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Current Opinion in Neurobiology, ISSN 0959-4388, 08/2019, Volume 57, pp. 171 - 178
Injury-induced axon degeneration in model organisms and cell culture has emerged as an area of growing interest due to its experimental tractability and to the... 
ACTIVATION | PROTEIN | REGENERATION | TRIGGERS | WALLERIAN DEGENERATION | SARM1 | REQUIRES | DEATH | ABSENCE | ENZYMATIC-ACTIVITY | NEUROSCIENCES | Physiological aspects | Nervous system diseases | Neurosciences | Analysis
Journal Article
ISSN 0960-9822, 2017
Axons require the axonal NAD-synthesizing enzyme NMNAT2 to survive. Injury or genetically induced depletion of NMNAT2 triggers axonal degeneration or defective... 
NAD | Wallerian degeneration | NMN deamidase | axon degeneration | WLD$^\text{s} | SARM1 | neurodegeneration | NMNAT2 | NMNAT | NMN
Journal Article
Experimental Neurology, ISSN 0014-4886, 11/2019, Volume 321, p. 113040
Traumatic brain injury (TBI) often damages axons in white matter tracts and causes corpus callosum (CC) atrophy in chronic TBI patients. Injured axons... 
Sterile alpha and TIR containing motif 1 | Myelin | Demyelination | SARM1 | Axon | TBI | Traumatic axonal injury | White matter | Corpus callosum | Myelin outfoldings
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 02/2019, Volume 28, Issue 3, pp. 448 - 458
Abstract Nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) is an endogenous axon maintenance factor that preserves axon health by blocking... 
TRANSPORT | NOCICEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | WALLERIAN DEGENERATION | MOUSE MODEL | VINCRISTINE | GENETICS & HEREDITY | SARM1 | REQUIRES | WLD(S) | EXPRESSION | DEFICIENCY
Journal Article
Cell Reports, ISSN 2211-1247, 10/2017, Volume 21, Issue 1, pp. 10 - 16
Studies with the mutant mouse have shown that axon and synapse pathology in several models of neurodegenerative diseases are mechanistically related to... 
axonopathy | neuromuscular junction | Sarm1 | synaptopathy | neurodegeneration | aging | motor function | NMNAT2-deficient mice | WldS | disease model | Wld
Journal Article
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 09/2019, Volume 431, Issue 19, pp. 3591 - 3605
SARM1 induces axonal degeneration in response to various insults and is therefore considered an attractive drug target for the treatment of neuro-degenerative... 
SAM domain | SARM1 | x-ray crystallography | electron microscopy | cell death | ACTIVATION | SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | SOFTWARE | ADAPTER SARM | SYMMETRY | FRAMEWORK | STERILE | BINDING | Oligomers | Interferon | Structure | Cell death | Analysis | Crystals
Journal Article
Developmental Cell, ISSN 1534-5807, 02/2019, Volume 48, Issue 4, pp. 506 - 522.e6
Glia continuously survey neuronal health during development, providing trophic support to healthy neurons while rapidly engulfing dying ones. These... 
FoxO | Spätzle | phagocytosis | Draper | SARM1 | neurodegeneration | Furin | find-me signal | Toll | glia | NERVOUS-SYSTEM | APOPTOTIC CELL CLEARANCE | ENGULFMENT ACTIVITY | DEBRIS CLEARANCE | ME SIGNAL | TOLL-LIKE RECEPTORS | DEVELOPMENTAL BIOLOGY | FIND-ME | EXPRESSION | DROSOPHILA | BRAIN | CELL BIOLOGY | Medical colleges | Neurons | Neurosciences
Journal Article
Pain, ISSN 0304-3959, 05/2019, Volume 160 Suppl 1, pp. S17 - S22
Peripheral neuropathy is the most common neurodegenerative disease affecting hundreds of millions of patients worldwide and is an important cause of chronic... 
ACTIVATION | PROTEIN | Sarmoptosis | DLK kinase | SELF-DESTRUCTION | WALLERIAN DEGENERATION | INJURY | NMNAT2 | NEUROSCIENCES | CLINICAL NEUROLOGY | CELL-DEATH | NAD | SYNAPTIC GROWTH | SARM1 | ANESTHESIOLOGY | NEUROMUSCULAR-JUNCTION | PHR1 ligase | LEUCINE-ZIPPER KINASE
Journal Article