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sb-334867 (85) 85
animals (73) 73
neurosciences (60) 60
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urea - analogs & derivatives (57) 57
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orexins (49) 49
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hypocretin (22) 22
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induced reinstatement (13) 13
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activation (11) 11
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conditioned place preference (8) 8
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hypocretins (8) 8
mental disorders (8) 8
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melanin-concentrating hormone (7) 7
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paraventricular nucleus (7) 7
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psychological phenomena and processes (7) 7
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European Journal of Neuroscience, ISSN 0953-816X, 01/2010, Volume 31, Issue 2, pp. 336 - 348
Journal Article
Neuroscience, ISSN 0306-4522, 2008, Volume 157, Issue 4, pp. 720 - 732
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2008, Volume 105, Issue 49, pp. 19480 - 19485
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 08/2009, Volume 30, Issue 3, pp. 493 - 503
Journal Article
Neuropsychiatric disease and treatment, ISSN 1178-2021, 2019, Volume 15, pp. 2221 - 2230
Purpose: Orexins are hypothalamic neuropeptides involved in the regulation of sleep, appetite and arousal. An altered orexin system has been implicated in the... 
orexin-A | SLEEP | PSYCHIATRY | schizophrenia | HYPOCRETIN-1 LEVELS | CEREBROSPINAL-FLUID | NEUROPEPTIDES | CLINICAL NEUROLOGY | bipolar disorder | major depressive disorder | ANTAGONIST SB-334867 BLOCKS | NEURONS | ANIMAL-MODEL | RHYTHM | plasma | RECEPTORS | Schizophrenia | Plasma | Bipolar disorder | Orexin-A | Major depressive disorder
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 07/2008, Volume 8, Issue 11, pp. 977 - 987
Actelion Pharmaceuticals achieved clinical proof-of-concept for the treatment of insomnia in 2007 with the release of Phase II data on Almorexant, a potent... 
Insomnia | Almorexant | GPCR | OX2R | Hypocretin | Orexin | Cataplexy | OX1R | SYSTEM | cataplexy | SLEEP | CHEMISTRY, MEDICINAL | SB-334867 | RATS | HUMANS | insomnia | P-GLYCOPROTEIN | NARCOLEPSY | GENE | PROMOTION | hypocretin | almorexant | MICE | orexin
Journal Article
Psychopharmacology, ISSN 0033-3158, 2012, Volume 226, Issue 1, pp. 155 - 165
The orexin/hypocretin system has recently been implicated in reward-seeking, especially for highly salient food and drug rewards. We reasoned that this system... 
Obesity | Neurosciences | Biomedicine | Addiction | Palatable food | Conditioned stimuli | Pharmacology/Toxicology | Reward-based feeding | Psychiatry | Orexin | DIFFERENTIAL EXPRESSION | INDUCED REINSTATEMENT | PSYCHIATRY | HIGH-FAT DIET | FOOD-INTAKE | RECEPTOR MESSENGER-RNA | NEUROSCIENCES | ANTAGONIST SB-334867 | CORTICAL ACETYLCHOLINE-RELEASE | HYPOTHALAMIC OREXIN NEURONS | OPIOID STIMULATION | PHARMACOLOGY & PHARMACY | NUCLEUS-ACCUMBENS SHELL | Immunohistochemistry | Benzoxazoles - pharmacology | Extinction, Psychological - drug effects | Male | Intracellular Signaling Peptides and Proteins - metabolism | Self Administration | Conditioning, Operant - drug effects | Urea - analogs & derivatives | Behavior, Animal - drug effects | Food Deprivation | Neurons - metabolism | Neurons - drug effects | Sucrose - administration & dosage | Orexins | Receptors, Neuropeptide - antagonists & inhibitors | Rats | Neuropeptides - metabolism | Orexin Receptors | Rats, Sprague-Dawley | Drug-Seeking Behavior - drug effects | Reinforcement Schedule | Animals | Analysis of Variance | Receptors, G-Protein-Coupled - antagonists & inhibitors | Reward | Urea - pharmacology | Neurotransmitters | Dosage and administration | Research | Food consumption | Health aspects | Drug interactions | Drugs | Sucrose | Animal behavior | Rodents | Self-administration | Extinction | Neurons | Hypothalamus (dorsomedial) | Immediate-early proteins | Fos protein | Motivation | Food availability | Reinstatement | Reinforcement | c-Fos protein | Food | reward-based feeding | orexin | palatable food | obesity | addiction | conditioned stimuli
Journal Article