Cold Spring Harbor perspectives in medicine, ISSN 2157-1422, 11/2012, Volume 2, Issue 11, pp. a009597 - a009597
Our purpose here is not to address specific issues of mucus pathology, but to illustrate how polymer networks theory and its remarkable predictive power can be...
MOLECULAR-MECHANISM | HETEROGENEITY | MEDICINE, RESEARCH & EXPERIMENTAL | GOBLET CELLS | ELECTRON-MICROSCOPY | PORCINE STOMACH MUCIN | CYSTIC-FIBROSIS | RELEASE | PRIMARY CULTURES | SECRETORY GRANULES | BICARBONATE SECRETION | Gels | Humans | Molecular Conformation | Hydrophobic and Hydrophilic Interactions | Respiratory System | Polymers - chemistry | Mucins - chemistry | Mucus - chemistry | Kinetics | Mucus - physiology | Phase Transition | 070
MOLECULAR-MECHANISM | HETEROGENEITY | MEDICINE, RESEARCH & EXPERIMENTAL | GOBLET CELLS | ELECTRON-MICROSCOPY | PORCINE STOMACH MUCIN | CYSTIC-FIBROSIS | RELEASE | PRIMARY CULTURES | SECRETORY GRANULES | BICARBONATE SECRETION | Gels | Humans | Molecular Conformation | Hydrophobic and Hydrophilic Interactions | Respiratory System | Polymers - chemistry | Mucins - chemistry | Mucus - chemistry | Kinetics | Mucus - physiology | Phase Transition | 070
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5140 - 17
The exocyst is a conserved octameric complex that tethers exocytic vesicles to the plasma membrane prior to fusion. Exocyst assembly and delivery mechanisms...
COMPLEX | FLUORESCENCE MICROSCOPY | PROTEIN | EXOCYTOSIS | STRUCTURAL BASIS | 2 SUBUNITS | MULTIDISCIPLINARY SCIENCES | RHO | SPATIAL REGULATION | SECRETORY PATHWAY | SEC3P | Cell Line | Green Fluorescent Proteins - metabolism | Epithelial Cells - metabolism | Membrane Fusion | Vesicular Transport Proteins - metabolism | Humans | Vesicular Transport Proteins - genetics | Secretory Vesicles - metabolism | Multiprotein Complexes - genetics | Green Fluorescent Proteins - genetics | Exocytosis | Mammary Glands, Animal - cytology | Protein Transport | Microscopy, Confocal | Multiprotein Complexes - metabolism | Algorithms | Animals | Models, Biological | HEK293 Cells | Female | Mice | Spectroscopy | Membrane fusion | Epithelial cells | Membrane vesicles | Tethering | Mammals | Monomers | Mammalian cells | Vesicles | Tethers | Mammary gland | Dismantling | Assembly | Genetic modification
COMPLEX | FLUORESCENCE MICROSCOPY | PROTEIN | EXOCYTOSIS | STRUCTURAL BASIS | 2 SUBUNITS | MULTIDISCIPLINARY SCIENCES | RHO | SPATIAL REGULATION | SECRETORY PATHWAY | SEC3P | Cell Line | Green Fluorescent Proteins - metabolism | Epithelial Cells - metabolism | Membrane Fusion | Vesicular Transport Proteins - metabolism | Humans | Vesicular Transport Proteins - genetics | Secretory Vesicles - metabolism | Multiprotein Complexes - genetics | Green Fluorescent Proteins - genetics | Exocytosis | Mammary Glands, Animal - cytology | Protein Transport | Microscopy, Confocal | Multiprotein Complexes - metabolism | Algorithms | Animals | Models, Biological | HEK293 Cells | Female | Mice | Spectroscopy | Membrane fusion | Epithelial cells | Membrane vesicles | Tethering | Mammals | Monomers | Mammalian cells | Vesicles | Tethers | Mammary gland | Dismantling | Assembly | Genetic modification
Journal Article
Diabetologia, ISSN 0012-186X, 8/2003, Volume 46, Issue 8, pp. 1029 - 1045
Glucose-induced insulin secretion in response to a step increase in blood glucose concentrations follows a biphasic time course consisting of a rapid and...
