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Journal of cell science, ISSN 0021-9533, 04/2017, Volume 130, Issue 8, pp. 1475 - 1485
MIM | CXCR4 | AIP4 | Rab7 | Ubiquitylation | MVBs | Life Sciences & Biomedicine | Science & Technology | Cell Biology | rab GTP-Binding Proteins - metabolism | Down-Regulation | Humans | Neoplasm Proteins - immunology | Neoplasm Proteins - metabolism | Endosomes - metabolism | Mice, Knockout | Protein Transport | Receptors, CXCR4 - metabolism | Ubiquitination | Animals | Chemokine CXCL12 - metabolism | Transport Vesicles - metabolism | Microfilament Proteins - immunology | Protein Binding | Endocytosis - genetics | Mice | Microfilament Proteins - metabolism | HeLa Cells | Neoplasm Proteins - genetics | Microfilament Proteins - genetics | Coils | Ubiquitin | GTP-binding protein | Membranes | CXCL12 protein | Guanosine triphosphatases | Metastasis | SDF-1 protein | CXCR4 protein | Metastases | Proteins | Clonal deletion | Rab5 protein | Internalization | Protein transport | Curvature | Ubiquitin-protein ligase | Cytoplasm | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 06/2019, Volume 38, Issue 26, pp. 5174 - 5190
Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Human Umbilical Vein Endothelial Cells | Chlorocebus aethiops | Recombinant Fusion Proteins - pharmacology | Humans | Carcinogenesis - genetics | Cells, Cultured | Gene Expression Regulation, Neoplastic | TATA-Binding Protein Associated Factors - genetics | Carcinogenesis - metabolism | RNA Stability - genetics | Protein Isoforms - physiology | AU Rich Elements - genetics | Animals | Breast Neoplasms - genetics | TATA-Binding Protein Associated Factors - physiology | Breast Neoplasms - pathology | Gain of Function Mutation - physiology | Recombinant Fusion Proteins - genetics | Female | Zinc Fingers - genetics | Mice | Mice, Inbred BALB C | COS Cells | Protein Isoforms - genetics | Care and treatment | Messenger RNA | Breast cancer | Genetic aspects | Research | Binding proteins | Vascular endothelial growth factor | Vimentin | CXCL12 protein | Mesenchyme | Medical innovations | Serine | Cell fusion | Drug resistance | Proteins | N-Cadherin | Clonal deletion | Fractalkine | Tumorigenesis | Fusion protein | Pentraxins | mRNA turnover | Tumor cell lines | SDF-1 protein | Cadherin | Endothelial cells | RNA-binding protein | Hypoxia | Monocyte chemoattractant protein 1 | Chemokines | Index Medicus | Life Sciences
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The Lim1 oncogene as a new therapeutic target for metastatic human renal cell carcinoma
Oncogene, ISSN 0950-9232, 01/2019, Volume 38, Issue 1, pp. 60 - 72
Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA, Small Interfering - genetics | Kidney Neoplasms - genetics | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Carcinoma, Renal Cell - genetics | Neoplasm Proteins - antagonists & inhibitors | LIM-Homeodomain Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Gene Knockdown Techniques | Lung Neoplasms - secondary | RNA Interference | Epithelial-Mesenchymal Transition | Neoplasm Proteins - genetics | Kidney Neoplasms - therapy | Oncogenes | Transcription Factors - physiology | Signal Transduction | Neoplasm Invasiveness | Von Hippel-Lindau Tumor Suppressor Protein - physiology | Transcription Factors - antagonists & inhibitors | Lung Neoplasms - therapy | Transcription Factors - genetics | LIM-Homeodomain Proteins - genetics | Lung Neoplasms - prevention & control | RNA, Small Interfering - therapeutic use | Carcinoma, Renal Cell - secondary | Carcinoma, Renal Cell - therapy | Cell Line, Tumor | LIM-Homeodomain Proteins - physiology | Cell Movement | Complications and side effects | Care and treatment | Transcription factors | Genetic aspects | Carcinoma, Renal cell | Metastasis | Gene expression | Health aspects | Risk factors | Cell proliferation | Intravenous administration | Mesenchyme | Fibronectin | Lymph nodes | Metastases | Cell adhesion & migration | Angiogenesis | Signal transduction | Cell adhesion | Gene transfer | Therapeutic applications | siRNA | SDF-1 protein | CXCR4 protein | Immune checkpoint | Hedgehog protein | Kidney cancer | Tumor suppressor genes | VHL protein | Neoplasia | Paxillin | Cell migration | Clear cell-type renal cell carcinoma | Apoptosis | Index Medicus | Life Sciences | Human health and pathology | Urology and Nephrology | Biochemistry, Molecular Biology | Genomics | Cancer
