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biochemistry & molecular biology (8) 8
animals (7) 7
index medicus (7) 7
lipids (7) 7
humans (6) 6
scap, srebp cleavage-activating protein (6) 6
cholesterol (5) 5
gene-expression (5) 5
lxr, liver x receptor (5) 5
article (4) 4
cell biology (4) 4
cells (4) 4
cholesterol - metabolism (4) 4
element-binding proteins (4) 4
er, endoplasmic reticulum (4) 4
hydroxymethylglutaryl coa reductases - metabolism (4) 4
mice (4) 4
research article (4) 4
scap (4) 4
srebp (4) 4
biophysics (3) 3
cholesterol - analogs & derivatives (3) 3
cleavage-activating protein (3) 3
digestive system (3) 3
dna-binding proteins - genetics (3) 3
endoplasmic-reticulum (3) 3
food and beverages (3) 3
insulin (3) 3
ldl, low-density lipoprotein (3) 3
liver-x-receptor (3) 3
polycyclic compounds (3) 3
promoter (3) 3
rna, messenger - genetics (3) 3
rna, messenger - metabolism (3) 3
steroid hydroxylases - genetics (3) 3
sterol regulatory element binding protein 1 (3) 3
sterol regulatory element binding protein 2 - genetics (3) 3
sterol regulatory element binding protein 2 - metabolism (3) 3
24,25-epoxycholesterol (2) 2
24s,25-epoxycholesterol (2) 2
24s-hydroxycholesterol (2) 2
25-hydroxycholesterol (2) 2
biochemistry (2) 2
brain (2) 2
brain - metabolism (2) 2
ccaat-enhancer-binding proteins - genetics (2) 2
cell line (2) 2
cells, cultured (2) 2
cholesterol - biosynthesis (2) 2
dna-binding proteins - metabolism (2) 2
endocrinology & metabolism (2) 2
esi, electrospray ionisation (2) 2
fas, fatty acid synthase (2) 2
fatty-acid synthesis (2) 2
female (2) 2
ffa, free fatty acid (2) 2
gastroenterology and hepatology (2) 2
gsk3, glycogen synthase kinase 3 (2) 2
hmg-coa, 3-hydroxy-3-methylglutaryl-coa (2) 2
hydroxycholesterols - metabolism (2) 2
identification (2) 2
insig, insulin-induced gene (2) 2
lc, liquid chromatography (2) 2
liver x receptor (2) 2
liver x receptors (2) 2
male (2) 2
mass-spectrometry (2) 2
membrane proteins - genetics (2) 2
membrane proteins - metabolism (2) 2
metabolism (2) 2
mice, inbred c57bl (2) 2
mice, knockout (2) 2
models, biological (2) 2
molecular biology (2) 2
mrm, multiple reaction monitoring (2) 2
ms, mass spectrometry or mass spectrum (2) 2
msn, mass spectrometry with multistage fragmentation (2) 2
nafld, nonalcoholic fatty liver disease (2) 2
nutritional and metabolic diseases (2) 2
phosphorylation (2) 2
promoter regions, genetic - genetics (2) 2
protein binding (2) 2
rat-liver (2) 2
rats (2) 2
research (2) 2
review (2) 2
scap, srebp cleavage activating protein (2) 2
srebp, sterol regulatory element-binding protein (2) 2
srebp, sterol-regulatory-element-binding protein (2) 2
statin (2) 2
steroid hydroxylases - metabolism (2) 2
sterol regulatory element binding protein 1 - metabolism (2) 2
tlr, toll-like receptor (2) 2
transcription (2) 2
transcription factor (2) 2
transcription factors (2) 2
wt, wild type (2) 2
代謝 (2) 2
脂質 (2) 2
脂質代謝 (2) 2
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Reproductive Toxicology, ISSN 0890-6238, 03/2019, Volume 84, pp. 9 - 17
Although most children conceived by assisted reproductive technology (ART) are healthy, there are concerns regarding the potential long-term health... 
