | Salvia divinorum | herkinorin | neoclerodanes | Opioids
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7398, pp. 327 - 332
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 01/2018, Volume 59, Issue 2, pp. 143 - 146
A -clerodane diterpenoid, salvihispin A ( ), as well as its glycoside, salvihispin A-2- - - -3-keto-glucopyranoside ( ) were isolated from the aerial parts of... 
Salvia hispanica | neo-Clerodane diterpenoids | Neurotrophic activities | CLERODANE DITERPENOIDS | SALVINORIN | CHEMISTRY, ORGANIC | BIOLOGICAL-ACTIVITIES
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 08/2019, Volume 856, pp. 172396 - 172396
Addiction to conventional opioid pain analgesics is a major societal problem that is increasing at an alarming rate. New drugs to combat the effects of opioid... 
Opioid | Analgesic | Pain | Peripheral | Kappa | DESIGN | ASYMMETRIC-SYNTHESIS | ACIDS | SALVINORIN | NONNATURAL ANALOGS | LYSINE | ARGININE | PHARMACOLOGY & PHARMACY | AGENTS
Journal Article