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BBA - Molecular Cell Research, ISSN 0167-4889, 06/2008, Volume 1783, Issue 6, pp. 1129 - 1139
The molecular mechanism of the presynaptic toxicity of secreted phospholipase A (sPLA ) neurotoxins, including that of ammodytoxin A (AtxA), has not been... 
Cytosolic protein | Synaptic vesicle | Neurotoxicity | Motoneuron | Ammodytoxin | Secreted phospholipase A2 | Secreted phospholipase A | Index Medicus
Journal Article
JOURNAL OF NEUROINFLAMMATION, ISSN 1742-2094, 07/2012, Volume 9
Background: Activation of microglia, the primary component of the innate immune response in the brain, is a hallmark of neuroinflammation in neurodegenerative... 
ARACHIDONIC-ACID RELEASE | ALZHEIMERS-DISEASE | FOCAL CEREBRAL-ISCHEMIA | Secreted phospholipase A-IIA | HUMAN GROUP-IIA | Proliferation | NEUROSCIENCES | Epidermal growth factor receptor | NEURODEGENERATIVE DISEASES | Microglia | PATHOLOGICAL BRAIN | REACTIVE ASTROCYTES | CENTRAL-NERVOUS-SYSTEM | RAT-BRAIN | Phagocytosis | FACTOR HB-EGF
Journal Article
Journal Article
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, ISSN 1388-1981, 11/2006, Volume 1761, Issue 11, pp. 1289 - 1300
Secreted phospholipases A(2) (sPLA(2)s) are enzymes detected in serum and biological fluids of patients with various inflammatory, autoimmune and allergic... 
cytokine | OXIDE SYNTHASE EXPRESSION | ARACHIDONIC-ACID RELEASE | GROUP-V | BRONCHOALVEOLAR LAVAGE FLUID | chemokine | GROUP-X | signal transduction | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN LUNG MACROPHAGES | GROUP-II PHOSPHOLIPASE-A2 | RECEPTOR-MEDIATED ACTIVATION | secreted PLA | HUMAN T-CELLS | CELL BIOLOGY | BIOPHYSICS | inflammation | NF-KAPPA-B
Journal Article
Acta Chimica Slovenica, ISSN 1318-0207, 2011, Volume 58, Issue 4, pp. 678 - 688
Secreted phospholipases A2 (sPLA2s) constitute, physiologically and pathologically, a very important family of enzymes. Most actions of sPLA2s have been... 
Physiological function | Secreted phospholipase A | Receptor | Pathological effect
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2014, Volume 445, Issue 1, pp. 230 - 235
Secreted phospholipases A (sPLA s) have recently been associated with several cancers, but their role in breast cancer is unknown. Here we demonstrate that... 
DNA methylation | Epigenetics | Histone acetylation | Breast cancer | Lipid signalling | Secreted phospholipase A2 | Secreted phospholipase A
Journal Article
Analytical Biochemistry, ISSN 0003-2697, 04/2006, Volume 351, Issue 1, pp. 11 - 17
Journal Article
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 02/2014, Volume 445, Issue 1, pp. 230 - 235
Secreted phospholipases A(2) (sPLA(2)s) have recently been associated with several cancers, but their role in breast cancer is unknown. Here we demonstrate... 
PATHWAYS | TARGET | COLLECTION | EMERGING ROLES | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLA2G2A | Histone acetylation | Breast cancer | LINES | Secreted phospholipase A | BIOPHYSICS | ENZYMES | DNA methylation | Epigenetics | Lipid signalling
Journal Article
Journal of Neuroinflammation, ISSN 1742-2094, 07/2012, Volume 9, Issue 1, pp. 170 - 170
Journal Article
Biotechnology Letters, ISSN 0141-5492, 08/2009, Volume 31, Issue 9, pp. 1373 - 1380
Journal Article
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, ISSN 0167-4889, 06/2008, Volume 1783, Issue 6, pp. 1129 - 1139
The molecular mechanism of the presynaptic toxicity of secreted phospholipase A(2) (sPLA(2)) neurotoxins, including that of ammodytoxin A (AtxA), has not been... 
secreted phospholipase A | SYNAPTIC VESICLES | GROUP-X | CHROMAFFIN CELLS | BETA-BUNGAROTOXIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPINAL-CORD | ammodytoxin | synaptic vesicle | CELL BIOLOGY | neurotoxicity | cytosolic protein | motoneuron | GROUP-II | ENZYMATIC-ACTIVITY | VIPERA-AMMODYTES VENOM | N-TERMINAL REGION | RAT-BRAIN CORTEX
Journal Article
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 09/2009, Volume 124, Issue 3, pp. 558 - U240
Background: Secreted phospholipases A(2) (sPLA(2)s) are released in plasma and other biologic fluids of patients with inflammatory, autoimmune, and allergic... 
arachidonic acid | ARACHIDONIC-ACID RELEASE | M-TYPE RECEPTOR | GROUP-V | secreted phospholipase A | BRONCHOALVEOLAR LAVAGE FLUID | GROUP-X | HUMAN BASOPHILS | HUMAN NEUTROPHILS | GROUP-II SUBFAMILY | IMMUNOLOGY | Lung mast cells | HUMAN EOSINOPHILS | EICOSANOID GENERATION | ALLERGY | leukotriene C-4
Journal Article
Journal of Molecular Medicine, ISSN 0946-2716, 07/2009, Volume 87, Issue 7, pp. 723 - 733
Journal Article
JOURNAL OF NEUROINFLAMMATION, ISSN 1742-2094, 07/2012, Volume 9
Background: Secreted phospholipase A(2)-IIA (sPLA(2)-IIA) is an inducible enzyme released under several inflammatory conditions. It has been shown that... 
STAT1 | NITRIC-OXIDE SYNTHASE | FOCAL CEREBRAL-ISCHEMIA | Secreted phospholipase A-IIA | HUMAN GROUP-IIA | Permeability | KAPPA-B | NEUROSCIENCES | Inducible NO synthase | Brain microvascular endothelial cells | CORTICAL-NEURONS | INTERFERON-GAMMA | Nitric oxide | Lipopolysaccharide | IMMORTALIZED ASTROCYTES | GENE-EXPRESSION | SMOOTH-MUSCLE-CELLS | RAT-BRAIN | JAK3
Journal Article
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 10/2000, Volume 1488, Issue 1-2, pp. 71 - 82
There is a considerable body of evidence to support the antibacterial properties of the group IIa phospholipase A as an important physiological function. This... 
Antimicrobial | Membrane hydrolysis | Bactericidal /permeability-increasing protein | Gram-negative | Gram-positive | Group IIa secreted phospholipase A
Journal Article
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