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Molecules (Basel, Switzerland), ISSN 1420-3049, 2018, Volume 23, Issue 3, p. 566
A promising means in the search of new small molecules for the treatment of schistosomiasis (amongst other parasitic ailments) is by targeting the parasitic... 
Epigenetics | Virtual screening | Histone deacetylase (HDAC) inhibitors | Schistosomiasis | Docking | Crystal structure | PROTEIN | virtual screening | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | GLIDE | OXAMNIQUINE | CHEMISTRY, MULTIDISCIPLINARY | epigenetics | PRAZIQUANTEL | docking | ACCURATE DOCKING | crystal structure | RESISTANCE | GENERATION | histone deacetylase (HDAC) inhibitors | schistosomiasis | MOLECULAR-BASIS | PROGRAM | Apoptosis - drug effects | Zinc - metabolism | Helminth Proteins - chemistry | Anthelmintics - chemical synthesis | Crystallography, X-Ray | Structure-Activity Relationship | Zinc - chemistry | Schistosoma mansoni - genetics | Pyrrolidines - pharmacology | Histone Deacetylase Inhibitors - chemical synthesis | Protein Interaction Domains and Motifs | Schistosoma mansoni - growth & development | Binding Sites | Helminth Proteins - metabolism | Hydroxamic Acids - pharmacology | Schistosoma mansoni - drug effects | Gene Expression | Histone Deacetylases - genetics | Protein Structure, Secondary | Schistosoma mansoni - enzymology | Histone Deacetylases - chemistry | Histone Deacetylases - metabolism | Helminth Proteins - genetics | Chelating Agents - pharmacology | Animals | Pyrrolidines - chemical synthesis | Anthelmintics - pharmacology | Protein Binding | Histone Deacetylase Inhibitors - pharmacology | Molecular Docking Simulation | Chelating Agents - chemical synthesis | Hydroxamic Acids - chemical synthesis | Helminth Proteins - antagonists & inhibitors | Histone deacetylase | Screening | Chromatin | Inhibitors | Catalysis | In vitro methods and tests | Chelates | Zinc | Chelating Agents/pharmacology | Helminth Proteins/antagonists & inhibitors | Schistosoma mansoni/enzymology | Pyrrolidines/pharmacology | Life Sciences | Histone Deacetylases/genetics | Anthelmintics/chemical synthesis | Schistosoma mansoni/genetics | Helminth Proteins/genetics | Biomolecules | Histone Deacetylase Inhibitors/chemical synthesis | Chelating Agents/chemical synthesis | Pyrrolidines/chemical synthesis | Schistosoma mansoni/growth & development | Hydroxamic Acids/chemical synthesis | Zinc/chemistry | Biochemistry, Molecular Biology | Apoptosis/drug effects | Helminth Proteins/metabolism | Histone Deacetylases/chemistry | Hydroxamic Acids/pharmacology | Anthelmintics/pharmacology | Schistosoma mansoni/drug effects | Histone Deacetylases/metabolism | Helminth Proteins/chemistry | Histone Deacetylase Inhibitors/pharmacology | Zinc/metabolism
Journal Article
Nature (London), ISSN 1476-4687, 2009, Volume 460, Issue 7253, pp. 352 - 358
Journal Article
Journal Article
The Journal of infectious diseases, ISSN 1537-6613, 2015, Volume 212, Issue 11, pp. 1787 - 1797
Journal Article
Journal Article
PLoS pathogens, ISSN 1553-7374, 2018, Volume 14, Issue 1, p. e1006718
Schistosomes are blood-dwelling trematodes with global impact on human and animal health. Because medical treatment is currently based on a single drug,... 
PARASITIC NEMATODES | MOLECULAR-BIOLOGY | FASCIOLA-HEPATICA | MALE-FEMALE INTERACTION | BEHAVIOR | SEX | MICROBIOLOGY | DROSOPHILA | CAENORHABDITIS-ELEGANS | VIROLOGY | GENE | PROTEIN-COUPLED-RECEPTORS | PARASITOLOGY | G-Protein-Coupled Receptor Kinases - genetics | Humans | Helminth Proteins - chemistry | Gene Expression Profiling | Phylogeny | Schistosoma mansoni - metabolism | Schistosoma mansoni - genetics | G-Protein-Coupled Receptor Kinases - chemistry | Genome, Helminth | Genomics - methods | Helminth Proteins - metabolism | Fasciola - drug effects | Fasciola - pathogenicity | Schistosoma mansoni - drug effects | G-Protein-Coupled Receptor Kinases - metabolism | Schistosoma mansoni - pathogenicity | Helminth Proteins - genetics | Organ Specificity | Fasciola - genetics | G-Protein-Coupled Receptor Kinases - antagonists & inhibitors | Animals | Signal Transduction - drug effects | Fasciola - metabolism | Models, Biological | Protein Kinase Inhibitors - pharmacology | Antiplatyhelmintic Agents - pharmacology | Helminth Proteins - antagonists & inhibitors | Cell receptors | Cellular signal transduction | Research | Analysis | Parasitology | G protein-coupled receptors | Praziquantel | Medical treatment | Genomes | Pharmacology | Parasites | Kinases | Gene expression | Biological activity | Exploitation | Proteins | Signaling | Receptors | Annotations | Animal health | Phylogenetics | Ligands | Parasitism | Drug discovery | Food supply
Journal Article
The FEBS Journal, ISSN 1742-464X, 09/2015, Volume 282, Issue 18, pp. 3632 - 3646
Journal Article