Medicine | secretory granules | insulin | confocal microscopy | Pancreatic islets | exocytosis | diabetes | Confocal microscopy | Diabetes | Exocytosis | Secretory granules | Insulin | EVANESCENT-WAVE MICROSCOPY | CHROMAFFIN CELLS | PERFUSED RAT PANCREAS | SENSITIVE K+ CHANNELS | CA2+ CHANNELS | B-CELLS | GREEN FLUORESCENT PROTEIN | ENDOCRINOLOGY & METABOLISM | ELECTRICAL-ACTIVITY | VESICULAR EXOCYTOTIC EVENTS | pancreatic islets | Islets of Langerhans - pathology | Humans | Cytoplasmic Granules - physiology | Endocytosis | Insulin - metabolism | Animals | Cytoplasmic Granules - ultrastructure | Diabetes Mellitus - physiopathology | Islets of Langerhans - metabolism | Models, Biological | Islets of Langerhans - ultrastructure | Insulin Secretion | Type 2 diabetes | Proteins | Glucose metabolism | Pancreatic beta cells | Blood sugar | Physiological aspects | Fluorescence | Clinical Medicine | Endokrinologi och diabetes | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Endocrinology and Diabetes
Medicine | secretory granules | insulin | confocal microscopy | Pancreatic islets | exocytosis | diabetes | Confocal microscopy | Diabetes | Exocytosis | Secretory granules | Insulin | EVANESCENT-WAVE MICROSCOPY | CHROMAFFIN CELLS | PERFUSED RAT PANCREAS | SENSITIVE K+ CHANNELS | CA2+ CHANNELS | B-CELLS | GREEN FLUORESCENT PROTEIN | ENDOCRINOLOGY & METABOLISM | ELECTRICAL-ACTIVITY | VESICULAR EXOCYTOTIC EVENTS | pancreatic islets | Islets of Langerhans - pathology | Humans | Cytoplasmic Granules - physiology | Endocytosis | Insulin - metabolism | Animals | Cytoplasmic Granules - ultrastructure | Diabetes Mellitus - physiopathology | Islets of Langerhans - metabolism | Models, Biological | Islets of Langerhans - ultrastructure | Insulin Secretion | Type 2 diabetes | Proteins | Glucose metabolism | Pancreatic beta cells | Blood sugar | Physiological aspects | Fluorescence | Clinical Medicine | Endokrinologi och diabetes | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Endocrinology and Diabetes
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 9, p. e74261
We introduce the software package ReaDDy for simulation of detailed spatiotemporal mechanisms of dynamical processes in the cell, based on reaction-diffusion...
SPACE | MOLECULAR-DYNAMICS | MEMBRANE | MULTIDISCIPLINARY SCIENCES | BIOLOGY | RHODOPSIN | SIMULATIONS | ALGORITHMS | MICROSCOPY | BROWNIAN DYNAMICS | SECRETORY GRANULES | Synaptic Vesicles - metabolism | Calcium Channels - metabolism | Humans | Retinal Rod Photoreceptor Cells - metabolism | Retinal Rod Photoreceptor Cells - chemistry | Molecular Dynamics Simulation | Particle Size | SNARE Proteins - chemistry | Algorithms | Models, Biological | Vision, Ocular | Calcium Channels - chemistry | Synaptic Vesicles - chemistry | Software | Kinetics | Diffusion | SNARE Proteins - metabolism | Chemical reaction, Rate of | Molecular dynamics | Membranes | Modular design | Computer simulation | Biology | Computer programs | Brownian motion | Geometry | Proteins | Signal transduction | Chemistry | Microprocessors | Microscopy | E coli | Chain dynamics | Reaction kinetics | Biomolecules | Trends | Localization
SPACE | MOLECULAR-DYNAMICS | MEMBRANE | MULTIDISCIPLINARY SCIENCES | BIOLOGY | RHODOPSIN | SIMULATIONS | ALGORITHMS | MICROSCOPY | BROWNIAN DYNAMICS | SECRETORY GRANULES | Synaptic Vesicles - metabolism | Calcium Channels - metabolism | Humans | Retinal Rod Photoreceptor Cells - metabolism | Retinal Rod Photoreceptor Cells - chemistry | Molecular Dynamics Simulation | Particle Size | SNARE Proteins - chemistry | Algorithms | Models, Biological | Vision, Ocular | Calcium Channels - chemistry | Synaptic Vesicles - chemistry | Software | Kinetics | Diffusion | SNARE Proteins - metabolism | Chemical reaction, Rate of | Molecular dynamics | Membranes | Modular design | Computer simulation | Biology | Computer programs | Brownian motion | Geometry | Proteins | Signal transduction | Chemistry | Microprocessors | Microscopy | E coli | Chain dynamics | Reaction kinetics | Biomolecules | Trends | Localization
Journal Article
PLoS Pathogens, ISSN 1553-7366, 01/2012, Volume 8, Issue 1, p. e1002466
The current model of hepatitis C virus (HCV) production involves the assembly of virions on or near the surface of lipid droplets, envelopment at the ER in...