Aging | Mice | Cardiometabolism | Assisted reproductive technologies | INSIG-SCAP-SREBP | DNA METHYLATION | MATURATION | CHILDREN | INSULIN | REPRODUCTIVE BIOLOGY | INFERTILITY | TOXICOLOGY | IN-VITRO FERTILIZATION | OUTCOMES | HEALTH | DYSFUNCTION | EMBRYOS | Medical colleges | Analysis | Liver | Reproductive technology | Blood lipids | Methylation | Cholesterol | Protein binding
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 08/2019, Volume 1864, Issue 8, pp. 1145 - 1156
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2016, Volume 113, Issue 38, pp. E5685 - E5693
Journal Article
Journal Article
Journal Article
Steroids, ISSN 0039-128X, 07/2015, Volume 99, Issue Pt B, pp. 219 - 229
Interferons (IFNs) play a central role in immunity and emerging evidence suggests that IFN-signalling coordinately regulates sterol biosynthesis in... 
Infection | CH25H | Macrophages | Immunity | 25-Hydroxycholesterol | Cholesterol biosynthesis | CELLS | CHOLESTEROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | HMG-COA REDUCTASE | ELEMENT-BINDING PROTEINS | IN-VITRO | STEROL-SENSING DOMAIN | FEEDBACK-REGULATION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | SCAP | TRANSCRIPTION FACTOR | Steroid Hydroxylases - metabolism | Transcription, Genetic - drug effects | Bone Marrow Cells - cytology | Mice, Inbred C57BL | RNA, Messenger - genetics | Cells, Cultured | RNA, Messenger - metabolism | Activating Transcription Factor 3 - metabolism | Proteolysis - drug effects | RNA - biosynthesis | Macrophages - metabolism | Animals | Hydroxymethylglutaryl CoA Reductases - metabolism | Time Factors | Models, Biological | Proteomics | Hydroxycholesterols - metabolism | Macrophages - drug effects | Kinetics | Proteasome Endopeptidase Complex - metabolism | Steroid Hydroxylases - genetics | Interferon-gamma - pharmacology | Sterol Regulatory Element Binding Protein 1 - metabolism | Activating Transcription Factor 3 - genetics | SREBP, sterol regulatory element-binding protein | TLR, Toll-like receptor | DCs, dendritic cells | SBGN, systems biology graphical notation | MEV, mevalonate | ERAD, ER-associated protein degradation | LS, lanosterol | HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase | IFN, interferon | FBS, fetal bovine serum | β receptor | IFNAR1, IFN-α | 25-HC, 25-hydroxycholesterol | LPDS, lipoprotein depleted serum | CH25H, cholesterol 25-hydroxylase | CHO, cholesterol | BMDMs, bone marrow derived macrophages | SCAP, SREBP cleavage activating protein | ER, endoplasmic reticulum | PRRs, Pattern recognition receptors
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2006, Volume 400, Issue 3, pp. 485 - 491
Cholesterol accumulation and removal are regulated by two different transcription factors. SREBP-2 (sterol-regulatory-element-binding protein-2) is best known... 
E-box | Liver x receptor (LXR) | ATP-binding-cassette transporter-A1 (ABCA1) | Statin | 24(S),25- epoxycholesterol | Sterol-regulatory-element-binding protein 2 (SREBP-2) | CELLS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | LOW-DENSITY-LIPOPROTEIN | CLEAVAGE | IDENTIFICATION | NUCLEAR RECEPTOR | sterol-regulatory-element-binding protein 2 (SREBP-2) | 24(S),25-epoxycholesterol | ELEMENT | statin | liver X receptor (LXR) | CASSETTE TRANSPORTER A1 | PROMOTER | LIVER-X-RECEPTOR | Cell Line | Cholesterol - analogs & derivatives | Up-Regulation | Cricetinae | Receptors, Steroid - metabolism | Humans | Gene Expression Regulation - physiology | Receptors, Cytoplasmic and Nuclear - genetics | Cholesterol - metabolism | DNA-Binding Proteins - genetics | DNA-Binding Proteins - metabolism | Animals | ATP-Binding Cassette Transporters - genetics | Liver X Receptors | Ligands | Transcription, Genetic | Sterol Regulatory Element Binding Protein 2 - genetics | Orphan Nuclear Receptors | Sterol Regulatory Element Binding Protein 2 - metabolism | ATP Binding Cassette Transporter 1 | Cholesterol - biosynthesis | Receptors, Cytoplasmic and Nuclear - metabolism | LDL-R, LDL receptor | SRE, sterol-regulatory element | 24(S) | HMG-CoA, 3-hydroxy-3-methylglutaryl-CoA | PBGD, porphobilinogen deaminase | SREBP, sterol-regulatory-element-binding protein | NBS, newborn calf serum | ABCA1, ATP-binding cassette transporter-A1 | 25-epoxycholesterol | LXR, liver X receptor | CHO cell, Chinese-hamster ovary cell | LPDS, lipoprotein-deficient serum | RT, reverse transcriptase | QRT–PCR, quantitative (‘real-time’) RT–PCR | LDL, low-density lipoprotein | SCAP, SREBP cleavage activating protein
Journal Article
Journal of Clinical and Experimental Hepatology, ISSN 0973-6883, 2015, Volume 5, Issue 2, pp. 147 - 158
Nonalcoholic fatty liver (NAFL) is an emerging global epidemic which progresses to nonalcoholic steatohepatitis (NASH) and cirrhosis in a subset of subjects.... 
