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Journal Article
STEM CELLS, ISSN 1066-5099, 11/2016, Volume 34, Issue 11, pp. 2744 - 2757
CXCR4 is a stem/progenitor cell surface receptor specific for the cytokine stromal cell‐derived factor‐1 (SDF‐1α). There is evidence that bone marrow‐derived... 
CXCR4/SDF‐1α | smooth muscle cell specific CXCR4 knockout | intimal hyperplasia | TGFβ/Smad3 | smooth muscle cell migration | CXCR4/SDF-1α | PROGENITOR CELLS | TGF-BETA | TGF beta/Smad3 | CHEMOKINE RECEPTOR CXCR4 | SDF-1-ALPHA/CXCR4 AXIS | NEOINTIMAL HYPERPLASIA | DEPENDENT PATHWAYS | CXCR4/SDF-1 alpha | CELL & TISSUE ENGINEERING | CELL BIOLOGY | VASCULAR INJURY | GROWTH-FACTOR-BETA | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CANCER METASTASIS | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | Carotid Arteries - metabolism | Phosphorylation | Male | Smad3 Protein - metabolism | Smad3 Protein - genetics | Neointima - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Receptors, CXCR4 - deficiency | Muscle Proteins - metabolism | Receptors, CXCR4 - genetics | Carotid Artery Injuries - genetics | Microfilament Proteins - metabolism | Myocytes, Smooth Muscle - drug effects | Microfilament Proteins - genetics | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Carotid Artery Injuries - metabolism | Carotid Artery Injuries - pathology | Promoter Regions, Genetic | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Gene Expression Regulation | Rats | Neointima - metabolism | Rats, Sprague-Dawley | Tunica Intima - injuries | Mice, Knockout | Muscle Proteins - genetics | Tunica Intima - metabolism | Transforming Growth Factor beta - pharmacology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Neointima - pathology | Mice | Primary Cell Culture | Transforming Growth Factor beta - metabolism | Cell Movement | Mitogen-Activated Protein Kinase 1 - metabolism | Bone morphogenetic proteins | RNA | Transforming growth factors | Hyperplasia | Stem cells | Rodents | Cell adhesion & migration | Chromatin | Femur | Immunoprecipitation | Leukocyte migration | Transforming growth factor-b | Stem cell transplantation | Smooth muscle | Smad3 protein | Wire | Assaying | Cell surface | Carotid arteries | Arteries | Homing | Protein folding | Bone marrow | Carotid artery | Therapeutic applications | Extracellular signal-regulated kinase | SDF-1 protein | CXCR4 protein | Restenosis | Injury prevention | Cell migration | Smad3 | SDF‐1α | TGFβ | CXCR4 | Tissue‐Specific Stem Cells
Journal Article
Journal of Computational Chemistry, ISSN 0192-8651, 04/2019, Volume 40, Issue 11, pp. 1233 - 1242
The prediction of peptide–protein or protein–protein interactions (PPI) is a challenging task, especially if amino acid sequences are the only information... 
protein–protein interactions | ProtDCal | EPI‐X4 | G‐protein‐coupled receptor | CXCR4 | PPI‐Detect | protein descriptor | DESCRIPTOR | DOMAIN | INFORMATION | G-protein-coupled receptor | SDF-1 | LESTR/FUSIN | EPI-X4 | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | protein-protein interactions | PEPTIDES | PPI-Detect | DATABASE | WEB SERVER | Proteins | Amino acids | Data mining | Protein-protein interactions | Machine learning
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2010, Volume 5, Issue 2, p. e9175
Background: CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple... 