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 12/2009, Volume 284, Issue 50, pp. 35240 - 35250
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Structure, Tertiary | Chemokine CXCL12 - chemistry | Chemokine CXCL12 - genetics | Chemokine CXCL12 - metabolism | Humans | Models, Molecular | Nuclear Magnetic Resonance, Biomolecular | Receptors, CXCR4 - genetics | Structure-Activity Relationship | Receptors, CXCR4 - chemistry | Receptors, CXCR4 - metabolism | CXCL12 protein | G protein-coupled receptors | Purification | Crystallization | Data processing | Guanine nucleotide-binding protein | SDF-1 protein | CXCR4 protein | Metastases | Infection | N.M.R | Signal transduction | Chemokines | Cancer | Index Medicus | Protein Structure and Folding
Journal Article
Gene therapy, ISSN 0969-7128, 10/2017, Volume 24, Issue 10, pp. 621 - 629
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Genetics & Heredity | Biotechnology & Applied Microbiology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Receptors, CXCR4 - antagonists & inhibitors | Humans | Heterocyclic Compounds - pharmacology | rhoA GTP-Binding Protein - metabolism | Mice, SCID | RNAi Therapeutics - methods | Receptors, CXCR4 - metabolism | Ovarian Neoplasms - genetics | Animals | Chemokine CXCL12 - genetics | Chemokine CXCL12 - metabolism | Cell Line, Tumor | Ovarian Neoplasms - therapy | Carcinoma - genetics | Carcinoma - therapy | Female | Mice, Inbred NOD | Receptors, CXCR4 - genetics | Mice | rac1 GTP-Binding Protein - metabolism | Care and treatment | RNA | Analysis | Development and progression | Metastasis | Health aspects | Ovarian cancer | Cancer | Cdc42 protein | Cell proliferation | Flow cytometry | CXCL12 protein | Ovarian carcinoma | Leukocyte migration | Toxicity | Cytotoxicity | RhoA protein | Rac1 protein | mRNA | Tumor cell lines | SDF-1 protein | CXCR4 protein | Metastases | Cytometry | Xenografts | Biocompatibility | Chemokines | Cell migration | Tumors | Index Medicus
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Oncogene, ISSN 0950-9232, 03/2018, Volume 37, Issue 9, pp. 1205 - 1219
Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Proliferation | Prognosis | Cancer-Associated Fibroblasts - metabolism | Stromal Cells - pathology | Coculture Techniques | Humans | Male | Intracellular Signaling Peptides and Proteins - metabolism | LIM Domain Proteins - metabolism | Azoxymethane - toxicity | Biomarkers, Tumor | Carcinogenesis - metabolism | Cytoskeletal Proteins - physiology | Tumor Cells, Cultured | Intracellular Signaling Peptides and Proteins - genetics | Colorectal Neoplasms - metabolism | Fibroblasts - metabolism | DNA-Binding Proteins - physiology | Signal Transduction | Mice, Inbred C57BL | Stromal Cells - metabolism | Fibroblasts - pathology | Colorectal Neoplasms - chemically induced | Protein-Lysine 6-Oxidase | Mice, Knockout | Carcinogenesis - pathology | Cancer-Associated Fibroblasts - pathology | Animals | LIM Domain Proteins - genetics | LIM Domain Proteins - physiology | Mice | Colorectal Neoplasms - pathology | Apoptosis | Extracellular matrix | Genetic aspects | Research | Carcinogenesis | Colorectal cancer | Cell culture | CXCL12 protein | Collagen (type I) | Hydrogen peroxide | Transcription | Colorectal carcinoma | Metastasis | SDF-1 protein | Lysyl oxidase | IL-1β | Metastases | Colon cancer | Azoxymethane | Rodents | Fibroblasts | Tumorigenesis | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 01/2013, Volume 32, Issue 2, pp. 209 - 221
non-small cell lung cancer | CXCR4 | STAT3 signaling | tumorigenicity | cancer stem cell | PI3K/PTEN/Akt/mTOR signaling | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Lung Neoplasms - drug therapy | Up-Regulation | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Neoplastic Stem Cells - drug effects | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Lung Neoplasms - metabolism | Heterocyclic Compounds - pharmacology | Drug Resistance, Neoplasm | Lung Neoplasms - pathology | Chemokine CXCL12 - secretion | RNA Interference | Female | Receptors, CXCR4 - genetics | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Neoplastic Stem Cells - physiology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | PTEN Phosphohydrolase - genetics | Signal Transduction | Receptors, CXCR4 