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1. Full Text LC–MS/MS analysis of metformin, saxagliptin and 5‐hydroxy saxagliptin in human plasma and its pharmacokinetic study with a fixed‐dose formulation in healthy Indian subjects
by Shah, Priyanka A and Shah, Jaivik V and Sanyal, Mallika and Shrivastav, Pranav S
Biomedical chromatography, ISSN 0269-3879, 03/2017, Volume 31, Issue 3, pp. np - n/a
metformin | saxagliptin | ion‐pair solid phase extraction | LC–MS/MS | human plasma | 5‐hydroxy saxagliptin | 5-hydroxy saxagliptin | ion-pair solid phase extraction | Reproducibility of Results | Adamantane - blood | Humans | Solid Phase Extraction | Chromatography, Liquid - methods | Tandem Mass Spectrometry - methods | Dipeptides - blood | Metformin - blood | Adamantane - analogs & derivatives | Surface active agents | Metabolites | Ionization | Analysis | Nitriles | Liquid chromatography | Hypoglycemic agents | Dosage and administration | Sulfates | Mass spectrometry | Index Medicus
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2. Full Text Comparative clinical pharmacokinetics of dipeptidyl peptidase-4 inhibitors
by Golightly, Larry K and Drayna, Caitlin C and McDermott, Michael T
Clinical pharmacokinetics, ISSN 0312-5963, 2012, Volume 51, Issue 8, pp. 501 - 514
CD26-antigen-inhibitors | type-2-diabetes-mellitus | linagliptin | sitagliptin | vildagliptin | alogliptin | pharmacokinetics | saxagliptin | Index Medicus
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3. Full Text A11466 Protective effect of Saxagliptin, a DPP-4 inhibitor, on myocardial ischemia reperfusion injury in STZ induced diabetic rats
by Bisht, Khushboo and Vir, Arya Dharam and Rajeev, Malhotra
Journal of hypertension, ISSN 0263-6352, 10/2018, Volume 36 Suppl 3, pp. e64 - e64
Myocardial ischemia | Drug therapy | Patient outcomes | Reperfusion injury | Saxagliptin
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4. Full Text Ammonolysis of -2-pyrroline with immobilized Candida antarctica lipase B in a packed bed reactor
by Tirunagari, Harini and Kuna, Lavanya and Shalini, Basetty and Thenkrishnan, Kumaraguru
Process biochemistry (1991), ISSN 1359-5113, 02/2018, Volume 65, p. 109
Ammonia | Biological products | Lipase | Enzyme kinetics | Chromatography | Saxagliptin
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5. Full Text Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin
by Barnett, Anthony H and Charbonnel, Bernard and Donovan, Mark and Fleming, Douglas and
Current medical research and opinion, ISSN 0300-7995, 04/2012, Volume 28, Issue 4, pp. 513 - 523
Dipeptidyl peptidase-4 inhibitor - DPP-4 - Hypoglycemia - Insulin - Saxagliptin - Type 2 diabetes | Dipeptidyl peptidase-4 inhibitor DPP-4 Hypoglycemia Insulin Saxagliptin Type 2 diabetes | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Double-Blind Method | Dipeptidyl-Peptidase IV Inhibitors - adverse effects | Dipeptides - adverse effects | Humans | Middle Aged | Insulin - administration & dosage | Male | Dipeptidyl-Peptidase IV Inhibitors - administration & dosage | Metformin - adverse effects | Dipeptides - administration & dosage | Drug Therapy, Combination - methods | Hypoglycemic Agents - administration & dosage | Adolescent | Adult | Female | Aged | Metformin - administration & dosage | Adamantane - administration & dosage | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Insulin - adverse effects | Adamantane - adverse effects | Adamantane - analogs & derivatives | Index Medicus
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6. Full Text The use of green spectroscopy with multivariate calibration models for simultaneous analysis of ternary drug mixture in combined oral antidiabetic pill
by Belal, Fathalla and El-Shabrawy, Yasser and Barseem, Aya and Ahmed, Hytham
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, ISSN 1386-1425, 11/2020, Volume 241, p. 118638
ANN | Sitagliptin | GA | Vildagliptin | PLS | Saxagliptin | Spectroscopy | Technology | Science & Technology
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7. Full Text Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk: The CARMELINA Randomized Clinical Trial