Endocrinology & Metabolism | Gastroenterology and Hepatology | PNPLA3 | adiponectin | cytokines | gut microbiota | lipotoxicity | Gut microbiota | Cytokines | Lipotoxicity | Adiponectin | PDGF, Platelet-derived growth factor | NK, Natural Killer | HOMA-IR, Homoestatic model assessment-insulin resistance | PARVB, Beta Parvin Gene | EFCAB4B, EF-hand calcium binding domain 4B | AMPK, AMP-activated protein Kinase | SOD2, Superoxide dismutase 2 gene | TLR, Toll like receptor | DAMP, Damage assocauted molecular pattern molecules | FFA, Free fatty acid | Hh, Hedgehog | HDL, High density lipoprotein | NAFL, Nonalcoholic fatty liver | HSC, Hepatic Stellate Cells | MCP, Monocyte chemotactic protein | IL6, Interleukin 6 | CD, Cluster of differentiation | NNMT, Nicotinamide N-methyltransferase gene | NCAN, Neurocan gene | SOCS3, Suppressor of cytokine signaling 3 | LPS, Lipopolysacharrides | COL13A1, Collagen, type XIII, alpha 1 | PUFA, Poly unsaturated fatty acid | PAMP, Pathogen-associated Molecular pattern | PPP1R3B, Protein phosphatase 1 R3B | LYPLAL1, Lypophospholipase like 1 | SFA, Saturated fatty acid | IR, Insulin Resistance | Review | NKL, Natural Killer T cells | BMI, Basal Metabolic Index | PPAR-α, Peroxisome proliferator activated receptor alpha | SNP, Single nucleotide polymorphism | NASH, Nonalcoholic steatohepatitis | NAFLD, Nonalcoholic fatty liver disease | SREBP-1C, Sterol regulatory Element—Binding Protein 1-C gene | GWAS, Genome wide association studies | NF-KB, Nuclear Factor Kappa B | GCKR, Glucokinase regulatory protein | SAMM, Sorting and assembly machinery component | ATP, Adenosine tri-phosphatase | FA, Fatty acid | FDFT1, Farnesyl-diphosphate farnesyltransferase 1 | AGE, Advanced glycation end products | PNPLA3, Patatin-like phospholipase domain-containing protein 3 | NAD, Nicotinamide adenine dinucleotide | OXLAM, Oxidized linolenic acid metabolite | UCP3, Uncoupling protein 3 gene | GLUT 5, Glucose transporter type 5 | PZP, Pregnancy-zone protein | APPL1 and 2, Adaptor protein 1 and 2 | SCAP, SREBP cleavage-activating protein | ALT, Alanine aminotransferase | HMGB1, High-mobility group protein B1 | ROS, Reactive oxygen species | KC, Kupffer Cells | NLR, NOD like receptor | TNF α, Tumor necrosis factor Alpha
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2014, Volume 449, Issue 2, pp. 229 - 234
24S,25-Epoxycholesterol is formed in a shunt of the mevalonate pathway that produces cholesterol. It is one of the most potent known activators of the liver X... 
