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11/2011
VPS33B is a Sec1/Munc18 protein required for the biogenesis of α-granules in megakaryocytes, which give rise to platelets. Mutations in VPS33B cause... 
0379 | SNAREs | VPS33B | megakaryocyte | platelet | Sec1/Munc18 | syntaxin-6
Dissertation
Journal Article
ELIFE, ISSN 2050-084X, 05/2014, Volume 3
Secretory and endolysosomal fusion events are driven by SNAREs and cofactors, including Sec17 (a-SNAP), Sec18 (NSF), and Sec1/Munc18 (SM) proteins. SMs are... 
SEC1/MUNC18 PROTEINS | BUDDING YEAST | Vps33 | CA2+-TRIGGERED EXOCYTOSIS | SACCHAROMYCES-CEREVISIAE | SNARE | membrane fusion | SM (Sec1/Munc18) | DEPENDENT MEMBRANE-FUSION | RAB GTPASE | Sly1 | VACUOLE FUSION | BIOLOGY | ALPHA-SNAP | SYNAPTIC VESICLE DOCKING | Sec17 (alpha-SNAP) | CIS-SNARE
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2012, Volume 446, Issue 3, pp. 383 - 394
Airway mucin secretion and MC (mast cell) degranulation must be tightly controlled for homoeostasis of the lungs and immune system respectively. We found the... 
Mast cell | Mucus | Mucin | Exocytosis | Secretion | Munc18 | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | REGULATED EXOCYTOSIS | mast cell | IDENTIFICATION | mucus | SNARE | secretion | mucin | MEDIATED MEMBRANE-FUSION | MUNC-18-2 | exocytosis | SYNTAXIN 3 | TRANSCRIPTIONAL REGULATION | SEC1 HOMOLOG | Munc18 Proteins - genetics | Mice, Inbred C57BL | Munc18 Proteins - metabolism | Rats | Mice, Transgenic | Genes, Essential | E-Box Elements | Epithelial Cells - secretion | Animals | Mast Cells - secretion | Female | Lung - metabolism | Mice | Passive Cutaneous Anaphylaxis - genetics | Disease Models, Animal | SNAP, soluble N-ethylmaleimide-sensitive factor-attachment protein | WT, wild-type | YFP, yellow fluorescent protein | OCT, optimal cutting temperature compound | MC, mast cell | GRE, glucocorticoid-response element | SCF, stem cell factor | HRP, horseradish peroxidase | FRT, flippase recognition target | SNARE, SNAP receptor | CCSP, Clara cell secretory protein | MFI, mean fluorescent intensity | TNFα, tumour necrosis factor α | PGK, phosphoglucokinase | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | CRE, cAMP-response element | mtCC, mouse transformed Clara cell | Schiff reagent | Clca3, chloride channel, calcium-activated, family member 3 | fluorescent Schiff reagent | PGD2, prostaglandin D2 | bHLH, basic helix–loop–helix | FBS, fetal bovine serum | TK, thymidine kinase | FcϵRIα, high-affinity IgE receptor, α subunit | HA, haemagglutinin | HSA, human serum albumin | PBST, PBS containing 0.05% Tween 20 | AB-PAS, Alcian Blue | SM, Sec1 | Stxbp2, syntaxin-binding protein 2 | IL-3, interleukin-3 | mClca3, mouse Clca3 | periodic acid | NK, natural killer | PAFS, periodic acid | INR, initiator | DNP, 2,4-dinitrophenol | mBMMC, mouse bone-marrow-derived MC | ISH, in situ hybridization
Journal Article
Journal Article
EMBO Journal, ISSN 0261-4189, 01/2013, Volume 32, Issue 1, pp. 159 - 171
Among SNARE proteins mediating synaptic vesicle fusion, syntaxin-1 uniquely includes an N-terminal peptide ('N-peptide') that binds to Munc18-1, and a large,... 
synapse | neurotransmitter release | SM proteins | syntaxin | membrane fusion | SEC1/MUNC18 PROTEINS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ASYNCHRONOUS RELEASE | CELL BIOLOGY | MEMBRANE-FUSION | 3-DIMENSIONAL STRUCTURE | NEUROTRANSMITTER | MUNC18-1 BINDING | MODES | NEURONAL SNARE COMPLEX | CONFORMATIONAL SWITCH
Journal Article
Traffic, ISSN 1398-9219, 07/2019, Volume 20, Issue 7, pp. 479 - 490
Vesicular transport between different membrane compartments is a key process in cell biology required for the exchange of material and information. The complex... 
Rab GTPases | CATCHR | tethering | golgin | Sec1/Munc18 | membrane fusion | SNARE | vesicular transport | Proteins | G proteins | Cells | Protein binding | Lipids | Budding | Vesicles
Journal Article