by Rosenstock, Julio and Perkovic, Vlado and Johansen, Odd Erik and Cooper, Mark E and Kahn, Steven E and Marx, Nikolaus and Alexander, John H and Pencina, Michael and Toto, Robert D and Wanner, Christoph and Zinman, Bernard and Woerle, Hans Juergen and Baanstra, David and Pfarr, Egon and Schnaidt, Sven and Meinicke, Thomas and George, Jyothis T and von Eynatten, Maximillian and McGuire, Darren K and CARMELINA Investigators and for the CARMELINA Investigators
JAMA : the journal of the American Medical Association, ISSN 0098-7484, 11/2018, Volume 321, Issue 1, pp. 69 - 79
KIDNEY-DISEASE | MORTALITY | GFR DECLINE | END-POINT | SAXAGLIPTIN | HEART-FAILURE | SITAGLIPTIN | DEATH | OUTCOMES | CKD | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Hypoglycemic Agents - therapeutic use | Kidney Failure, Chronic - mortality | Cardiovascular Diseases - etiology | Double-Blind Method | Cardiovascular Diseases - prevention & control | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Humans | Middle Aged | Risk Factors | Linagliptin - adverse effects | Proportional Hazards Models | Male | Linagliptin - therapeutic use | Glycated Hemoglobin A | Cardiovascular Diseases - mortality | Female | Aged | Diabetes Mellitus, Type 2 - drug therapy | Drug Therapy, Combination | Hypoglycemia - chemically induced | Hypoglycemic Agents - adverse effects | Diabetes Mellitus, Type 2 - complications | Kidney Failure, Chronic - etiology | Type 2 diabetes | Usage | Clinical trials | Research | Risk factors | Complications and side effects | Analysis | Placebos | Linagliptin | Dosage and administration | Kidney diseases | Cardiovascular diseases | Drug therapy | Myocardial infarction | End-stage renal disease | Adjudication | Risk | Effects | Incidence | Vascular diseases | Hemoglobin | Diabetes mellitus (non-insulin dependent) | Urine | Creatinine | Cerebral infarction | Stroke | Kidneys | Peptidase | Epidermal growth factor receptors | Diabetes mellitus | Pancreatitis | Health risks | Hypoglycemia | Insulin | Patients | Placebo effect | Prescription drugs | Renal failure | Infarction | Adults | Diabetes | Index Medicus | Abridged Index Medicus | Online First | Original Investigation
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8. Full Text The DPP-4 inhibitor saxagliptin ameliorates ox-LDL-induced endothelial dysfunction by regulating AP-1 and NF-[kappa]B
by Ma, Suxia and Bai, Zhifeng and Wu, Huiying and Wang, Wei
European journal of pharmacology, ISSN 0014-2999, 05/2019, Volume 851, p. 186
Oxidases | Phosphates | Niacinamide | Diabetics | Interleukins | Low density lipoproteins | Lectins | Cardiology | Saxagliptin | Endothelium
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9. Full Text Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus
by Scirica, Benjamin M and Bhatt, Deepak L and Braunwald, Eugene and Steg, P. Gabriel and Davidson, Jaime and Hirshberg, Boaz and Ohman, Peter and Frederich, Robert and Wiviott, Stephen D and Hoffman, Elaine B and Cavender, Matthew A and Udell, Jacob A and Desai, Nihar R and Mosenzon, Ofri and McGuire, Darren K and Ray, Kausik K and Leiter, Lawrence A and Raz, Itamar and Savor-Timi Steering Comm Investig and SAVOR-TIMI 53 Steering Committee and Investigators
The New England journal of medicine, ISSN 0028-4793, 10/2013, Volume 369, Issue 14, pp. 1317 - 1326
no | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | General aspects | Diabetes. Impaired glucose tolerance | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Dipeptidyl-Peptidase IV Inhibitors - adverse effects | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Humans | Middle Aged | Hospitalization - statistics & numerical data | Male | Adamantane - therapeutic use | Aged, 80 and over | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Female | Hypoglycemia - chemically induced | Heart Failure - epidemiology | Diabetes Mellitus, Type 2 - complications | Adamantane - adverse effects | Adamantane - analogs & derivatives | Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - etiology | Dipeptides - therapeutic use | Double-Blind Method | Pancreatitis - epidemiology | Dipeptides - adverse effects | Kaplan-Meier Estimate | Pancreatitis - chemically induced | Aged | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Type 2 diabetes | Complications and side effects | Patient outcomes | Dosage and administration | Drug therapy | Heart diseases | Risk factors | Saxagliptin | Myocardial infarction | Cerebral infarction | Heart attacks | Peptidase | Diabetes mellitus | Pancreatitis | Cardiovascular disease | Angina | Patients | Heart rate | Ischemia | Diabetes | Cardiovascular diseases | Diabetes mellitus (non-insulin dependent) | Index Medicus | Abridged Index Medicus | Medicin och hälsovetenskap
