Diabetologia, ISSN 0012-186X, 5/2011, Volume 54, Issue 5, pp. 1052 - 1056
By combining multiple genome-wide association (GWA) studies and comprehensive replication efforts, 12 novel type 2 diabetes associated loci have recently been...
Type 2 diabetes | Medicine & Public Health | Human Physiology | Genetic epidemiology | Metabolic Diseases | Association study | Internal Medicine | Beta cell function | TOLERANCE | ENDOCRINOLOGY & METABOLISM | SUSCEPTIBILITY LOCI | RESISTANCE | SENSITIVITY | BETA-CELL FUNCTION | KCNQ1 Potassium Channel - genetics | Hepatocyte Nuclear Factor 1-alpha - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Male | Diabetes Mellitus, Type 2 - metabolism | Molecular Epidemiology - methods | Diabetes Mellitus, Type 2 - epidemiology | Heat-Shock Proteins - genetics | Insulin-Secreting Cells - metabolism | Dual-Specificity Phosphatases - genetics | HMGA2 Protein - genetics | Cell Cycle Proteins - genetics | Adult | Female | Nuclear Proteins - genetics | Insulin Secretion | Genome-Wide Association Study | Glucose Tolerance Test | Genotype | Glucose - pharmacology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mitogen-Activated Protein Kinase Phosphatases - genetics | Carrier Proteins - genetics | Insulin - metabolism | Insulin-Secreting Cells - drug effects | Adaptor Proteins, Signal Transducing - genetics | Alleles | Sp Transcription Factors - genetics | GTPase-Activating Proteins - genetics | Pancreatic beta cells | Chromosomal proteins | Genomics | Insulin resistance | Universities and colleges | Glucose | Glucose tolerance tests | Insulin | Risk factors | Dextrose | Glucose metabolism | Resveratrol
Type 2 diabetes | Medicine & Public Health | Human Physiology | Genetic epidemiology | Metabolic Diseases | Association study | Internal Medicine | Beta cell function | TOLERANCE | ENDOCRINOLOGY & METABOLISM | SUSCEPTIBILITY LOCI | RESISTANCE | SENSITIVITY | BETA-CELL FUNCTION | KCNQ1 Potassium Channel - genetics | Hepatocyte Nuclear Factor 1-alpha - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Male | Diabetes Mellitus, Type 2 - metabolism | Molecular Epidemiology - methods | Diabetes Mellitus, Type 2 - epidemiology | Heat-Shock Proteins - genetics | Insulin-Secreting Cells - metabolism | Dual-Specificity Phosphatases - genetics | HMGA2 Protein - genetics | Cell Cycle Proteins - genetics | Adult | Female | Nuclear Proteins - genetics | Insulin Secretion | Genome-Wide Association Study | Glucose Tolerance Test | Genotype | Glucose - pharmacology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mitogen-Activated Protein Kinase Phosphatases - genetics | Carrier Proteins - genetics | Insulin - metabolism | Insulin-Secreting Cells - drug effects | Adaptor Proteins, Signal Transducing - genetics | Alleles | Sp Transcription Factors - genetics | GTPase-Activating Proteins - genetics | Pancreatic beta cells | Chromosomal proteins | Genomics | Insulin resistance | Universities and colleges | Glucose | Glucose tolerance tests | Insulin | Risk factors | Dextrose | Glucose metabolism | Resveratrol
Journal Article
Diabetologia, ISSN 0012-186X, 5/2011, Volume 54, Issue 5, pp. 1075 - 1086
The genetic engineering of pancreatic beta cells could be a powerful tool for examining the role of key genes in the cause and treatment of diabetes. Here we...
Beta cells | Medicine & Public Health | Human Physiology | Gene transfer | Metabolic Diseases | Internal Medicine | Diabetes | Gene therapy | Pancreas | Adeno-associated vectors | HEPATOCYTE GROWTH-FACTOR | TRANSDUCTION | DELIVERY | THERAPY | MASS | ENDOCRINOLOGY & METABOLISM | ISLET | MICE | EXPRESSION | EFFICIENT | VIRUS VECTORS | Genetic Engineering - methods | Immunohistochemistry | Dependovirus - genetics | Green Fluorescent Proteins - metabolism | Insulin-Secreting Cells - metabolism | Animals | Transduction, Genetic | Male | Green Fluorescent Proteins - genetics | Mice | Pancreas - metabolism | Genetic Vectors - genetics | Virus diseases | Pancreatic beta cells | Anopheles | Type 1 diabetes | Analysis | Genetically modified organisms | Genetic research | Genetic engineering | Genetic vectors | Genes | Cells
Beta cells | Medicine & Public Health | Human Physiology | Gene transfer | Metabolic Diseases | Internal Medicine | Diabetes | Gene therapy | Pancreas | Adeno-associated vectors | HEPATOCYTE GROWTH-FACTOR | TRANSDUCTION | DELIVERY | THERAPY | MASS | ENDOCRINOLOGY & METABOLISM | ISLET | MICE | EXPRESSION | EFFICIENT | VIRUS VECTORS | Genetic Engineering - methods | Immunohistochemistry | Dependovirus - genetics | Green Fluorescent Proteins - metabolism | Insulin-Secreting Cells - metabolism | Animals | Transduction, Genetic | Male | Green Fluorescent Proteins - genetics | Mice | Pancreas - metabolism | Genetic Vectors - genetics | Virus diseases | Pancreatic beta cells | Anopheles | Type 1 diabetes | Analysis | Genetically modified organisms | Genetic research | Genetic engineering | Genetic vectors | Genes | Cells
Journal Article
Biotechnology and Applied Biochemistry, ISSN 0885-4513, 05/2012, Volume 59, Issue 3, pp. 205 - 212
Pancreatic duodenum homeobox protein-1 (PDX1) is a master regulatory gene in pancreatic development. Reprogramming of mesenchymal stem cells (MSCs) is a...
