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1. Full Text Biophysical Characterization of a Novel SCN5A Mutation Associated With an Atypical Phenotype of Atrial and Ventricular Arrhythmias and Sudden Death
by Mohammad-Reza Ghovanloo and Joseph Atallah and Carolina A. Escudero and Peter C. Ruben
Frontiers in physiology, ISSN 1664-042X, 01/2020, Volume 11, pp. 610436 - 610436
ventricular arrhythmia | Nav1.5 | atrial arrhymia | SCN5A | channelopathy
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2. Full Text The role of the gap junction perinexus in cardiac conduction: Potential as a novel anti-arrhythmic drug target
by Hoagland, Daniel T and Santos, Webster and Poelzing, Steven and Gourdie, Robert G
Progress in biophysics and molecular biology, ISSN 0079-6107, 07/2019, Volume 144, pp. 41 - 50
Heart | Conduction | NaV1.5/Scn5a | β1/Scn1b | Arrhythmia | Gap junctions | Perinexus | Ephaptic | 1.5/Scn5a | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Gap Junctions - metabolism | Animals | Anti-Arrhythmia Agents - pharmacology | Heart - physiology | Humans | Myocardium - metabolism | Heart - drug effects | Gap Junctions - drug effects | Action Potentials - drug effects | Molecular Targeted Therapy - methods | Myocardium - cytology | Medical colleges | Analysis | Emergency medicine | Mortality | Anti-arrhythmia drugs | Research institutes | Electric properties | Biomedical engineering | Index Medicus | gap junctions | arrhythmia | ephaptic | conduction | Scn5a | perinexus | NaV1.5 | heart | Scn1b
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3. Full Text A common co-morbiditymodulates disease expression and treatment efficacy in inherited cardiac sodiumchannelopathy
by Rivaud, Mathilde R and Jansen, John A and Postema, Pieter G and Nannenberg, Eline A and Mizusawa, Yuka and van der Nagel, Roel and Wolswinkel, Rianne and van der Made, Ingeborg and Marchal, Gerard A and Rajamani, Sridharan and Belardinelli, Luiz and van Tintelen, J. Peter and Tanck, Michael W. T and van DerWal, Allard C and de Bakker, Jacques M. T and van Rijen, Harold V and Creemers, Esther E and Wilde, Arthur A. M and van den Berg, Maarten P and van Veen, Toon A. B and Bezzina, Connie R and Remme, Carol Ann
European heart journal, ISSN 0195-668X, 2018, Volume 39, Issue 31, pp. 2898 - 2907
Hypertension | Ventricular arrhythmias | Cardiac hypertrophy | SCN5A | Conduction delay | Sudden death
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4. Full Text Lack of influence of sex hormones on Brugada syndrome: The role of S-nitrosylation of SCN5A
by Patanè, Salvatore
Journal of electrocardiology, ISSN 0022-0736, 11/2020, Volume 63, pp. 186 - 186
Gender | SCN5A | Brugada syndrome | S-nitrosylation | Index Medicus
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5. Full Text SCN5A mutation type and topology are associated with the risk of ventricular arrhythmia by sodium channel blockers
by Amin, Ahmad S and Reckman, Yolan J and Arbelo, Elena and Spanjaart, Anne M and Postema, Pieter G and Taos, Rafik and Tanck, Michael W and Van den Berg, Maarten P and Wilde, Arthur A. M and Tan, Hanno L
International journal of cardiology, ISSN 0167-5273, 09/2018, Volume 266, pp. 128 - 132
BRUGADA-SYNDROME | Brugada syndrome | Arrhythmia | GENES | SCN5A | Mutation | Ajmaline | PVC
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6. Full Text Common and rare susceptibility genetic variants predisposing to Brugada syndrome in Thailand
by Makarawate, Pattarapong and Glinge, Charlotte and Khongphatthanayothin, Apichai and Walsh, Roddy and Mauleekoonphairoj, John and Amnueypol, Montawatt and Prechawat, Somchai and Wongcharoen, Wanwarang and Krittayaphong, Rungroj and Anannab, Alisara and Lichtner, Peter and Meitinger, Thomas and Tjong, Fleur V.Y and Lieve, Krystien V.V and Amin, Ahmad S and Sahasatas, Dujdao and Ngarmukos, Tachapong and Wichadakul, Duangdao and Payungporn, Sunchai and Sutjaporn, Boosamas and Wandee, Pharawee and Poovorawan, Yong and Tfelt-Hansen, Jacob and Tanck, Michael W.T and Tadros, Rafik and Wilde, Arthur A.M and Bezzina, Connie R and Veerakul, Gumpanart and Nademanee, Koonlawee
