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Cancer Letters, ISSN 0304-3835, 2012, Volume 330, Issue 1, pp. 22 - 32
Highlights ► Sonic hedgehog pathway regulates pancreatic cancer stem cell characteristics. ► Inhibition of Gli transcription by GANT-61 suppresses pancreatic... 
Hematology, Oncology and Palliative Medicine | Sonic hedgehog | Pancreatic cancer stem cells | Gli transcription factor | GANT-61 | SURVIVAL | METASTASIS | TUMOR PROGRESSION | GENOMIC ANALYSES | CARCINOMA PROLIFERATION | EPITHELIAL-MESENCHYMAL TRANSITIONS | GLI TRANSCRIPTION FACTORS | ONCOLOGY | MEDULLOBLASTOMA | TUMORIGENESIS | HEDGEHOG SIGNALING PATHWAY | RNA, Small Interfering - genetics | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Zinc Finger Protein Gli2 | Hedgehog Proteins - metabolism | Pancreatic Neoplasms - drug therapy | Transfection | Neoplastic Stem Cells - metabolism | HEK293 Cells | Neoplastic Stem Cells - pathology | Gene Expression Regulation, Neoplastic - drug effects | Nuclear Proteins - genetics | Cell Growth Processes - drug effects | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Pyrimidines - pharmacology | Transcription Factors - genetics | Down-Regulation - drug effects | Mice, SCID | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Cell Line, Tumor | Mice, Inbred NOD | Mice | Pyridines - pharmacology | Zinc Finger Protein GLI1 | RNA, Small Interfering - administration & dosage | Kruppel-Like Transcription Factors - genetics | Growth | Pancreatic cancer | Stem cells | Cell growth | Pancreas | Rodents | Cell cycle | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 05/2005, Volume 174, Issue 10, pp. 6477 - 6489
Journal Article
BLOOD, ISSN 0006-4971, 01/2007, Volume 109, Issue 1, pp. 212 - 218
Critical to the development of an effective HIV/AIDS model is the production of an animal model that reproduces long-lasting active replication of HIV-1... 
PROGENITOR CELLS | HU MOUSE | PBL-SCID MICE | IN-VIVO | CENTRAL-NERVOUS-SYSTEM | MODEL | HUMAN-IMMUNODEFICIENCY-VIRUS | HEMATOLOGY | BLOOD CD34(+) CELLS | T-LYMPHOCYTES | RHESUS MACAQUES
Journal Article
BLOOD, ISSN 0006-4971, 03/2012, Volume 119, Issue 12, pp. 2778 - 2788
Immunodeficient mice engrafted with human HSCs support multidisciplinary translational experimentation, including the study of human hematopoiesis. Heightened... 
CATALYTIC SUBUNIT | SEVERE COMBINED IMMUNODEFICIENCY | HUMAN-BLOOD | NOD/SCID MICE | STEM-CELL FACTOR | GROWTH-FACTOR | HUMAN IMMUNE-SYSTEM | HEMATOLOGY | MAST-CELL | KIT-LIGAND | MOUSE MODELS
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 07/2010, Volume 107, Issue 29, pp. 13022 - 13027
Journal Article
STEM CELLS, ISSN 1066-5099, 2009, Volume 27, Issue 1, pp. 175 - 182
Journal Article
TRANSPLANTATION, ISSN 0041-1337, 03/2010, Volume 89, Issue 5, pp. 527 - 536
Background. Transplantation of human skin on immunodeficient mice that support engraftment with functional human immune systems would be an invaluable tool for... 
SURGERY | RECRUITMENT | CELLS | NSG | INJURY | MONOCYTES | SUBSETS | Skin transplantation | IMMUNOLOGY | IL2rg | Humanized mice | SCID | CHALLENGES | TRANSPLANTATION | ENGRAFTMENT | DISEASE | NOD/SCID | GAMMA-CHAIN GENE | MICE
Journal Article
EXPERIMENTAL BIOLOGY AND MEDICINE, ISSN 1535-3702, 08/2008, Volume 233, Issue 8, pp. 997 - 1012
Umbilical cord blood (UCB) is increasingly being used for human hematopoietic stem cell (HSC) transplantation in children but often requires pooling multiple... 
NOD-scid IL2r gamma(null) mice | PROGENITOR CELLS | REPOPULATING CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | TNF alpha | COMBINED IMMUNODEFICIENT MICE | BONE-MARROW | UNRELATED DONORS | PERIPHERAL-BLOOD | SCID | ex vivo expansion | CULTURE-INITIATING CELLS | EX-VIVO EXPANSION | immune response | HEMATOPOIETIC STEM-CELLS | umbilical cord blood | human | MARROW STROMAL CELLS
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 11/2012, Volume 189, Issue 9, pp. 4313 - 4320
Xenograft animal models using immunodeficient mice have been widely applied in medical research on various human diseases. NOD/Shi-scid-IL2r gamma(null) (NOG)... 
NATURAL-KILLER | XENOGRAFT REJECTION | STEM-CELLS | KILLER DENDRITIC CELLS | NK CELLS | NOD/SCID/GAMMA(NULL)(C) NOG MICE | PRODUCE IFN-GAMMA | MOUSE | MODEL | IMMUNOLOGY | SUBSET
Journal Article
CLINICAL IMMUNOLOGY, ISSN 1521-6616, 07/2011, Volume 140, Issue 1, pp. 102 - 116
Hematopoietic humanized mice generated via transplantation of human hematopoietic stem cells (hHSCs) into immunodeficient mice are a valuable tool for studying... 
Humanized mouse | PROGENITOR CELLS | REPOPULATING CELLS | Human cord blood | Cytokine | BONE-MARROW | IMMUNOLOGY | STEM-CELL EXPANSION | Immunodeficient mouse | EX-VIVO EXPANSION | CD34(+) CELLS | IN-VITRO | SCID IL2R-GAMMA(NULL) MICE | IMMUNE-SYSTEM | Hematopoietic stem cell | Hematopoietic chimerism | UMBILICAL-CORD BLOOD
Journal Article
JOURNAL OF VIROLOGY, ISSN 0022-538X, 12/2007, Volume 81, Issue 23, pp. 13259 - 13264
In a previous study, we demonstrated that humanized NOD/SCID/IL2R gamma(null) (hNOG) mice constructed with human hematopoietic stem cells (HSCs) allow... 
ENGRAFTMENT | VIROLOGY | MACROPHAGE | SCID-HU MOUSE | DEPLETION | MODEL | HIV-1 INFECTION | BLOOD CD34(+) CELLS | T-CELLS
Journal Article
Clinical Immunology, ISSN 1521-6616, 2015, Volume 157, Issue 2, pp. 156 - 165
Abstract Both the thymus (T) and bone (B) are necessary hematopoietic niches in adult humans. We previously showed that co-transplantation of human fetal T and... 
Allergy and Immunology | Young adult NOD/SCID IL2Rγnull | Bone | Humanized mice | Hematopoiesis | Thymus | CD34+ cells | CD34 + cells | Young adult NOD/SCID IL2Rγ null
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 8, pp. e23419 - e23419
Journal Article
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