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10. Full Text Saxagliptin regulates M1/M2 macrophage polarization via CaMKK[beta]/AMPK pathway to attenuate NAFLD
by Yang, Yang and Lu, Yunhong and Han, Fei and Chang, Yunpeng and Li, Xiaoyu and Han, Zhe and Xue, Mei and Cheng, Ying and Sun, Bei and Chen, Liming
Biochemical and biophysical research communications, ISSN 0006-291X, 09/2018, Volume 503, Issue 3, p. 1618
Interleukins | Liver | Nitric oxide | Insulin resistance | Diabetes | Macrophages | Protein kinases | Mitogens | Saxagliptin
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11. Full Text HPTLC-densitometric analysis of selected antidiabetic drugs in presence of their degradation products
by Ahmed, Hytham M and Omar, Mahmoud A and Batakoushy, Hany A and Hamid, Mohamed A. Abdel
Microchemical journal, ISSN 0026-265X, 05/2020, Volume 154, p. 104560
Dosage form | Separation | Dapagliflozin | Stability indicating | Saxagliptin | Physical Sciences | Chemistry | Chemistry, Analytical | Science & Technology
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12. Full Text Dual Add-on Therapy in Type 2 Diabetes Poorly Controlled With Metformin Monotherapy: A Randomized Double-Blind Trial of Saxagliptin Plus Dapagliflozin Addition Versus Single Addition of Saxagliptin or Dapagliflozin to Metformin
by Rosenstock, Julio and Hansen, Lars and Zee, Pamela and Li, Yan and Cook, William and Hirshberg, Boaz and Iqbal, Nayyar
Diabetes care, ISSN 0149-5992, 03/2015, Volume 38, Issue 3, pp. 376 - 383
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Benzhydryl Compounds - administration & dosage | Humans | Middle Aged | Male | Metformin - adverse effects | Benzhydryl Compounds - adverse effects | Urinary Tract Infections - chemically induced | Adult | Female | Metformin - administration & dosage | Adamantane - administration & dosage | Drug Therapy, Combination | Hypoglycemia - chemically induced | Glucosides - adverse effects | Adamantane - adverse effects | Adamantane - analogs & derivatives | Double-Blind Method | Dipeptides - adverse effects | Treatment Outcome | Blood Glucose - drug effects | Dipeptides - administration & dosage | Diabetes Mellitus, Type 2 - blood | Glucosides - administration & dosage | Aged | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Care and treatment | Usage | Analysis | Clinical trials | Dosage and administration | Glycemic index | Metformin | Saxagliptin | Drug therapy | Diabetes | Index Medicus
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13. Full Text Covalent Inhibition Mechanism of Antidiabetic DrugsVildagliptin vs Saxagliptin
by Wang, Yong-Heng and Zhang, Fan and Diao, Hongjuan and Wu, Ruibo
ACS catalysis, ISSN 2155-5435, 03/2019, Volume 9, Issue 3, pp. 2292 - 2302
DPP-4 | enzyme catalysis | saxagliptin | QM/MM | vildagliptin | Physical Sciences | Chemistry | Chemistry, Physical | Science & Technology
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14. Full Text Effect of saxagliptin on renal outcomes in the SAVOR-TIMI 53 trial
by Mosenzon, Ofri and Leibowitz, Gil and Bhatt, Deepak L and Cahn, Avivit and Hirshberg, Boaz and Wei, Cheryl and Im, Kyung Ah and Rozenberg, Aliza and Yanuv, Ilan and Stahre, Christina and Ray, Kausik K and Iqbal, Nayyar and Braunwald, Eugene and Scirica, Benjamin M and Raz, Itamar
Diabetes care, ISSN 0149-5992, 01/2017, Volume 40, Issue 1, pp. 69 - 76
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Albuminuria - etiology | Double-Blind Method | Diabetic Nephropathies - etiology | Humans | Middle Aged | Diabetic Nephropathies - drug therapy | Male | Serum Albumin - analysis | Dipeptidyl-Peptidase IV Inhibitors - administration & dosage | Blood Glucose - drug effects | Dipeptides - administration & dosage | Glomerular Filtration Rate - drug effects | Albuminuria - drug therapy | Creatinine - blood | Female | Aged | Adamantane - administration & dosage | Diabetes Mellitus, Type 2 - drug therapy | Diabetes Mellitus, Type 2 - complications | Adamantane - analogs & derivatives | Type 2 diabetes | Complications and side effects |