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1. Full Text Group IID, IIE, IIF and III secreted phospholipase A 2 s
by Murakami, Makoto and Miki, Yoshimi and Sato, Hiroyasu and Murase, Remi and Taketomi, Yoshitaka and Yamamoto, Kei
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 06/2019, Volume 1864, Issue 6, pp. 803 - 818
Among the 11 members of the secreted phospholipase A (sPLA ) family, group IID, IIE, IIF and III sPLA s (sPLA -IID, -IIE, -IIF and -III, respectively) are... 
Lipidomics | Pathophysiological function | Knockout mice | Secreted phospholipase A | Lipid-metabolic pathways | Transgenic mice
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2. Full Text Group IID, IIE, IIF and III secreted phospholipase A2s
by Murakami, Makoto and Miki, Yoshimi and Sato, Hiroyasu and Murase, Remi and Taketomi, Yoshitaka and Yamamoto, Kei
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 06/2019, Volume 1864, Issue 6, pp. 803 - 818
Among the 11 members of the secreted phospholipase A (sPLA ) family, group IID, IIE, IIF and III sPLA s (sPLA -IID, -IIE, -IIF and -III, respectively) are... 
Lipidomics | Pathophysiological function | Knockout mice | Secreted phospholipase A2 | Transgenic mice | Lipid-metabolic pathways
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3. Full Text Group IID, IIE, IIF and III secreted phospholipase A(2)s
by Murakami, M and Miki, Y and Sato, H and Murase, R and Taketomi, Y and Yamamoto, K
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, ISSN 1388-1981, 06/2019, Volume 1864, Issue 6, pp. 803 - 818
Among the 11 members of the secreted phospholipase A(2) (sPLA(2)) family, group IID, IIE, IIF and III sPLA(2)s (sPLA(2)-IID, -IIE, -IIF and -III, respectively)... 
GROUP-V | MAST-CELL MATURATION | Knockout mice | GROUP-X | DIFFERENTIATION-DEPENDENT REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | Transgenic mice | LOW-MOLECULAR-WEIGHT | LOW-DENSITY-LIPOPROTEIN | Lipidomics | Pathophysiological function | RECOMBINANT EXPRESSION | CELL BIOLOGY | Secreted phospholipase A | BIOPHYSICS | ARACHIDONATE-RELEASING FUNCTION | DOCOSAHEXAENOIC ACID | Lipid-metabolic pathways | POLYUNSATURATED FATTY-ACIDS
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4. Full Text The expanding superfamily of phospholipase A2 enzymes: Classification and characterization
by Six, David A and Dennis, Edward A
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 10/2000, Volume 1488, Issue 1-2, pp. 1 - 19
The phospholipase A (PLA ) superfamily consists of a broad range of enzymes defined by their ability to catalyze the hydrolysis of the middle (sn-2) ester bond... 
Calcium-independent phospholipase A | Platelet activating factor acetylhydrolase | Secreted phospholipase A | Arachidonic acid | Phospholipase B | Cytosolic phospholipase A
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5. Full Text Secreted Phospholipase A2 Specificity on Natural Membrane Phospholipids
by Yamamoto, K and Miki, Y and Sato, H and Murase, R and Taketomi, Y and Murakami, M
Methods in Enzymology, ISSN 0076-6879, 2017, Volume 583, pp. 101 - 117
The secreted phospholipase A (sPLA ) family contains 10 catalytically active isoforms. Current in vitro biochemical studies have shown that individual sPLA s... 
Secreted phospholipase A | Knockout mouse | Lysophospholipid | Phospholipid | Polyunsaturated fatty acid | Lipidomics | Transgenic mouse | Arachidonic acid | Docosahexaenoic acid | Mass spectrometry
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6. Full Text Emerging roles of secreted phospholipase A2 enzymes: The 3rd edition
by Murakami, Makoto and Taketomi, Yoshitaka and Miki, Yoshimi and Sato, Hiroyasu and Yamamoto, Kei and Lambeau, Gérard
Biochimie, ISSN 0300-9084, 12/2014, Volume 107, pp. 105 - 113
Within the phospholipase A (PLA ) superfamily, secreted PLA (sPLA ) enzymes comprise the largest family that contains 11 to 12 mammalian isoforms with a... 