MIGRATION | CELL-DERIVED FACTOR-1-ALPHA | IN-VITRO | ACTIVATION | CHEMOKINE RECEPTOR CXCR4 | ENDOTHELIAL-CELLS | BIOLOGY | SDF-1 | LIGAND | PROTEIN-KINASE B | T-LYMPHOCYTES | Chemokine CXCL11 - genetics | Humans | Embryo, Nonmammalian - metabolism | Male | Green Fluorescent Proteins - genetics | Recombinant Fusion Proteins - metabolism | Chemokine CXCL12 - genetics | Flow Cytometry | Transfection | Receptors, CXCR - metabolism | Myocardium - metabolism | Female | Cell Membrane - metabolism | Receptors, CXCR - physiology | Cell Line | Green Fluorescent Proteins - metabolism | Endothelial Cells - metabolism | Receptors, CXCR - genetics | Cells, Cultured | Zebrafish | Endocytosis - physiology | Microscopy, Confocal | Animals | Chemokine CXCL12 - metabolism | Endothelial Cells - cytology | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Ligands | Mice | Mice, Inbred BALB C | HeLa Cells | Chemokine CXCL11 - metabolism | Proteins | B cells | Heart | CXCL12 protein | Biomedical research | Amino acids | Metastasis | Phylogeny | Kinases | Human tissues | Cell adhesion & migration | Mammalian cells | Degradation | Signal transduction | Receptors | Rodents | Animal tissues | Penicillin | Bone marrow | Organs | Mammals | Embryos | Chemokine receptors | CXCR4 protein | Hemopoiesis | Endothelium | Signaling | Plasmids | Internalization | CXCL11 protein | Mutation | Umbilical vein | Prostate cancer | Chemokines
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2016, Volume 59, Issue 9, pp. 4342 - 4351
CXCL12 is a human chemokine that recognizes the CXCR4 receptor and is involved in immune responses and metastatic cancer. Interactions between CXCL12 and CXCR4... 
CXCR4 SULFOTYROSINE | CHEMISTRY, MEDICINAL | RECOGNITION | DOCKING | DRUG DESIGN | MONOMER-DIMER EQUILIBRIUM | SDF-1/CXCL12 | RESIDUES | DISCOVERY | BINDING HOT-SPOTS | CONFORMATIONS | Chemokine CXCL12 - metabolism | Magnetic Resonance Spectroscopy | Humans | Ligands | Molecular Structure | Binding Sites | Receptors, CXCR4 - metabolism
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 09/2013, Volume 52, Issue 36, pp. 9550 - 9553
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, p. e104746
CXCL12 (stromal cell-derived factor-1, SDF-1) is a potent chemokine for homing of CXCR4(+) fibrocytes to injury sites of lung tissue, which contributes to... 
REGULATED KINASE | SIGNALING AXIS | CANCER CELLS | EPITHELIAL-CELLS | MULTIDISCIPLINARY SCIENCES | GENE-REGULATION | CIRCULATING FIBROCYTES | FACTOR-I | IDIOPATHIC PULMONARY-FIBROSIS | NF-KAPPA-B | FOCAL ADHESIONS | Cell Line | Chemokine CXCL12 - physiology | Fibroblasts - enzymology | Phosphorylation | Humans | Actins - metabolism | rac GTP-Binding Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | DNA Primers | Lung - cytology | Transcription Factor AP-1 - metabolism | Lung - enzymology | Receptors, CXCR4 - metabolism | MAP Kinase Kinase 4 - metabolism | Base Sequence | Polymerase Chain Reaction | Connective Tissue Growth Factor - genetics | Lung - metabolism | Connective Tissue Growth Factor - metabolism | Fibroblasts - metabolism | Muscle proteins | Respiratory tract diseases | Luciferase | CXCL12 protein | Transcription factors | Smooth muscle | Kinases | Cell adhesion & migration | Proteins | Homing | Connective tissues | Pathways | Actin | Fibroblasts | Curcumin | Inhibition | Growth factors | c-Fos protein | Respiratory therapy | Phenotypes | Internal medicine | Lung diseases | Activator protein 1 | Muscles | Extracellular signal-regulated kinase | c-Jun protein | p21-activated kinase | MAP kinase | Connective tissue growth factor | Rac1 protein | siRNA | Gene expression | SDF-1 protein | Ribonucleic acid--RNA | CXCR4 protein | Medicine | Signaling | Pulmonary fibrosis | Inhibitors | Protein kinase | Fibrosis | Cell migration | Chemokines | RNA | Ribonucleic acid
Journal Article
Oncogene, ISSN 0950-9232, 01/2019, Volume 38, Issue 1, pp. 60 - 72
Metastatic clear cell renal cell carcinoma (CCC) remains incurable despite advances in the development of anti-angiogenic targeted therapies and the emergence... 