NONSTRUCTURAL PROTEIN 5A | MICROBIOLOGY | CORE PROTEIN | APOLIPOPROTEIN-E | IN-VITRO | LOW-DENSITY LIPOPROTEINS | VIROLOGY | INFECTIOUS VIRUS | RECYCLING ENDOSOME | CELL-CULTURE | ENDOPLASMIC-RETICULUM | REPLICATION COMPLEX | PARASITOLOGY | Cell Line | Apolipoproteins E - secretion | Endoplasmic Reticulum - genetics | Humans | Secretory Vesicles - metabolism | Endoplasmic Reticulum - metabolism | Endoplasmic Reticulum - virology | Virus Assembly - physiology | Biological Transport, Active - genetics | Golgi Apparatus - virology | Secretory Vesicles - virology | Secretory Vesicles - genetics | Apolipoproteins E - genetics | Virus Release - physiology | Golgi Apparatus - metabolism | Hepacivirus - physiology | Vesicle-Associated Membrane Protein 1 - genetics | Vesicle-Associated Membrane Protein 1 - metabolism | Golgi Apparatus - genetics | Physiological aspects | Hepatitis C virus | Genetic aspects | Proteins | Medical research | Hepatitis | Cell culture | Microscopy | Colleges & universities | Lipids | Apolipoproteins | Cancer
NONSTRUCTURAL PROTEIN 5A | MICROBIOLOGY | CORE PROTEIN | APOLIPOPROTEIN-E | IN-VITRO | LOW-DENSITY LIPOPROTEINS | VIROLOGY | INFECTIOUS VIRUS | RECYCLING ENDOSOME | CELL-CULTURE | ENDOPLASMIC-RETICULUM | REPLICATION COMPLEX | PARASITOLOGY | Cell Line | Apolipoproteins E - secretion | Endoplasmic Reticulum - genetics | Humans | Secretory Vesicles - metabolism | Endoplasmic Reticulum - metabolism | Endoplasmic Reticulum - virology | Virus Assembly - physiology | Biological Transport, Active - genetics | Golgi Apparatus - virology | Secretory Vesicles - virology | Secretory Vesicles - genetics | Apolipoproteins E - genetics | Virus Release - physiology | Golgi Apparatus - metabolism | Hepacivirus - physiology | Vesicle-Associated Membrane Protein 1 - genetics | Vesicle-Associated Membrane Protein 1 - metabolism | Golgi Apparatus - genetics | Physiological aspects | Hepatitis C virus | Genetic aspects | Proteins | Medical research | Hepatitis | Cell culture | Microscopy | Colleges & universities | Lipids | Apolipoproteins | Cancer
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2011, Volume 121, Issue 6, pp. 2118 - 2125
Insulin secretion is a highly dynamic process regulated by various factors including nutrients, hormones, and neuronal inputs. The dynamics of insulin...
