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Tetrahedron, ISSN 0040-4020, 04/2019, Volume 75, Issue 16, pp. 2385 - 2399
An extensive medicinal chemistry campaign and subsequent SAR studies led to the discovery of the highly potent and selective JAK1/3 inhibitor R545. To support... 
Oxidative metabolite | Oxidative olefin cleavage | JAK1/3 inhibitor | Kinase | Protecting group-directed halogenation | Aryne reaction | SECONDARY ALCOHOLS | CHEMISTRY, ORGANIC | TOFACITINIB | RUXOLITINIB | Metabolites
Journal Article
Journal Article
Journal Article
Planta, ISSN 0032-0935, 11/2018, Volume 248, Issue 5, pp. 1289 - 1306
Elicitation of Linum album hairy roots by Piriformospora indica cell wall induced the target genes and specific metabolites in phenylpropanoid pathway and... 
Life Sciences | Hairy root | Forestry | Lignan | Linum album | Agriculture | Ecology | Elicitation | Phenylpropanoids | Gene expression | Plant Sciences | SECONDARY METABOLITES | PHENOLIC-COMPOUNDS | PHENYLALANINE AMMONIA-LYASE | PLANT SCIENCES | ENHANCED PRODUCTION | SCROPHULARIA-STRIATA BOISS | SALICYLIC-ACID | BOUND PHENOLICS | SUSPENSION-CULTURES | AMINO-ACIDS | LIGNAN BIOSYNTHESIS | Gene Expression Regulation, Fungal | Plant Roots - metabolism | Flax - metabolism | Hydroxybenzoates - metabolism | Transcriptome | Lignans - metabolism | Chromatography, High Pressure Liquid | Plant Roots - microbiology | Basidiomycota - metabolism | Amino Acids - metabolism | Flax - microbiology | Metabolic Networks and Pathways | Cell Wall - metabolism | Flavonoids - metabolism | Gene Expression Regulation, Plant | Tyrosine | Lignin | Plant physiology | Phenylalanine | Genes | Genetic research | Glutamate | Plant metabolites | Isoflavones | Glutamic acid | Cell culture | Phenylalanine ammonia-lyase | Podophyllotoxin | Roots | Cinnamic acid | Gene regulation | Lignans | Amino acids | Biosynthesis | Alcohol dehydrogenase | Phenolic acids | Alcohols | Fungi | Secondary metabolites | Metabolites | Precursors | Drug tolerance | Salicylic acid | Plants (botany) | Alanine | Kaempferol | Metabolism | Ferulic acid | Ammonia | Flavonoids | Phenols | Cinnamoyl-CoA reductase | Reductase
Journal Article
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 09/2013, Volume 2013, Issue 26, pp. 5952 - 5960
(+)‐Phenguignardic acid, a phytotoxic metabolite of the grape black rot fungus Guignardia bidwellii was synthesized, as well as its enantiomer, in eight steps... 
Heterocycles | Natural products | Phytotoxins | Total synthesis | Phenguignardic acid | SECONDARY METABOLITES | ALCOHOLS | AMINO-ACIDS | CHEMISTRY, ORGANIC | Synthesis | Metabolites | Enantiomers | Organic compounds
Journal Article
Journal of the Science of Food and Agriculture, ISSN 0022-5142, 07/2017, Volume 97, Issue 9, pp. 3039 - 3049
BACKGROUND Saccharomyces cerevisiae var. boulardii is the only yeast species with probiotic properties. It is considered to have therapeutic significance in... 
stress‐tolerance | Saccharomyces cerevisiae var. boulardii NCYC 3264 | probiotic | Saccharomyces cerevisiae BY4742 | global metabolite profiling | antioxidant capacity | stress-tolerance | STRAINS | Saccharomyces cerevisiae var | BY4742 | TOLERANCE | FOOD SCIENCE & TECHNOLOGY | BAKERS-YEAST | boulardii | IDENTIFICATION | METHODOLOGY | GLUCOSE-INDUCED ACIDIFICATION | AGRICULTURE, MULTIDISCIPLINARY | CHROMATOGRAPHY-MASS SPECTROMETRY | VANILLIC ACID | CHEMISTRY, APPLIED | NCYC 3264 | NEURO-2A CELLS | Saccharomyces cerevisiae | LACTOBACILLUS | Saccharomyces cerevisiae - metabolism | Antioxidants - chemistry | Antioxidants - metabolism | Flavonoids - metabolism | Flavonoids - chemistry | Probiotics - chemistry | Saccharomyces cerevisiae - chemistry | Probiotics - metabolism | Secondary Metabolism | Antioxidants | Chemical industry | Herbicides | Pesticides industry | Flavonoids | Flavones | Gastrointestinal diseases | Analysis | Bioflavonoids | Physiological aspects | Erythromycin | Plant metabolites | Industrial production | Yeasts | Correlation | Baking yeast | Yeast | Profiling | Fingerprints | Gastrointestinal tract diseases | Cinnamic acid | Disorders | Assaying | Alcohols | Secondary metabolites | Metabolites | Drug tolerance | Vanillic acid | Physiology | Stresses | Ethanol | Principal components analysis | Cultures | Phenolic compounds | Stress | Screening | Probiotics | Rose oil | Oil | Amphetamine | Growth patterns | Phenols | Phenylethyl alcohol | Genetic recombination | Vitamin B6
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 01/2013, Volume 2013, Issue 3, pp. 525 - 532
The stereoselective total synthesis of dinemasone A has been accomplished. The key reactions, Sharpless asymmetric epoxidation, lithium‐mediated epoxy alcohol... 
Michael addition | Asymmetric synthesis | Natural products | Total synthesis | Spiro compounds | NATURAL-PRODUCTS | CHEMISTRY, ORGANIC | HETERO-MICHAEL ADDITION | STRATEGIES | SECONDARY ALCOHOLS | SPIROKETAL SYNTHESIS | BIOLOGICAL-ACTIVITY | ASYMMETRIC EPOXIDATION | TRIOXADISPIROKETAL | Synthesis | Lactic acid | Metabolites | Epoxy resins | Organic compounds
Journal Article