Phospholipid | Prostaglandin | Lipid mediator | Fatty acid | Secreted phospholipase A2 | Secreted phospholipase A | Signal Transduction - immunology | Animals | Bacterial Infections - immunology | Models, Biological | Humans | Substrate Specificity | Lipid Metabolism | Phospholipases A2, Secretory - immunology | Phospholipases A2, Secretory - metabolism | Phospholipids - metabolism | Receptors, Phospholipase A2 - metabolism
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7. Full Text Emerging roles of secreted phospholipase A(2) enzymes: The 3rd edition
by Murakami, M and Taketomi, Y and Miki, Y and Sato, H and Yamamoto, K and Lambeau, G
BIOCHIMIE, ISSN 0300-9084, 12/2014, Volume 107, pp. 105 - 113
Within the phospholipase A(2) (PLA(2)) superfamily, secreted PLA(2) (sPLA(2)) enzymes comprise the largest family that contains 11 to 12 mammalian isoforms... 
M-TYPE RECEPTOR | GROUP-V | MAST-CELL MATURATION | GROUP-X | Prostaglandin | BIOCHEMISTRY & MOLECULAR BIOLOGY | Phospholipid | RECOMBINANT EXPRESSION | LIPID MEDIATORS | DEFICIENT MICE | DIET-INDUCED OBESITY | PATHOGENIC ROLE | Lipid mediator | ALLERGIC PULMONARY INFLAMMATION | Secreted phospholipase A | Fatty acid
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8. Full Text Roles of secreted phospholipase A 2 group IIA in inflammation and host defense
by Dore, Etienne and Boilard, Eric
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 06/2019, Volume 1864, Issue 6, pp. 789 - 802
Among all members of the secreted phospholipase A (sPLA ) family, group IIA sPLA (sPLA -IIA) is possibly the most studied enzyme. Since its discovery, many... 
Inflammation | Infectious diseases | Secreted phospholipase A | Platelets | Microbiome
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9. Full Text Harmful and protective roles of group V phospholipase A(2): Current perspectives and future directions
by Samuchiwal, SK and Balestrieri, B
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, ISSN 1388-1981, 06/2019, Volume 1864, Issue 6, pp. 819 - 826
Group V Phospholipase A(2) (Pla2g5) is a member of the PLA(2) family of lipid-generating enzymes. It is expressed in immune and non-immune cell types and is... 
GROUP-X | HUMAN NEUTROPHILS | CYSTEINYL LEUKOTRIENE SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | Eicosanoids | linoleic acid | LOW-MOLECULAR-WEIGHT | RECOMBINANT EXPRESSION | INNATE LYMPHOID-CELLS | Macrophages | IL-33 | Asthma | Free fatty acids | CELL BIOLOGY | BIOPHYSICS | ARACHIDONIC-ACID MOBILIZATION | GROUP IVA | SECRETED PHOSPHOLIPASE-A | GROUP-II
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10. Full Text Roles of secreted phospholipase A(2) group IIA in inflammation and host defense
by Dore, E and Boilard, E
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, ISSN 1388-1981, 06/2019, Volume 1864, Issue 6, pp. 789 - 802
Among all members of the secreted phospholipase A(2) (sPLA(2)) family, group IIA sPLA(2) (sPLA(2)-IIA) is possibly the most studied enzyme. Since its... 
ARACHIDONIC-ACID RELEASE | MAJOR PHYSIOLOGICAL-ROLE | GROUP-X | BIOCHEMISTRY & MOLECULAR BIOLOGY | Inflammation | FACTOR-KAPPA-B | MITOCHONDRIAL-DNA | HUMAN T-CELLS | CELL BIOLOGY | Secreted phospholipase A | Infectious diseases | BIOPHYSICS | SMOOTH-MUSCLE-CELLS | STAPHYLOCOCCUS-AUREUS | KRUPPEL-LIKE FACTOR-2 | Platelets | CELL-MEMBRANE HYDROLYSIS | Microbiome
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11. Full Text Roles of secreted phospholipase A2 group IIA in inflammation and host defense
by Dore, Etienne and Boilard, Eric
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 06/2019, Volume 1864, Issue 6, pp. 789 - 802
Among all members of the secreted phospholipase A (sPLA ) family, group IIA sPLA (sPLA -IIA) is possibly the most studied enzyme. Since its discovery, many... 