MEDICINE, RESEARCH & EXPERIMENTAL | INTRAVENOUS GLUCOSE | CYCLIC-AMP | GRANULE EXOCYTOSIS | GLUCAGON-LIKE PEPTIDE-1 | MINIMAL-MODEL ANALYSIS | IN-VIVO | PANCREATIC BETA-CELLS | IMPAIRED GLUCOSE-TOLERANCE | PLASMA-GLUCOSE | GASTRIC-INHIBITORY POLYPEPTIDE | Guanine Nucleotide Exchange Factors - physiology | Obesity - drug therapy | Humans | Potassium Channels - physiology | Glucose Metabolism Disorders - physiopathology | Eating - physiology | Cyclic AMP - physiology | Insulin Resistance - physiology | Islets of Langerhans - metabolism | Cytoplasmic Granules - metabolism | Secretory Rate | Insulin Secretion | Incretins - physiology | Hypoglycemic Agents - therapeutic use | Diabetes Mellitus - drug therapy | Obesity - physiopathology | Circadian Rhythm - physiology | Potassium Channels - drug effects | Guanine Nucleotide Exchange Factors - agonists | Hypoglycemic Agents - pharmacology | Insulin - metabolism | Animals | Signal Transduction - drug effects | Diabetes Mellitus - physiopathology | Models, Biological | Signal Transduction - physiology | Obesity | Glucose metabolism | Pancreatic beta cells | Diabetes | Glucose | Insulin | Dextrose | Review
MEDICINE, RESEARCH & EXPERIMENTAL | INTRAVENOUS GLUCOSE | CYCLIC-AMP | GRANULE EXOCYTOSIS | GLUCAGON-LIKE PEPTIDE-1 | MINIMAL-MODEL ANALYSIS | IN-VIVO | PANCREATIC BETA-CELLS | IMPAIRED GLUCOSE-TOLERANCE | PLASMA-GLUCOSE | GASTRIC-INHIBITORY POLYPEPTIDE | Guanine Nucleotide Exchange Factors - physiology | Obesity - drug therapy | Humans | Potassium Channels - physiology | Glucose Metabolism Disorders - physiopathology | Eating - physiology | Cyclic AMP - physiology | Insulin Resistance - physiology | Islets of Langerhans - metabolism | Cytoplasmic Granules - metabolism | Secretory Rate | Insulin Secretion | Incretins - physiology | Hypoglycemic Agents - therapeutic use | Diabetes Mellitus - drug therapy | Obesity - physiopathology | Circadian Rhythm - physiology | Potassium Channels - drug effects | Guanine Nucleotide Exchange Factors - agonists | Hypoglycemic Agents - pharmacology | Insulin - metabolism | Animals | Signal Transduction - drug effects | Diabetes Mellitus - physiopathology | Models, Biological | Signal Transduction - physiology | Obesity | Glucose metabolism | Pancreatic beta cells | Diabetes | Glucose | Insulin | Dextrose | Review
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Biological Reviews, ISSN 1464-7931, 02/2017, Volume 92, Issue 1, pp. 60 - 107
ABSTRACT In ciliates, unicellular representatives of the bikont branch of evolution, inter‐ and intracellular signalling pathways have been analysed mainly in...
Euplotes | Tetrahymena | ciliates | Paramecium | transport | protozoa | signalling | traffic | PARAMECIUM-TETRAURELIA CELLS | HETEROTRIMERIC G-PROTEINS | CORTICAL CALCIUM STORES | DEPENDENT PROTEIN-KINASE | SECRETORY GRANULE BIOGENESIS | IN-VITRO PHOSPHORYLATION | EXOCYTOSIS-SENSITIVE PHOSPHOPROTEIN | CONTRACTILE VACUOLE COMPLEX | BIOLOGY | BASAL BODY DUPLICATION | PROGRAMMED NUCLEAR DEATH | Signal Transduction | Ciliophora - physiology | Cell Membrane - metabolism | Proteins | Eukaryotes | Evolutionary biology | Cellular biology
Euplotes | Tetrahymena | ciliates | Paramecium | transport | protozoa | signalling | traffic | PARAMECIUM-TETRAURELIA CELLS | HETEROTRIMERIC G-PROTEINS | CORTICAL CALCIUM STORES | DEPENDENT PROTEIN-KINASE | SECRETORY GRANULE BIOGENESIS | IN-VITRO PHOSPHORYLATION | EXOCYTOSIS-SENSITIVE PHOSPHOPROTEIN | CONTRACTILE VACUOLE COMPLEX | BIOLOGY | BASAL BODY DUPLICATION | PROGRAMMED NUCLEAR DEATH | Signal Transduction | Ciliophora - physiology | Cell Membrane - metabolism | Proteins | Eukaryotes | Evolutionary biology | Cellular biology
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, p. e0178288
Tau protein can be released by neurons, an event linked to the propagation of Tau pathology in Alzheimer'disease (AD). Neuronal hyperexcitability was shown to...