PDX1 | Insulin-producing cells | Lentivirus | Mesenchymal stem cells | insulin-producing cells | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | BONE-MARROW | BETA-CELLS | PANCREAS | INSULIN-SECRETING CELLS | HUMAN UMBILICAL-CORD | DIFFERENTIATE | IN-VITRO | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | mesenchymal stem cells | GENE-THERAPY | VECTORS | lentivirus | Homeodomain Proteins - metabolism | Rats | Male | Diabetes Mellitus, Experimental - therapy | Genetic Vectors - genetics | Homeodomain Proteins - genetics | Cell Differentiation - genetics | Mesenchymal Stromal Cells - cytology | Animals | Islets of Langerhans - cytology | Fluorescent Antibody Technique | Polymerase Chain Reaction | Trans-Activators - genetics | Mesenchymal Stromal Cells - virology | Lentivirus - genetics | Trans-Activators - metabolism
PDX1 | Insulin-producing cells | Lentivirus | Mesenchymal stem cells | insulin-producing cells | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | BONE-MARROW | BETA-CELLS | PANCREAS | INSULIN-SECRETING CELLS | HUMAN UMBILICAL-CORD | DIFFERENTIATE | IN-VITRO | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | mesenchymal stem cells | GENE-THERAPY | VECTORS | lentivirus | Homeodomain Proteins - metabolism | Rats | Male | Diabetes Mellitus, Experimental - therapy | Genetic Vectors - genetics | Homeodomain Proteins - genetics | Cell Differentiation - genetics | Mesenchymal Stromal Cells - cytology | Animals | Islets of Langerhans - cytology | Fluorescent Antibody Technique | Polymerase Chain Reaction | Trans-Activators - genetics | Mesenchymal Stromal Cells - virology | Lentivirus - genetics | Trans-Activators - metabolism
Journal Article
24.
Full Text
The differentiation of alpha and beta cells in the pancreatic islets of the guinea pig
The Anatomical record, ISSN 0003-276X, 03/1946, Volume 94, p. 467
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Tabulae biologicae, 1948, Volume 19, Issue 3, p. 1
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The Journal of biological chemistry, ISSN 0021-9258, 02/1948, Volume 172, Issue 2, p. 857
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The Biological bulletin, ISSN 0006-3185, 10/1948, Volume 95, Issue 2, p. 239
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Proceedings of the Society for Experimental Biology and Medicine, ISSN 0037-9727, 2/1949, Volume 70, Issue 2, pp. 352 - 355
Summary The beta cells of the rat's pancreas can be completely degranulated within 15 minutes by a single intra-cardiac injection of glucose. Dosage: 3.0 g...
DIABETES MELLITUS/experimental | PANCREAS/pathology | GLUCOSE/effects | Pancreas - pathology | Rats | Glucose - pharmacology | Animals | Insulin-Secreting Cells | Diabetes Mellitus, Experimental
DIABETES MELLITUS/experimental | PANCREAS/pathology | GLUCOSE/effects | Pancreas - pathology | Rats | Glucose - pharmacology | Animals | Insulin-Secreting Cells | Diabetes Mellitus, Experimental
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29.
Effect of prolonged intravenous administration of dextrose on beta cells of islets of Langerhans
Archives of pathology, ISSN 0361-7017, 10/1949, Volume 48, Issue 4, pp. 297 - 304
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Klinische Wochenschrift, ISSN 0023-2173, 06/1950, Volume 28, Issue 23-24, p. 388
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31.
The insular alpha and beta cells as the source of the antagonistic principles glucagon and insulin
Mikroskopie, ISSN 0026-3702, 1951, Volume 6, Issue 1-2, p. 1
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Acta anatomica, ISSN 0001-5180, 1951, Volume 12, Issue 4, p. 358
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33.
Experimental destruction of alpha cells of the endocrine islets of the pancreas in the guinea pig
Comptes rendus des seances de la Societe de biologie et de ses filiales, ISSN 0037-9026, 06/1951, Volume 145, Issue 11-12, p. 933
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The Journal of Pathology and Bacteriology, ISSN 0368-3494, 07/1952, Volume 64, Issue 3, pp. 575 - 584
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Biotechnic & Histochemistry, ISSN 1052-0295, 1952, Volume 27, Issue 5, pp. 267 - 268
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Endocrinology, ISSN 0013-7227, 1952, Volume 50, Issue 1, pp. 140 - 142
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Annales d'endocrinologie, ISSN 0003-4266, 1952, Volume 13, Issue 2, p. 216
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Metabolism: clinical and experimental, ISSN 0026-0495, 11/1952, Volume 1, Issue 6, pp. 544 - 548
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Minerva medica, ISSN 0026-4806, 12/1952, Volume 43, Issue 102, p. 1403
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Proceedings of the Society for Experimental Biology and Medicine, ISSN 0037-9727, 3/1953, Volume 82, Issue 3, pp. 406 - 411
Summary The intravenous injection of cobalt chloride is accompained by a transent yperglycemic episode and causes rapid selective injury to the alpha cells of...
COBALT/effects | ISLANDS OF LANGERHANS/effect of drugs on | Glucagon-Secreting Cells | Islets of Langerhans - drug effects | Rabbits | Animals | Cobalt - pharmacology | Blood Glucose | Pharmaceutical Preparations | Lagomorpha | Islands
COBALT/effects | ISLANDS OF LANGERHANS/effect of drugs on | Glucagon-Secreting Cells | Islets of Langerhans - drug effects | Rabbits | Animals | Cobalt - pharmacology | Blood Glucose | Pharmaceutical Preparations | Lagomorpha | Islands
Journal Article
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