Brain | 24S,25-Epoxycholesterol | 24S-hydroxycholesterol | 25-epoxide | 3β,7α-Dihydroxycholest-5-en-24S | Cytochrome P450 7b1 | 3β,7α- Dihydroxycholest-5-en-24S | BIOCHEMISTRY & MOLECULAR BIOLOGY | STEROLS | BILE-ACID SYNTHESIS | MASS-SPECTROMETRY | 24(S),25-EPOXYCHOLESTEROL | 3 beta,7 alpha-Dihydroxycholest-5-en-24S | BIOPHYSICS | CENTRAL-NERVOUS-SYSTEM | MICE | CHOLESTEROL HOMEOSTASIS | KNOCKOUT MOUSE | LIVER-X-RECEPTOR | OXYSTEROLS | Cholesterol - analogs & derivatives | Sterols - metabolism | Mice, Inbred C57BL | Rats | Male | Cholesterol - metabolism | Mevalonic Acid - metabolism | Rats, Sprague-Dawley | Mice, Knockout | Brain - metabolism | Animals | Spectrometry, Mass, Electrospray Ionization | Cytochrome P450 Family 7 | Metabolic Networks and Pathways | Models, Biological | Steroid Hydroxylases - deficiency | Female | Mice | Mice, Congenic | Steroid Hydroxylases - genetics | HMG-CoA, 3-hydroxy-3-methyl-glutaryl-CoA | RICs, reconstructed ion chromatogram | SCAP, SREBP-cleavage activating protein | MS, mass spectrometry or mass spectrum | DDA, data dependent analysis | GP, Girard P | Insig, insulin-induced gene | wt, wild type | LC, liquid chromatography | GC, gas chromatography | Vm, ventral midbrain | SREBP-2, sterol regulatory element-binding protein-2 | ESI, electrospray ionisation | MSn, mass spectrometry with multistage fragmentation | Ctx, cortex | API, atmospheric pressure ionisation | CNS, central nervous system | APCI, atmospheric pressure chemical ionisation | LIT, linear ion-trap | BBB, blood brain barrier | MRM, multiple reaction monitoring | LXRs or Lxrs, liver X receptors | CYP or Cyp, cytochrome P450 | ER, endoplasmic reticulum
Journal Article
Biochemical Journal, ISSN 0264-6021, 11/2006, Volume 400, Issue 1, pp. 179 - 188
In the present study, we aimed to decipher the mechanisms involved in the transcriptional effect of insulin on the SREBP-1c specific promoter of the human... 
Promoter | Sterol-response element | Transcription | Insulin | Sterol-regulatory-element-binding protein-1c (SREBP-1c) | Liver X receptor (LXR) | sterol-response element | CELLS | TRANSCRIPTIONAL ACTIVITY | FATTY-ACID SYNTHESIS | insulin | transcription | INSIG-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | LXR | HUMAN SKELETAL-MUSCLE | MESSENGER-RNA | liver X receptor (LXR) | GENE-EXPRESSION | promoter | sterol-regulatory-element-binding protein-1c (SREBP-1c) | LIVER-X-RECEPTOR | ADIPOSE-TISSUE | Humans | Muscle, Skeletal - metabolism | Muscle, Skeletal - cytology | RNA, Messenger - metabolism | Promoter Regions, Genetic - genetics | Adipose Tissue - metabolism | Chromatin Immunoprecipitation | Muscle, Skeletal - drug effects | Response Elements - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Cell Line | Insulin - pharmacology | RNA, Messenger - genetics | Cells, Cultured | Insulin - administration & dosage | Binding Sites - genetics | Mutation - genetics | Reverse Transcriptase Polymerase Chain Reaction | Gene Expression Regulation - drug effects | Sterol Regulatory Element Binding Protein 1 - genetics | Perfusion | Protein Binding | Adipose Tissue - drug effects | LXRE, LXR-response element | HEK-293 cells, human embryonic kidney cells | NF-Y, nuclear factor-Y | SRE, sterol-response element | sterolregulatory-element-binding protein-1c (SREBP-1c) | ACC-2, acetyl-CoA carboxylase-2 | GSK3, glycogen synthase kinase 3 | SREBP, sterol-regulatory-element-binding protein | ChIP, chromatin immunoprecipitation | SCAP, SREBP cleavage-activating protein | Insig, insulin-induced gene | LXR, liver X receptor | FAS, fatty acid synthase | RT–qPCR, reverse transcription–quantitative PCR | HKII, hexokinase II | ER, endoplasmic reticulum | LDL, low-density lipoprotein
Journal Article