NEURONAL-ACTIVITY | ALZHEIMERS-DISEASE BRAIN | BETA PRODUCTION | AMYLOID-BETA | MULTIDISCIPLINARY SCIENCES | PAIRED HELICAL FILAMENTS | HIPPOCAMPAL HYPERACTIVITY | PURINE ANALOGS | CEREBROSPINAL-FLUID | CYCLIN-DEPENDENT KINASE-5 | TRANSGENIC MICE | Animals | Humans | Cells, Cultured | Rats | tau Proteins - metabolism | Golgi Apparatus - metabolism | Male | HeLa Cells | Cerebral Cortex - cytology | Rats, Sprague-Dawley | Cerebral Cortex - metabolism | Cyclin-Dependent Kinase 5 - metabolism | Physiological aspects | Development and progression | Genetic aspects | Research | Alzheimer's disease | Tau proteins | Brain | Membranes | Neurosciences | Kinases | Inactivation | Cyclin-dependent kinase 5 | Fragmentation | Proteins | Neurodegeneration | Dynamics | Transgenic animals | Rodents | Cell cycle | Physiology | Deactivation | Neurodegenerative diseases | Neurons | Secretion | Cyclin-dependent kinases | Golgi apparatus | Pathology | Hospitals | Tau protein | Guanosinetriphosphatase
NEURONAL-ACTIVITY | ALZHEIMERS-DISEASE BRAIN | BETA PRODUCTION | AMYLOID-BETA | MULTIDISCIPLINARY SCIENCES | PAIRED HELICAL FILAMENTS | HIPPOCAMPAL HYPERACTIVITY | PURINE ANALOGS | CEREBROSPINAL-FLUID | CYCLIN-DEPENDENT KINASE-5 | TRANSGENIC MICE | Animals | Humans | Cells, Cultured | Rats | tau Proteins - metabolism | Golgi Apparatus - metabolism | Male | HeLa Cells | Cerebral Cortex - cytology | Rats, Sprague-Dawley | Cerebral Cortex - metabolism | Cyclin-Dependent Kinase 5 - metabolism | Physiological aspects | Development and progression | Genetic aspects | Research | Alzheimer's disease | Tau proteins | Brain | Membranes | Neurosciences | Kinases | Inactivation | Cyclin-dependent kinase 5 | Fragmentation | Proteins | Neurodegeneration | Dynamics | Transgenic animals | Rodents | Cell cycle | Physiology | Deactivation | Neurodegenerative diseases | Neurons | Secretion | Cyclin-dependent kinases | Golgi apparatus | Pathology | Hospitals | Tau protein | Guanosinetriphosphatase
Journal Article
Trends in Plant Science, ISSN 1360-1385, 08/2015, Volume 20, Issue 8, pp. 515 - 524
Seeds from various angiosperm species produce polysaccharide mucilage facilitating germination and, therefore, conferring major evolutionary advantages. The...
polysaccharides | cell wall dynamics | co-expression networks | pectins | Arabidopsis | seed mucilage secretory cells | Polysaccharides | Seed mucilage secretory cells | Co-expression networks | Cell wall dynamics | Pectins | ENCODES | CELLULOSE SYNTHESIS | GENETIC-ANALYSIS | THALIANA | WALL POLYSACCHARIDES | LEUNIG-HOMOLOG | COAT MUCILAGE | TRANSCRIPTION FACTOR | ADHERENT MUCILAGE | IN-SITU | PLANT SCIENCES | Arabidopsis Proteins - metabolism | Arabidopsis - cytology | Cell Wall - metabolism | Gene Expression Regulation, Plant | Arabidopsis - metabolism | Polysaccharides - metabolism | Arabidopsis thaliana
polysaccharides | cell wall dynamics | co-expression networks | pectins | Arabidopsis | seed mucilage secretory cells | Polysaccharides | Seed mucilage secretory cells | Co-expression networks | Cell wall dynamics | Pectins | ENCODES | CELLULOSE SYNTHESIS | GENETIC-ANALYSIS | THALIANA | WALL POLYSACCHARIDES | LEUNIG-HOMOLOG | COAT MUCILAGE | TRANSCRIPTION FACTOR | ADHERENT MUCILAGE | IN-SITU | PLANT SCIENCES | Arabidopsis Proteins - metabolism | Arabidopsis - cytology | Cell Wall - metabolism | Gene Expression Regulation, Plant | Arabidopsis - metabolism | Polysaccharides - metabolism | Arabidopsis thaliana
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