Heart rhythm, ISSN 1547-5271, 12/2020, Volume 17, Issue 12, pp. 2145 - 2153
Genetics | SCN5A | Brugada syndrome | Genome-wide association study | Thailand | Index Medicus
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7. Full Text Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients
by Milman, Anat and Gourraud, Jean-Baptiste and Andorin, Antoine and Postema, Pieter G and Sacher, Frederic and Mabo, Philippe and Conte, Giulio and Giustetto, Carla and Sarquella-Brugada, Georgia and Hochstadt, Aviram and Kim, Sung-Hwan and Juang, Jimmy J.M and Maeda, Shingo and Takahashi, Yoshihide and Kamakura, Tsukasa and Aiba, Takeshi and Leshem, Eran and Michowitz, Yoav and Rahkovich, Michael and Mizusawa, Yuka and Arbelo, Elena and Huang, Zhengrong and Denjoy, Isabelle and Wijeyeratne, Yanushi D and Napolitano, Carlo and Brugada, Ramon and Casado-Arroyo, Ruben and Champagne, Jean and Calo, Leonardo and Tfelt-Hansen, Jacob and Priori, Silvia G and Takagi, Masahiko and Veltmann, Christian and Delise, Pietro and Corrado, Domenico and Behr, Elijah R and Gaita, Fiorenzo and Yan, Gan-Xin and Brugada, Josep and Leenhardt, Antoine and Wilde, Arthur A.M and Brugada, Pedro and Kusano, Kengo F and Hirao, Kenzo and Nam, Gi-Byoung and Probst, Vincent and Belhassen, Bernard
Heart rhythm, ISSN 1547-5271, 10/2018, Volume 15, Issue 10, pp. 1457 - 1465
Ethnicity | Brugada ECG | Sudden cardiac death | Implantable cardioverter-defibrillatorEthnicity | SCN5A mutation | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Japan - epidemiology | Prevalence | Brugada Syndrome - physiopathology | Death, Sudden, Cardiac - epidemiology | Humans | Middle Aged | Child, Preschool | Death, Sudden, Cardiac - prevention & control | Infant | Male | Brugada Syndrome - complications | Death, Sudden, Cardiac - etiology | Young Adult | Defibrillators, Implantable | Aged, 80 and over | Electrocardiography | Adult | Female | Surveys and Questionnaires | Republic of Korea - epidemiology | Child | Europe - epidemiology | Adolescent | Sex Factors | Brugada Syndrome - epidemiology | Sex Distribution | Aged | Index Medicus
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8. Full Text Multiple mechanisms underlie increased cardiac late sodium current
by Kroncke, Brett M and Yang, Tao and Roden, Dan M
Heart rhythm, ISSN 1547-5271, 07/2019, Volume 16, Issue 7, pp. 1091 - 1097
Genetics | hiPSC-CMs | SCN5A/NaV1.5 | Late/persistent current | Human-induced pluripotent stem cell cardiomyocytes | LQT3 | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Medicine, Experimental | Medical research | Analysis | Stem cells | Index Medicus | Late | genetics | human induced pluripotent stem cell cardiomyocytes hiPSC-CMs | SCN5A | persistent current | NaV1.5
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9. Full Text UBC9 regulates cardiac sodium channel Nav1.5 ubiquitination, degradation and sodium current density
by Tang, Bo and Hu, Yushuang and Wang, Zhijie and Cheng, Chen and Wang, Pengyun and Liang, Lina and Xiong, Hongbo and Luo, Chunyan and Xu, Chengqi and Chen, Qiuyun and Wang, Qing Kenneth
Journal of molecular and cellular cardiology, ISSN 0022-2828, 04/2019, Volume 129, pp. 79 - 91
Ubiquitination | SCN5A | UBC9 | Arrhythmia | Nedd4–2 | Nav1.5 sodium channel | Index Medicus | Nedd4-2 | ubiquitination | arrhythmia
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10. Full Text A common co-morbiditymodulates disease expression and treatment efficacy in inherited cardiac sodiumchannelopathy
