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site-directed mutagenesis (13) 13
index medicus (12) 12
sdm (10) 10
biochemistry & molecular biology (9) 9
mutagenesis (7) 7
humans (6) 6
mutagenesis, site-directed - methods (5) 5
sdm, site-directed mutagenesis (5) 5
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animals (3) 3
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mutagenesis, site-directed (3) 3
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research article (3) 3
restriction endonucleases (3) 3
software (3) 3
amino acid substitution (2) 2
analysis (2) 2
article (2) 2
bacterial proteins - metabolism (2) 2
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deletion (2) 2
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directed evolution (2) 2
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drug discovery (2) 2
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epitopes (2) 2
escherichia coli - genetics (2) 2
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expression (2) 2
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wt, wild-type (2) 2
3d, three-dimensional (1) 1
5-ht 2b and 5-ht 2c , human 5-hydroxytryptamine receptors 2b and 2c, respectively (1) 1
5-ht2b and 5-ht2c, human 5-hydroxytryptamine receptors 2b and 2c, respectively (1) 1
7tm, seven-transmembrane domain (1) 1
acidification (1) 1
acrylic resins (1) 1
act, artemisinin-based combination therapies (1) 1
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adenosine - pharmacology (1) 1
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alpha 1b adrenergic receptor (1) 1
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amino-acid transporter (1) 1
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atcc, american type culture collection (1) 1
azoverbindung (1) 1
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Methods in Molecular Biology, ISSN 1064-3745, 2017, Volume 1652, pp. 135 - 143
Journal Article
Analytical Biochemistry, ISSN 0003-2697, 05/2015, Volume 476, pp. 26 - 28
Journal Article
BMC Bioinformatics, ISSN 1471-2105, 2013, Volume 14, Issue 1, p. 105
Journal Article
Indonesian Journal of Biotechnology, ISSN 0853-8654, 06/2019, Volume 24, Issue 1, p. 8
Recombinant human epidermal growth factor (rh-EGF) has high value in therapies for h-EGF deficiency-related diseases. The expression of the h-EGF gene was... 
Journal Article
浙江大学学报:B卷英文版, ISSN 1673-1581, 2012, Volume 13, Issue 4, pp. 244 - 247
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2015, Volume 466, Issue 1, pp. 177 - 188
The proton-linked monocarboxylate transporters (MCTs) are required for lactic acid transport into and out of all mammalian cells. Thus, they play an essential... 
Xenopus oocytes | Lactate transport | Molecular modelling | Molecular dynamics (MD) simulations | Monocarboxylate transporter 1 (MCT1) | Monocarboxylate transporter 4 (MCT4) | TRANSMEMBRANE HELICES | molecular modelling | monocarboxylate transporter 4 (MCT4) | BIOCHEMISTRY & MOLECULAR BIOLOGY | PYRUVATE TRANSPORT | lactate transport | molecular dynamics (MD) simulations | MONOCARBOXYLATE | ANCILLARY PROTEIN | SKELETAL-MUSCLE | INHIBITION | monocarboxylate transporter 1 (MCT1) | HUMAN-ERYTHROCYTES | ASCITES TUMOR-CELLS | LACTIC-ACID EFFLUX | Humans | Oocytes - cytology | Monocarboxylic Acid Transporters - antagonists & inhibitors | Monocarboxylic Acid Transporters - metabolism | Biological Transport | Symporters - antagonists & inhibitors | Muscle Proteins - metabolism | Female | Binding Sites | Uracil - chemistry | Monocarboxylic Acid Transporters - chemistry | Recombinant Proteins - metabolism | Gene Expression | Lactic Acid - chemistry | Mutagenesis, Site-Directed | Oocytes - metabolism | Lactic Acid - metabolism | Xenopus laevis | Rats | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Symporters - chemistry | Amino Acids | Symporters - metabolism | Muscle Proteins - genetics | Animals | Symporters - genetics | Protein Binding | Mice | Molecular Docking Simulation | Muscle Proteins - chemistry | Monocarboxylic Acid Transporters - genetics | Thiophenes - chemistry | Amino Acid Substitution | Uracil - analogs & derivatives | Index Medicus | OPLS–AA, optimized potentials for liquid simulations–all atoms | WT, wild-type | MCT, monocarboxylate transporter | CHC, α-cyano-4-hydroxycinnamate | POPC, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine | DIDS, 4,4′-diisothiocyano-2,2′-stilbenedisulfonic acid | MD, molecular dynamics | SPC, simple point charge | TM, transmembrane helix | SDM, site-directed mutagenesis
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 8/2015, Volume 388, Issue 8, pp. 883 - 903
G-protein coupled receptors (GPCRs) are the targets of over half of all prescribed drugs today. The UniProt database has records for about 800 proteins... 
