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BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, ISSN 1984-8250, 2018, Volume 54, Issue 4
A liquid chromatography method was developed and validated for the determination of gemifloxacin in human plasma using chloramphenicol as internal standard to... 
Gemifloxacin/determination | SB-265805 | Plasma | IN-VITRO | LB20304 | Bioequivalence | PHARMACOLOGY & PHARMACY | SERUM | HPLC
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 2011, Volume 420, Issue 1, pp. 26 - 33
Fluoroquinolones are broad spectrum antibiotics widely indicated in the treatment of both human and animal diseases. The primary objective of this study was to... 
P-glycoprotein | Gemifloxacin | Efflux | Pregnane X receptor | Cellular translocation | Multidrug resistance associated protein-2 | DRUG | SB-265805 LB20304 | PREGNANE-X-RECEPTOR | TRANSPORT | PHARMACOKINETICS | PHARMACOLOGY & PHARMACY | AGENTS | GLYCOPROTEIN | MULTIDRUG-RESISTANCE | IN-VITRO ACTIVITY | Receptors, Steroid - metabolism | Fluoresceins - metabolism | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Cell Membrane Permeability | Erythromycin - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Fluoroquinolones - metabolism | Transfection | Biological Transport | Time Factors | Adenosine Triphosphate - metabolism | Multidrug Resistance-Associated Proteins - genetics | Real-Time Polymerase Chain Reaction | Binding, Competitive | Cell Line | Gene Expression Regulation | Anti-Bacterial Agents - metabolism | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Fluoroquinolones - pharmacology | Dogs | ATP Binding Cassette Transporter, Sub-Family B | Anti-Bacterial Agents - pharmacology | Multidrug Resistance-Associated Proteins - metabolism | Naphthyridines - pharmacology | Naphthyridines - metabolism | Drug resistance in microorganisms | cellular translocation | multidrug resistance associated protein-2 | pregnane X receptor | efflux | gemifloxacin
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 2000, Volume 44, Issue 11, pp. 3008 - 3011
From 1997 to 1999, 94 study centers in 15 European, 3 North American, and 2 South American countries contributed 2,632 isolates of Streptococcus pneumoniae to... 
SB-265805 | IN-VITRO | FLUORONAPHTHYRIDONE | LB20304 | SUSCEPTIBILITY | GUIDELINES | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | PREVALENCE | ANTIMICROBIAL RESISTANCE | Gemifloxacin | North America | Europe
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 04/2001, Volume 29, Issue 4, pp. 435 - 442
Journal Article
The Annals of Pharmacotherapy, ISSN 1060-0280, 03/2002, Volume 36, Issue 3, pp. 530 - 532
We believe, especially in an era of increasing antimicrobial resistance, that the integration of PK/PD models and stochastic techniques provides a powerful new... 
SB-265805 | FLUORONAPHTHYRIDONE | QUALITY-CONTROL GUIDELINES | LEVOFLOXACIN | RESISTANCE | PHARMACOLOGY & PHARMACY | CIPROFLOXACIN | Streptococcus pneumoniae - drug effects | Area Under Curve | Humans | Drug Therapy | Pharmacology | Pharmacokinetics | Microbial Sensitivity Tests - methods
Journal Article
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 2010, Volume 52, Issue 2, pp. 216 - 226
Journal Article
Chromatographia, ISSN 0009-5893, 5/2009, Volume 69, Issue 9, pp. 853 - 858
Journal Article
Journal Article
Drugs of Today, ISSN 1699-3993, 2001, Volume 37, Issue 6, pp. 401 - 410
Gemifloxacin is a novel antibiotic and the first fluoroquinolone with a pyrrolidine derivative at the C-7 position. Because of the added pyrrolidine... 
SB-265805 | EXPERIMENTAL PNEUMOCOCCAL MENINGITIS | LB20304 | FLUORONAPHTHYRIDONE | IN-VITRO ACTIVITIES | QUINOLONES | ANTIMICROBIAL AGENTS | PHARMACOLOGY & PHARMACY | PNEUMONIAE | FLUOROQUINOLONE | CIPROFLOXACIN
Journal Article
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