by Rivaud, Mathilde R and Jansen, John A and Postema, Pieter G and Nannenberg, Eline A and Mizusawa, Yuka and van der Nagel, Roel and Wolswinkel, Rianne and van der Made, Ingeborg and Marchal, Gerard A and Rajamani, Sridharan and Belardinelli, Luiz and van Tintelen, J Peter and Tanck, Michael W T and van der Wal, Allard C and de Bakker, Jacques M T and van Rijen, Harold V and Creemers, Esther E and Wilde, Arthur A M and van den Berg, Maarten P and van Veen, Toon A B and Bezzina, Connie R and Remme, Carol Ann
European heart journal, ISSN 0195-668X, 08/2018, Volume 39, Issue 31, p. 2898
Hypertension | Ventricular arrhythmias | Conduction delay | Sudden death | Cardiac hypertrophy | SCN5A | Cardiology and Cardiovascular Medicine
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11. Full Text Sodium channel beta 1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans
by Watanabe, Hiroshi and Koopmann, Tamara T and Le Scouarnec, Solena and Yang, Tao and Ingram, Christiana R and Schott, Jean-Jacques and Demolombe, Sophie and Probst, Vincent and Anselme, Frederic and Escande, Denis and Wiesfeld, Ans C. P and Pfeufer, Arne and Kaeaeb, Stefan and Wichmann, H. -Erich and Hasdemir, Can and Aizawa, Yoshifusa and Wilde, Arthur A. M and Roden, Dan M and Bezzina, Connie R
The Journal of clinical investigation, ISSN 0021-9738, 06/2008, Volume 118, Issue 6, pp. 2260 - 2268
SKELETAL-MUSCLE | SCN5A MUTATION | BETA-1 SUBUNIT | FUNCTIONAL EXPRESSION | EXTRACELLULAR DOMAIN | XENOPUS OOCYTES | LONG-QT SYNDROME | FEBRILE SEIZURES | ST-SEGMENT ELEVATION | UMCG Approved | BETA SUBUNIT | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine
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12. Full Text Structure and function of splice variants of the cardiac voltage-gated sodium channel Nav1.5
by Schroeter, Annett and Walzik, Stefan and Blechschmidt, Steve and Haufe, Volker and Benndorf, Klaus and Zimmer, Thomas
Journal of molecular and cellular cardiology, ISSN 0022-2828, 07/2010, Volume 49, Issue 1, pp. 16 - 24
Alternative splicing | Sodium channel | SCN5A | Cellular electrophysiology | Arrhythmias
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13. Full Text Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels
by Plant, Leigh D and Xiong, Dazhi and Romero, Jesus and Dai, Hui and Goldstein, Steve A.N
Cell reports (Cambridge), ISSN 2211-1247, 02/2020, Volume 30, Issue 7, pp. 2225 - 2236.e4
sudden death | hypoxia | arrythmia | SENP | SUMO | ILATE | cardiomyocyte | SCN5A | NaV1.5 | late current | Index Medicus
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14. Full Text Modulation of the cardiac sodium channel NaV1.5 peak and late currents by NAD+ precursors
by Matasic, Daniel S and Yoon, Jin-Young and McLendon, Jared M and Mehdi, Haider and Schmidt, Mark S and Greiner, Alexander M and Quinones, Pravda and Morgan, Gina M and Boudreau, Ryan L and Irani, Kaikobad and Brenner, Charles and London, Barry
Journal of molecular and cellular cardiology, ISSN 0022-2828, 04/2020, Volume 141, pp. 70 - 81
Sirtuins | Arrhythmia | NAD+/NADH | Cardiac Sodium Channel (NaV1.5, SCN5A) | Metabolic regulation | Nicotinamide | Acetylation | Nicotinamide riboside | Index Medicus
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15. Full Text Life Cycle of the Cardiac Voltage-Gated Sodium Channel NaV1.5
by Dong, Caijuan and Wang, Ya and Ma, Aiqun and Wang, Tingzhong
Frontiers in physiology, ISSN 1664-042X, 12/2020, Volume 11, pp. 609733 - 609733
degradation | SCN5A | anchoring | NaV1.5 | trafficking | biosynthesis
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16. Full Text SCN5A gene variants as potential markers of the progression of chronic chagasic cardiac alterations
by Blasco, Romina Laura and Strauss, Mariana and Velázquez López, Daniela Alejandra and Tabares, Sandra and Sembaj, Adela and Rivarola, Héctor Walter and Paglini, Patricia Adriana and Lo Presti, María Silvina
Parasitology international, ISSN 1383-5769, 02/2021, Volume 80, pp. 102213 - 102213
Chagas disease | A572D | SCN5A gene variants | H558R | Cardiac alterations | Index Medicus
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