Neurosciences | CXCR 1 , CXCR 2 , CCR 4 and CCR 5 , chemokine receptors | TM, trans-membrane helix | β 2 AR, β 2 -adrenergic receptor | ProS, pairwise protein similarity method | CRF1, corticotropin releasing factor receptor 1 | T4L, T4-lysozyme | ECL, extracellular loop | GLP-1, Glucagon-like peptide-1 receptor | hM 3 R, human muscarinic M3 receptor | α1B Adrenergic receptor | Pharmacology/Toxicology | 7TM, seven-transmembrane domain | HGMP, hierarchical GPCR modelling protocol | PDB, Protein Data Bank | XFELs, x-ray free electron lasers | 5-HT 2B and 5-HT 2C , human 5-hydroxytryptamine receptors 2B and 2C, respectively | GLAS, GPCR-likeness assessment score | H 1 , histamine receptor 1 | 3D, three-dimensional | Biomedicine | CCK 2 R, cholecystokinin receptor-2 | MD, molecular dynamic simulations | GPCRs, G-protein coupled receptors | Dopamine D 2 receptor | BRIL, apocytochrome b 562 RIL | δ-OR, delta-opioid receptor | SDM, site-directed mutagenesis | CCK2R, cholecystokinin receptor-2 | PEPTIDE-1 RECEPTOR | DESIGN | CXCR1, CXCR2, CCR4, and CCR5, chemokine receptors | beta 2AR, beta 2-adrenergic receptor | hMR, human muscarinic M3 receptor | HUMAN OREXIN-1 | PHARMACOLOGY & PHARMACY | ANTAGONISTS | Dopamine D-2 receptor | PROTEIN-COUPLED RECEPTORS | SITE-DIRECTED MUTAGENESIS | alpha 1B Adrenergic receptor | LIPIDIC CUBIC PHASE | delta-OR, delta-opioid receptor | 5-HT2B and 5-HT2C, human 5-hydroxytryptamine receptors 2B and 2C, respectively | H-1, histamine receptor 1 | SERIAL FEMTOSECOND CRYSTALLOGRAPHY | BINDING | SELECTIVITY | BRIL, apocytochrome bRIL | Animals | Receptors, G-Protein-Coupled - metabolism | Computer Simulation | Drug Industry | Humans | Cooperative Behavior | Models, Molecular | Crystallography | Drug Discovery | Universities | Drug discovery | BRIL, apocytochrome b562RIL | Meeting Report | H1, histamine receptor 1 | β2AR, β2-adrenergic receptor | CXCR1, CXCR2, CCR4 and CCR5, chemokine receptors | hM3R, human muscarinic M3 receptor | Dopamine D2 receptor
Journal Article
Computational and Structural Biotechnology Journal, ISSN 2001-0370, 2015, Volume 13, Issue C, pp. 229 - 240
The molecular structure modeling of the β1 subunit of the skeletal muscle voltage-gated sodium channel (Na 1.4) was carried out in the twilight zone of very... 
Ig-like | MD-2 | Analogy modeling | Patch-clamp | Site-directed mutagenesis | CDR1
Journal Article
International Journal of Virology, ISSN 1816-4900, 2014, Volume 10, Issue 2, pp. 84 - 93
HA is a critical determinant of the pathogenicity of avian influenza viruses. The HA proteins of highly pathogenic H5 and H7 viruses contain multiple basic... 
HACS | H5N1 | HPAI | SDM | Sequencing | LPAI
Journal Article
AIMS Bioengineering, ISSN 2375-1495, 2015, Volume 2, Issue 3, pp. 126 - 143
OneClick is a user-friendly web-based program, developed specifically for quick-and-easy design of focused mutagenesis experiments (e.g., site-directed... 
enzyme engineering | protein engineering | QuikChange | saturation mutagenesis | site-directed mutagenesis (SDM) | focused mutagenesis | biocatalysis | directed evolution
Journal Article
Journal Article
Journal Article