LDB1 | ONCOLOGY | PATHWAY | LHX1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | GROWTH | GENETICS & HEREDITY | DIFFERENTIATION | EXPRESSION | REQUIREMENT | CELL BIOLOGY | RNA, Small Interfering - genetics | Kidney Neoplasms - genetics | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Carcinoma, Renal Cell - genetics | Neoplasm Proteins - antagonists & inhibitors | LIM-Homeodomain Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Gene Knockdown Techniques | Lung Neoplasms - secondary | RNA Interference | Epithelial-Mesenchymal Transition | Neoplasm Proteins - genetics | Kidney Neoplasms - therapy | Oncogenes | Transcription Factors - physiology | Signal Transduction | Neoplasm Invasiveness | Von Hippel-Lindau Tumor Suppressor Protein - physiology | Transcription Factors - antagonists & inhibitors | Lung Neoplasms - therapy | Transcription Factors - genetics | LIM-Homeodomain Proteins - genetics | Lung Neoplasms - prevention & control | RNA, Small Interfering - therapeutic use | Carcinoma, Renal Cell - secondary | Carcinoma, Renal Cell - therapy | Cell Line, Tumor | LIM-Homeodomain Proteins - physiology | Cell Movement | Complications and side effects | Care and treatment | Transcription factors | Genetic aspects | Carcinoma, Renal cell | Metastasis | Gene expression | Health aspects | Risk factors | Cell proliferation | Intravenous administration | Mesenchyme | Fibronectin | Lymph nodes | Metastases | Cell adhesion & migration | Angiogenesis | Signal transduction | Cell adhesion | Gene transfer | Therapeutic applications | siRNA | SDF-1 protein | CXCR4 protein | Immune checkpoint | Hedgehog protein | Kidney cancer | Cell lines | Tumor suppressor genes | VHL protein | Skin | Neoplasia | Paxillin | Cell migration | Clear cell-type renal cell carcinoma | Apoptosis
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 08/2018, Volume 284, pp. 240 - 247
In order to provide best control of the regeneration process for each individual patient, the release of protein drugs administered during surgery may need to... 
Proteins | On-demand release | Poly(ɛ-caprolactone) networks | Near infrared light triggered shape-recovery | Shape-memory polymer | Poly(epsilon-caprolactone) networks | MATRIX | HYDROGELS | DRUG-DELIVERY | SDF-1 | CHEMISTRY, MULTIDISCIPLINARY | NANOPARTICLES | REPAIR | PHARMACOLOGY & PHARMACY | GROWTH-FACTOR | Product introduction | Biological products
Journal Article
Journal Article
Leukemia, ISSN 0887-6924, 01/2004, Volume 18, Issue 1, pp. 29 - 40
It has been suggested that bone marrow (BM)-derived hematopoietic stem cells transdifferentiate into tissue-specific stem cells (the so-called phenomenon of... 
SDF-1 | CXCR4 | Stem cell mobilization | Stem cell homing | Stem cell plasticity | stem cell plasticity | PROGENITOR CELLS | stem cell mobilization | FUSION | CHEMOKINE RECEPTOR CXCR4 | stem cell homing | PERIPHERAL-BLOOD | FACTOR-I | MICE LACKING | SKELETAL-MUSCLE | EPITHELIAL-CELLS | ONCOLOGY | STEM/PROGENITOR CELLS | HEMATOLOGY | Glial Fibrillary Acidic Protein - genetics | Nestin | Antigens, CD34 - metabolism | MyoD Protein - genetics | Humans | Blood Cells - metabolism | Muscle, Skeletal - metabolism | Glial Fibrillary Acidic Protein - metabolism | RNA, Messenger - metabolism | Blood Cells - cytology | Keratins - metabolism | Bone Marrow - metabolism | Intermediate Filament Proteins - genetics | Muscle Proteins - metabolism | Female | Neurons - metabolism | Hematopoietic Stem Cell Mobilization | DNA-Binding Proteins | alpha-Fetoproteins - metabolism | Hematopoietic Stem Cells - drug effects | Cell Line | Chemokine CXCL12 | alpha-Fetoproteins - genetics | Liver - metabolism | RNA, Messenger - genetics | Trans-Activators | Biomarkers - analysis | Hematopoietic Stem Cells - metabolism | MyoD Protein - metabolism | Nerve Tissue Proteins | Biomarkers - blood | Myogenic Regulatory Factor 5 | Chemokines, CXC - genetics | Receptors, CXCR4 - metabolism | Muscle Proteins - genetics | Granulocyte Colony-Stimulating Factor - pharmacology | Animals | Chemokines, CXC - metabolism | Mice | Mice, Inbred BALB C | Keratins - genetics | Intermediate Filament Proteins - metabolism
Journal Article