Inflammation | Infectious diseases | Platelets | Secreted phospholipase A2 | Microbiome
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12. Full Text The expanding superfamily of phospholipase A(2) enzymes: classification and characterization
by Six, DA and Dennis, EA
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, ISSN 1388-1981, 10/2000, Volume 1488, Issue 1-2, pp. 1 - 19
The phospholipase A(2) (PLA(2)) superfamily consists of a broad range of enzymes defined by their ability to catalyze the hydrolysis of the middle (sn-2) ester... 
arachidonic acid | secreted phospholipase A | phospholipase B | FACTOR-ACETYLHYDROLASE-II | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LOW-MOLECULAR-WEIGHT | LOW-DENSITY-LIPOPROTEIN | MURINE P388D MACROPHAGES | CELL BIOLOGY | ARACHIDONOYL-HYDROLYZING PHOSPHOLIPASE-A2 | AMINO-ACID-SEQUENCE | BIOPHYSICS | cytosolic phospholipase A | calcium-independent phospholipase A | platelet activating factor acetylhydrolase | PLATELET-ACTIVATING-FACTOR | ARTHRITIC SYNOVIAL-FLUID | 85-KDA CYTOSOLIC PHOSPHOLIPASE-A
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13. Full Text Group IIA-Secreted Phospholipase A2 in Human Serum Kills Commensal but Not Clinical Enterococcus faecium Isolates
by Paganelli, Fernanda L and Leavis, Helen L and He, Samantha and van Sorge, Nina M and Payré, Christine and Lambeau, Gérard and Willems, Rob J. L and Rooijakkers, Suzan H. M
Infection and Immunity, ISSN 0019-9567, 05/2018, Volume 86, Issue 8
ABSTRACT Human innate immunity employs cellular and humoral mechanisms to facilitate rapid killing of invading bacteria. The direct killing of bacteria by... 
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14. Full Text Phospholipase A2s: Developing drug targets for atherosclerosis
by Suckling, Keith
Atherosclerosis, ISSN 0021-9150, 10/2010, Volume 212, Issue 2, pp. 357 - 366
The potential for phospholipases as targets for treating atherogenesis has become more prominent over the past year with the publication of the results of... 
Phospholipase | Secreted | Darapladib | Lipoprotein-associated | Atherosclerosis | Drug development | Varespladib | Atherosclerosis - drug therapy | Humans | Enzyme Inhibitors - pharmacology | Benzaldehydes - pharmacology | Phospholipases A2 - metabolism | Animals | Drug Design | Lipoproteins - metabolism | Biomarkers | Oximes - pharmacology | Cytosol - metabolism | Indoles - pharmacology | Acetates - pharmacology | Mice | Phospholipase A2 Inhibitors
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15. Full Text Subcellular localization and function study of a secreted phospholipase C from Nocardia seriolae
by Xia, Liqun and Liang, Haiying and Xu, Liang and Chen, Jianlin and Bekaert, Michäel and Zhang, Honglian and Lu, Yishan
FEMS Microbiology Letters, ISSN 0378-1097, 09/2017, Volume 364, Issue 17
Fish nocardiosis is a chronic systemic granulomatous disease, and Nocardia seriolae is the main pathogen that causes it. The pathogenesis and virulence factors... 
Nocardia seriolae | Secreted protein | Overexpression | Cell apoptosis | Subcellular localization | Phospholipase C | phospholipase C | APOPTOSIS | subcellular localization | MITOCHONDRIA | MICROBIOLOGY | PERFRINGENS ALPHA-TOXIN | DEATH | secreted protein | overexpression | INNATE IMMUNE-RESPONSES | cell apoptosis | FISH | PC12 CELLS | STRAIN | EXPRESSION | PATHOGENS | Mitochondria - enzymology | Type C Phospholipases - metabolism | Green Fluorescent Proteins - genetics | Nocardia - cytology | Phylogeny | Mitochondria - ultrastructure | Recombinant Fusion Proteins - metabolism | Nocardia - enzymology | Transfection | Cloning, Molecular | Epithelial Cells - cytology | Cell Line | Cytoplasm - enzymology | Gene Expression | Epithelial Cells - ultrastructure | Virulence Factors - chemistry | Type C Phospholipases - chemistry | Host-Pathogen Interactions | Animals | Escherichia coli - genetics | Epithelial Cells - microbiology | Nocardia - genetics | Type C Phospholipases - genetics | Virulence Factors - metabolism | Cyprinidae - microbiology | Microscopy, Fluorescence | Apoptosis
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16. Full Text Inhibitors of secreted phospholipase A2 suppress the release of PGE2 in renal mesangial cells
by Vasilakaki, Sofia and Barbayianni, Efrosini and Magrioti, Victoria and Pastukhov, Oleksandr and Constantinou-Kokotou, Violetta and Huwiler, Andrea and Kokotos, George
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2016, Volume 24, Issue 13, pp. 3029 - 3034
The upregulation of PGE by mesangial cells has been observed under chronic inflammation condition. In the present work, renal mesangial cells were stimulated... 