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - metabolism | PTEN Phosphohydrolase - metabolism | Tyrphostins - pharmacology | Mice, SCID | Receptors, CXCR4 - metabolism | Animals | Mice, Nude | Cell Line, Tumor | Mice | Pyridines - pharmacology | RNA, Small Interfering | Carcinoma, Non-Small-Cell Lung - drug therapy | STAT3 Transcription Factor - antagonists & inhibitors | Care and treatment | Stem cells | Cancer cells | Development and progression | Research | Lung cancer, Non-small cell | Cancer | Signal transduction | Drug resistance | Lung cancer | TOR protein | Secretion | Stat3 protein | Non-small cell lung carcinoma | AKT protein | Data processing | Tumorigenicity | siRNA | Tumor cell lines | SDF-1 protein | CXCR4 protein | 1-Phosphatidylinositol 3-kinase | Transfection | PTEN protein | Index Medicus
Journal Article
International journal of molecular sciences, ISSN 1661-6596, 12/2020, Volume 21, Issue 23, pp. 1 - 16
Endothelial dysfunction | Adhesion molecules | Coronary artery disease | Fatty acid‐binding protein 4 | Atherosclerosis | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Cell culture | Phosphorylation | Vascular cell adhesion molecule 1 | Antibodies | Cardiovascular disease | Leukocytes (mononuclear) | Adipocytes | Kinases | Proteins | Body mass index | Signal transduction | Cell activation | Tumor necrosis factor-TNF | Stat1 protein | Diabetes mellitus (non-insulin dependent) | Vascular endothelial growth factor | Heart diseases | Hypertension | Creatinine | Intercellular adhesion molecule 1 | Coronary artery | Extracellular signal-regulated kinase | Metabolism | SDF-1 protein | Insulin | Endothelial cells | Monocytes | Arteriosclerosis | Coronary vessels | Body size | Diabetes | P-selectin | Index Medicus | atherosclerosis | coronary artery disease | fatty acid-binding protein 4 | endothelial dysfunction
Journal Article
Circulation research, ISSN 0009-7330, 01/2017, Volume 120, Issue 5, pp. e7 - e23
chemokine CXCL12 | angiogenesis | endothelial progenitor cells | hindlimb ischemia | CXC chemokine receptor type 7 | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Diabetes Mellitus - pathology | Humans | Oxidative Stress - physiology | Cells, Cultured | Diabetes Mellitus - metabolism | Ischemia - metabolism | Male | Mice, Transgenic | Glycogen Synthase Kinase 3 beta - metabolism | Gene Knockdown Techniques | Neovascularization, Physiologic - physiology | Endothelial Progenitor Cells - physiology | Animals | Proto-Oncogene Proteins c-fyn - metabolism | Hindlimb - blood supply | NF-E2-Related Factor 2 - metabolism | HEK293 Cells | Hindlimb - pathology | Receptors, CXCR - biosynthesis | Mice | Proto-Oncogene Proteins c-akt - metabolism | Hindlimb - metabolism | Ischemia - pathology | Oxidative stress | Phosphorylation | Glucose kinase | AKT protein | Glucose | Kinases | Proteins | Angiogenesis | Ischemia | Catalase | Rodents | Heme | Localization | Fyn protein | Glycogen | Quinone | Diabetes mellitus | Glycogen synthase kinase 3 | Heme oxygenase (decyclizing) | SDF-1 protein | Progenitor cells | Chemokine receptors | CXCR4 protein | Nuclear transport | 1-Phosphatidylinositol 3-kinase | NAD | Oxygenase | Lipoproteins | NAD(P)H dehydrogenase | Stem cells | Diabetes | Apoptosis | Index Medicus | Mechanisms | Signal Transduction | Endothelial progenitor celsl | Cell Signaling | Cell Therapy | chemokine receptor CXCR7 | hind limb ischemia | chemoreceptor | Basic Science Research
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Journal of cellular biochemistry, ISSN 0730-2312, 03/2018, Volume 119, Issue 3, pp. 2939 - 2950
stromal cell‐derived factor‐1 (SDF‐1) | homing | precondition | liver | resveratrol | bone marrow‐derived mesenchymal stem cells (BMSCs) | bone marrow-derived mesenchymal stem cells (BMSCs) | stromal cell-derived factor-1 (SDF-1) | Flow cytometry | CXCL12 protein | Mesenchyme | Liver | p53 Protein | Stem cell transplantation | Transplantation | Matrix metalloproteinase | Homing | Rodents | Resveratrol | Bone marrow | Metalloproteinase | Pretreatment | Spleen | Injection | SDF-1 protein | SIRT1 protein | CXCR4 protein | Bile duct | Cirrhosis | Cytometry | Animals | Hepatocytes | Lungs | Stem cells | Strategy | Protein expression | Immunofluorescence | Preconditioning | Liver cirrhosis | Cell migration | Liver transplantation | Bile | Index Medicus
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