Mesangial cells | Prostaglandin E2 | Inhibitors | Phospholipase A2 | Secreted phospholipase A2 | Secreted phospholipase A | Prostaglandin E | Phospholipase A | Dinoprostone - metabolism | Animals | Models, Biological | Phospholipases A2, Secretory - antagonists & inhibitors | Cells, Cultured | Mesangial Cells - enzymology | Phospholipase A2 Inhibitors - chemistry | Rats | Molecular Structure | Mesangial Cells - drug effects | Phospholipase A2 Inhibitors - pharmacology
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17. Full Text Lipid droplets induced by secreted phospholipase A2 and unsaturated fatty acids protect breast cancer cells from nutrient and lipotoxic stress
by Jarc, Eva and Kump, Ana and Malavašič, Petra and Eichmann, Thomas O and Zimmermann, Robert and Petan, Toni
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 03/2018, Volume 1863, Issue 3, pp. 247 - 265
Cancer cells driven by the Ras oncogene scavenge unsaturated fatty acids (FAs) from their environment to counter nutrient stress. The human group X secreted... 
Unsaturated fatty acids | Adipose triglyceride lipase | Breast cancer | Lipotoxicity | Lipid droplets | Secreted phospholipase A2 | Secreted phospholipase A
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18. Full Text Group IIA-secreted phospholipase A 2 in human serum kills commensal but not clinical Enterococcus faecium isolates
by Paganelli, Fernanda L and Leavis, Helen L and He, Samantha and van Sorge, Nina M and Payré, Christine and Lambeau, Gérard and Willems, Rob J.L and Rooijakkers, Suzan H.M
Infection and Immunity, ISSN 0019-9567, 08/2018, Volume 86, Issue 8
Human innate immunity employs cellular and humoral mechanisms to facilitate rapid killing of invading bacteria. The direct killing of bacteria by human serum... 
Enterococcus faecium | Pathogens | Innate immune system | Commensals | Group IIA secreted phospholipase A2
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19. Full Text Lipid droplets induced by secreted phospholipase A(2) and unsaturated fatty acids protect breast cancer cells from nutrient and lipotoxic stress
by Jarc, E and Kump, A and Malavasic, P and Eichmann, TO and Zimmermann, R and Petan, T
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, ISSN 1388-1981, 03/2018, Volume 1863, Issue 3, pp. 247 - 265
Cancer cells driven by the Ras oncogene scavenge unsaturated fatty acids (FAs) from their environment to counter nutrient stress. The human group X secreted... 
GROUP-V | PPAR-ALPHA | GROUP-X | OXIDATIVE STRESS | GROUP-IIA | Lipid droplets | BIOCHEMISTRY & MOLECULAR BIOLOGY | Breast cancer | ENDOPLASMIC-RETICULUM STRESS | CHOLESTERYL ESTER ACCUMULATION | CELL BIOLOGY | Unsaturated fatty acids | Adipose triglyceride lipase | Secreted phospholipase A | BIOPHYSICS | LIPOLYSIS | GROWTH | Lipotoxicity
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20. Full Text Quantitative trait locus mapping in mice identifies phospholipase Pla2g12a as novel atherosclerosis modifier
by Nicolaou, Alexandros and Northoff, Bernd H and Sass, Kristina and Ernst, Jana and Kohlmaier, Alexander and Krohn, Knut and Wolfrum, Christian and Teupser, Daniel and Holdt, Lesca M
Atherosclerosis, ISSN 0021-9150, 10/2017, Volume 265, pp. 197 - 206
In a previous work, a female-specific atherosclerosis risk locus on chromosome (Chr) 3 was identified in an intercross of atherosclerosis-resistant FVB and... 
Vascular endothelial cells | Quantitative trait locus (QTL) mapping | Secreted phospholipases | Inbred mouse strains | Cell adhesion | BRACHIOCEPHALIC ARTERY | CARDIAC & CARDIOVASCULAR SYSTEMS | DEFICIENT MICE | GROUP-III | KNOCKOUT MICE | APOLIPOPROTEIN-E | INTEGRINS ALPHA-V-BETA-3 | AORTIC ROOT | BINDING-SITE | PERIPHERAL VASCULAR DISEASE | GROUP-XII | WIDE ASSOCIATION | Animals | Atherosclerosis - genetics | Female | Chromosome Mapping | Mice | Mice, Congenic | Quantitative Trait Loci | Phospholipases - genetics | Phospholipases | Low density lipoproteins | Atherosclerosis | Quantitative genetics | Analysis | Genes | Cells | Endothelium
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